Toxicology and the Immune System: a Perspective

1991 ◽  
Vol 10 (6) ◽  
pp. 445-449 ◽  
Author(s):  
I. Kimber

The relationship of immunology to toxicology has not always been an easy one, and the product of this association, immunotoxicology, has not infrequently been viewed with a certain scepticism by some of those who consider themselves 'classical' toxicologists. A recent meeting of the British Toxicology Society ('Toxicology and the Immune System', New College Oxford, March 21-22, 1991) provided an opportunity for some remedial work toward a wider appreciation of the issues which exercise immunotoxicologists, and the ways in which they are being addressed. It is not the purpose of this short article to provide a comprehensive account of the scientific presentations, but rather to give a perspective, necessarily a personal one, of immunotoxicology in the context of the meeting.

Author(s):  
Farah Iylia Binti Fauzi ◽  
Siti Fatimah Binti Salleh ◽  
Mohammad Shahadat Hossen

COVID-19 is a highly contagious virus that first appeared in China in December 2019. It has affected over 157 million people and killed over 3.2 million. The paper reviews the function of the immune system for COVID-19 prevention, depression, and anxiety due to COVID-19 and their effects on the immune system and the relationship of aging with the immune system and depression and anxiety. It has been found that several elderly people lack the coping mechanisms required to deal with the stress caused by COVID-19. Hence, identifying the factors and mechanisms that lead to this resilience will aid in the development of preventive measures for certain elderly people and groups with more severe mental health problems. Additionally, it would be beneficial to understand how technology could be leveraged to accomplish this goal. During the pandemic, various steps such as social isolation, quarantine, and self-isolation are needed to be implemented properly to slow the spread of the virus. Meanwhile, to help halt the pandemic, everybody must be vaccinated as soon as possible until any bans on social gatherings and social isolation can be removed, allowing other sectors such as schooling, social activities, and life to resume normalcy.


Author(s):  
Olabambo Ogunbambi ◽  
Yusuf I. Patel

Parasitic infections remain prevalent, particularly in the developing world. However, increasing global travel poses a risk of contracting parasitic infections while travelling through endemic areas and therefore all medical practitioners should remain aware of parasitic infections and investigate for them when appropriate. Increased understanding of the relationship of parasites with the immune system has led to some progress with therapeutics but this still lags behind other infectious diseases. In this chapter we outline the musculoskeletal manifestations of parasitic infection and updated therapeutic approaches to these infections. The burden of disease may change with increasing use of potent biologic immunosuppressants and global travel, as seen in HIV-related immunosuppression, but as yet no significant increased incidence of parasitic infection has been reported within 'rheumatic diseases' cohorts around the world.


2020 ◽  
Author(s):  
Mei Yamagata ◽  
Tsukasa Teraguchi ◽  
Asako Miura

Amidst the worldwide outbreak of COVID-19 in January 2020, this study focused on the preventive behaviours against COVID-19 infection and the exclusionary attitude towards foreigners in Japan. Particularly, we examined the effects of individual differences in the infection-avoidance tendency based on the behavioural immune system. A web survey of 1,248 Japanese citizens aged 18 years or above living in Japan who were registrants of a crowdsourcing service indicated that as the threat of the COVID-19 spread increased, there were tendencies for infection-preventive behaviours to increase. In addition, people with a strong infection-avoidance tendency adopted more preventive actions, regardless of whether they were under normal circumstances or the threat of infection, indicating their strong rejective attitudes towards the Chinese and other foreigners under the threat of infection. This study recorded the behavioural and psychological states of people who were in the midst of rapid and unpredictable real-world changes in the early stages of the infection. Data collected in Japan, where the infection had begun earlier, will provide valuable knowledge to countries worldwide where major social changes are expected in the future.


Author(s):  
Iván Enrique Naranjo Logroño ◽  
Leslie Gricel Cuzco Macías ◽  
Alison Tamara Ruiz Chico ◽  
Anthony Alfonso Naranjo Coronel

