Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning

2019 ◽  
Vol 38 (11) ◽  
pp. 1235-1243
Author(s):  
O Teksam ◽  
S Sabuncuoğlu ◽  
G Girgin ◽  
H Özgüneş
Keyword(s):  
Oxidative Stress ◽  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Venous Blood ◽  
Treatment Modalities ◽  
Control Group ◽  
Co Poisoning ◽  
Erythrocyte Catalase ◽  
Significant Difference ◽  
Before And After

Objective: In this study, we aimed to investigate oxidative stress and antioxidant parameter levels in patients with carbon monoxide (CO) poisoning. Methods: The study was conducted prospectively between March 1, 2015 and April 30, 2016 in the pediatric emergency department. Eligible patients included children aged 0–18 years old with a diagnosis of CO poisoning. To determination of oxidative stress and antioxidant parameter levels, venous blood with heparinized and urine samples were drawn during the admission and after normobaric oxygen (NBO) and hyperbaric oxygen (HBO) treatment. Results: Forty-seven children with CO poisoning for study group and 29 patients as control group were included to the study. Sixteen patients treated with HBO. Basal plasma malondialdehyde levels were found to be significantly higher in the CO poisoning group when compared with the control group ( p = 0.019). There is no significant difference in oxidative stress and antioxidant parameter levels except erythrocyte catalase enzyme levels in patients treated with NBO when comparing before and after NBO treatment ( p > 0.05). Decreasing of basal erythrocyte catalase enzyme levels were found statistically significant after NBO treatment ( p = 0.04). There was no significant difference in oxidative stress and antioxidant parameter levels in patients treated with HBO before and after therapy ( p > 0.05). Conclusions: CO poisoning is associated with increased lipid peroxidation in children immediately after the poisoning. However, both treatment modalities including NBO or HBO do not have a significant effect on oxidative stress or antioxidant parameter levels.

Low-Level Carbon-Monoxide Poisoning: Inability of Neuropsychological Testing to Identify Patients Who Benefit from Hyperbaric Oxygen Therapy

1995 ◽  
Vol 10 (4) ◽  
pp. 276-282 ◽  
Author(s):  
Steven J. Rottman ◽  
Nancy Kaser-Boyd ◽  
Timothy Cannis ◽  
John Alexander
Keyword(s):  
Carbon Monoxide ◽  
Hyperbaric Oxygen ◽  
Test Scores ◽  
Carbon Monoxide Poisoning ◽  
Neuropsychological Testing ◽  
Memory Loss ◽  
Control Group ◽  
Co Poisoning ◽  
Low Level ◽  
Before And After

AbstractIntroduction:Although major sequelae of carbon-monoxide (CO) poisoning and its treatment with hyperbaric oxygen (HBO) are well-documented, a syndrome of low-level CO poisoning has received relatively little attention. Subtle symptoms of poor concentration, language difficulty, problems with calculations, and memory loss were noted after an acute exposure of 131 dormitory residents to low levels of CO. The CO Neuropsychological Screening Battery (CONSB), a series of tests reported by others as useful to identify victims of CO poisoning, was performed on a subset of 46 victims. It was hypothesized that their test scores would improve after treatment with HBO.Methods:Testing was performed both before and after HBO on 35 CO-exposed victims. A control group of 20 students residing on the same college campus, but not involved with the CO incident, also were tested on two separate occasions to assess the ability of the test to identify selectively victims of low-level CO poisoning, as well as to evaluate its validity when administered serially.Results:Both CO-exposed and control subjects demonstrated significant performance improvement when completing the testing for the second time. In addition, the baseline test scores were not significantly different for either the CO-exposed or the control groups. Nonetheless, all CO-exposed victims reported immediate subjective improvement of their symptoms after HBO therapy.Conclusion:These observations and a review of the literature suggest that there might exist a syndrome of subtle neurological disturbances in victims of low-level CO poisoning. Whether this is permanent or might regress spontaneously over time is unknown. As a diagnostic adjunct, the CONSB does not appear to be as useful in low-level CO poisoning.

