Regional Brain Volumes and ADHD Symptoms in Middle-Aged Adults: The PATH Through Life Study

2014 ◽  
Vol 21 (13) ◽  
pp. 1073-1086 ◽  
Author(s):  
Debjani Das ◽  
Nicolas Cherbuin ◽  
Kaarin J. Anstey ◽  
Walter Abhayaratna ◽  
Simon Easteal
Keyword(s):  
Brain Volume ◽  
Brain Regions ◽  
Equation Modeling ◽  
Depression Symptoms ◽  
Middle Aged ◽  
Brain Volumes ◽  
Automated Method ◽  
Inattention And Hyperactivity ◽  
Middle Aged Adults ◽  
Anxiety Depression

Objective: We investigated whether volumetric differences in ADHD-associated brain regions are related to current symptoms of inattention and hyperactivity in healthy middle-aged adults and whether co-occurring anxiety/depression symptoms moderate these relationships. Method: ADHD Self-Report Scale and Brief Patient Health Questionnaire were used to assess current symptoms of inattention, hyperactivity, anxiety, and depression in a population-based sample ( n = 269). Brain volumes, measured using a semi-automated method, were analyzed using multiple regression and structural equation modeling to evaluate brain volume–inattention/hyperactivity symptom relationships for selected regions. Results: Volumes of the left nucleus accumbens and a region overlapping the dorsolateral prefrontal cortex were positively associated with inattention symptoms. Left hippocampal volume was negatively associated with hyperactivity symptoms. The brain volume–inattention/hyperactivity symptom associations were stronger when anxiety/depression symptoms were controlled for. Conclusion: Inattention and hyperactivity symptoms in middle-aged adults are associated with different brain regions and co-occurring anxiety/depression symptoms moderate these brain–behavior relationships.

IC-P-030: The influence of AD family history and ApoE4 on vulnerable brain regions in cognitively normal middle-aged adults

2006 ◽  
Vol 2 ◽  
pp. S667-S667
Author(s):  
Sterling C. Johnson ◽  
Taylor W. Schmitz ◽  
Michele L. Ries ◽  
Mehul A. Trivedi ◽  
Craig Atwood ◽  
...  
Keyword(s):  
Family History ◽  
Brain Regions ◽  
Middle Aged ◽  
Cognitively Normal ◽  
Middle Aged Adults

P2-377: CSF biomarkers correlate with regional brain volume and fMRI activation patterns in middle-aged adults at risk for Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S356-S356
Author(s):  
Cynthia M. Carlsson ◽  
Mehul A. Trivedi ◽  
Kimberly Arnold ◽  
Hanna M. Blazel ◽  
Zachary J. Clark ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Brain Volume ◽  
Csf Biomarkers ◽  
Middle Aged ◽  
Activation Patterns ◽  
Regional Brain ◽  
Middle Aged Adults ◽  
Regional Brain Volume

scholarly journals O4-01-01: The influence of AD family history and APOE4 on vulnerable brain regions in cognitively normal middle-aged adults

2006 ◽  
Vol 2 ◽  
pp. S74-S74
Author(s):  
Sterling C. Johnson ◽  
Taylor W. Schmitz ◽  
Michele L. Ries ◽  
Mehul A. Trivedi ◽  
Craig S. Atwood ◽  
...  
Keyword(s):  
Family History ◽  
Brain Regions ◽  
Middle Aged ◽  
Cognitively Normal ◽  
Middle Aged Adults

scholarly journals Regional abdominal adiposity is associated with BMI‐related brain regions in middle‐aged adults at high risk of Alzheimer’s dementia

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Sapir Golan ◽  
Ethel Boccara ◽  
Ramit Ravona‐Springer ◽  
Yael Inbar ◽  
Iscka Yore ◽  
...  
Keyword(s):  
High Risk ◽  
Brain Regions ◽  
Alzheimer’S Dementia ◽  
Abdominal Adiposity ◽  
Middle Aged ◽  
Alzheimer's Dementia ◽  
Middle Aged Adults

Musculoskeletal complaints, anxiety–depression symptoms, and neuroticism: A study of middle-aged twins.

2017 ◽  
Vol 36 (8) ◽  
pp. 729-739 ◽  
Author(s):  
Olav Vassend ◽  
Espen Røysamb ◽  
Christopher Sivert Nielsen ◽  
Nikolai Olavi Czajkowski
Keyword(s):  
Depression Symptoms ◽  
Musculoskeletal Complaints ◽  
Middle Aged ◽  
Anxiety Depression

scholarly journals Visceral fat is associated with lower brain volume in healthy middle-aged adults

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Stéphanie Debette ◽  
Alexa Beiser ◽  
Udo Hoffmann ◽  
Charles DeCarli ◽  
Christopher J. O'Donnell ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Brain Volume ◽  
Middle Aged ◽  
Middle Aged Adults

Semantic intrusion errors as a function of age, amyloid, and volumetric loss: a confirmatory path analysis

2021 ◽  
pp. 1-11
Author(s):  
D. Diane Zheng ◽  
Rosie E. Curiel Cid ◽  
Ranjan Duara ◽  
Marcela Kitaigorodsky ◽  
Elizabeth Crocco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Education ◽  
Stress Test ◽  
Brain Regions ◽  
Equation Modeling ◽  
Semantic Interference ◽  
Modeling Framework ◽  
Brain Volumes ◽  
Intrusion Errors