Introduction: The human microbiome refers to the presence of microorganisms that live with its host. Objective: To analyze the relationship between the maternal perinatal microbiome and the development of the infant’s immune system, at the origins of the development of health and disease. Methodology: A non-systematic bibliographic review was carried out, including those controlled and randomized clinical trials focused on the relationship of the prenatal maternal microbiome and the infant’s immune system. And all those works whose approach was different from the topic raised were excluded. Discussion: 20 min after birth, the microbiome of newborns by vaginal delivery resembles the microbiota of their mother’s vagina, while those born by caesarean section house microbial communities that are usually found in human skin. The acquisition of the microbiome continues during the first years of life, with a microbiome of the baby’s gastrointestinal tract beginning to resemble that of an adult from the first year of life. Conclusion: Bacteria are microorganisms that have managed to colonize the vast majority of land surfaces, showing great adaptability. The human being is not indifferent, and hypotheses have been raised that affirm his participation in the development of health and the onset of the disease. Keywords: microbiota, inmune system, infant nutritional physiological phenomena. RESUMEN Introducción: El microbioma humano se refiere a la presencia de microorganismos que conviven con su hospedero. Objetivo: Analizar la relación existente entre el microbioma materno perinatal y el desarrollo del sistema inmune del lactante, en los orígenes del desarrollo de la salud y enfermedad. Metodología: Se realizó una revisión bibliográfica no sistemática, donde se incluyeron aquellos ensayos clínicos controlados y randomizados enfocados en la relación del microbioma materno prenatal y el sistema inmune del lactante. Y se excluyeron todos aquellos trabajos cuyo enfoque fue diferente al tema planteado. Resultados: Se encontraron 61 fuentes bibliográficas, de las cuales se incluyeron 53 artículos que contenían la información relacionada al tema y publicados en los últimos 11 años. Discusión: 20 min después del nacimiento, el microbioma de los recién nacidos por parto vaginal se asemeja a la microbiota de la vagina de su madre, mientras que los nacidos por cesárea albergan comunidades microbianas que generalmente se encuentran en la piel humana. La adquisición del microbioma continúa durante los primeros años de vida, con un el microbioma del tracto gastrointestinal del bebé comienza a parecerse al de un adulto desde el primer año de vida. Conclusiones: Las bacterias, son microorganismos que han logrado colonizar la gran mayoría de las superficies terrestres, mostrando una gran capacidad de adaptación. El ser humano, no es indiferente, y se han planteado hipótesis que aseveran su participación en el desarrollo de la salud e inicio de la enfermedad. Palabras clave: microbiota, sistema inmunológico, fenómenos fisiológicos nutricionales del lactante.


2020 ◽  
Vol 168 (4) ◽  
pp. 417-425
Author(s):  
Fan Liu ◽  
Jianyu Zhang

Abstract Human catechol-O-methyltransferase, a key enzyme related to neurotransmitter metabolism, catalyses a methyl transfer from S-adenosylmethionine to catechol. Although extensive studies aim to understand the enzyme mechanisms, the connection of protein dynamics and enzyme catalysis is still not clear. Here, W38in (Trp143Phe) and W38in/Y68A (Trp143Phe with Tyr68Ala) mutants were carried out to study the relationship of dynamics and catalysis in nano-second timescale using time-resolved fluorescence lifetimes and Stokes shifts in various solvents. The comprehensive data implied the mutant W38in/Y68A with lower activity is more rigid than the ‘WT’−W38in, suggesting the importance of flexibility at residue 38 to maintain the optimal catalysis.


2016 ◽  
Vol 55 (3) ◽  
pp. 899-903 ◽  
Author(s):  
Jose Enrique de la Rubia Ortí ◽  
Sandra Sancho Castillo ◽  
Maria Benlloch ◽  
Mariano Julián Rochina ◽  
Silvia Corchón Arreche ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Elena Spronk ◽  
Gina Sykes ◽  
Sarina Falcione ◽  
Danielle Munsterman ◽  
Twinkle Joy ◽  
...  

Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier (BBB) into the brain following ischemic stroke. Preventing HT is important as it worsens stroke outcome and increases mortality. Factors associated with increased risk of HT include stroke severity, reperfusion therapy (thrombolysis and thrombectomy), hypertension, hyperglycemia, and age. Inflammation and the immune system are important contributors to BBB disruption and HT and are associated with many of the risk factors for HT. In this review, we present the relationship of inflammation and immune activation to HT in the context of reperfusion therapy, hypertension, hyperglycemia, and age. Differences in inflammatory pathways relating to HT are discussed. The role of inflammation to stratify the risk of HT and therapies targeting the immune system to reduce the risk of HT are presented.


Author(s):  
Ю.Ю. Косенкова

В данном исследовании была сделана попытка установить связь между стадией экономического развития государства со сформировавшейся моделью налоговой системы на примере налоговой системы КНР. В рамках проведенного анализа первоначально обосновывалось отнесение национальной экономики к той или иной стадии экономического развития. Далее на основе изучения особенностей налоговой системы был сформирован перечень характеристик, присущих налоговым системам государств, находящихся на индустриальном этапе развития. The study establishes a connection between the stage of economic development of the state and the established model of the tax system using the example of the tax system in China. First of all, the attribution of the national economy to a particular stage of economic development is justified. Then, on the basis of studying the features of the tax system, a list of characteristics inherent to the tax systems of states at the industrial stage of development was formed.


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