Determination of netrin-1 levels and its relationship with neurotoxicity in carbon monoxide poisoning

2019 ◽  
Vol 38 (5) ◽  
pp. 561-566 ◽  
Author(s):  
U Gedikli ◽  
E Emektar ◽  
SK Corbacioglu ◽  
S Dagar ◽  
H Uzunosmanoglu ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Patient Group ◽  
Carbon Monoxide Poisoning ◽  
Neurological Impairment ◽  
Neurological Involvement ◽  
Control Group ◽  
Co Poisoning ◽  
Cross Sectional ◽  
Significant Difference ◽  
Neurological Effects

Objective: The aim of the study was to assess netrin-1 levels in carbon monoxide (CO) poisoning to determine its relationship with poisoning severity and neurotoxicity. Methods: This is a cross-sectional prospective study. The patients older than 18 years with CO poisoning were included. The patients were categorized into two groups on the basis of neurological involvement. Both the patient and the control groups were sampled for netrin-1 at 0th hour, and the patient group only was sampled for netrin-1 at 4th hour. Results: A total of 84 patients and 50 healthy controls were enrolled. The median 0th hour netrin-1 level of the patient group (765.1 pg/mL (619.8-983.1) was significantly higher than the control group (484 pg/mL (376-1031.6)) ( p < 0.001). There was also a significant difference between the 0th hour and 4th hour netrin-1 (888.9 pg/mL (700.3–1175.5)) levels in the patient group ( p < 0.001).There was no significant statistical difference between patients with and without neurological involvement ( p = 0.62) and between those who underwent hyperbaric oxygen therapy (HBOT) and those who did not ( p = 0.76) with respect to 4th hour netrin-1 levels. Conclusion: The significantly higher netrin-1 levels in patients with CO poisoning, suggests that netrin-1 is elevated as a stress marker. Although there is no significant difference in netrin-1 levels in patients with neurological impairment in CO poisonings, netrin-1 may show subclinically neurological effects. Hence, we believe that netrin-1 cannot be used as a marker of poisoning severity.

scholarly journals Evaluation of Oxidative Stress in Patients with Fracture Admitted to Khatam Al-Anbia Hospital in Zahedan

2020 ◽  
Vol 18 (3) ◽  
Author(s):  
Mansour Karajibani ◽  
Farzaneh Montazerifar ◽  
Faezeh Kazemi ◽  
Ali Reza Dashipour
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activities ◽  
Control Group ◽  
Case Group ◽  
Cross Sectional ◽  
Stress Markers ◽  
Significant Difference ◽  
Before And After ◽  
Markers Of Oxidative Stress ◽  
The Mean

Background: Caused by an imbalance in the body’s oxidant and antioxidant status, oxidative stress can give rise to tissue damage and exacerbation of many diseases. Objectives: This study investigated the oxidative stress markers in patients with fractures and healthy subjects. Methods: In a cross-sectional case-control study, 40 patients with fractures admitted to an orthopedic ward and 40 healthy, non-fractured patients were selected using convenience sampling. Serum was analyzed for oxidant and antioxidant activities based on standard methods. P < 0.05 was considered statistically significant. Results: There was a significant difference in mean TAC between the case (748.2 ± 302.83 μmol/L) and control (984.90 ± 207.02 μmol/L) groups (P = 0.003). The mean MDA was 16.61 ± 4.16 µmol/L in the case group and 18.45 ± 5.43 µmol/L in the control group (P = 0.09). The mean SOD was 63.41 ± 16.67 U/g Hb in the case group and 58.54 ± 21.83 U/g Hb in the control group (P = 0.2). There was no significant difference between the two groups in terms of BMI and other variables. Conclusions: A significant difference existed in TAC between the two groups, which indicated increased oxidative stress in patients. However, oxidative stress could occur before and after undergoing fractures. The results suggested a slight, but not significant, difference between the two groups in the SOD and MDA scores. More conclusive results are required to determine the enzymatic and non-enzymatic markers of oxidative stress in larger sample sizes and during different stages of treatment.

scholarly journals Fasudil attenuates Neuro-Inflammation and Oxidative Stress via Rhoa/Rock Pathways in Delayed Neuropsychologic Sequelae Mice Model

