Major post-prostate biopsy complications under antibiotic augmentation prophylaxis protocol

2021 ◽  
pp. 205141582098403
Author(s):  
Antônio Antunes Rodrigues ◽  
Valdair Muglia ◽  
Emanuel Veras de Albuquerque ◽  
Rafael Ribeiro Mori ◽  
Rafael Neuppmann Feres ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Antibiotic Prophylaxis ◽  
Body Mass ◽  
Bacterial Resistance ◽  
Univariate Analysis ◽  
Specific Antigen ◽  
Outlet Obstruction ◽  
Psa Density ◽  
Biopsy Complications

Objective: To identify risk factors for major post-biopsy complications under augmented prophylaxis protocol. The risk factors already described mainly comprise outdated antibiotic prophylaxis protocols. Material and methods: This retrospective cohort study included patients that underwent transrectal ultrasound-guided biopsies, from 2011 to 2016. All patients had received antibiotic prophylaxis with ciprofloxacin and gentamicin. Patients were grouped according to the presence or absence of post-biopsy complications. Demographic variables and possible risk factors based on routine clinical assessment were registered. Correlation tests, univariate and multivariate analyses were used to identify risk factors for post-biopsy complications. Results: Of the 404 patients that were included, 25 (6.2%) presented 27 post-biopsy complications, distributed as follows: acute urinary retention ( n = 14, 3.5%), infections ( n = 11, 2.7%) and hemorrhage ( n = 2, 0.5%). On univariate analysis, patients who presented complications showed higher body mass index and post-voiding residual volumes. Multivariate analysis identified ethnicity and prostate-specific antigen (PSA) density as possible risk factors for biopsy complications. The presence of bacterial resistance identified by rectal swabs did not correlate with the incidence of complications and infections. Conclusions: Non-infectious post-biopsy complications were more frequent than infectious ones in this cohort. Higher post-voiding residual volumes and PSA density, that indicates prostate enlargement, were identified as risk factors and interpreted as secondary to bladder outlet obstruction. The higher body mass index and ethnicity were also identified as risk factors and attributed to the heterogeneity of the patients included. Level of evidence: Not applicable for this multicentre audit.

scholarly journals FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN OSTEOPOROSIS

2020 ◽  
Vol 3 (2) ◽  
pp. 337-343
Author(s):  
Helfrida Situmorang
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Research Design ◽  
Univariate Analysis ◽  
The Body ◽  
Nutritional Deficiencies ◽  
Bivariate Analysis ◽  
History Of

The irreversible risk factors for osteoporosis are age, gender, race, family / hereditary history, body shape and history of fractures. The risk factors for osteoporosis that can be changed are smoking, vitamin and nutritional deficiencies, lifestyle, eating disorders (anorexia nervosa), early menopause, and the use of certain drugs such as corticosteroids, glucocorticosteroids, and diuretics. The purpose of this study was to determine the factors associated with the incidence of osteoporosis. The research design used was non-experimental, namely a correlational research design, namely research conducted to determine the relationship between two variables. The population in this study were all osteoporosis patients with age. over 45 years old who seek treatment at the Puskesmas Gunting Saga Kec. Kualuh Selatan District of North Labuhan Batu totaling 45 people. The sampling method used was the total sampling technique, which was the same as the population of 45 people. Data collection used is the method of filling out a questionnaire which includes written questions used to obtain data information from the questionnaire. The data analysis conducted was univariate analysis and bivariate analysis. In this study, researchers still adhere to ethical principles. The results illustrate that the respondents are mostly 51-65 years old as many as 27 people (60%). Most of the sex of respondents were women as many as 37 people (82.2 %%). Most of the respondents had no history of osteoporosis as many as 31 people (68.9%). Most of the body mass index of respondents whose body mass index was over 34 people (75.6%). Most of the respondents in the smoking category did not smoke as many as 32 people (71.7%). Most of the respondents' physical activity in the category of independent physical activity was 38 people (84.4%). The conclusion is that there is no relationship between age, sex, family history, body mass index, and smoking with the incidence of osteoporosis. Meanwhile, physical activity has a relationshipwithosteoporosis.   Abstrak Faktor-faktor resiko osteoporosis yang tidak dapat diubah yaitu usia, jenis kelamin, ras, riwayat keluarga/keturunan, bentuk tubuh dan sejarah patah tulang. Faktor–faktor resiko osteoporosis yang dapat diubah adalah merokok, defisiensi vitamin dan gizi, gaya hidup, gangguan makan (anoreksia nervosa), menopause dini, serta penggunaan obat-obatan tertentu seperti kortikosteroid, glukokortikosteroid, serta diuretik. Tujuan penelitian ini adalah untuk mengetahui mengetahui faktor-faktor yang berhubungan dengan kejadian osteoporosis Rancangan penelitian yang digunakan adalah non eksperimen yaitu rancangan atau desain penelitian yang bersifat korelasional yaitu penelitian yang dilakukan untuk mengetahui hubungan dua variabel.Populasi dalam penelitian ini adalah semua pasien osteoporosis dengan usia diatas 45 tahun yang berobat di Puskesmas Gunting Saga Kec. Kualuh Selatan Kab Labuhan Batu Utara berjumlah 45 orang.Metode pengambilan sampel yang digunakan dengan teknik total sampling yaitu sama dengan populasi adalah sebanyak 45 orang. Pengumpulan data yang digunakan yaitu metode pengisian kuesioner yang meliputi pertanyaan tertulis yang digunakan untuk memperoleh informasidata dari kuesioner.Analisa data yang dilakukan adalah analisis univariat dan analisis bivariat. Dalam penelitian ini peneliti tetap berpedoman pada prinsip-prinsip etik.Hasil penelitian menggambarkan bahwa responden sebagian besar berumur 51-65 tahun sebanyak 27 orang (60%). Jenis kelamin responden sebagian besar wanita sebanyak  37 orang (82.2%%).Riwayat keluarga responden sebagian besar berstatus tidak ada riwayat osteoporosis sebanyak 31 orang (68.9%).Indeks masa tubuh responden sebagian besar Indeks masa tubuh lebih sebanyak 34 orang (75.6%).Merokok responden sebagian besar kategori tidak merokok sebanyak 32 orang (71.7%).Aktivitas fisik responden sebagian besar kategori aktivitas fisik mandiri sebanyak 38 orang (84.4%).Kesimpulan bahwa tidak ada hubungan umur, jeniskelamin, riwayat keluarga,indeks massa tubuh,dan merokok dengan kejadian osteoporosis. Sedangkan aktivitas fisikada hubungan dengan kejadian osteoporosis.

