scholarly journals Risk factors attributed to failure of ultrasound-guided compression for post-cardiac catheterization femoral artery pseudoaneurysms

2019 ◽  
Vol 7 ◽  
pp. 205031211984370 ◽  
Author(s):  
Nawaf J Shatnawi ◽  
Nabil A Al-zoubi ◽  
Jadallah Jarrah ◽  
Yousef Khader ◽  
Mowafeq Heis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Cardiac Catheterization ◽  
Odds Ratio ◽  
Univariate Analysis ◽  
Time Lag ◽  
Ultrasound Guided ◽  
Tract Length ◽  
Neck Diameter

Background: Femoral pseudoaneurysm is the most important access site complication following cardiac catheterization. Ultrasound-guided compression repair is a safe and effective therapeutic modality with variable failure rates and risk factors. The aim of this study was to investigate which factors were associated with a higher incidence of ultrasound-guided compression repair failure for post-cardiac catheterization femoral pseudoaneurysm. Methods: Data were retrospectively collected from medical records at King Abdullah University Hospital during the period from January 2011 to December 2016. A total of 42 patients with post-cardiac catheterization femoral pseudoaneurysm had attempted ultrasound-guided compression repair. Data regarding patients, procedure and aneurysm-related factors were evaluated by univariate analysis and multivariate logistic regression. Results: Ultrasound-guided compression repair failed in 31% of the patients. Patients with body mass index of ⩾28 kg/m2, platelet count of ⩽180,000/L, time lag (age of aneurysm) of >48 h following puncture time, aneurysmal neck diameter of ⩾4 mm and communicating tract length of <8 mm were associated with higher rate of ultrasound-guided compression repair failure in the univariate analysis. In the multivariate analysis, time lag (age of aneurysm) > 48 h (odds ratio = 5.7), body mass index ⩾ 28 kg/m2 (odds ratio = 7.8), neck diameter > 4 mm (odds ratio = 14.4) and tract length < 8 mm (odds ratio = 18.6) were significantly associated with ultrasound-guided compression repair failure. Conclusion: Ultrasound-guided compression repair for patients with post-cardiac catheterization femoral pseudoaneurysm was successful in 69% of the patients. Risk factors for failed ultrasound-guided compression repair were as follows: delayed ultrasound-guided compression repair of >48 h, body mass index ⩾ 28 kg/m2, wide neck diameter > 4 mm and short aneurysmal communication tract < 8 mm.

Major post-prostate biopsy complications under antibiotic augmentation prophylaxis protocol

2021 ◽  
pp. 205141582098403
Author(s):  
Antônio Antunes Rodrigues ◽  
Valdair Muglia ◽  
Emanuel Veras de Albuquerque ◽  
Rafael Ribeiro Mori ◽  
Rafael Neuppmann Feres ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Antibiotic Prophylaxis ◽  
Body Mass ◽  
Bacterial Resistance ◽  
Univariate Analysis ◽  
Specific Antigen ◽  
Outlet Obstruction ◽  
Psa Density ◽  
Biopsy Complications

Objective: To identify risk factors for major post-biopsy complications under augmented prophylaxis protocol. The risk factors already described mainly comprise outdated antibiotic prophylaxis protocols. Material and methods: This retrospective cohort study included patients that underwent transrectal ultrasound-guided biopsies, from 2011 to 2016. All patients had received antibiotic prophylaxis with ciprofloxacin and gentamicin. Patients were grouped according to the presence or absence of post-biopsy complications. Demographic variables and possible risk factors based on routine clinical assessment were registered. Correlation tests, univariate and multivariate analyses were used to identify risk factors for post-biopsy complications. Results: Of the 404 patients that were included, 25 (6.2%) presented 27 post-biopsy complications, distributed as follows: acute urinary retention ( n = 14, 3.5%), infections ( n = 11, 2.7%) and hemorrhage ( n = 2, 0.5%). On univariate analysis, patients who presented complications showed higher body mass index and post-voiding residual volumes. Multivariate analysis identified ethnicity and prostate-specific antigen (PSA) density as possible risk factors for biopsy complications. The presence of bacterial resistance identified by rectal swabs did not correlate with the incidence of complications and infections. Conclusions: Non-infectious post-biopsy complications were more frequent than infectious ones in this cohort. Higher post-voiding residual volumes and PSA density, that indicates prostate enlargement, were identified as risk factors and interpreted as secondary to bladder outlet obstruction. The higher body mass index and ethnicity were also identified as risk factors and attributed to the heterogeneity of the patients included. Level of evidence: Not applicable for this multicentre audit.

