scholarly journals Towards non-conventional methods of designing register-based epidemiological studies: An application to pediatric research

2017 ◽  
Vol 45 (17_suppl) ◽  
pp. 30-35 ◽  
Author(s):  
Tong Gong ◽  
Bronwyn Brew ◽  
Arvid Sjölander ◽  
Catarina Almqvist
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Epidemiological Studies ◽  
Case Control ◽  
Observational Research ◽  
Advantages And Disadvantages ◽  
Study Population ◽  
Family Based ◽  
Study Designs ◽  
Residual Confounding

Aims: Various epidemiological designs have been applied to investigate the causes and consequences of fetal growth restriction in register-based observational studies. This review seeks to provide an overview of several conventional designs, including cohort, case-control and more recently applied non-conventional designs such as family-based designs. We also discuss some practical points regarding the application and interpretation of family-based designs. Methods: Definitions of each design, the study population, the exposure and the outcome measures are briefly summarised. Examples of study designs are taken from the field of low birth-weight research for illustrative purposes. Also examined are relative advantages and disadvantages of each design in terms of assumptions, potential selection and information bias, confounding and generalisability. Kinship data linkage, statistical models and result interpretation are discussed specific to family-based designs. Results: When all information is retrieved from registers, there is no evident preference of the case-control design over the cohort design to estimate odds ratios. All conventional designs included in the review are prone to bias, particularly due to residual confounding. Family-based designs are able to reduce such bias and strengthen causal inference. In the field of low birth-weight research, family-based designs have been able to confirm a negative association not confounded by genetic or shared environmental factors between low birth weight and the risk of asthma. Conclusions: We conclude that there is a broader need for family-based design in observational research as evidenced by the meaningful contributions to the understanding of the potential causal association between low birth weight and subsequent outcomes.

scholarly journals Hubungan Berat Badan Lahir Rendah dan Penyakit Infeksi dengan Kejadian Stunting pada Baduta di Desa Maron Kidul Kecamatan Maron Kabupaten Probolinggo

2018 ◽  
Vol 2 (4) ◽  
pp. 373
Author(s):  
Novianti Tysmala Dewi ◽  
Dhenok Widari
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Age Groups ◽  
Sampling Technique ◽  
Case Control ◽  
Observational Research ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
Infection Disease

Background: Stunting is a nutritional problem that has a high prevalence in Indonesia. Stunting among children under two years of age has a higher risk compared to other age groups because it will permanently affect the physical and cognitive development of children in the future. Factors that can cause stunting include low birth weight and infectious diseases.Objectives: The aim of this study was to determine the relationship between low birth weight and infection disease with incident of stunting among children under two years of age in Maron sub district, District of Probolinggo, East Java. Methods: This research was an observational research with case-control design. Sampling technique using multistage random sampling. the study was conducted in June until July 2018. The samples of study were 52 children (26 stunted children in case group and 26 normal growth children in control group. Data collection of infectious diseases was carried out by structured questionnaire interviews and medical records while low birth weight was obtained by looking at KIA book. Stunting was determined from measurement of children's recumbent length by metline. Data were analyzed by using chi square test for determining odds ratio. Results: The results showed that low birth weight (p=0.042; OR=0.157; 95% CI: 0.030-0.822) and infection disease (p=0.049; OR=3.071; 95% CI: 1.155-11.861) had significant relation with stunting among children under two years of age. Conclusions: Low birth weight and infection disease in the last 3 months increased the risk of 0.157 and 3.017 times stunting among children under two years of age. It is recommended for children under two years of age who have low birth weight and infectious disease should be given special attention by Integrated Health Post and there should be a monitoring related development routinely so developmental disruptions can be identified and immediately get the treatment. ABSTRAKLatar Belakang:Stunting merupakan masalah gizi yang memiliki prevalensi tinggi di Indonesia. Stunting pada baduta memiliki risiko lebih tinggi jika dibanding dengan kelompok usia lain karena akan berdampak secara permanen terhadap perkembangan fisik dan kognitif anak dimasa depan. Faktor penyebab stunting diantaranya adalah berat badan lahir rendah dan penyakit infeksi.Tujuan: Penelitian ini bertujuan untuk untuk menganalisis hubungan antara berat badan lahir rendah dan penyakit infeksi dengan kejadian stunting pada baduta di Desa Maron Kidul Kecamatan Maron, Kabupaten Probolinggo.Metode: Jenis penelitian menggunakan desain case-control. Sampel diambil dengan teknik sampel acak bertahap. Penelitian dilakukan pada bulan Juni hingga Juli 2018. Besar sampel sebanyak 52 baduta (26 anak stunting dan 26 anak non-stunting). Pengumpulan data penyakit infeksi dilakukan dengan wawancara kuisioner terstruktur dan rekam medik sedangkan berat badan lahir rendah diperoleh dengan melihat buku KIA. Penentuan stunting baduta diperoleh melalui pengukuran panjang badan dengan metline. Data dianalisis menggunakan chi-square untuk menentukan odds ratio.Hasil:  Hasil penelitian menunjukkan ada hubungan berat badan lahir rendah (p=0.042; OR=0,157; 95% CI: 0,030-0,822), dan penyakit infeksi (p=0,049; OR=3,071; 95% CI: 1,155-11,861) dengan kejadian stunting pada baduta.  Kesimpulan:Berat badan lahir rendah dan Rerat badan lahir rendah dan dutdah diperoleh dengan melihat buku KIA. of alcohol penyakit infeksi dalam 3 bulan terakhir meningkatkan risiko sebesar 0,157 dan 3,017 kali terhadap kejadian stunting pada baduta. Disarankan untuk baduta yang memiliki masalah BBLR dan penyakit infeksi diberikan perhatian khusus oleh posyandu serta perlu dilakukan peninjauan terkait perkembangan secara rutin agar gangguan perkembangan yang mungkin terjadi dapat segera dikenali dan diatasi.

