scholarly journals Is alcohol dependence a mediator between alcohol consumption and alcohol-related problems? A study from a clinical population in Stockholm County

2003 ◽  
Vol 20 (2-3) ◽  
pp. 101-111
Author(s):  
Anders Romelsjö ◽  
Robin Room ◽  
Elisabeth Ellström
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Addiction Treatment ◽  
Social Problems ◽  
Addiction Severity Index ◽  
Clinical Population ◽  
Substantial Part ◽  
Stockholm County ◽  
Alcohol Dependence Syndrome ◽  
Alcohol Related Problems

Several studies have been done on the prevalence of the alcohol dependence syndrome, while other studies have focused on whether the dependence syndrome can be seen as a unity, or not. Few studies have analysed the association between alcohol consumption, the alcohol dependence syndrome (ADS) and alcohol-related problems. A main issue is to what extent an association between alcohol consumption and problems is explained by the dependence syndrome or by its sub-components (drinking despite a health problem, craving, impaired control, preoccupation with alcohol, withdrawal symptoms and increased tolerance). The purpose in this paper is to elucidate this issue in analyses of data from the health care-based clinical sample of the study “Women and Men in Swedish Addiction Treatment”, comprising comprehensive interviews of almost 1000 inpatients and outpatients in Stockholm County. These data cover e.g. alcohol and drug use, alcohol dependence (ICD-10) measured by the Composite International Diagnostic Interview (CIDI), the composite-scores part of the Addiction Severity Index (ASI), sociodemographics and alcohol-related problems. Three measures of alcohol-related problems were constructed covering health and psychological problems, self-defined social problems, and social problems defined by others. In these exploratory analyses of patients with alcohol dependence as a dominating problem, a series of logistic regression analyses were done. A substantial part of the association between the consumption measures and the three outcomes could be accounted for by measures of the ADS. The predictive power of the six criteria composing the ADS varied considerably for the different outcomes. The interpretation is not straightforward, not least as the alcohol dependence syndrome also includes items of alcohol-related problems.

Symptoms of Alcohol Dependence Predict Suicide Ideation Among Alaskan Undergraduates

Crisis ◽  
2016 ◽  
Vol 37 (3) ◽  
pp. 232-235 ◽  
Author(s):  
Christopher R. DeCou ◽  
Monica C. Skewes
Keyword(s):  
Depressive Symptoms ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Suicide Ideation ◽  
Alcohol Problems ◽  
Future Research ◽  
Causal Mechanism ◽  
Students At Risk ◽  
The Relationship ◽  
Alcohol Related Problems

Abstract. Background: Previous research has demonstrated an association between alcohol-related problems and suicidal ideation (SI). Aims: The present study evaluated, simultaneously, alcohol consequences and symptoms of alcohol dependence as predictors of SI after adjusting for depressive symptoms and alcohol consumption. Method: A sample of 298 Alaskan undergraduates completed survey measures, including the Young Adult Alcohol Consequences Questionnaire, the Short Alcohol Dependence Data Questionnaire, and the Beck Depression Inventory – II. The association between alcohol problems and SI status was evaluated using sequential logistic regression. Results: Symptoms of alcohol dependence (OR = 1.88, p < .05), but not alcohol-related consequences (OR = 1.01, p = .95), emerged as an independent predictor of SI status above and beyond depressive symptoms (OR = 2.39, p < .001) and alcohol consumption (OR = 1.08, p = .39). Conclusion: Alcohol dependence symptoms represented a unique risk for SI relative to alcohol-related consequences and alcohol consumption. Future research should examine the causal mechanism behind the relationship between alcohol dependence and suicidality among university students. Assessing the presence of dependence symptoms may improve the accuracy of identifying students at risk of SI.

