Cross-Sectional Design: Link Between Parkinson’s Pain and Restless Leg Syndrome

2021 ◽  
pp. 089198872110361
Author(s):  
Dion A. Paul ◽  
Abdul Rehman Qureshi ◽  
Muhammad K. Jamal ◽  
Abdul Qayyum Rana
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pain Perception ◽  
Brief Pain Inventory ◽  
Insufficient Evidence ◽  
Restless Leg Syndrome ◽  
Cross Sectional ◽  
Holistic Treatment ◽  
Cross Sectional Design ◽  
The Relationship

Objective: Prior research suggests that restless leg syndrome (RLS) is prevalent in Parkinson’s disease (PD) with insufficient evidence to support the relationship between RLS, PD, and pain. This study explored the relationship between pain in PD patients and its association with the prevalence and severity of RLS. Method: 127 PD patients were assessed for PD and RLS using the U.K. Brain bank Criteria and the Restless Leg Syndrome diagnostic criteria, respectively. These patients were also assessed for pain perception and interference using the Brief Pain Inventory. Results: The results demonstrated Parkinson’s disease patients who reported pain scored 23 more Restless Leg Syndrome prevalence points ( p < 0.05), and 8.5 counts higher for Restless Leg Syndrome severity ( p < 0.05) compared to the group of Parkinson’s disease patients denying pain. Discussion: The presence of pain in PD patients indicated a higher RLS prevalence and an increased RLS severity. This finding suggests patients suffering from pain interference may experience more severe RLS symptoms. This demonstrates an inextricable link and association between pain in PD patients and RLS. Further robust investigations are required to elucidate any potential causative links, which can inform more holistic treatment principles.

scholarly journals FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON

2020 ◽  
Vol 5 (1) ◽  
pp. 343
Author(s):  
Attiya Istarini ◽  
Yuliarni Syafrita ◽  
Restu Susanti
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Age At Onset ◽  
Motor Symptom ◽  
Disease Stage ◽  
Motor Symptoms ◽  
Research Subjects ◽  
Cross Sectional ◽  
Duration Of Disease ◽  
Cross Sectional Design

<p><strong><em>Background</em></strong><em>: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some  factors that influence motor symptoms in Parkinson's disease.</em><strong><em>Methods:</em></strong><em> This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values &lt;0.05 were considered statistically significant.</em><strong><em>Results:</em></strong><em> This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p &lt;0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.</em><strong><em>Conclusions:</em></strong><em> There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.</em></p>

scholarly journals The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease

2021 ◽  
Vol 5 (9) ◽  
pp. 856-861
Author(s):  
Ahmad Afdal ◽  
Syarif Indra ◽  
Hendra Permana
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Cross Sectional Study ◽  
Research Subjects ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Relationship ◽  
Dopaminergic Degeneration

Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial. Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows. Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05. Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.

Factors related to sleep disturbances for individuals with Parkinson’s disease: a regional perspective

2019 ◽  
Vol 32 (7) ◽  
pp. 827-838
Author(s):  
Rachael Wade ◽  
Nancy A. Pachana ◽  
George Mellick ◽  
Nadeeka Dissanayaka
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Cross Sectional ◽  
Sleep Dysfunction ◽  
Cross Sectional Design ◽  
Positive Correlations

ABSTRACTObjectives:Sleep disturbances negatively impact the quality of life of patients with Parkinson’s disease (PD). While persons living in regional areas are at higher risk of PD, PD is poorly managed in regional communities. This study examined factors associated with sleep problems in PD in a regional context.Design:A mixed-methods cross-sectional design was used.Participants:Patients with PD were recruited from the Queensland Parkinson’s Project database.Measurements:Those who agreed to participate were sent a questionnaire assessing aspects of sleep, depression, anxiety, quality of life, and PD severity. Qualitative information was also gathered. Correlations between variables were examined; thematic analyses were performed for qualitative data.Results:All participants (n = 49) reported sleep disturbances, with 73% (n = 36) reporting sleep disturbance to be problematic. Global sleep dysfunction positively correlated with daytime napping (r = .34, p = .01), watching the clock when unable to sleep (r = .38, p = <.01), staying in bed when unable to sleep (r = .43, p = <.01), and going to bed hungry (r = .31, p = .03) and negatively correlated with daytime exercise (r = -.32, p = .02). Positive correlations were observed between global sleep dysfunction and depression (r = .55, p = <.01), anxiety (r = .31, p = .04), and dysfunctional sleep beliefs (r = .39, p = <.01).Conclusion:There is a clear need for identifying factors related to sleep disturbances in PD for effective management.

scholarly journals Dysautonomia Differentially Influences the Effect of Affective Pain Perception on Quality of Life in Parkinson’s Disease Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
D. Rada ◽  
J. Seco ◽  
E. Echevarría ◽  
B. Tijero ◽  
L. C. Abecia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pain Perception ◽  
Critical Role ◽  
Life Quality ◽  
Prognostic Indicator ◽  
Cross Sectional ◽  
Affective Pain

