The effect of noise and dust exposure on oxidative stress among livestock and poultry feed industry workers

2020 ◽  
Vol 36 (11) ◽  
pp. 908-915
Author(s):  
Seyedtaghi Mirmohammadi ◽  
Narges Khanjani ◽  
Fereshteh Nazarkhani ◽  
Saeid Abediankenari ◽  
Jamshid Yazdani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Noise Exposure ◽  
Cross Sectional Study ◽  
Low Noise ◽  
Exposed Group ◽  
Dust Exposure ◽  
Poultry Feed ◽  
Control Group ◽  
Simultaneous Exposure ◽  
Cross Sectional

Introduction: Simultaneous exposure to noise and dust may have detrimental health effects. This study was conducted to determine the effect of exposure to noise and dust on oxidative stress. Methods: In this cross-sectional study, 82 employees of two livestock and poultry feed factories in Golestan Province, Iran, were selected as the exposed group and 82 office workers were selected as the control group. Occupational noise and dust exposure were measured using a dosimeter, sampling pump, and vinyl chloride filter. Oxidative stress was determined by measuring the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in blood samples. T-tests, one-way analysis of variance, and multivariate linear regression were used to analyze the data. Results: The levels of MDA and SOD in the exposed group were significantly higher and lower than the control group ( p < 0.001), respectively. The results showed the subgroup with both over the threshold dust and noise exposure had the highest MDA levels. The SOD level among those exposed to noise more than the recommended level, in the subgroup with more dust exposure, was significantly less than the subgroup with low noise exposure ( p = 0.017). Conclusion: Noise and dust exposure probably increase the level of oxidative stress by increasing the level of lipid peroxidation (MDA) and reducing the level of antioxidant enzymes (SOD).

Pengaruh bising lalu lintas terhadap penurunan fungsi pendengaran pada juru parkir di kota Denpasar

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Ni Ketut Susilawati ◽  
Wayan Sudana ◽  
Eka Putra Setiawan
Keyword(s):  
Hearing Impairment ◽  
Noise Exposure ◽  
Traffic Noise ◽  
Hearing Threshold ◽  
Noise Pollution ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Hearing Function

Background: Noise pollution or noise is an unwanted sound which is disturbing to human beings.However small or soft the sound, if it is undesirable it is considered as noise. Noise induced hearingloss is a sensorineural hearing loss that is commonly encountered second to presbycusis. Purpose: Toknow the effect of traffic noise exposure on hearing impairment to the employees of the Parking DistrictCompany of the Denpasar city and to improve diagnostic detection on hearing impairment caused bynoise. Method: A cross sectional study was conducted at the Parking District Company office. Thepopulations of this study were the employees of the Parking District Company. Samples of this study were the employees who were exposed to traffic noise and control samples were an employee who was unexposed. Samples were selected by simple random sampling. Results: From 40 parking attendants,27 persons (67.5%) aged above 35 years old. The parking attendants who had been working for ten to fifteen years were 36 persons (90%) and no history using ear protection when working. Seven persons(17.5%) had referred DPOAE upon examination with increase hearing threshold on audiogram result.In this study the parking attendants who had hearing deficit induced by noise were 7 persons (17.5%)and only one person (2.5%) in control group. There was a statistically significant effect of traffic noiseto hearing function deficit (p<0.05). Conclusion: Traffic noise has effect in hearing function deficit onthe parking attendants.ORLI Vol. 40 No. 2 Tahun 2010Key words: NIHL, parking attendant, audiometry, DPOAE.

scholarly journals Characterization of buccal cell DNA after exposure to azo compounds: a cross-sectional study

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1053
Author(s):  
Juni Handajani ◽  
Urfa Tabtila ◽  
Nadia Rully Auliawati ◽  
Abdul Rohman
Keyword(s):  
Principal Component ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Azo Compounds ◽  
Buccal Cell ◽  
Control Group ◽  
Synthetic Dyes ◽  
Sectional Study ◽  
Cross Sectional ◽  
Principle Component

