Stability of Intravenous Famotidine Stored in Polyvinyl Chloride Syringes

DICP ◽  
1989 ◽  
Vol 23 (7-8) ◽  
pp. 588-590 ◽  
Author(s):  
Linda S. Bullock ◽  
Joseph F. Fitzgerald ◽  
Helen I. Mazur
Keyword(s):  
Polyvinyl Chloride ◽  
Repeated Measures ◽  
High Performance ◽  
Hplc Analysis ◽  
Time Effect ◽  
Sterile Water ◽  
Reverse Phase ◽  
Repeated Measures Analysis ◽  
The Stability ◽  
Over Time

The stability of intravenous famotidine in dextrose 5% injection (D5W), NaCl 0.9% injection (NS), and sterile water for injection stored in polyvinyl chloride (PVC) syringes at 4°C for 14 days was studied. The concentration of famotidine samples was determined at time 0, 7 days, and 14 days by reverse-phase high-performance liquid chromatography. Samples were inspected for visual changes and tested for changes in pH. Results of the HPLC analysis indicated that the famotidine samples remained within 94-100 percent and 99-103 percent of the time 0 concentrations at 7 and 14 days, respectively. Repeated measures analysis of variance demonstrated a significant time effect on famotidine concentration as concentrations changed over time (p<0.01). This change was small in magnitude, however, and concentrations decreased at 7 days and increased at 14 days. Famotidine is stable at a concentration of 2 mg/mL in D5W, NS, and sterile water for injection stored in PVC syringes at 4°C for 14 days.

Lorazepam Stability in Parenteral Solutions for Continuous Intravenous Administration

1996 ◽  
Vol 30 (4) ◽  
pp. 343-346 ◽  
Author(s):  
Lori L Hoey ◽  
Kyle Vance-Bryan ◽  
Diann M Clarens ◽  
David H Wright ◽  
Frank N Konstantinides ◽  
...  
Keyword(s):  
Polyvinyl Chloride ◽  
Hplc Analysis ◽  
Visual Inspection ◽  
Degradation Products ◽  
Significant Loss ◽  
Test Solution ◽  
Reverse Phase Hplc ◽  
Reverse Phase ◽  
Concentration Determination ◽  
The Stability

OBJECTIVE: To determine the stability of lorazepam over a 24-hour period when prepared in polyvinyl chloride (PVC) bags at initial concentrations of 0.08 and 0.5 mg/mL. DESIGN: Each concentration was studied at room (21°C) and refrigerator (4°C) temperatures in dextrose 5% (D5W) and NaCl 0.9% solutions. Duplicate test solution admixtures were prepared for each lorazepam concentration, diluent, and temperature. At 0, 1, 4, 8, and 24 hours, duplicate samples were obtained for visual inspection, pH determination, and concentration determination by stability-indicating, reverse-phase HPLC analysis. Compared with baseline, peaks for lorazepam degradation products were not found on any of the study chromatograms. RESULTS: In D5W and NaCl 0.9% solutions, lorazepam loss in excess of 10% by HPLC analysis occurred for concentrations of 0.08 and 0.5 mg/mL at 1 and 4 hours, respectively. CONCLUSIONS: These data suggest that significant loss of lorazepam occurs as the probable result of sorption to PVC bags when admixed in both D5W and NaCl 0.9% solutions at 21 and 4°C.

Compatibility of Tacrolimus Ointment with Corticosteroid Ointments of Varying Potencies

2009 ◽  
Vol 13 (3) ◽  
pp. 140-145 ◽  
Author(s):  
Lisa Pappas ◽  
Alex Kiss ◽  
Jacob Levitt
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Clobetasol Propionate ◽  
Reverse Phase ◽  
Drug Degradation ◽  
Significant Difference ◽  
The Stability ◽  
Over Time

