Impacts of age, diabetes, gender, and access type on costs associated with vascular access among Chinese patients on hemodialysis

2020 ◽  
pp. 039139882096211
Author(s):  
Yuqin Xiong ◽  
Yang Yu ◽  
Yuan Yang ◽  
Liya Wang ◽  
Ping Shi ◽  
...  
Keyword(s):  
Vascular Access ◽  
Venous Catheter ◽  
Cost Effective ◽  
Chinese Patients ◽  
Chi Square ◽  
West China Hospital ◽  
Tertiary Hospitals ◽  
Materials Used ◽  
Gender Groups

Objectives: Examine the impacts of age, diabetes, gender, and access type on vascular access (VA) associated costs among Chinese hemodialysis (HD) patients. Methods: We retrospectively included patients whose first permanent VA was created at the West China Hospital. Clinical characteristics, maturation, intervention, utilization, and exchange of every VA, as well as VA-related infection were collected. The study period for each patient was from HD initiation to the last follow-up. VA-related costs, including those for placement and intervention procedures, were calculated according to the standards set in 2019 for Chinese tertiary hospitals. Mann-Whitney U and Chi-square tests were conducted for comparisons between groups. Results: A total of 358 Chinese HD patients experienced functionally 143 arteriovenous fistula (AVF), 22 arteriovenous graft (AVG), and 439 tunneled cuffed central venous catheter (tcCVC) during a median study period of 26 (IQR 13–44) months, of which 42.5% used more than one permanent VA. The median annual VA-related cost in the groups of age >75 years and ⩽75 years, diabetes and non-diabetes, male and female, was $525 and $397 ( p = 0.016), $459 and $462 ( p = 0.64), $476 and $445 ( p = 0.94), respectively. The median monthly costs for AVF ($18), AVG ($289), and tcCVC ($37) were significantly different. Conclusion: HD patients aged >75 years had significantly higher annual VA-related costs. However, the annual VA-related costs did not differ across the diabetes groups or the gender groups. AVF was the most cost-effective permanent VA type in China, partly due to the inexpensive materials used compared to AVG or tcCVC.

Vascular Access Type Was Not Associated with Mortality and the Predictors for Cardiovascular Death in Elderly Chinese Patients on Hemodialysis

2019 ◽  
Vol 49 (1-2) ◽  
pp. 63-70
Author(s):  
Yang Yu ◽  
Yuqin Xiong ◽  
Chunle Zhang ◽  
Martina Fu ◽  
Yi Li ◽  
...  
Keyword(s):  
Vascular Access ◽  
Venous Catheter ◽  
Multivariate Regression Analysis ◽  
Cardiovascular Death ◽  
Chinese Patients ◽  
West China Hospital ◽  
Kaplan Meier ◽  
Elderly Chinese ◽  
The Impact

Objectives: Current studies suggest arteriovenous fistula (AVF) and arteriovenous graft as superior vascular access (VA) types for elderly hemodialysis (HD) patients due to better outcomes. This study aimed to examine the impact of VA type on cardiovascular and all-cause mortality as well as the predictors for outcome in elderly Chinese patients. Methods: Patients who initiated HD aged ≥70 years and received a primary VA creation at the West China Hospital were enrolled in this retrospective study. Clinical characteristics, maturation, utilization, conversion of VA, and outcomes were collected. The observational period for each patient was from the point of the first permanent VA creation to the last time of follow-up. Kaplan-Meier and multivariate regression analysis were employed. Results:A total of 358 elderly Chinese HD patients with a median age of 74 (72–78) years were analyzed. During the study period of 25.8 (12–43) months, 54 (15.1%) and 113 patients (15.1%) died of cardiovascular events and all-cause, respectively. With regard to VA type, the modality of AVF, tunneled cuffed central venous catheter (tcCVC), or AVF and tcCVC was not associated with mortality. Furthermore, diastolic blood pressure (DBP) and congestive heart failure (CHF) were the independent predictors for cardiovascular mortality. Conclusions: The modality of VA types showed an insignificant effect on mortality in elderly Chinese population, while preoperative DBP and the presence of CHF might be used for the risk assessment of cardiovascular death. Disparities among nations in the areas of VA and HD necessitate additional studies.