Background. Our aim was to evaluate the real effect of dysautonomic symptoms on the influence of affective pain perception on quality of life in PD patients.Methods. An observational cross-sectional study was carried out using 105 Parkinson’s disease (PD) patients of the Movement Disorders Unit, Hospital de Cruces (Bilbao, Spain) [men 59 (56.2%), women 46 (43.85%)]. Statistical analysis was made in order to evaluate the possible association of pain with life quality.Results. Quality of life measured by PDQ-39 (Parkinson’s Disease Questionnaire for quality of life) was statistically associated with affective dimension of pain (PRIA, affective pain rating index). However, the influence of this dimension on PDQ-39 was different in the specific case of PD patients that experimented a high score (>12) in SCOPA-AUT (Scale for Outcomes in PD-Autonomic scale).Conclusions. These results confirm the effect of affective perception of pain in life quality of PD patients, indicating the critical role of autonomic symptoms in the modulation of the influence of pain on quality of life and showing the possible utility of dysautonomia as clinical prognostic indicator of quality of life in PD patients affected by pain.

scholarly journals The Relationship between Personal Hygiene and Household Insecticide Use with Parkinsonism on Farmers at Juhar Ginting Sadanioga

2020 ◽  
Vol 2 (1) ◽  
pp. 102-107
Author(s):  
Andin Rizqika Aliunputri Andin ◽  
Taufik Ashar ◽  
Rahayu Lubis
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Significant Relationship ◽  
Quantitative Research ◽  
Pesticide Exposure ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Personal Hygiene ◽  
Cross Sectional ◽  
The Relationship

Parkinson's disease is a neurodegenerative disease which the most frequently affected humans. Parkinson's disease attacked millions of people in the world or about 1% of the world's total population. The cause of Parkinson's disease is unclear, but one of them is an environmental factor. Environmental factors that lead to this disease is pesticide exposure. The purpose of this research to analyze the relationship between personal hygiene and the household insecticide use with Parkinsonism to farmers in Juhar Ginting Sadanioga village. This research was an observational analytic, quantitative research with cross-sectional design. The sample of this study amounted to 30 people and taken by simple random sampling technique. The data obtained through interviews and observations using a questionnaire. This study resulted that 47% of farmers had Parkinsonism. As many as 20% of farmers had poor personal hygiene, and 60% of farmers were household insecticide use. The chi-square test showed that there was a significant relationship between personal hygiene with Parkinsonism (p = 0.003), and there was a significant relationship between household insecticide use with Parkinsonism (p = 0.017).

scholarly journals ASSOCIATION BETWEEN SEVERITY AND DEPRESSION IN PARKINSON'S PATIENTS

2020 ◽  
Vol 7 (8) ◽  
pp. 81-86
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Significant Relationship ◽  
Psychiatric Symptoms ◽  
Primary Data ◽  
P Value ◽  
Cross Sectional ◽  
Clinical Criteria ◽  
Spearman Correlation Test ◽  
Cross Sectional Design

Background: Parkinson disease (PD) has motor manifestations namely resting tremor, rigidity, bradykinesia and postural instability. In addition, non-motor symptoms such as psychiatric symptoms such as depression, anxiety, hallucinations, psychosis, delusions and sleep. Accompanying depression is the most common nonmotor symptom in Parkinson's. Depression in Parkinson's occurs in about 40% of patients and on average there is major depression and minor depression. Objective: To determine the relationship of severity with depression in Parkinson's patients. Method: This study used a cross sectional design. Sampling was conducted at H. Adam Malik General Hospital Medan and network hospital. The study sample was taken as many as 25 subjects consecutively, with primary data sources obtained from all patients who had been diagnosed with Parkinson's disease based on the UKPD Society Bank's Clinical Criteria for Probable Parkinson's Disease criteria. Data analysis using the Spearman correlation test. Results: The demographic characteristics of the study subjects were 19 (76%) men and 6 people (24%) women, with the oldest age being 77 years and the youngest 49 years, mean age was 61.52 ± 6.97 years. The majority of the patients are senior high school, self-employed, and the Batak ethnic group. There is a significant relationship between the MDS-UPDRS subscale and the level of depression in Parkinson's patients with a p value <0.05. Conclusion: There is a significant relationship between severity and depression in Parkinson's patients.

scholarly journals KARAKTERISTIK KLINIS DAN DERAJAT BERAT GEJALA MOTORIK PENYAKIT PARKINSON DI RSUP SANGLAH DAN RSUD WANGAYA DENPASAR

2020 ◽  
Vol 3 (1) ◽  
pp. 6-11
Author(s):  
Pristanova Larasanti ◽  
Dewa Putu Gede Purwa Samatra ◽  
Sri Yenni Trisnawati ◽  
I Ketut Sumada
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
General Hospital ◽  
Neurodegenerative Disorder ◽  
Cross Sectional ◽  
Disability Adjusted Life ◽  
Life Years ◽  
The Status ◽  
Cross Sectional Design ◽  
Global Burden Disease