Alcohol-related seizures may be associated with more severe depression, alcohol dependence syndrome, and more pronounced alcohol-related problems

2019 ◽  
Vol 91 ◽  
pp. 81-85 ◽  
Author(s):  
Evija Gutmane ◽  
Normunds Suna ◽  
Anastasija Tomilova ◽  
Lelde Liepina ◽  
Valdis Folkmanis ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Severe Depression ◽  
Alcohol Dependence Syndrome ◽  
Alcohol Related Problems

scholarly journals REGIONAL EPIDEMIOLOGY OF ALCOHOLIC DEPENDENCE SYNDROME

2019 ◽  
Vol 63 (2) ◽  
pp. 79-85
Author(s):  
Raisa Ya. Khamitova ◽  
D. V. Loskutov
Keyword(s):  
Public Health ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Urban Areas ◽  
Psychotic Disorders ◽  
Chronic Alcoholism ◽  
Alcoholic Beverages ◽  
Consumption Pattern ◽  
Positive Trend ◽  
Alcohol Dependence Syndrome

Introduction. There are variable patterns of alcohol consumption in Russia that differ significantly between the regions. Awareness and knowledge of those regional differences are key to the effectiveness of measures to prevent and minimise possible damage to public health caused by alcohol consumption. The purpose. To identify regional characteristics of the dynamics of alcoholism and alcoholic psychosis and dependencies with indicators of the implementation and consumption of alcohol in Mari El in 2006-2017. Material and methods. In a retrospective analysis, they included state statistics and bulletins of the Office of Rospotrebnadzor on RME on the primary incidence and prevalence of alcohol dependence syndrome, chronic alcoholism, AP, acute alcohol poisoning, sales of alcohol through a distribution network in 2006-2017. Results. In the reported period of 2006-2017 there was a decline in determination coefficient (R2) from 0.76 to 0.96 for newly diagnosed cases of alcohol dependence in general, alcoholic psychosis and alcoholism in Mari El. There was a significant decline from 221.6 to 47.5 per 100 thousand in the range of values between regions, but higher rates remained among the rural and urban areas (p = 0.0002). The dynamics of the prevalence of alcoholic psychotic disorders and alcoholism were also on decline. Conclusion. The direction and extent of changes in the medical consequences of alcohol consumption (such as primary morbidity and prevalence of alcohol dependence syndrome, alcoholic psychosis and alcoholism, average duration of the course, number of alcoholic psychosis) in the region and indicators of the implementation and consumption of alcoholic beverages in the reported period can be evaluated as positive. It is crucial to ensure the positive trend in the alcohol consumption pattern and impact on public health in the region becomes a long-lasting one. At the same time, it is necessary to increase attention to the assistance and treatment provided to drug users patient.

Predictors of Posttreatment Drinking Outcomes in Patients with Alcohol Dependence

2014 ◽  
Vol 21 (1) ◽  
pp. 19-30 ◽  
Author(s):  
Gerardo Flórez ◽  
Pilar A. Saiz ◽  
Paz García-Portilla ◽  
Francisco J. De Cos ◽  
Sonia Dapía ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Biological Markers ◽  
Relapse Prevention ◽  
Treatment Initiation ◽  
Positive Impact ◽  
Severity Index ◽  
Addiction Severity Index ◽  
Obsessive Compulsive ◽  
Timeline Followback

Aim: This cohort study examined how predictors of alcohol dependence treatment outcomes work together over time by comparing pretreatment and posttreatment predictors. Methods: A sample of 274 alcohol-dependent patients was recruited and assessed at baseline, 6 months after treatment initiation (end of the active intervention phase), and 18 months after treatment initiation (end of the 12-month research follow-up phase). At each assessment point, the participants completed a battery of standardized tests [European Addiction Severity Index (EuropASI), Obsessive Compulsive Drinking Scale (OCDS), Alcohol Timeline Followback (TLFB), Fagerström, and International Personality Disorder Examination (IPDE)] that measured symptom severity and consequences; biological markers of alcohol consumption were also tested at each assessment point. A sequential strategy with univariate and multivariate analyses was used to identify how pretreatment and posttreatment predictors influence outcomes up to 1 year after treatment. Results: Pretreatment variables had less predictive power than posttreatment ones. OCDS scores and biological markers of alcohol consumption were the most significant variables for the prediction of posttreatment outcomes. Prior pharmacotherapy treatment and relapse prevention interventions were also associated with posttreatment outcomes. Conclusions: The findings highlight the positive impact of pharmacotherapy during the first 6 months after treatment initiation and of relapse prevention during the first year after treatment and how posttreatment predictors are more important than pretreatment predictors.

scholarly journals Corticostriatal oscillations predict high vs. low drinkers in a preclinical model of limited access alcohol consumption