P1325VASCULAR ACCESS OUTCOMES IN A FRAIL HAEMODIALYSIS POPULATION

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Alice Radley ◽  
Wan Wong ◽  
Tara Collidge ◽  
Peter Thomson
Keyword(s):  
Vascular Access ◽  
Demographic Data ◽  
Venous Catheter ◽  
Blood Cultures ◽  
Dialysis Access ◽  
Local Data ◽  
Clinical Frailty Scale ◽  
Significant Difference ◽  
Bed Days

Abstract Background and Aims Current guidelines recommend the pursuit of arteriovenous (AV) access over central venous catheter (CVC) access in haemodialysis (HD) populations. The limitations of this approach are increasingly recognised, and are particularly relevant when considering frail patients with relatively high levels of comorbidity and limited life expectancy. In such patients AV access may incur more invasive procedures, whereas CVC access may incur heightened risks of infection. This study aimed to evaluate the association between HD access modality and access complications, hospitalisation and mortality in a cohort of HD patients with frailty. Method We performed a retrospective analysis of prospectively recorded data from the Strathclyde Electronic Renal Patient Record concerning HD patients from 01/10/2017 to 21/09/2019. HD patients with a Rockwood clinical frailty scale (CFS) ≥6 were identified with baseline demographic data being recorded from date of first CFS ≥6 to census date 21/09/19 or death. We recorded the first vascular access modality at study inception and the modality at the time of census or death. Episodes of TCVC associated sepsis were determined using both clinical diagnosis in patient case records and positive blood cultures. Episodes were regarded as separate where positive blood cultures occurred ≥14 days apart. An inpatient admission was regarded as a discharge date ≥24 hours following admission. These were then further categorised as unscheduled or elective. Results 139 patients were identified with CFS ≥6. Median age was 72 years and 51% were female. Median follow-up was 1.1 years with total 50861 observed HD days. 52.3% patients were deceased at census. Table 1 illustrates vascular access modality at initial CFS. CVC accounted for the greatest proportion of dialysis access days (50.3%) compared to AVF (40.7%) and AVG (8.9 %). There was no significant difference in mortality between vascular access modalities over the follow-up period (50.7% CVC; 55% AVF; 54.5% AVG, p=0.18). In total, 5244 HD exposed days (10.3%) were spent as an inpatient during follow-up, of which 5120 (98%) were unscheduled and 119 (2%) were elective. The AVG group had the highest rate of inpatient bed days (138/1000 HD days) when compared to CVC (107/1000 HD days) and AVF (94/1000 HD days). Both AVG and CVC were associated with more inpatient bed days than AVF (p<0.0001 for each). Patients who started with CVC and transitioned to AV access had a rate of 86/1000 HD days. This was significantly lower than those who remained CVC throughout (p=0.0001). There were 24 recorded events of CVC associated sepsis during follow-up, occurring at a rate of 0.8 per 1000 HD days. Rates of CVC associated sepsis were similar between CFS 6 (0.6 per 1000 HD days) and CFS 7 (1.1 per 1000 HD days), p=0.21. The CVC associated staphylococcus aureus bacteraemia (SAB) rate for the overall population was 0.2 per 1000 HD days. AVG sepsis occurred at a rate of 0.2 per 1000 HD days and there were no incidences of AVF sepsis in those who continued with AVF throughout the follow-up period. Conclusion CVC was the most prevalent access modality in this frail HD population. Rates of CVC associated sepsis and SAB were similar to published bloodstream infection rates and existing local data (Murray et al QJM 2014). Although absolute events were low, increasing frailty from CFS 6 “moderately frail” to CFS 7 “severely frail” did not appear to influence rate of CVC associated sepsis. Patients with CVC and AVG had greater inpatient bed days than those with AVF. Transitioning from CVC to AV access reduced inpatient bed days. However, the choice of vascular access modality did not influence mortality overall.

scholarly journals Aspiration sclerotherapy: a novel and cost-effective approach to the management of hydroceles in a developing country