ABSTRACT Objective: To examine the direct and indirect effects of age, APOE ϵ4 genotype, amyloid positivity, and volumetric reductions in AD-prone brain regions as it relates to semantic intrusion errors reflecting proactive semantic interference (PSI) and the failure to recover from proactive semantic interference (frPSI) on the Loewenstein-Acevedo Scales of Semantic Interference and Learning (LASSI-L), a cognitive stress test that has been consistently more predictive of preclinical and prodromal Alzheimer’s disease (AD) than traditional list-learning tests. Design: Cross-sectional study. Setting: 1Florida Alzheimer’s Disease Research Center baseline study. Participants: Two-hundred and twelve participants with Mini-Mental State Examination (MMSE) score above 16 and a broad array of cognitive diagnoses ranging from cognitively normal (CN) to dementia, of whom 58% were female, mean age of 72.1 (SD 7.9). Measures: Participants underwent extensive clinical and neuropsychological evaluations, MR and amyloid Positron Emission Tomography/Computer/Computer Tomography (PET/CT) imaging, and analyses of APOE ϵ4 genotype. Confirmatory path analyses were conducted in the structural equation modeling framework that estimated multiple equations simultaneously while controlling for important covariates such as sex, education, language of evaluation, and global cognitive impairment. Results: Both amyloid positivity and decreased brain volumes in AD-prone regions were directly related to LASSI-L Cued B1 and Cued B2 intrusions (sensitive to PSI and frPSI effects) even after controlling for covariates. APOE ϵ4 status did not evidence direct effects on these LASSI-L cognitive markers, but rather exerted their effects on amyloid positivity, which in turn related to PSI and frPSI. Similarly, age did not have a direct relationship with LASSI-L scores, but exerted its effects indirectly through amyloid positivity and volumes of AD-prone brain regions. Conclusions: Our study provides insight into the relationships among age, APOE ϵ4, amyloid, and brain volumetric reductions as it relates to semantic intrusion errors. The investigation expands our understanding of the underpinnings of PSI and frPSI intrusions in a large cohort.

scholarly journals The Effects Of Latent Classes Of Stress On Health Outcomes In Korean Middle-aged Adults: A Focus On Gender Differences

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 874-874
Author(s):  
Kyuyoung Cho
Keyword(s):  
Health Status ◽  
Health Outcomes ◽  
Psychological Health ◽  
Latent Profile Analysis ◽  
High Stress ◽  
Latent Classes ◽  
Middle Aged ◽  
Class Model ◽  
Middle Aged Adults ◽  
Anxiety Depression

Abstract This study indicated the effect of the latent classes of stress on the physical and psychological health outcomes in Korea. Using the 2010 Korea Health Panel Study, 1,689 middle-aged adults (women: n=793, men: n=896) were analyzed to identify the latent classes of stress by gender using Latent Profile Analysis (LPA). After the determination of the number of latent classes, health outcomes (anxiety/depression and health status) were also regressed on the latent classes including covariates (age, marital status, and education level). The perceived stresses (financial diversity, disease of self or family, children’s education, and family conflicts) are classified as the 2-class model for women and the 3-class model for men. The classes of women are named ‘high stress and ‘low stress; however, the classes of men are named ‘family-related stress’, ‘disease stress’, and ‘low stress.’ The different combinations of stress are associated with anxiety/depression and health status respectively. This study will discuss the difference of latent stress classes by gender and extend the understanding of stress groups and health outcomes.

scholarly journals Circulating cortisol and cognitive and structural brain measures

Neurology ◽  
2018 ◽  
Vol 91 (21) ◽  
pp. e1961-e1970 ◽  
Author(s):  
Justin B. Echouffo-Tcheugui ◽  
Sarah C. Conner ◽  
Jayandra J. Himali ◽  
Pauline Maillard ◽  
Charles S. DeCarli ◽  
...  
Keyword(s):  
White Matter ◽  
Visual Perception ◽  
Gray Matter ◽  
Brain Volume ◽  
Brain Mri ◽  
Serum Cortisol ◽  
Community Dwelling ◽  
White Matter Hyperintensity ◽  
Middle Aged ◽  
Middle Aged Adults

ObjectiveTo assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia.MethodsWe evaluated dementia-free Framingham Heart Study (generation 3) participants (mean age 48.5 years, 46.8% men) who underwent cognitive testing for memory, abstract reasoning, visual perception, attention, and executive function (n = 2,231) and brain MRI (n = 2018) to assess total white matter, lobar gray matter, and white matter hyperintensity volumes and fractional anisotropy (FA) measures. We used linear and logistic regression to assess the relations of cortisol (categorized in tertiles, with the middle tertile as referent) to measures of cognition, MRI volumes, presence of covert brain infarcts and cerebral microbleeds, and voxel-based microstructural white matter integrity and gray matter density, adjusting for age, sex, APOE, and vascular risk factors.ResultsHigher cortisol (highest tertile vs middle tertile) was associated with worse memory and visual perception, as well as lower total cerebral brain and occipital and frontal lobar gray matter volumes. Higher cortisol was associated with multiple areas of microstructural changes (decreased regional FA), especially in the splenium of corpus callosum and the posterior corona radiata. The association of cortisol with total cerebral brain volume varied by sex (p for interaction = 0.048); higher cortisol was inversely associated with cerebral brain volume in women (p = 0.001) but not in men (p = 0.717). There was no effect modification by the APOE4 genotype of the relations of cortisol and cognition or imaging traits.ConclusionHigher serum cortisol was associated with lower brain volumes and impaired memory in asymptomatic younger to middle-aged adults, with the association being evident particularly in women.

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