Background: Azo compounds, containing naphthol and diazonium salts, are synthetic dyes widely used in the batik industry. Azo compounds are considered toxic when they are exposed to human tissue. The purpose of this study was to analyze buccal cell DNA exposed to azo compounds in batik workers. Methods: A cross-sectional study involving 20 male subjects divided into two groups (n=10 group), namely azo-exposed and non-exposed (control group). Inclusion criteria were batik workers of the colouring division who have been exposed to azo for at least 5 years. Buccal cells were taken using cytobrush then DNA were isolated from buccal cell. DNA isolation was done by buccal DNA kit, while the purity and concentration of the DNA was determined using spectrophotometer and electrophoresis. Results: The azo-exposed group revealed higher purity DNA than those in the control group. The purity of the DNA in the azo-exposed group and control group was 0.61±0.93 and 0.21±0.09, respectively, while the concentration of DNA was of 59.02 and 19.35 ng/UL, respectively. The ratio at 260/280 nm was 1.84-1.94 (azo-exposed) and 1.85-1.92 (control). Principal component analysis using the first principle component (PC1) and second principle component (PC2) could successfully classify subjects in the control and azo-exposed groups. Conclusion: Characteristics of DNA could be used as an indication of exposure to azo compounds in workers of batik industries.

scholarly journals Influence of Insulin Resistance and TNF-αon the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Neide Tomimura Costa ◽  
Tatiana Mayumi Veiga Iriyoda ◽  
Ana Paula Kallaur ◽  
Francieli Delongui ◽  
Daniela Frizon Alfieri ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Insulin Resistance ◽  
Disease Activity ◽  
Inflammatory Process ◽  
Cross Sectional Study ◽  
Stress Index ◽  
Control Group ◽  
Cross Sectional ◽  
Clinical Trials Registry

The aim of this study was to evaluate the involvement of TNF-αand insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group,n=97) and RA patients (n=173). RA patients were divided into four groups: the first group without IR and not using antitumor necrosis factor-α(TNF-) (G1, IR− TNF−); the second group without IR and using anti-TNF-α(G2,IR-TNF+); the third group with IR and not using anti-TNF-α(G3, IR+TNF-); and the fourth group with IR and using anti-TNF-α(G4, IR+ TNF+). G3 and G4 had higher (p<0.05) advanced oxidation protein products (AOPPs) and oxidative stress index (OSI) compared to G1. G4 group presented higher (p<0.05) AOPPs and OSI than G2. TRAP was significantly lower in G3 compared to G1. Plasma TNF-αlevels were significantly higher in G4 and G2 compared to G1 (p<0.0001) and G3 (p<0.0001andp<0.01, resp.). The presence of insulin resistance was robustly associated with both oxidative stress and TNF-αlevels. More studies are warranted to verify if IR can be involved in therapeutic failure with TNF-αinhibitors. This trial is registered with Brazilian Clinical Trials Registry Register numberRBR-2jvj92.

Insomnia as a Sequela of Sarin Toxicity Several Years after Exposure in Tokyo Subway Trains

2005 ◽  
Vol 100 (3_suppl) ◽  
pp. 1121-1126 ◽  
Author(s):  
Tomoyuki Kawada ◽  
Masao Katsumata ◽  
Hiroko Suzuki ◽  
Qing Li ◽  
Hirofumi Inagaki ◽  
...  
Keyword(s):  
Toxic Substance ◽  
Early Morning ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Control Group ◽  
Poor Sleep ◽  
Related Factors ◽  
Sleep Difficulty ◽  
Cross Sectional ◽  
Falling Asleep

More than 5,000 passengers on Tokyo subway trains were injured with toxic chemicals including the nerve gas “sarin” on March 20, 1995. The purpose of this study was to identify the effect of sarin exposure on insomnia in a cross-sectional study. A self-administered questionnaire concerning sleep-related items was distributed to victims of sarin exposure in October and November, 2003. Questionnaires were completed by 161 of the 163 participants (98.8%), who were selected from 1,500 subjects. Among them, the authors selected 75 women 30 to 69 years of age. Control participants were collected from inhabitants living in Maebachi City, Gunma Prefecture, Japan. For the younger exposed group (under 50 yr. of age), percentages of poor sleep, difficulty falling asleep, intermittent awakening, early morning awakening, a feeling of light overnight sleep, and insomnia were significantly higher than those for the control group. In contrast, the older exposed group (ages 50 to 69 years) had significantly higher prevalence of poor sleep, a feeling of light overnight sleep, and early morning awakening for the exposed group when compared with the control group. The high prevalence of insomnia and insomnia-related factors for victims especially under 50 years of age suggests a need for research on sleep quality after sarin exposure. Although posttraumatic stress disorder is assumed to be a psychological effect of exposure to a toxic substance, a cause-and-effect relationship has not been established.