Background: Tacrolimus is often coadministered with various topical corticosteroids in the treatment of steroid-responsive dermatoses; however, the stability of these products in combination has not been examined extensively. Objective: To assess the in vitro compatibility of three tacrolimus-corticosteroid ointment combinations compared with unmixed controls. Methods: Tacrolimus-clobetasol propionate, tacrolimus-desoximetasone, and tacrolimus-hydrocortisone-17-valerate ointment combinations were prepared, stored with unmixed ointments at three temperature/humidity conditions, and evaluated for stability at days 0, 1, 2, 7, 14, and 28 via reverse-phase high-performance liquid chromatography. Results: There was no significant difference in the rate of drug degradation in mixed and unmixed ointments over time or across temperatures for tacrolimus (time p = .94; temperature p = .44), clobetasol (time p = .98, temperature p = .30), desoximetasone (time p = .98; temperature p = .94), or hydrocortisone-17-valerate (time p = .87, temperature p = .36). Limitations: This study did not examine the compatibility of tacrolimus with nonointment formulations. Conclusion: Tacrolimus-clobetasol propionate (superpotent), tacrolimus-desoximetasone (high potent), and tacrolimus-hydrocortisone-17-valerate (midpotent) ointment combinations are chemically compatible for at least 4 weeks.

The effects of tibial intraosseous versus intravenous amiodarone administration in a hypovolemic cardiac arrest procine model

2016 ◽  
Vol 11 (4) ◽  
pp. 253-260 ◽  
Author(s):  
Kathryn Hampton, BSN ◽  
Eric Wang, BSN ◽  
Jerome Ivan Argame, BSN ◽  
Tom Bateman, BSN ◽  
William Craig, DNP, CRNA ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Analysis Of Variance ◽  
Repeated Measures ◽  
High Performance ◽  
Plasma Concentrations ◽  
Spontaneous Circulation ◽  
Repeated Measures Analysis ◽  
Liquid Chromatography Tandem Mass ◽  
Intravenous Amiodarone ◽  
Over Time

Objective: This study compared the effects of amiodarone via tibial intraosseous (TIO) and intravenous (IV) routes on return of spontaneous circulation (ROSC), time to ROSC, maximum drug concentration (Cmax), time to maximum concentration (Tmax), and mean concentrations over time in a hypovolemic cardiac arrest model.Design: Prospective, between subjects, randomized experimental design.Setting: TriService Research Facility.Subjects: Yorkshire-cross swine (n = 28).Intervention: Swine were anesthetized and placed into cardiac arrest. After 2 minutes, cardiopulmonary resuscitation (CPR) was initiated. After an additional 2 minute, 300 mg of amiodarone were administered via the TIO or the IV route. Blood samples were collected over 5 minutes. The plasma concentrations were analyzed using high-performance liquid chromatography tandem mass spectrometry.Main Outcome Measurements: ROSC, time to ROSC, Cmax, Tmax, and mean concentrations over time.Results: A multivariate analysis of variance indicated that there were no significant differences in the TIO and IV groups in ROSC (p = 0.515), time to ROSC (p = 0.300), Cmax (p = 0.291), or Tmax (p = 0.475). The mean Cmax of the TIO group was 56,292 ± 11,504 ng/mL compared to 74,258 ± 11,504 ng/mL for the IV group. The Tmax for TIO and IV groups were 120 ± 25 and 94 ± 25, respectively. A repeated measures analysis of variance indicated that there were no significant differences between the groups relative to concentrations over time (p 0.05).Conclusion: The TIO provides rapid and reliable access to administer lifesaving medications during cardiac arrest.

scholarly journals Mood and Global Symptom Changes among Psychotherapy Clients with Depressive Personality

2012 ◽  
Vol 2012 ◽  
pp. 1-12
Author(s):  
Rachel E. Maddux ◽  
Lars-Gunnar Lundh
Keyword(s):  
Repeated Measures ◽  
Mixed Model ◽  
Psychological Symptoms ◽  
Self Report ◽  
Treatment Results ◽  
Repeated Measures Analysis ◽  
Depressive Personality ◽  
Symptom Changes ◽  
Psychotherapy Clients ◽  
Over Time