scholarly journals Estimated and projected burden of multiple sclerosis attributable to smoking and childhood and adolescent high body-mass index: a comparative risk assessment

2020 ◽  
Author(s):  
Julia Pakpoor ◽  
Klaus Schmierer ◽  
Jack Cuzick ◽  
Gavin Giovannoni ◽  
Ruth Dobson
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Body Mass ◽  
Early Life ◽  
Time Lag ◽  
Early Adulthood ◽  
High Body Mass Index ◽  
High Body ◽  
High Bmi

Abstract Background Smoking and childhood and adolescent high body-mass index (BMI) are leading lifestyle-related risk factors of global premature morbidity and mortality, and have been associated with an increased risk of developing multiple sclerosis (MS). This study aims to estimate and project the proportion of MS incidence that could be prevented with elimination of these risk factors. Methods Prevalence estimates of high BMI during childhood/adolescence and smoking in early adulthood, and relative risks of MS, were obtained from published literature. A time-lag of 10 years was assumed between smoking in early adulthood and MS incidence, and a time-lag of 20 years was assumed between childhood/adolescent high BMI and MS incidence. The MS population attributable fractions (PAFs) of smoking and high BMI were estimated as individual and combined risk factors, by age, country and sex in 2015, 2025 and 2035 where feasible. Results The combined estimated PAFs for smoking and high BMI in 2015 were 14, 11, 12 and 12% for the UK, USA, Russia and Australia in a conservative estimate, and 21, 20, 19 and 16% in an independent estimate, respectively. Estimates for smoking are declining over time, whereas estimates for high early life BMI are rising. The PAF for high early life BMI is highest in the USA and is estimated to increase to 14% by 2035. Conclusions Assuming causality, there is the potential to substantially reduce MS incidence with the elimination of lifestyle-related modifiable risk factors, which are the target of global public health prevention strategies.

scholarly journals Female Urinary Incontinence: Prevalence, Risk Factors and Impact on the Quality of Life of Gynecological Clinic Attendees in Lagos, Nigeria

2020 ◽  
Vol 15 (1) ◽  
pp. 31-38
Author(s):  
Fatimat Motunrayo Akinlusi ◽  
Tawaqualit Abimbola Ottun ◽  
Yusuf Abisowo Oshodi ◽  
Bilkees Oluwatoyin Seriki ◽  
Folasade D. Haleemah Olalere ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Body Mass Index ◽  
Urinary Incontinence ◽  
Body Mass ◽  
Odds Ratio ◽  
High Body Mass Index ◽  
Female Urinary Incontinence ◽  
Substantial Impact

Aims: To determine the prevalence of urinary incontinence, risk factors and impact on the quality of life in gynecological clinic attendees of a University Hospital. Methods: A cross sectional descriptive study was conducted amongst gynecological clinic attendees in a Teaching Hospital in Nigeria from 1st February to 31st July 2017. Structured questionnaires were used to ascertain the presence of urinary incontinence. Socio-demographic and medical factors; impact on daily activities and treatment history were assessed. Women with and without urinary incontinence were compared. Univariate, bivariate and multivariable analyses were performed. Results: There were 395 women of 25 - 67 years (mean age = 38.81±10.1). About 33% had experienced urinary incontinence in the previous 6 months with Urgency, Mixed and Stress urinary incontinence occurring in 18.0%, 7.6% and 7.3% respectively. Independent risk factors for urinary incontinence were age (odds ratio=0.49, 95% confidence interval [CI] =0.26 - 0.92, P =0.026), higher body mass index (odds ratio=1.92, 95% CI =1.53 - 3.00, P =0.004) and history of constipation (odds ratio=2.11, 95% CI =1.30 - 3.43, P =0.003). About 47% of those with urinary incontinence admitted to negative feelings like anxiety and depression; 45% had moderate to severe impact on their quality of life in all domains but only 27.7% sought help. Conclusions: Urinary incontinence is common and risk factors include older age, high body mass index and constipation. Despite its substantial impact on the quality of life, majority do not seek help. Addressing modifiable risks factors and improving treatment seeking behaviour will assist in reducing the prevalence of urinary incontinence. Keywords: female urinary incontinence; quality of life; risk factors; stress incontinence; urgency incontinence.