2018 ◽  
Author(s):  
Angela M. Henricks ◽  
Lucas L. Dwiel ◽  
Nicholas H. Deveau ◽  
Amanda A. Simon ◽  
Metztli J. Ruiz-Jaquez ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Drinking Behavior ◽  
Clinical Population ◽  
Preclinical Model ◽  
Sprague Dawley ◽  
Nucleus Accumbens Shell ◽  
Limited Access ◽  
The Impact ◽  
Corticostriatal Circuit

AbstractIndividuals differ in their vulnerability to develop alcohol dependence that are determined by innate and environmental factors. The corticostriatal circuit is heavily involved in the development of alcohol dependence and may contain neural information regarding vulnerability to drink excessively. In the current experiment, we hypothesized that we could characterize high and low alcohol-drinking rats (HD and LD, respectively) based on corticostriatal oscillations, and that these subgroups would differentially respond to corticostriatal brain stimulation. Rats were trained to drink 10% alcohol in a limited access paradigm. In separate sessions, local field potentials (LFPs) were recorded from the nucleus accumbens shell (NAcSh) and medial prefrontal cortex (mPFC) of male Sprague-Dawley rats (n=13). Based on training alcohol consumption levels, we classified rats using a median split as HD or LD. Then, using machine-learning, we built predictive models to classify rats as HD or LD by corticostriatal LFPs and compared the model performance from real data to the performance of models built on data permutations. Additionally, we explored the impact of NAcSh or mPFC stimulation on alcohol consumption in HD vs. LD. Corticostriatal LFPs were able predict HD vs. LD group classification with greater accuracy than expected by chance (>80% accuracy). Additionally, NAcSh stimulation significantly reduced alcohol consumption in HD, but not LD (p<0.05), while mPFC stimulation did not alter drinking behavior in either HD or LD (p>0.05). These data collectively show that the corticostriatal circuit is differentially involved in regulating alcohol intake in HD vs. LD rats, and suggests that corticostriatal activity may have the potential to predict a vulnerability to develop alcohol dependence in a clinical population.

An efficient approach on alcohol dependence syndrome

2018 ◽  
Vol 8 (3) ◽  
pp. 24-27
Author(s):  
Thejaswini Karanth ◽  
Someswar Deb ◽  
Pranathi R ◽  
Kasthuri P
Keyword(s):  
Peripheral Neuropathy ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Chronic Alcoholism ◽  
Total Lifetime ◽  
Diagnostic And Statistical Manual ◽  
Standard Population ◽  
History Of ◽  
Alcohol Dependence Syndrome ◽  
Racial Factors

Alcohol consumption results in multiple end-organ damages. Predominantly the nervous system is affected in the form of Wernicke encephalopathy, Korsakoff psychosis, cerebellar ataxia and peripheral neuropathy. Neuropathy due to alcohol consumption depends on the period and extent of total lifetime of alcohol consumption. Cultural and racial factors also play a role in the development of alcohol neuropathy. Alcohol consumption results in multiple end-organ damages. Alcoholic neuropathy is the most common harmful effects of excessive alcohol intake. The incidence of alcoholic neuropathy in the standard population is not accurate as the percentage varies extensively contingent on the description of chronic alcoholism and the criteria used to detect and classify neuropathy. According to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), studies involving clinical and electrodiagnostic tests prove that neuropathy is present in 25-66%. Alcoholic neuropathy depends on the extent and extent of total lifetime of alcohol consumption. Cultural and racial factors also play a role in resulting in alcohol neuropathy. Few studies suggest that the incidence of peripheral neuropathy is higher in alcoholic patients who have a family history of alcohol dependence syndrome. This is study finds the Common peroneal and sural nerves are the most common nerves to be involved in neuropathy. Predominantly axonal degeneration is the main pathology. Units of alcohol and CAGE criteria score has a 100% specificity in detecting patients prone to neuropathy.

scholarly journals Electrophysiological Detection of Asymptomatic Neuropathy in Alcohol Dependence Syndrome Patients- A Cross Sectional Observational Study

2021 ◽  
pp. 26-31
Author(s):  
Arvind Visweshwar ◽  
Mohamed Hanifah ◽  
. Murugesan ◽  
. Avudaiappan ◽  
Arun Prakash
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Nerve Conduction ◽  
General Medicine ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Alcohol Dependence Syndrome ◽  
Male Patients ◽  
Gandhi Medical College