2017 ◽  
Vol 4 (12) ◽  
pp. 3884
Author(s):  
Arijit Roy ◽  
Vijay Jain ◽  
Jahar Majumdar
Keyword(s):  
Success Rate ◽  
Indirect Costs ◽  
Cost Effective ◽  
Prophylactic Antibiotics ◽  
Chi Square ◽  
Cost Effective Approach ◽  
High Satisfaction ◽  
Chi Square Test ◽  
A Prospective Study

Background: The present study was carried out with an aim to perform a prospective study to establish the role of sodium tetradecyl sulfate (3 %) (STDS) as a safe and effective sclerosant in the management of primary hydroceles.Methods: Sclerotherapy was performed with 3 % STDS on an outdoor basis. The amount of sclerosant injected depended on the amount of fluid drained. All patients were given prophylactic antibiotics. Patients were clinically reassessed at 1 week, 1 month, 3 months, and 6 months and earlier if complications occurred. All patients were given prophylactic antibiotics.  The data were analyzed using Statistical Package for Social Sciences Version 15.0. The data have been represented as frequencies and percentages. Chi-square test was used to compare the data. A total of 57 patients with primary vaginal hydrocele gave consent for being enrolled in the study. The age of patients ranged from 18 to 65 years with a mean age of 35.72±13.18 years.Results: The success rate at the end of the study was observed to be 84.2 %. As regards patient satisfaction, in present study, in a limited time period of follow up, all the patients who had a successful procedure were satisfied.Conclusion: Overall, sclerotherapy was observed to be a relatively cost-effective (including both direct and indirect costs) procedure with low complications, high satisfaction, faster return to work and a high success rate within the limited period of follow-up.

scholarly journals Treatment outcome of the retreatment tuberculosis patients under RNTCP in eastern Uttar Pradesh

2017 ◽  
Vol 4 (8) ◽  
pp. 2701
Author(s):  
Praveen B. Gautam ◽  
Ashwini Kumar Mishra ◽  
Santosh Kumar
Keyword(s):  
Treatment Outcome ◽  
Statistical Significance ◽  
Uttar Pradesh ◽  
Cost Effective ◽  
Control Programme ◽  
Chi Square ◽  
Loss To Follow Up ◽  
Tuberculosis Patients ◽  
Chi Square Test

Background: India has the highest tuberculosis (TB) burden in the world. The directly observed treatment strategy is the most systemic and cost-effective approach to the disease. Furthermore, understanding the reasons for treatment outcome is important for the improvement of treatment systems. The objective was to study the treatment outcome of retreatment tuberculosis patients under RNTCP in eastern UP.Methods: A longitudinal cohort study was undertaken among total 205 patients registered in category II under DOTS from June 2015 to May 2016. These patients were followed up to November 2016 till the completion of treatment. At the end of study period, treatment outcomes were analysed. The chi-square test was used to assess the statistical significance of each ratio. P<0.05 was considered significant.Results: Out of 205 re-treatment patients, 174 (84.4%) had pulmonary tuberculosis while 31 (15.1%) had extra-pulmonary TB. In the cohort of category II patients 93 (45.3%) were relapse, 58 (28.2%) belonged to others category, 31 (15.1%) were treatment after loss to follow-up and 23 (11.2%) were on treatment after failure. Maximum patients were male 133 (64.8%) and most of the patients were belonged to the age group of 20-40 years. Among retreatment cases the cure rate for relapse, treatment after failure, treatment after loss to follow-up and others cases were 74.1%, 60.8%, 35.4% and 55.1% respectively.Conclusions: The relapse cases were the most commonly found in the re-treatment category however these patients were more likely to be cured with the category II regimen and treatment after loss to follow-up had high risk of retreatment failure. Continuous monitoring, adherence and treatment completion are essential for controlling the need of retreatment as well as improvement of tuberculosis control programme. 

scholarly journals Hemodialysis vascular access in children – A retrospective study in a pediatric dialysis unit

2021 ◽  
Vol 35 (3) ◽  
Author(s):  
Gabriela Teixeira ◽  
◽  
Paulo Almeida ◽  
Norton Matos ◽  
Maria Faria ◽  
...  
Keyword(s):  
Central Venous Catheter ◽  
Vascular Access ◽  
Failure Time ◽  
Venous Catheter ◽  
Maintenance Hemodialysis ◽  
Secondary Patency ◽  
Central Venous ◽  
Dialysis Unit