scholarly journals Risk factors for gastric perforation after cytoreductive surgery in patients with peritoneal carcinomatosis: Splenectomy and increased body mass index

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248205
Author(s):  
Martina Aida Angeles ◽  
Carlos Martínez-Gómez ◽  
Mathilde Del ◽  
Federico Migliorelli ◽  
Manon Daix ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Peritoneal Carcinomatosis ◽  
Body Mass ◽  
Cytoreductive Surgery ◽  
Gastric Perforation ◽  
Univariate Analysis ◽  
Rare Event ◽  
Comprehensive Cancer Center ◽  
Cancer Center

Background Gastric perforation after cytoreductive surgery (CRS) is an infrequent complication. There is lack of evidence regarding the risk factors for this postoperative complication. The aim of this study was to assess the prevalence of postoperative gastric perforation in patients undergoing CRS for peritoneal carcinomatosis (PC) and to evaluate risk factors predisposing to this complication. Methods We designed a unicentric retrospective study to identify all patients who underwent an open upfront or interval CRS after a primary diagnosis of PC of different origins between March 2007 and December 2018 at a French Comprehensive Cancer Center. The main outcome was the occurrence of postoperative gastric perforation. Results Five hundred thirty-three patients underwent a CRS for PC during the study period and 13 (2.4%) presented a postoperative gastric perforation with a mortality rate of 23% (3/13). Neoadjuvant chemotherapy was administered in 283 (53.1%) patients and 99 (18.6%) received hyperthermic intraperitoneal chemotherapy (HIPEC). In the univariate analysis, body mass index (BMI), peritoneal cancer index, splenectomy, distal pancreatectomy, and histology were significantly associated with postoperative gastric perforation. After multivariate analysis, BMI (OR [95%CI] = 1.13 [1.05–1.22], p = 0.002) and splenectomy (OR [95%CI] = 26.65 [1.39–509.67], p = 0.029) remained significantly related to the primary outcome. Conclusions Gastric perforation after CRS is a rare event with a high rate of mortality. While splenectomy and increased BMI are risk factors associated with this complication, HIPEC does not seem to be related. Gastric perforation is probably an ischemic complication due to a multifactorial process. Preventive measures such as preservation of the gastroepiploic arcade and prophylactic suture of the greater gastric curvature require further assessment.