scholarly journals Lung Function and Respiratory Health of Populations Living Close to Quarry Sites in Palestine: A Cross-Sectional Study

2020 ◽  
Vol 17 (17) ◽  
pp. 6068
Author(s):  
Maysaa Nemer ◽  
Rita Giacaman ◽  
Abdullatif Husseini
Keyword(s):  
Lung Function ◽  
Health Effects ◽  
Respiratory Health ◽  
Forced Expiratory Volume ◽  
Exposed Group ◽  
Dust Exposure ◽  
Control Group ◽  
Nasal Allergy ◽  
Cross Sectional ◽  
At Home

Environmental exposure to dust from quarrying activities could pose health dangers to the population living nearby. This study aimed to investigate the health effects of dust exposure on people living close to quarry sites and compared them with those who live far from the quarry sites. A cross-sectional comparative study was conducted among 79 exposed participants, who lived less than 500 m away from the quarry sites, and 79 control participants who lived more than 500 m away. All participants answered a questionnaire on dust exposure at home and health effects, as well as performed a lung function test in which both reported and measured health effects were investigated. People who live in close proximity to the quarry sites reported exposure to dust at home (98%), land destruction (85%), plant leaves covered with dust (97%), and an inability to grow crops (92%). The exposed group reported significantly higher eye and nasal allergy (22% vs. 3%), eye soreness (18% vs. 1%), and dryness (17% vs. 3%), chest tightness (9% vs. 1%), and chronic cough (11% vs. 0%) compared to the control group. Lung function parameters were significantly lower among the exposed group compared to the control group; mean forced vital capacity (FVC) was 3.35 L vs. 3.71 L (p = 0.001), mean forced expiratory volume in the first second (FEV1) was 2.78 L vs. 3.17 L (p = 0.001). Higher levels of airway restriction were found among the exposed group. Among the exposed group, lung function parameters worsened with the increasing closeness of home to the quarry site. This study demonstrates the negative health effects of environmental dust exposure among two communities living near quarry sites in Palestine. The results highlight the importance of developing and strictly enforcing rules and regulations in Palestine to protect population health.

Pulmonary Function Study in Female Grinders Exposed to Agate Dust

1990 ◽  
Vol 6 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Subodh K. Rastogi ◽  
Brahma N. Gupta ◽  
Neeraj Mathur ◽  
Tanveer Husain ◽  
Prakash N. Mahendra
Keyword(s):  
Pulmonary Function ◽  
Complex Form ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Control Group ◽  
Cross Sectional ◽  
Radiologic Findings ◽  
Important Observation ◽  
Significant Difference ◽  
Exposed Workers

This paper reports a cross-sectional study of a non-smoking population of silica exposed female workers compared with a group of healthy non-exposed females. The exposed group is divided into cohorts according to the presence or absence of pneumoconiosis in either simple or complex form. The study revealed statistically significant difference in pulmonary function between each of the pneumoconiosis group and the controls and healthy exposed workers. Furthermore, there was statistically significant difference between the values of pulmonary function parameters of the healthy exposed group and the controls. The most important observation of the study is that almost equal decrement of pulmonary function values was observed in the diseased groups and in the healthy exposed group compared to the decrement seen between the latter group and the control group. VC and FVC showed a mean fall of 11.0 and 11.5% in the healthy exposed group as compared to those observed in the unexposed controls (p < 0.01 and p < 0.05) while in the pneumoconiosis group VC and FVC showed 16.9 and 18.2% decrease as compared with the values obtained in the healthy grinders (p < 0.01). Similarly FEV1 showed almost same decrease in the healthy (17.9%) and diseased (20.7%) exposed groups (p < 0.001). However, FEV0.75 and MVV parameters showed greater decrement (25.4 and 33.7%) in the pneumoconiosis group as compared to 15.7 and 18.5% observed in the healthy exposed workers. The important observation made in this study is that potential pulmonary debilitation may occur in pneumoconiosis before, or in the absence of, any radiologic findings.