The present study assessed the rate of depressive personality (DP), as measured by the self-report instrument depressive personality disorder inventory (DPDI), among 159 clients entering psychotherapy at an outpatient university clinic. The presenting clinical profile was evaluated for those with and without DP, including levels of depressed mood, other psychological symptoms, and global severity of psychopathology. Clients were followed naturalistically over the course of therapy, up to 40 weeks, and reassessed on these variables again after treatment. Results indicated that 44 percent of the sample qualified for DP prior to treatment, and these individuals had a comparatively more severe and complex presenting disposition than those without DP. Mixed-model repeated-measures analysis of variance was used to examine between-groups changes on mood and global severity over time, with those with DP demonstrating larger reductions on both outcome variables, although still showing more symptoms after treatment, than those without DP. Only eleven percent of the sample continued to endorse DP following treatment. These findings suggest that in routine clinical situations, psychotherapy may benefit individuals with DP.

Classification Based on Multivariate Repeated Measures with Time Effect on Mean Vector and an AR (1) Correlation Structure on the Repeated Measures

2005 ◽  
Vol 57 (1-2) ◽  
pp. 49-66 ◽  
Author(s):  
Anuradba Roy ◽  
Ravindra Khattree
Keyword(s):  
Maximum Likelihood ◽  
Repeated Measures ◽  
Likelihood Estimation ◽  
Covariance Matrices ◽  
Time Effect ◽  
Population Parameters ◽  
Time Effects ◽  
Mean Vectors ◽  
Mean Vector ◽  
Over Time

In repeated measures studies how observations change over time is often of prime interest. Modelling this time effect in the context of discrimination, is the objective of this article. We study the problem of classification with multiple q-variate observations with time effect on each individual. The covariance matrices as well as mean vectors are mordelled respectively to accommodate the correlation between the successive repeated measures and to describe the time effects. Computation schemes for maximum likelihood estimation of required population parameters are provided.

scholarly journals Determinants of Ceftazidime Clearance by Continuous Venovenous Hemofiltration and Continuous Venovenous Hemodialysis

2000 ◽  
Vol 44 (6) ◽  
pp. 1639-1644 ◽  
Author(s):  
Gary R. Matzke ◽  
Reginald F. Frye ◽  
Melanie S. Joy ◽  
Paul M. Palevsky
Keyword(s):  
Repeated Measures ◽  
High Performance ◽  
Mixed Model ◽  
Random Effect ◽  
Quantitative Information ◽  
Continuous Venovenous Hemofiltration ◽  
Linear Relationships ◽  
Repeated Measures Analysis ◽  
Continuous Venovenous Hemodialysis ◽  
Dosing Strategies

ABSTRACT Although several dosage adjustment regimens have been proposed, there is little quantitative information to guide the initiation of ceftazidime therapy in patients who are receiving continuous renal replacement therapy. To determine the clearance of ceftazidime by continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodialysis (CVVHD), we performed controlled clearance studies with stable hemodialysis patients with three hemofilters: a 0.6-m2 acrylonitrile copolymer (AN69; Hospal) filter, a 2.1-m2 polymethylmethacrylate filter (PMMA; Toray) filter and a 0.65-m2 polysulfone (PS; Fresenius) filter. Subjects received 1,000 mg of ceftazidime intravenously prior to the start of a clearance study. The concentration of ceftazidime in multiple plasma and dialysate or ultrafiltrate samples was determined by high-performance liquid chromatography. The diffusional clearances (CIdiffusion) and sieving coefficients of ceftazidime were compared by a mixed-model repeated-measures analysis of variance with filter and blood, dialysate inflow, or ultrafiltration rate as the main effect and the patient as a random effect. The fraction of ceftazidime bound to plasma proteins was 17% ± 7% (range, 10 to 25%). The clearances of ceftazidime, urea, and creatinine by CVVHD were essentially constant at blood flow rates of 75 to 250 ml/min for all three filters. Significant linear relationships (P < 0.0001) were observed between CIdiffusion of ceftazidime and clearance of urea for all three filters: AN69 (slope = 0.83), PMMA (slope = 0.89), and PS (slope = 1.03). Ceftazidime clearance was membrane independent during CVVH and CVVHD. CVVH and CVVHD can significantly augment the clearance of ceftazidime. Dosing strategies for initiation of ceftazidime therapy in patients receiving CVVH and CVVHD are proposed.