2021 ◽  
Author(s):  
Xiang Yan ◽  
Meng Fu ◽  
Ye Gao ◽  
Qin Han ◽  
Shuang Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neuroprotective Effect ◽  
Carbon Monoxide Poisoning ◽  
Immunofluorescence Staining ◽  
Control Group ◽  
Spatial Learning And Memory ◽  
Mrna Levels ◽  
Co Poisoning ◽  
Mice Model ◽  
Tnf Α

Abstract Background Delayed neuropsychologic sequelae is common in patients after carbon monoxide poisoning without effective methods worldwide. Fasudil exerts neuroprotective effect and alleviates oxidative stress in some neurodegenerative disorders. However, the mechanism between DNS and FS remains unclear. The study aims to explore the efficacy and mechanism of Fasudil in DNS mice model. Objective The delayed neuropsychologic sequelae model was induced with a hyperbaric oxygen chamber. All rats were randomly assigned to three groups (n=10): air control group (AC), CO poisoning group (CO), and CO poisoning +Fasudil group (CO+FS). Rats in the CO+FS group were given Fasudil (10 mg/kg/day, ip). The morris water maze was documented to estimate spatial learning and memory of mice. The demyelination state in brain was observed through LFB staining. The protein of MBP was examined with immunofluorescence staining. The levels of IL-6, TNF-α, TGF-β, SOD, and MDA were examined by ELISA. The mRNA levels of Rho, ROCK2, MLC1 and MYPT1 were analyzed by rt-PCR. Result The cognitive impairment in the CO+FS group were significantly reduced than those of the CO group (P<0.05). LFB staining and immunofluorescence staining of MBP results showed that FS significantly treatment attenuated demyelination (P<0.05). Compared with the CO group, the levels of TNF-α, IL-6, MDA, ROCK2, MLC1, and MYPT1 significantly decreased (P<0.05), and the levels of SOD were significantly increased in the CO+FS group (P<0.05). Conclusion In a word, Fasudil attenuated delayed neuropsychologic sequelae by inhibiting inflammation, oxidative stress and downregulating Rho/ROCK pathway in DNS mice model. We conclude that Fasudil may be a novel treatment for delayed neuropsychologic sequelae.

The impact of hyperthermia after acute carbon monoxide poisoning on neurological sequelae

2018 ◽  
Vol 38 (4) ◽  
pp. 455-465 ◽  
Author(s):  
JM Moon ◽  
BJ Chun ◽  
SD Lee ◽  
MH Shin
Keyword(s):  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Early Period ◽  
Maximum Temperature ◽  
Co Poisoning ◽  
Neurological Sequelae ◽  
Neurological Outcomes ◽  
Significant Difference ◽  
The Impact

This study investigated whether hyperthermia within the first 24 h after presentation was associated with long-term neurological outcomes after acute carbon monoxide (CO) poisoning. This retrospective study included 200 patients with acute severe CO poisoning. Hyperthermia (≥ 37.5°C) developed during the first 24 h after presentation in 55 (27.5%) patients, and poor long-term neurological sequelae assessed at 23 months after acute CO poisoning developed in 19.5% of the patients. The incidence of poor long-term neurological outcomes was significantly higher in the hyperthermia group than in the normothermia group. Patients with poor long-term neurological outcomes had higher maximum temperatures than patients with good outcomes. No significant difference was found in the time of hyperthermia onset within the first day according to the neurological outcomes. Hyperthermia (adjusted odds ratio (aOR) 5.009 (95% confidence interval (CI) 1.556–16.126)) and maximum temperature (aOR 2.581 (95% CI 1.098–6.063)) within the first 24 h after presentation to the emergency department were independently associated with poor long-term neurological outcomes. Body temperature measurements, which are easily and noninvasively recorded at the bedside in any facility, help to predict the risk for poor long-term neurological outcomes. This study carefully emphasizes fastidious control of pyrexia, particularly during the early period after acute CO poisoning.