scholarly journals Assessing the suitability of 8-OHdG and micronuclei as genotoxic biomarkers in chromate-exposed workers: a cross-sectional study

BMJ Open ◽  
2014 ◽  
Vol 4 (10) ◽  
pp. e005979 ◽  
Author(s):  
Ping Li ◽  
Yongen Gu ◽  
Shanfa Yu ◽  
Yang Li ◽  
Jinglin Yang ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Micronucleus Test ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Inductively Coupled ◽  
Positive Correlations

ObjectivesWe aimed to investigate suitable conditions of 8-hydroxy-2′-deoxyguanosine (8-OHdG) and micronucleus (MN) as genotoxic biomarkers at different levels of occupational chromate exposure.DesignA cross-sectional study was used.Participants84 workers who were exposed to chromate for at least 1 year were chosen as the chromate exposed group, while 30 non-exposed individuals were used as controls.Main outcome measuresEnvironmental and biological exposure to chromate was respectively assessed by measuring the concentration of chromate in the air (CrA) and blood (CrB) by inductively coupled plasma mass spectrometer (ICP-MS) in all participants. MN indicators, including micronucleus cell count (MNCC), micro-nucleus count (MNC), nuclear bridge (NPB) and nuclear bud (NBUD) were calculated by the cytokinesis-block micronucleus test (CBMN), while the urinary 8-OHdG was measured by the ELISA method and normalised by the concentration of Cre.ResultsCompared with the control group, the levels of CrA, CrB, MNCC, MNC and 8-OHdG in the chromate-exposed group were all significantly higher (p<0.05). There were positive correlations between log(8-OHdG) and LnMNCC or LnMNC (r=0.377 and 0.362). The levels of LnMNCC, LnMNC and log (8-OHdG) all have parabola correlations with the concentration of CrB. However, there was a significantly positive correlation between log (8-OHdG) and CrB when the CrB level was below 10.50 µg/L (r=0.355), while a positive correlation was also found between LnMNCC or LnMNC and CrB when the CrB level was lower than 9.10 µg/L (r=0.365 and 0.269, respectively).ConclusionsMN and 8-OHdG can be used as genotoxic biomarkers in the chromate-exposed group, but it is only when CrB levels are lower than 9.10 and 10.50 µg/L, respectively, that they can accurately reflect the degree of genetic damage.

scholarly journals Evaluation of Oxidative Stress and Biochemical Biomarkers, and Psychological Parameters in Cement Plant Workers

2020 ◽  
Author(s):  
Faezeh Darabi ◽  
Majid Keshavarzi ◽  
Media Noori Abdullah ◽  
Fatemeh Dehghani ◽  
Saeed Yousefinejad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cross Sectional Study ◽  
Cement Industry ◽  
Control Group ◽  
Cement Plant ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Hazardous Chemical ◽  
Wide Range ◽  
Psychological Parameters

Abstract BackgroundThe cement industry is one of the main world industries with exposure to a wide range of hazardous chemical and physical occupational agents that can increase free radicals and cause diseases. The aim of this study was to evaluate oxidative stress, and biochemical markers and psychological parameters among cement plant workers who were exposed to variety of hazardous occupational agents.MethodsIn this cross-sectional study 40 workers exposed to cement and 40 office employees, were selected as the exposed and control group, respectively. Exposure to cement dust, silica and noise were respectively assessed using the NIOSH 0600, NIOSH 7601 and noise dosimetry methods. Oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and biochemical parameters were measured in the serum of all participants. Depression, anxiety and stress were assessed by Depression Anxiety Stress Scales (DASS-21) questioner. Statistical analysis was performed by SPSS22 software. Independent t-test, Mann-Whitney U, Chi-square were used to evaluate the relation between variables. ResultsThe results demonstrated that the level of MDA as a marker of oxidative stress was significantly higher in the exposed group.Antioxidant enzymes including SOD and CAT were significantly higher, and TAC was insignificantly lower in the exposed group. Alkaline phosphatase (ALP), aspartate transaminase (AST), depression and stress were also significantly higher in the exposure group. It seems like working in cement plants, can have hazardous effects on liver function, enzyme activity and mental health.