scholarly journals FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN OSTEOPOROSIS

2020 ◽  
Vol 3 (2) ◽  
pp. 337-343
Author(s):  
Helfrida Situmorang
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Research Design ◽  
Univariate Analysis ◽  
The Body ◽  
Nutritional Deficiencies ◽  
Bivariate Analysis ◽  
History Of

The irreversible risk factors for osteoporosis are age, gender, race, family / hereditary history, body shape and history of fractures. The risk factors for osteoporosis that can be changed are smoking, vitamin and nutritional deficiencies, lifestyle, eating disorders (anorexia nervosa), early menopause, and the use of certain drugs such as corticosteroids, glucocorticosteroids, and diuretics. The purpose of this study was to determine the factors associated with the incidence of osteoporosis. The research design used was non-experimental, namely a correlational research design, namely research conducted to determine the relationship between two variables. The population in this study were all osteoporosis patients with age. over 45 years old who seek treatment at the Puskesmas Gunting Saga Kec. Kualuh Selatan District of North Labuhan Batu totaling 45 people. The sampling method used was the total sampling technique, which was the same as the population of 45 people. Data collection used is the method of filling out a questionnaire which includes written questions used to obtain data information from the questionnaire. The data analysis conducted was univariate analysis and bivariate analysis. In this study, researchers still adhere to ethical principles. The results illustrate that the respondents are mostly 51-65 years old as many as 27 people (60%). Most of the sex of respondents were women as many as 37 people (82.2 %%). Most of the respondents had no history of osteoporosis as many as 31 people (68.9%). Most of the body mass index of respondents whose body mass index was over 34 people (75.6%). Most of the respondents in the smoking category did not smoke as many as 32 people (71.7%). Most of the respondents' physical activity in the category of independent physical activity was 38 people (84.4%). The conclusion is that there is no relationship between age, sex, family history, body mass index, and smoking with the incidence of osteoporosis. Meanwhile, physical activity has a relationshipwithosteoporosis.   Abstrak Faktor-faktor resiko osteoporosis yang tidak dapat diubah yaitu usia, jenis kelamin, ras, riwayat keluarga/keturunan, bentuk tubuh dan sejarah patah tulang. Faktor–faktor resiko osteoporosis yang dapat diubah adalah merokok, defisiensi vitamin dan gizi, gaya hidup, gangguan makan (anoreksia nervosa), menopause dini, serta penggunaan obat-obatan tertentu seperti kortikosteroid, glukokortikosteroid, serta diuretik. Tujuan penelitian ini adalah untuk mengetahui mengetahui faktor-faktor yang berhubungan dengan kejadian osteoporosis Rancangan penelitian yang digunakan adalah non eksperimen yaitu rancangan atau desain penelitian yang bersifat korelasional yaitu penelitian yang dilakukan untuk mengetahui hubungan dua variabel.Populasi dalam penelitian ini adalah semua pasien osteoporosis dengan usia diatas 45 tahun yang berobat di Puskesmas Gunting Saga Kec. Kualuh Selatan Kab Labuhan Batu Utara berjumlah 45 orang.Metode pengambilan sampel yang digunakan dengan teknik total sampling yaitu sama dengan populasi adalah sebanyak 45 orang. Pengumpulan data yang digunakan yaitu metode pengisian kuesioner yang meliputi pertanyaan tertulis yang digunakan untuk memperoleh informasidata dari kuesioner.Analisa data yang dilakukan adalah analisis univariat dan analisis bivariat. Dalam penelitian ini peneliti tetap berpedoman pada prinsip-prinsip etik.Hasil penelitian menggambarkan bahwa responden sebagian besar berumur 51-65 tahun sebanyak 27 orang (60%). Jenis kelamin responden sebagian besar wanita sebanyak  37 orang (82.2%%).Riwayat keluarga responden sebagian besar berstatus tidak ada riwayat osteoporosis sebanyak 31 orang (68.9%).Indeks masa tubuh responden sebagian besar Indeks masa tubuh lebih sebanyak 34 orang (75.6%).Merokok responden sebagian besar kategori tidak merokok sebanyak 32 orang (71.7%).Aktivitas fisik responden sebagian besar kategori aktivitas fisik mandiri sebanyak 38 orang (84.4%).Kesimpulan bahwa tidak ada hubungan umur, jeniskelamin, riwayat keluarga,indeks massa tubuh,dan merokok dengan kejadian osteoporosis. Sedangkan aktivitas fisikada hubungan dengan kejadian osteoporosis.