Oxidative stress increases in carbon monoxide poisoning patients

2010 ◽  
Vol 30 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Havva Sahin Kavakli ◽  
Ozcan Erel ◽  
Orhan Delice ◽  
Gizem Gormez ◽  
Semra Isikoglu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Monoxide ◽  
Antioxidant Status ◽  
Carbon Monoxide Poisoning ◽  
Total Antioxidant Status ◽  
Control Group ◽  
Total Oxidant Status ◽  
Oxidative Stress Parameters ◽  
Total Antioxidant ◽  
Oxidant Status

Objective: Carbon monoxide poisoning (COP) is one of the important causes of morbidity and mortality in toxicological cases. In this study, we aimed to find out more about the pathophysiology of COP by investigating the effects of COP on oxidative stress parameters such as total oxidant status (TOS) and total antioxidant status (TAS). Methods: Eighty-eight patients admitted to the emergency department of our hospital with acute COP and 35 healthy adults as control group were included in this study. Blood samples were collected from all COP patients at the time of initial emergency department evaluation to determine the oxidative stress parameters. Then, serum levels of total antioxidant status and total oxidant status levels were measured. Results: A total of 88 patients poisoned by carbon monoxide (CO; mean age 37.1 ± 18.2 years; 54’% women) were enrolled. TOS and carboxyhemoglobin (COHb) levels in COP patients were increased when compared to control group (p = 0.001). TOS, oxidative stress index (OSI) and COHb levels in COP patients were significantly lower after the treatment. (respectively, p = 0.016; p = 0.023; p = 0.001). On the other hand, no statistical differences were observed in TAS levels of study and control group as well as there were no changes with treatment. Conclusion: Measurements of TOS, TAS and OSI levels may be useful markers to find out the pathophsiology of COP.

scholarly journals The effect of planned training given to women with preeclamptic pregnancy on oxidative stress and anxiety levels: non-randomised controlled-study

2021 ◽  
Author(s):  
emel tasci ◽  
serdal ogut ◽  
mehmet özkaya
Keyword(s):  
Oxidative Stress ◽  
Controlled Study ◽  
Control Group ◽  
Randomised Controlled Study ◽  
Significant Difference ◽  
Stress Levels ◽  
Before And After ◽  
Anxiety Levels ◽  
Randomised Controlled ◽  
Experimental Group

This study aimed to studying the effects of planned training given to women with preeclamptic pregnancy on stress-anxiety and oxidative stress levels. A non-randomised controlled-study study, carried out in Gynecology and Obstetrics Clinics of Research and Application Hospital of one university. In the study, 28 preeclamptic patients matching the sampling criteria were taken as the experimental group and 22 other preeclamptic patients who also match the sampling criteria constituted the control group. Questionnaire, scale application and laboratory evaluation for the control group were performed only once. In the experimental group, there is a statistically significant difference between the TAS (mmol trolox equ./L) (t = -9.71 P = 0.00) and the TOS (lmol H2O2 equ./L) (t = 6.56 P = 0.00) measurements before and after the training and there is a statistically significant difference between the State-Trait Anxiety Inventory (t = 3.64 P = 0.00) before and after the training. It has been determined in the study that the planned training given to the pregnant women who received a diagnosis of preeclampsia has decreased their oxidative stress levels and state anxiety levels.

scholarly journals An Analysis of Patients With Carbon Monoxide Poisoning Transported by a Physician-Staffed Helicopter

2019 ◽  
pp. 43-47
Author(s):  
iroki Nagasawa ◽  
Youichi Yanagawa
Keyword(s):  
Carbon Monoxide ◽  
Study Design ◽  
Carbon Monoxide Poisoning ◽  
Male Gender ◽  
Co Poisoning ◽  
Middle Aged ◽  
Normobaric Oxygen ◽  
Base Hospital ◽  
Oxygen Treatment ◽  
Before And After

OBJECTIVE: We retrospectively investigated a series of patients with carbon monoxide (CO) poisoning transported by a physician-staffed helicopter (DH) to seek evidence supporting the daily management of patients with CO poisoning. STUDY DESIGN: Subjects were divided into two groups: the carboxyhemoglobin saturation (SpCO) (+) group, which included patients who had a pulse CO-oximeter attached during transportation; and the SpCO (-) group, which included all other patients. We compared the level of SpCO before and after transportation when the level was noted. RESULTS: The subjects were predominantly middle-aged and male. Seventeen subjects (53.1%) received a diagnosis of CO poisoning based on the situation in which the subjects were found, without the carboxyhemoglobin level being measured. No subjects show deterioration of their condition after transportation, and none ultimately died. The frequency of male gender, normobaric oxygen treatment and return to the base hospital in the SpCO (+) group was significantly greater than in the SpCO (-) group. The SpCO levels after transportation were significantly lower than they had been before transportation. CONCLUSION: This is the first study to show the results of the analysis of patients with CO poisoning transported by the DH. All patients with CO poisoning were safely transported.