Objective: Permanent access in the form of a fistula is the preferred form of vascular access for most pediatric patients on maintenance hemodialysis (HD) therapy; however, the technical aspects of the procedure that are unique to the pediatric population, the expectation of a short waiting time for kidney transplantation and the need to cannulate every other day (with the pain and fear associated with it) limit its use. Our objective was to analyze the long-term outcomes of pediatric arteriovenous fistulas in our institution. Methods: A retrospective review was performed of all arteriovenous fistula (AVF) created in a HD population aged 0 to 18 years at a single institution from 2007 to 2019. Data abstracted included age, weight, etiology of renal failure, time on dialysis, central venous catheter history and transplantation history. Data were analyzed to determine the primary and secondary patency. Results: During the study period, 19 AVFs were performed in 16 patients, of whom 9 patients (56.3%) were male. Mean patient age was 12.3 years (range 5-17 years), and mean weight was 38.3kg (range 12-83kg). At the time of AVF creation, 9 patients were on dialysis and 7 patients had a central venous catheter (CVC), with a median length of CVC dependence of 10 months. Procedures performed included 4 radiocephalic fistulas, 11 brachiocephalic fistulas and 4 brachiobasilic. Five accesses failed to mature (26.3%). Mean follow-up was 6 years. The 2-year primary and secondary patency rates were 92.3% and 100%, respectively. The 4-year primary and secondary patency rates were 76.9% and 100%, respectively. No thrombosis was documented during follow-up. During the postoperative period, 10 patients (62.5%) received a kidney transplant, in a mean time of 23 months. Conclusions: AVFs demonstrate excellent long-term patency in pediatric HD patients. No significant complications were reported and no thrombosis occurred.

scholarly journals Study protocol for a multicentre, randomised, controlled trial to assess the effectiveness of antimicrobial central venous catheters versus ordinary central venous catheters at reducing catheter related infections in critically ill Chinese patients

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e016564 ◽  
Author(s):  
Minming Wu ◽  
Yao Chen ◽  
Bin Du ◽  
Yan Kang
Keyword(s):  
Controlled Trial ◽  
Venous Catheter ◽  
Central Venous Catheters ◽  
Chinese Patients ◽  
Central Venous ◽  
West China Hospital ◽  
All Cause Mortality ◽  
Registration Number ◽  
Randomised Controlled ◽  
Catheter Colonisation

IntroductionCatheter use is associated with many complications and is an iatrogenic source of morbidity and mortality in intensive care units (ICU). The catheter being studied (Certofix Protect) was developed to reduce the risk of catheter related infections. This clinical trial will compare the safety and efficiency of Certofix Protect with that of an ordinary Certofix catheter.Methods and analysisIn this multicentre trial, we will randomly assigned dual lumen central venous catheterisation (≥5 ds) in patients in the adult ICU to the antimicrobial central venous catheter (CVC) group or the ordinary CVC group. We plan to recruit 12–16 medical centres in China. Our main objective is to assess the effectiveness of antimicrobial CVCs in reducing catheter related bloodstream infection (CRBSI), all cause mortality, catheter colonisation, catheter related thrombosis and other catheter related complications. The primary outcome is the incidence of CRBSI.Ethics and disseminationThe ethics committee of West China Hospital of Sichuan University has granted ethics approval for this study (27 January 2015). The results will be published in peer reviewed journals and presented at conferences.Trial registration numberNCT02645682.

MO1022CENTRAL VENOUS CATHETERS FIRST - THE ACHILLES’ HEEL IN PEDIATRIC HEMODIALYSIS VASCULAR ACCESS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Ana Domingos ◽  
Ana Teixeira ◽  
Paula Matos ◽  
Liliana Rocha ◽  
Paulo Almeida ◽  
...  
Keyword(s):  
Vascular Access ◽  
Waiting Times ◽  
Venous Catheter ◽  
High Rate ◽  
Expected Improvement ◽  
Chronic Glomerulonephritis ◽  
Age Related ◽  
Pediatric Hemodialysis ◽  
End Stage