scholarly journals Randomized Split-Mouth Study on Postoperative Effects of Palmitoylethanolamide for Impacted Lower Third Molar Surgery

ISRN Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Christian Bacci ◽  
Giulia Cassetta ◽  
Bruno Emanuele ◽  
Mario Berengo
Keyword(s):  
Postoperative Pain ◽  
Repeated Measures ◽  
Third Molar ◽  
Third Molar Surgery ◽  
Third Molar Extraction ◽  
Drug Tolerability ◽  
Repeated Measures Analysis ◽  
Surgical Extraction ◽  
Over Time ◽  
Molar Extraction

The aim of this study was to assess the efficacy of Normast 300 mg in reducing swelling and pain after the surgical extraction of impacted lower third molars. Materials and Methods. A randomized, split-mouth, single-blind study was conducted on 30 patients between 18 and 30 years of age requiring lower third molar extraction. Patients underwent bilateral extractions in a randomized sequence, one extraction being performed under Normast treatment. The Normast treatment involved 2 tablets a day for 15 days. The parameters assessed at each procedure were trismus, swelling, pain, NSAID consumption, postoperative complications, drug tolerability, and safety. The results obtained were processed using repeated measures analysis of variance. Results. Perceived postoperative pain was reportedly significantly milder on Normast treatment than control. The trend of the means differed over time (P<.0001) and between the two extraction groups (P<.0221). On the other hand, for edema and trismus, the trend differed over time for both groups but did not differ between the two groups. Discussion. Our analyses indicate that patients experienced significantly less postoperative pain when they were treated with Normast. Conclusions. Administering Normast improves the postoperative course—in terms of pain—after lower third molar extraction.

scholarly journals Evaluation of intra-articular injection of bupivacaine with morphine or methylprednisolone or alone on pain after knee arthroscopy

2020 ◽  
pp. 314-322
Keyword(s):  
Side Effects ◽  
Pain Intensity ◽  
Repeated Measures ◽  
Knee Arthroscopy ◽  
Sedative Effect ◽  
Visual Analog Scales ◽  
Repeated Measures Analysis ◽  
Recorded Data ◽  
Spss Software ◽  
Over Time

Background and Aim: Knee arthroscopy is used to diagnose and treat intra-articular lesions. Controlling acute pain after arthroscopy requires the use of a method with the least side effects and the most efficiency. The aim of this study was to compare the sedative effect after intra-articular injection of bupivacaine combination with morphine or methylprednisolone or alone in knee arthroscopy. Materials and Methods: In this study clinical-randomized three-blind trial, 99 volunteer patients with knee arthroscopy were randomly divided into three groups: 1. Bupivacaine (0.5%), 2. Morphine (5 mg)+ bupivacaine (0.5%) and 3. Methylprednisolone (40 mg) + bupivacaine (0.5%). At the end of the operation, drugs were injected intra-articular and the amount of postoperative pain was evaluated and recorded based on visual analog scales 6, 12, 18, and 24 hours after injection. Also, receiving the injected analgesic within 24 hours, was recorded. Data were analyzed using SPSS software and repeated measures analysis of variance. Results: In all three groups, the pain intensity decreased significantly over time. The pain intensity of the methylprednisolone + bupivacaine and morphine+bupivacaine group was the similar, at different postoperative periods, but the pain intensity of these groups was significantly lower than the control. Also, consumption of the analgesics was significantly reduced in methylprednisolone+bupivacaine group compared to the two other groups. Conclusion: The results of this study showed that intra-articular injection of methylprednisolone + bupivacaine and morphine+bupivacaine was more effective than bupivacaine alone in reducing pain and the need for injectable analgesia.

scholarly journals Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil

Gels ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 5 ◽  
Author(s):  
Evelina Parisi ◽  
Ana Garcia ◽  
Domenico Marson ◽  
Paola Posocco ◽  
Silvia Marchesan
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
High Performance ◽  
Supramolecular System ◽  
Reverse Phase ◽  
Transmission Electron ◽  
Oscillatory Rheometry ◽  
Ft Ir ◽  
Dynamics Simulations ◽  
Over Time

In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations.

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