scholarly journals Auditory effects of recreational and occupational noise exposure among dental students: a cross-sectional study

Revista CEFAC ◽  
2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Eduardo Fuentes-López ◽  
Francisco García-Huidobro Nuñez ◽  
Pamela Acuña Caro ◽  
Nicolás Castro Becerra ◽  
Gabriela Jalil García ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Noise Exposure ◽  
Cross Sectional Study ◽  
Dental Students ◽  
Multivariate Model ◽  
Health Science ◽  
Control Group ◽  
Occupational Noise ◽  
Cross Sectional ◽  
Occupational Noise Exposure

ABSTRACT Purpose: to determine the auditory effects of noise exposure from recreational and occupational sources among dentistry students. Methods: forty-two dentistry students, routinely exposed to occupational noise, and 72 students from other health science schools were recruited (control group). Audiometric testing, otoacoustic emissions and questionnaires to assess recreational and occupational noise were applied to the sample. The presence of a notch was determined for each participant audiometry´s test based on the criteria proposed by Coles et al. Differences in notch prevalence were analyzed by applying univariate regression models as well as a multivariate model adjusted by covariates. Results: non-significant differences in auditory thresholds between groups were found. The controls exhibited a significantly higher prevalence of a notch at 4 kHz than the group exposed to noise. However, the differences were not statistically significant in the multivariate model adjusted by recreational noise exposure. Conclusions: the occupational noise exposure was not significantly associated to auditory system dysfunction. In addition, the differences in notch prevalence could be related to recreational noise exposure.

scholarly journals Serum malondialdehyde (MDA) level as a potential biomarker of cancer progression for patients with bladder cancer

2020 ◽  
Vol 58 (3) ◽  
pp. 146-152
Author(s):  
Zahid Lepara ◽  
Orhan Lepara ◽  
Almir Fajkić ◽  
Damir Rebić ◽  
Jasmin Alić ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Progression ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Potential Biomarker ◽  
Significant Difference ◽  
Progression Risk ◽  
T1 And T2

AbstractIntroduction. Bladder cancer is the most common malignancy involving the urinary system. Recent research tends to emphasize the role of oxidative stress products in the carcinogenesis of bladder cancer. The level of oxidative stress can be measured by assessing the MDA levels. This study aimed to evaluate serum MDA levels in patients with bladder cancer, as well as to determine its potential role as a biomarker in the diagnosis of the disease and progression risk considerations.Methods. The study was designed as a cross-sectional study and included 90 patients, divided into three groups with 30 patients each: Ta, T1and T2–T4 group, based on histopathological findings after transurethral resection of the tumor. The control group included 30 healthy volunteers. MDA level was determined using the spectrophotometric method.Results. Serum MDA level in patients with bladder cancer [0.86 (0.78–1.05) μmol/L] was significantly higher than the serum MDA level in control group [0.70 (0.69–0.72) μmol/L] (p < 0.001). Serum MDA level in Ta group [0.73 (0.70–1.05) μmol/L], T1 group [0.85 (0.80–1.12) μmol/L] and in T2–T4 group [0.91 (0.84–1.04) μmol/L] was significantly higher than the serum MDA level in control group [0.70 (0.69–0.72) μmol/L] (p < 0.01). MDA level in T1 and T2–T4 group was significantly higher than the MDA level in Ta group (p < 0.01). No significant difference was observed in MDA level between T1 and T2–T4 group (p = NS). A statistically significant positive correlation was found between tumor size and serum MDA level in patients with bladder cancer (rho = 0.254 p < 0.01).Conclusions. The results of the present study suggest that MDA serum level might play a significant role as a biomarker in the diagnosis of bladder cancer, as well as in the monitoring of its progression.

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