Amelioration of Decline in Immune Function in Athletes after High-Intensity Training by Bovine Colostrum

2018 ◽  
Vol 17 (2) ◽  
pp. 219-222
Author(s):  
Zhang Haimin
Keyword(s):  
Immune Function ◽  
High Intensity ◽  
Venous Blood ◽  
Bovine Colostrum ◽  
Control Group ◽  
Intensive Training ◽  
High Intensity Training ◽  
Significant Difference ◽  
Before And After ◽  
Intensity Training

Long-term high-intensity training can cause a decline in immune function in athletes. In this study, we have explored whether bovine colostrum could improve the immune function in athletes undergoing intensive training. Thirty professional athletes were randomly divided into control group and bovine colostrum group; both groups received one month of intensive training. The control group received usual colostrum-free diet and the bovine colostrum group was fed bovine colostrum-rich milk every day. The venous blood was collected from both groups before and after the treatment period. The results showed that the lymphocyte population increased significantly in the bovine colostrum group compared to the control group (P < 0.05). There was no significant change in CD4+ and CD8+ in the two groups (P < 0.05), but the CD3+ and CD4+/CD8+ of the bovine colostrum group were significantly higher than those of the control group. There were significant differences in albumin, globulin and albumin/globulin ratio in the control group (P < 0.05), but not in the bovine colostrum group after training. The bovine colostrum group had lower serum albumin and albumin/globulin (P < 0.05) and higher globulin (P < 0.05) compared to the control group. There was no significant difference in immunologic indexes before and after training in both groups (P > 0.05). The decline in the markers of immune function after high-intensity training was ameliorated by the intake of bovine colostrum.

The relationship among plasma copeptin, carboxyhemoglobin, and lactate levels in carbon monoxide poisoning

2019 ◽  
Vol 39 (3) ◽  
pp. 311-318
Author(s):  
S Ozkan ◽  
O Salt ◽  
P Durukan ◽  
A Sen ◽  
E Bulbul ◽  
...  
Keyword(s):  
Emergency Department ◽  
Carbon Monoxide ◽  
Plasma Levels ◽  
Carbon Monoxide Poisoning ◽  
Serum Lactate ◽  
Co Poisoning ◽  
Stress Hormone ◽  
Significant Difference ◽  
Lactate Levels ◽  
The Relationship

Objective: The aim of our study is to determine whether there is a change in the plasma levels of copeptin and there is a relationship among the plasma levels of carboxyhemoglobin (COHb), lactate, and copeptin levels in patients presenting to the emergency department with carbon monoxide (CO) poisoning. Methods: Fifty-seven patients admitted to the emergency department with CO poisoning were included in the study. The blood samples of the patients were collected on arrival 0th, 6th, and 12th hours for copeptin, lactate, and COHb levels. Data were analyzed using SPSS-17 statistical software. Results: Arrival serum copeptin levels of the patients were compared to copeptin levels of healthy individuals and a statistically significant difference was found between them ( p = 0.008). There was a statistically significant difference between the arrival levels of copeptin and 6th-hour ( p = 0.006) and 12th-hour ( p = 0.001) levels of copeptin. There was no significant difference between 6th-hour and 12th-hour copeptin levels ( p = 0.51). In terms of serum lactate levels, there was a significant difference between arrival and 6th h ( p < 0.001), arrival and 12th h ( p < 0.001), and 6th and 12th h ( p < 0.001). Likewise, in terms of serum COHb levels, there was a significant difference between arrival and 6th h ( p < 0.001), arrival and 12th h ( p < 0.001), and 6th and 12th h ( p < 0.001). There was a positive correlation between COHb and lactate levels on arrival ( r = 0.52; p = 0.001). Conclusion: Copeptin as a stress hormone can be used in the diagnosis and monitoring of patients with CO poisoning. However, the copeptin level was not superior to COHb and lactate levels.

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