Abstract Background and Aims Management of children with end-stage kidney disease (ESKD) requiring dialysis is always challenging and particular concerns exists regarding vascular access. International reports through the years are not satisfactory, with a high rate of central venous catheter (CVC), when “Fistula First” is the goal in Hemodialysis (HD). Suggested reasons for this phenomenon include, for example, age-related anatomical limitations, shorter awaiting times for or “scheduled” transplantation, pain and anxiety related to punctures or lack of pediatric/surgical expertise. Here we present the results of the last 13 years of experience in pediatric HD vascular access from a reference center in northern Portugal. Method A retrospective descriptive study of patients admitted to our pediatric HD Unit between January 2007 and December 2020. Clinical data was collected from medical records. Results 40 patients were enrolled, mainly boys (n=22, 55%), mean age at admission 10.9±5.3 years (1-17 years), 63% weighing more than 30 kg (n =25) and 15% less than 15kg (n=6). More than half were incident patients starting on HD (n=22, 55%), 42.5% were transferred from peritoneal dialysis (PD) and one patient had a previous kidney transplant (KT). Regarding CKD etiology, 52.5% (n=21) were mainly due to congenital anomalies of the kidney and urinary tract; chronic glomerulonephritis was responsible for 20% of cases (n=8). Most patients initiated HD with a CVC (n=35, 87.5%), including two patients with an arteriovenous fistula (AVF) who required a temporary CVC until fistula maturation. At the end of follow-up, about 45% of the patients ended up with an AVF (comparing to 17.5% at the beginning) and, not unexpectedly, 88.9% (n=16) of them weighed more than 30kg and only one child less than 15 kg. The mean duration of dialysis was 1.2±1.8 years (1 month-8 years); 24 patients were submitted to KT (60%), 6 transferred to PD (15%) and only 4 remain on HD. Average waiting times for KT are quite longer in patients with AFV (1.7±2 years), in comparison to CVC (0.4±0.3 years). Conclusion CVC is by far the most used access in incident patients starting on HD. In our center it seems justified by the anatomical limitations of younger and smaller patients, as wells as expected shorter awaiting time for KT. Infectious and mechanical complications must be weighed when using CVC, mainly considering the probable need for different renal replacing techniques over the years. Although our data is quite similar to several international reports and other center experiences, we still aim for the best, with an expected improvement of these results within the coming years. For now, a notable increase in AVF placement at the end of the follow-up is already an encouraging fact.

scholarly journals Male circumcision performed with 8-figure non-absorbable suture technique

2014 ◽  
Vol 8 (3-4) ◽  
pp. 142 ◽  
Author(s):  
Ren Chong Xi ◽  
Yin Rui Sheng ◽  
Wang Hong Chen ◽  
Li Sheng ◽  
Ji Jing Gang ◽  
...  
Keyword(s):  
Complication Rate ◽  
Cost Effective ◽  
Suture Technique ◽  
Control Group ◽  
Absorbable Suture ◽  
Adult Males ◽  
Chi Square ◽  
Absorbable Sutures ◽  
Significant Difference

Introduction: We analyze the outcome of circumcisions performed with 8-figure non-absorbable suture (8FNS) and assess the feasibility of using the technique in male circumcision.Methods: We randomly divided 317 patients who would undergo circumcision between February 2009 and January 2012 into 2 groups. Each group was subdivided into children (age range: 7 to 15 years) and adult (range: 16 to 85 years). In the experiment group (n =166), we used 8FNS and in the control group (n = 151), commonly absorbable sutures (CAS) were used for the circumcised wound closure. The results of 2 groups were compared. We also performed a cost analysis and a mean 6-month follow-up (range:1-12). Chi-square and Student’s t-test were used in statistical analysis. Differences were considered significant (p ＜ 0.05).Results: No patients were required to remove their sutures postoperatively.Among them, the sutures of the 8FNS for circumcision felloff spontaneously within 9 days (6.2 ± 1.57). There was no statisticallysignificant difference between the 2 groups in surgical duration (16.2 ± 1.73 vs. 15.8 ± 2.01) and follow-up time (6.4 ± 3.82 vs. 6.2 ± 2.39). The overall complication rate of the 2 groups was 6.63% and 10.53% (p = 0.15), respectively. In addition, the complication rate among the adults was significantly lower in the 8FNS group compared to children (2.53% vs. 10.34%, p = 0.04). Also, the average cost (in US dollars) of 8FNS for circumcision was $20.7 ± $3.83 less than $35.8 ± $5.02 of CAS, which is a very significant difference (p < 0.0001).Conclusions: 8FNS for circumcision is feasible, easy, safe and cost-effective, especially for adult males.