Impact of Body Mass Index and Bacterial Resistance in Osteomyelitis after Antibiotic Prophylaxis of Open Lower-Extremity Fractures

2017 ◽  
Vol 18 (3) ◽  
pp. 368-373 ◽  
Author(s):  
Derek Bremmer ◽  
Brandon Bookstaver ◽  
Mark Cairns ◽  
Kenneth Lindley ◽  
Martin Durkin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Lower Extremity ◽  
Antibiotic Prophylaxis ◽  
Body Mass ◽  
Bacterial Resistance

scholarly journals Analysis of risk factors for post-bacillus Calmette–Guerin-induced prostatitis in patients with non-muscle invasive bladder cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tae Jin Kim ◽  
Young Dong Yu ◽  
Sung Il Hwang ◽  
Hak Jong Lee ◽  
Sung Kyu Hong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Bladder Cancer ◽  
Body Mass ◽  
Prostate Volume ◽  
Specific Antigen ◽  
Invasive Bladder Cancer ◽  
Bacillus Calmette Guerin ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive

Abstract The objective of this study was to evaluate risk factors for bacillus Calmette–Guerin-induced prostatitis in patients with non-muscle invasive bladder cancer following bacillus Calmette–Guerin therapy. Clinical findings from patients with non-muscle invasive bladder cancer who underwent multi-parametric magnetic resonance imaging before transurethral resection of bladder tumor and post-bacillus Calmette–Guerin therapy from March 2004 to August 2018 were evaluated. The population was grouped into patients with or without newly developed lesions on multi-parametric magnetic resonance imaging performed 3 months after bacillus Calmette–Guerin instillation. Patients with prostate-specific antigen levels ≥ 4 ng/mL or prostate cancer were excluded. Univariable and multivariable analyses were performed to determine the predictors of prostate lesions in patients with prior bacillus Calmette–Guerin exposure. Post bacillus Calmette–Guerin-induced prostatitis was found in 50 of the 194 patients (25.8%). No significant differences were observed between the groups except for prostate volumes (33.8 mL vs. 30.8 mL, P = 0.012) and body mass index (25.2 kg/m2 vs. 24.1 kg/m2, P = 0.044). After bacillus Calmette–Guerin exposure, no significant differences in prostate-specific antigen levels, international prostate symptom scores, or post-voiding residual volume were noted. Multivariable regression analysis showed that body mass index (odds ratio, OR = 1.115, P = 0.038) and prostate volume (OR = 3.080, P = 0.012) were significant predictors of post-bacillus Calmette–Guerin prostate lesions. Body mass index and prostate volume may be clinical predictors of prostate lesions after bacillus Calmette–Guerin exposure. Awareness of potential risk factors for this entity should contribute to the clinical decision-making process for patients following bacillus Calmette–Guerin therapy.

scholarly journals Body mass index in relation to prostate-specific antigen-related parameters

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dandan Lin ◽  
Ting Liu ◽  
Luling Chen ◽  
Zongtao Chen
Keyword(s):  
Body Mass Index ◽  
Linear Regression ◽  
Prostate Specific Antigen ◽  
Body Mass ◽  
Fasting Blood Glucose ◽  
Specific Antigen ◽  
Systolic Pressure ◽  
Linear Regression Models ◽  
Psa Density ◽  
The Relationship

Abstract Background Only a few previous studies conducted to assess the association between body mass index (BMI) and prostate-specific antigen (PSA) related parameters have taken prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese adult men. Methods A total of 86,912 men who have received annual physical examination at the First Affiliated Hospital of Army Medical University from 1 January 2011 to 31 December 2018 were included in this study. Linear regression models were performed to assess the relationship between BMI, PV, BV and PSA, and analyze the correlation between BMI and PSA, PSA density and PSA mass. Results The univariable linear regression showed that PV, BV, systolic pressure (SBP), pulse, fasting blood glucose (FBG) and age were significantly associated with PSA level (P < 0.05). The multivariate linear regression demonstrated that PV, BV, FBG and age were significantly associated with PSA level (P < 0.05). WHR and BMI is negatively associated with PSA and PSA density (P < 0.05), and no statistically significant association was found between PSA mass and WHR and (P = 0.268) or BMI (P = 0.608). Conclusions The findings of this large-sample, hospital-based study in China indicate that PV was positively associated with serum PSA concentrations, while BMI and BV were inversely related with PSA levels. PSA mass can be used to estimate the PSA concentration without being affected by obesity in Chinese men.

scholarly journals Risk factors attributed to failure of ultrasound-guided compression for post-cardiac catheterization femoral artery pseudoaneurysms

2019 ◽  
Vol 7 ◽  
pp. 205031211984370 ◽  
Author(s):  
Nawaf J Shatnawi ◽  
Nabil A Al-zoubi ◽  
Jadallah Jarrah ◽  
Yousef Khader ◽  
Mowafeq Heis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Cardiac Catheterization ◽  
Odds Ratio ◽  
Univariate Analysis ◽  
Time Lag ◽  
Ultrasound Guided ◽  
Tract Length ◽  
Neck Diameter

