The Possible Role of Antioxidant Vitamin C in Alzheimer’s Disease Treatment and Prevention
2013 ◽
Vol 28
(2)
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pp. 120-125
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Keyword(s):
Oxidative stress is suggested to play a major role in the pathogenesis of Alzheimer’s disease (AD). Among the antioxidants, vitamin C has been regarded as the most important one in neural tissue. It also decreases β-amyloid generation and acetylcholinesterase activity and prevents endothelial dysfunction by regulating nitric oxide, a newly discovered factor in the pathogenesis and progression of AD. However, clinical trials using antioxidants, including vitamin C, in patients with AD yielded equivocal results. The current article discusses the relevance of vitamin C in the cellular and molecular pathogenesis of AD and explores its therapeutic potential against this neurodegenerative disorder.
2020 ◽
Vol 20
(9)
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pp. 1383-1390
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2020 ◽
Vol 18
(4)
◽
pp. 354-359
2020 ◽
Vol 17
(1)
◽
pp. 29-43
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2018 ◽
Vol 2018
◽
pp. 1-15
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2022 ◽
Vol 119
(3)
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pp. e2115082119
2020 ◽