Adjuvant chemotherapy for gastric cancer: Less drug, same efficacy.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 114-114
Author(s):  
T. Liu ◽  
W. Li ◽  
Y. Sun ◽  
K. Shen
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Disease Free Survival ◽  
Cost Effective ◽  
Chi Square ◽  
Similar Disease ◽  
Chi Square Test ◽  
Grade 3 ◽  
Meta Analyses

114 Background: Adjuvant chemotherapy is proved to improve survival in gastric cancer by meta-analyses. However, no evidence showed the best regimen. We conducted a retrospective analysis to compare triplets with doublets in the adjuvant setting. Methods: We collected data from January 2004 to December 2008 from patients performed radical surgery and adjuvant chemotherapy. Doublets were defined as 5-FU 750 mg/m2 (d1- 5) or capecitabine 1,000 mg/m2 (d1-14) plus cisplatin 60 mg/m2 (d1) or oxaliplatin 130 mg/m2 (d1), while triplets had epirubicin 50 mg/m2 (d1) added. Chemotherapy was initiated within 6 weeks after surgery, repeated every three weeks and planned for 6 cycles. Patients were followed up in the outpatient clinic until death or April 30, 2010. Cox proportional-hazard model and chi-square test were used to test statistical difference. Results: A total of 316 patients (210 in doublets, 106 in triplets) had a median follow-up time of 47 months. 77 patients died at the end of follow-up (3-year survival of 67.4%).Two groups were well balanced except age (median age of 57 in doublets, 51 in triplets, p < 0.001). All the patients tolerated well, with few grade 3/4 side effects (21.9% in doublets, 30.2% in triplets, p = 0.107). Two groups had similar disease-free survival (median DFS, 16 months vs. 23 months, p = 0.656) and overall survival (3-year survival rate, 59.6% vs. 64.8%, p = 0.293). Subgroup analysis showed the same benefit on survival between the two groups. Conclusions: Our study suggested doublets and triplets had the same efficacy as the adjuvant chemotherapy. Furthermore, doublets seem more cost-effective. [Table: see text] No significant financial relationships to disclose.

Association Analysis between the IRF6 G820A Polymorphism and Nonsyndromic Cleft Lip and/or Cleft Palate in a Chinese Population

2009 ◽  
Vol 46 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Wei Tang ◽  
Xinya Du ◽  
Fan Feng ◽  
Jie Long ◽  
Yunfeng Lin ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Chinese Patients ◽  
Controlled Study ◽  
Reaction Products ◽  
Chi Square ◽  
West China Hospital ◽  
Increased Risk ◽  
History Of ◽  
Polymerase Chain

Objective: To investigate whether an association occurred between the IRF6 G820A polymorphism and nonsyndromic cleft lip with or without cleft palate (CL±P) or cleft palate only (CPO) in Chinese patients. Design and Setting: Case-controlled study at the West China Hospital of Stomatology, Sichuan University, China. Subjects: A total of 91 patients with cleft lip and/or palate (CL/P) and 96 unrelated, healthy individuals with no family history of CL/P were genotyped. Methods: The IRF6 G820A polymorphism was genotyped by restriction digestion of polymerase chain reaction products with BseLI. Chi-square statistics were used to make case-controlled comparisons. Results: The frequency of the A allele was significantly increased and the frequency of the G allele was reduced in CPO patients in comparison with control subjects. The 820GG genotype had a significantly lower frequency in patients with CPO than in controls, with an odds ratio of 0.25 (95% confidence interval, −0.061 to 0.57). No difference in the distribution of genotypes was noted between CL±P patients and the total group of CL/P patients compared with controls. Conclusions: The present findings indicate that the 820A allele is more frequent in the Chinese CPO population and may confer an increased risk for CPO in these individuals. The G820A variant may be in linkage disequilibrium with other disorder-causing mutations. CL±P or CPO results should be analyzed separately and stratified in future studies.

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