Prevalence, Risk Factors, and Short-Term Outcomes of Full-Term Low Birth Weight Infants Born at a Tertiary Academic Center: A Prospective Case–Control Study

2021 ◽  
Author(s):  
Heidi K. Al-Wassia ◽  
Shahd K. Baarimah ◽  
Asmaa H. Mohammedsaleh ◽  
Manal O. Alsulami ◽  
Ragad S. Abbas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Case Control Study ◽  
Case Control ◽  
Adverse Outcomes ◽  
Chromosomal Anomalies ◽  
Short Term ◽  
Term Infants ◽  
Control Study

Objective Low birth weight (LBW) infants (<2,500 g) continued to be a global health problem because of the associated short- and long-term adverse outcomes. The study aimed to determine the prevalence, risk factors, and short-term outcomes of term LBW infants Study Design A prospective and case–control study. All infants born consecutively from September 1, 2018 to August 31, 2019 were included. Cases, term LBW infants, were 1:1 matched to controls, appropriate for gestational age (AGA) term infants. Major congenital or chromosomal anomalies and multiple pregnancies were excluded. Results The prevalence of term LBW in the studied period was 4.8%. Mothers of term LBW infants had significantly lower body mass index (p = 0.05), gained less weight (p = 0.01), had a history of previous LBW (p = 0.01), and lower monthly income (p = 0.04) compared with mothers of term AGA infants even after adjustment for confounders. A nonsignificant higher number of term LBW infants needed NICU admission, while their need for phototherapy was deemed significant. Conclusion We identified nutritional and socioeconomic maternal factors that are significantly associated with LBW infants and should be targeted during antenatal visits to improve neonatal outcomes. Key Points

Risk factors for low birth weight: Results from a case-control study in southern Spain

1998 ◽  
Vol 105 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Miguel Delgado-Rodríguez ◽  
Rocío Pérez-Iglesias ◽  
Montserrat Gómez-Olmedo ◽  
Aurora Bueno-Cavanillas ◽  
Ramón Gálvez-Vargas
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Case Control Study ◽  
Case Control ◽  
Southern Spain ◽  
Control Study

scholarly journals A Case Control Study on Risk Factors Associated with Low Birth Weight Babies in Eastern Nepal

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ravi Kumar Bhaskar ◽  
Krishna Kumar Deo ◽  
Uttam Neupane ◽  
Subhadra Chaudhary Bhaskar ◽  
Birendra Kumar Yadav ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Maternal Education ◽  
Case Control Study ◽  
Calcium Supplementation ◽  
Case Control ◽  
Maternal Body Mass Index ◽  
Targeted Interventions ◽  
Factors Associated ◽  
Control Study

Background. This study was done to assess the maternal and sociodemographic factors associated with low birth weight (LBW) babies.Methods. An unmatched case control study was done involving 159 cases (mothers having LBW singleton babies) and 159 controls (mothers having normal birth weight singleton babies).Results. More than 50% of LBW babies were from the mothers with height ≤145 cm while only 9.43% of NBW babies were from the mothers with that height. Finally, after multivariate logistic regression analysis, maternal height, time of first antenatal care (ANC) visit, number of ANC visits, iron supplementation, calcium supplementation, maternal education, any illness during pregnancy, and hypertension were found as the significant predictors of LBW. However, maternal blood group AB, normal maternal Body Mass Index (BMI), mother’s age of 30 or more years, and starting ANC visit earlier were found to be protective for LBW.Conclusion. Study findings suggest that selectively targeted interventions such as delay age at first pregnancy, improving maternal education and nutrition, and iron and calcium supplementation can prevent LBW in Nepal.