Background: Femoral pseudoaneurysm is the most important access site complication following cardiac catheterization. Ultrasound-guided compression repair is a safe and effective therapeutic modality with variable failure rates and risk factors. The aim of this study was to investigate which factors were associated with a higher incidence of ultrasound-guided compression repair failure for post-cardiac catheterization femoral pseudoaneurysm. Methods: Data were retrospectively collected from medical records at King Abdullah University Hospital during the period from January 2011 to December 2016. A total of 42 patients with post-cardiac catheterization femoral pseudoaneurysm had attempted ultrasound-guided compression repair. Data regarding patients, procedure and aneurysm-related factors were evaluated by univariate analysis and multivariate logistic regression. Results: Ultrasound-guided compression repair failed in 31% of the patients. Patients with body mass index of ⩾28 kg/m2, platelet count of ⩽180,000/L, time lag (age of aneurysm) of >48 h following puncture time, aneurysmal neck diameter of ⩾4 mm and communicating tract length of <8 mm were associated with higher rate of ultrasound-guided compression repair failure in the univariate analysis. In the multivariate analysis, time lag (age of aneurysm) > 48 h (odds ratio = 5.7), body mass index ⩾ 28 kg/m2 (odds ratio = 7.8), neck diameter > 4 mm (odds ratio = 14.4) and tract length < 8 mm (odds ratio = 18.6) were significantly associated with ultrasound-guided compression repair failure. Conclusion: Ultrasound-guided compression repair for patients with post-cardiac catheterization femoral pseudoaneurysm was successful in 69% of the patients. Risk factors for failed ultrasound-guided compression repair were as follows: delayed ultrasound-guided compression repair of >48 h, body mass index ⩾ 28 kg/m2, wide neck diameter > 4 mm and short aneurysmal communication tract < 8 mm.

Body Mass Index is a Risk Factor of Pancreatic Fistula after Pancreaticoduodenectomy

2012 ◽  
Vol 78 (2) ◽  
pp. 190-194 ◽  
Author(s):  
Mitsugi Shimoda ◽  
Masato Katoh ◽  
Iso Yukihiro ◽  
Junji Kita ◽  
Tokihiko Sawada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Risk Factor ◽  
Pancreatic Fistula ◽  
Body Mass ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Remnant Pancreas ◽  
Soft Pancreas

Pancreatic fistula (PF) after pancreaticoduodenectomy (PD) is still a severe complication and a challenging problem. The common risk factors are the soft pancreas and small pancreatic duct of the remnant pancreas. Those two risk factors were recognized during surgery. On the other hand, a preoperatively determined risk factor of PF is unclarified. We conducted a retrospective analysis of 203 patients consecutively treated by PD from April 2000 to October 2010. PF was defined according to the criteria of the International Study Group of Pancreatic Fistula. Clinical and pre-and intraoperative data were compared between PF and non-PF patients. The recommended cutoff value of body mass index (BMI) as 20 kg/m2 was defined by receiver operating characteristic curve analysis. PF occurred in 53 (26.1%) of 203 patients. In univariate analysis, BMI and soft remnant pancreas were found to be risk factors of PF ( P = 0.027, P = 0.005). In multivariate analysis, BMI and soft pancreas were also risk factors of PF ( P = 0.040, P = 0.005). Patients with PF had a significantly longer hospital stay than non-PF patients ( P = 0.005). High BMI and soft pancreas were significant risk factors for PF.

1480: The Association of Body Mass Index and Serum Prostate Specific Antigen Levels in a Population-Based Study

2005 ◽  
Vol 173 (4S) ◽  
pp. 401-401
Author(s):  
Javier Hernandez ◽  
Jacques Baillargeon ◽  
Brad Pollock ◽  
Alan R. Kristal ◽  
Patrick Bradshaw ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Prostate Specific Antigen ◽  
Body Mass ◽  
Specific Antigen ◽  
Population Based ◽  
Population Based Study ◽  
Serum Prostate Specific Antigen

Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery

2013 ◽  
Vol 36 (6) ◽  
pp. 297 ◽  
Author(s):  
Peng Xing ◽  
Ji-Guang Li ◽  
Feng Jin ◽  
Ting-Ting Zhao ◽  
Qun Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Body Mass ◽  
Hormone Receptor ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Axillary Lymph ◽  
Nodal Stage ◽  
Hormone Receptor Positive ◽  
High Bmi

Purpose: Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer. Methods: In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI < 23.0 kg/m2) and overweight or obese (BMI ≥23.0 kg/m2). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed. Results: A high BMI was significantly (P < 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P < 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases. Conclusion: A high BMI (≥23.0 kg/m^2) is independently associated with poor prognosis in hormone receptor-positive breast cancer.

Sign in / Sign up

Export Citation Format

Share Document