Background: Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The Global Burden Disease (GBD) report published in 2018 estimated there were 6.1 million individuals suffering from PD globally and causing 3.2 million Disability-Adjusted Life Years (DALY) and 211,296 deaths in 2016. Disability mainly caused by motor symptoms. This study aims to determine the clinical characteristics and motor severity in PD patients in Sanglah and Wangaya General Hospital Denpasar. Method: Descriptive observational study with cross-sectional design. Samples taken consecutively from all patients diagnosed with PD at Neurology Polyclinic in Sanglah and Wangaya General Hospital from December 2018 - February 2019. Result: From 47 subjects with PD, 72.3% were male, 83% had onset within 1-5 years, and the mean age was 63.87 ± 8.67 years. As many as 44.7% subjects had Hoehn-Yahr 2 stadium, with an average MDS-UPDRS III score of 35.11 ± 21.39, and 48.9% subjects had mild severity. As many as 59.6% subjects had the status of ON. Motor severity showed a trend that increases with increasing staging, but was not seen when compared to the onset. This result might be affected by the ON/OFF status during examination. Conclusion: Parkinson's disease in Sanglah and Wangaya General Hospital is more common in men and over the age of 50 years, and most are found in moderate severity. There is a trend of worsening motor severity with the increasing Hoehn-Yahr stadium. Examination using UPDRS-III is recommended to be done both on ON and OFF state to get more sensitive results

scholarly journals Characterization of pain in patients with Parkinson’s disease: a descriptive cross-sectional study

2020 ◽  
Vol 9 (10) ◽  
pp. e6069109057
Author(s):  
Midia Wolff Marques ◽  
Andréia Fuentes dos Santos ◽  
Eduarda Carolina Amaral ◽  
Vivian Francielle França ◽  
Durcelina Schiavoni Bortoloti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Joint Stiffness ◽  
Brief Pain Inventory ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Functional Changes ◽  
The Individual

Parkinson's disease affects the central nervous system, causing dysfunctional dopamine production. This directly affects the motor system, leading to the loss of voluntary movements, joint stiffness, limb tremors, and imbalance. Palliative treatments are applied to alleviate symptoms of the disease and improve quality of life. Considering functional changes and symptoms that are generated by Parkinson's disease, pain is also a debilitating factor that can severely affect the individual. The present study investigated the mean age, duration of involvement, body locus incidence, and interference with quality of life by pain in patients with Parkinson's disease. We applied a one-dimensional, subjective, and qualitative Visual Analog Scale and the multidimensional and interpretative Wisconsin Brief Pain Inventory. The study was conducted with 36 participants of both genders (mean age: 65.5 years for men and 72.0 years for women). The incidence of pain was detected in 87.5% of the participants. We found that pain occurred more frequently in the upper limbs and interfered with the performance of general activities. Treatment by a multidisciplinary team in all dimensions of the disease is needed to alleviate patients’ pain and consequently improve their quality of life.

scholarly journals The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease

2021 ◽  
Vol 5 (3) ◽  
pp. 823-828
Author(s):  
Ahmad Afdal ◽  
Syarif Indra ◽  
Hendra Permana
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Cross Sectional Study ◽  
Research Subjects ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Relationship ◽  
Dopaminergic Degeneration

Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial. Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows. Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05. Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.

scholarly journals The Relationship Between Ankle Proprioception and Functional Mobility in People With Parkinson's Disease: A Cross-Sectional Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Yejun Wang ◽  
Jeremy Witchalls ◽  
Elisabeth Preston ◽  
Zhen Wang ◽  
Jie Zhuang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Step Length ◽  
Performance Measure ◽  
Functional Mobility ◽  
Active Movement ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Ankle Proprioception ◽  
The Relationship

Previous research has found ankle proprioception to be impaired in people with Parkinson's disease (PD). However, the relationship between ankle proprioception and functional mobility in people with PD has not been fully investigated. The purpose of this study was to examine whether ankle proprioception is related to the functional mobility of people with PD. Forty-two participants with mild to moderate PD volunteered. Ankle proprioceptive acuity was measured in standing, by using active movement extent discrimination assessment (AMEDA). Functional mobility measures included the timed-up-and-go test (TUG), 30 s sit-to-stand test (30s-STS) and 10-meter walking test (10MWT). Step length and step cadence were recorded during the 10MWT. No significant correlation was found between ankle proprioceptive discrimination scores and any mobility performance measure in people with PD (−0.20&lt;r&lt;0.04, all p &gt; 0.05). However, ankle proprioception scores were significantly correlated with step length (r = 0.38, p &lt; 0.05) and step cadence (r = −0.30, p &lt; 0.05), and were significantly and negatively correlated with the stage of modified Hoehn and Yahr (rho = −0.53, p &lt; 0.01). The lack of relationship between ankle proprioceptive acuity and functional mobility in PD suggests that people with PD may be more limited by reduced sensorimotor integration or may rely more on other sensory input, rather than ankle proprioception, to achieve functional mobility, a finding consistent with sensory reweighting theory. In addition, poorer ankle proprioceptive acuity was associated with decreased step length and increased step cadence, suggesting that the shuffling gait observed in PD may be related to impaired ankle proprioception, which has important clinical implications for gait retraining in people with PD. Given that ankle proprioception was significantly and negatively correlated with the stage of modified Hoehn and Yahr, it may warrant being used as an objective biomarker to monitor the progression of PD.

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