Aim: To detect the prevalence of asymptomatic neuropathy using nerve conduction study among alcohol dependence syndrome patients and to investigate the existence or not of correlation between duration, quantity of alcohol consumption and neuropathy. Study Design: Observational cross-sectional study. Place and Duration of Study: Department of General Medicine and Department of Psychiatry, Mahatma Gandhi Medical College and Research Institute, Pondicherry, affiliated to Sri Balaji Vidyapeeth (Deemed to be) University, India between February 2019 and August 2020. Methods: Alcohol dependence syndrome patients, asymptomatic for neuropathy were prospectively included and, patients who were symptomatic and had other comorbid conditions that can cause neuropathy were excluded. Patients were then submitted to nerve conduction studies. In patients who had neuropathy, duration and quantity of alcohol consumption were compared for correlation. Results: This study included 65 male patients who were mostly middle aged heavy drinkers of alcohol. 73.8% (n=48) had neuropathy. Our research showed longer the duration, larger the quantity of alcohol consumption, and higher the Cut-Annoyed-Guilty-Eye (CAGE score), more were the prevalence of neuropathy. This research also used Severity Of Alcohol Dependence Questionnaire (SAD-Q) scoring for screening alcohol dependence which showed patients with neuropathy were moderate drinkers. We did not find correlation with age of patients and neuropathy. Conclusion: This research results like correlation of prevalence of neuropathy and duration of alcohol consumption and quantity of alcohol consumption were in contrast with previous studies on alcoholic neuropathy. This research used SAD-Q scoring for dependence, future researches can throw light on usage of SAD-Q score in asymptomatic neuropathy and the correlation of neuropathy with alcohol consumption.

scholarly journals Blood pressure profile in freshly detected alcohol dependence syndrome patients

2021 ◽  
Vol 8 (4) ◽  
pp. 517
Author(s):  
M. M. Pasha ◽  
Harpreet Singh Dhillon ◽  
Bhupendra Yadav ◽  
Anil Dalal ◽  
Shibu Sasidharan
Keyword(s):  
Blood Pressure ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Diastolic Blood Pressure ◽  
Time Intervals ◽  
Positive Correlation ◽  
Alcohol Dependence Syndrome ◽  
R Value ◽  
Glutamyl Transferase

Background: Alcohol consumption and raised Blood pressure (BP) are among the top five risk factors responsible for the growing global non-communicable diseases (NCD) burden. The present study was undertaken to study the relation between alcohol dependence syndrome (ADS) and hypertension and the effect of reduction in alcohol consumption on BP.Methods: A prospective observational study was conducted at a tertiary care hospital over a period of 02 years from 08 Oct 2016 to 02 Oct 2018. A total of fifty freshly diagnosed ADS patients with BP in the pre- hypertensive or hypertensive range after the withdrawal subsided, were recruited into the study. The study group was subjected to repeated BP measurements, serum Gamma glutamyl transferase (GGT) measurements and status of alcohol consumption at 03, 06, 09 and 12 monthly intervals. The data was analyzed with ANOVA, Post-hoc Bonferroni and Pearson’s correlation tests.Results: There was a statistically significant mean decrease in systolic and diastolic blood pressure from the baseline till 03 months and between 03 months and 06 months of follow-up. The correlation between GGT levels and systolic and diastolic BP at different time intervals showed that there was a statistically non-significant weak positive correlation at baseline (r value=0.125) (p value= 0.38). During follow-up period there was a negative correlation between GGT and systolic BP at 12 months (r value= -0.40), which was statistically significant. The correlation between alcohol consumption and BP at different time intervals showed a moderate positive correlation at baseline with systolic BP(r value= 0.478), which was statistically significant.Conclusions: This study evaluated changes in blood pressure occurring during Alcohol dependence syndrome treatment. Observed decreases in systolic and diastolic blood pressure were substantially accounted for by reductions in alcohol consumption and occurred largely in the first 03 months of treatment. There was no significant fall in systolic blood pressure between 06 months and 01-year duration of follow-up. 

Sign in / Sign up

Export Citation Format

Share Document