THE AGE OF ATTAINING BLADDER CONTROL

PEDIATRICS ◽  
1968 ◽  
Vol 42 (4) ◽  
pp. 614-626
Author(s):  
Wallace C. Oppel ◽  
Paul A. Harper ◽  
Rowland V. Rider
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Prospective Study ◽  
Life Table ◽  
Median Duration ◽  
The Other ◽  
Large Contribution ◽  
Median Length ◽  
Bladder Control ◽  
Study Population

Data in life table form are presented from a 12-year prospective study of 859 children on the age of attaining bladder control for waking and sleeping hours by three indices: (1) age of initial dryness, (2) age of final dryness, and (3) the prevalence of dryness. By use of these indices the large contribution of relapsers to enuresis is seen. The prevalence of bedwetting in the study population was greater than that reported in other studies; the validity of this finding is defended. A larger proportion of female than male children attained both day and night dryness during the first 2 years of life. The percentage of Negro boys who first attained dryness was less than that of the other three race-sex groups after 2 years of age and was significantly less than that of Negro girls until 9 years of age. One quarter of the 817 children who attained initial nighttime dryness by age 12 relapsed; these relapsing episodes had a median duration of 2.5 years. One tenth of 855 children who attained initial daytime dryness had relapses, and the median length of these was 1.2 years. Relapsing occurred much more frequently in Negro than Caucasian children; it also was seen more often in Caucasian males than in Caucasian females. Low birth weight children had a higher percentage of children wet for both waking and sleeping hours than did full birth weight children.

scholarly journals High Blood Pressure during Pregnancy is not a Protective Factor for Preterm Infants with Very Low Birth Weight. A Case-Control Study

2017 ◽  
Vol 39 (04) ◽  
pp. 155-161 ◽  
Author(s):  
Annibal Sabino ◽  
Eduardo de Souza ◽  
Ana Goulart ◽  
Adriana Lima ◽  
Nelson Sass
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Protective Factor ◽  
Case Control Study ◽  
Very Low Birth Weight ◽  
Case Control ◽  
World Health ◽  
Control Group ◽  
Control Study

Objective To evaluate whether the presence of maternal blood pressure reduces the risks of morbidity, perinatal mortality and morbidity at 24 months of age in very low birth weight infants (VLBWIs) compared with a control group. Methods A retrospective, observational, case-control study. Total 49 VLBWIs were allocated to the study group, called the maternal arterial hypertension group (AHG), and matched with 44 in the control group (CG). The infants were assessed during hospitalization and at 12 and 24 months corrected age at a specialized clinic. For the assessment of growth, the World Health Organization (WHO) Anthro software (Geneva, 2006) was used, and for the psychomotor assessment, the Denver II test was used. Results In relation to the antenatal variables, the infants of the AHG had more centralized circulation assessed by Doppler, received more corticosteroids and magnesium sulfate, and were born by cesarean section more frequently. In terms of the postnatal and in-hospital outcomes, the AHG had a higher gestational age at birth (30.7 versus 29.6 weeks) and a lower frequency of 5-minute Apgar scores of less than 7 (26.5% versus 52.3%). The CG had a higher rate of pulmonary dysplasia (30.2% versus 8.3%). There were no differences in terms of hospital mortality, complications, somatic growth and functional problems at 24 months of corrected age. Conclusion The presence of maternal hypertension, especially preeclampsia, was not a protective factor against morbidity, mortality and evolution in VLBWIs aged up to 24 months. Therefore, the clinical practice should be focused on prolonging the pregnancy for as long as possible in these conditions as well.

scholarly journals Use of a Simple Anthropometric Measurement to Identify Low-Birth-Weight Infants in Enugu, Nigeria

2018 ◽  
Vol 5 ◽  
pp. 2333794X1878817
Author(s):  
Ndubuisi Kennedy Chukwudi ◽  
Huldah Ijeoma Nwokeukwu ◽  
Gilbert Nwadiakanma Adimorah
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Statistical Tests ◽  
Statistical Significance ◽  
Linear Regression Analysis ◽  
Cutoff Point ◽  
Chest Circumference ◽  
Anthropometric Measurement ◽  
Suitable Alternative ◽  
Study Population

Background. This prospective study was conducted to identify a suitable alternative to birth weight and establish its cutoff point to facilitate the identification of low-birth-weight (LBW) infants in Enugu, Southeast Nigeria. Methods. The study involved newborn babies within the first 48 hours of life. Five anthropometric measurements (head, chest, mid-arm and calf circumferences, as well as abdominal girth) were taken using a tape measure while supine length was measured with an aluminum infantometer. Birth weight was also recorded. Linear regression analysis was done to identify the measurement with the highest coefficient of determination with birth weight while its cutoff point was defined using a receiver operating characteristic curve. Standard statistical tests were used to determine the statistical significance of the findings. Results. The LBW prevalence for the study population was 21.41%. Chest circumference had the highest R2 value of 0.83 for the general study population and 0.72 for the LBW infants. The identified cutoff point for chest circumference is ⩽30 cm. Conclusion. Chest circumference is the best alternative to birth weight in identifying LBW babies within the first 48 hours of life in this environment.

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