scholarly journals Risk factors for gastric perforation after cytoreductive surgery in patients with peritoneal carcinomatosis: Splenectomy and increased body mass index

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248205
Author(s):  
Martina Aida Angeles ◽  
Carlos Martínez-Gómez ◽  
Mathilde Del ◽  
Federico Migliorelli ◽  
Manon Daix ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Peritoneal Carcinomatosis ◽  
Body Mass ◽  
Cytoreductive Surgery ◽  
Gastric Perforation ◽  
Univariate Analysis ◽  
Rare Event ◽  
Comprehensive Cancer Center ◽  
Cancer Center

Background Gastric perforation after cytoreductive surgery (CRS) is an infrequent complication. There is lack of evidence regarding the risk factors for this postoperative complication. The aim of this study was to assess the prevalence of postoperative gastric perforation in patients undergoing CRS for peritoneal carcinomatosis (PC) and to evaluate risk factors predisposing to this complication. Methods We designed a unicentric retrospective study to identify all patients who underwent an open upfront or interval CRS after a primary diagnosis of PC of different origins between March 2007 and December 2018 at a French Comprehensive Cancer Center. The main outcome was the occurrence of postoperative gastric perforation. Results Five hundred thirty-three patients underwent a CRS for PC during the study period and 13 (2.4%) presented a postoperative gastric perforation with a mortality rate of 23% (3/13). Neoadjuvant chemotherapy was administered in 283 (53.1%) patients and 99 (18.6%) received hyperthermic intraperitoneal chemotherapy (HIPEC). In the univariate analysis, body mass index (BMI), peritoneal cancer index, splenectomy, distal pancreatectomy, and histology were significantly associated with postoperative gastric perforation. After multivariate analysis, BMI (OR [95%CI] = 1.13 [1.05–1.22], p = 0.002) and splenectomy (OR [95%CI] = 26.65 [1.39–509.67], p = 0.029) remained significantly related to the primary outcome. Conclusions Gastric perforation after CRS is a rare event with a high rate of mortality. While splenectomy and increased BMI are risk factors associated with this complication, HIPEC does not seem to be related. Gastric perforation is probably an ischemic complication due to a multifactorial process. Preventive measures such as preservation of the gastroepiploic arcade and prophylactic suture of the greater gastric curvature require further assessment.

PS02.154: RISK FACTORS FOR WEIGHT LOSS 1 MONTH AFTER ESOPHAGECTOMY FOR ESOPHAGEAL CANCER

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 165-165
Author(s):  
Hiromi Mohizuki ◽  
Shinji Mine ◽  
Takashi Nakahama ◽  
Masayuki Watanabe ◽  
Naoki Hiki
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Weight Loss ◽  
Esophageal Cancer ◽  
Body Weight ◽  
Body Mass ◽  
Odds Ratio ◽  
High Body Mass Index ◽  
Body Weight Loss ◽  
High Body

Abstract Background Post-operative body weight loss (BWL) of patients who underwent esophagectomy is common. One month after esophagectomy, some patients lose weight remarkably, and others not. If preoperative or operative risk factors influencing body weight loss are identified, it will be possible that nutritional intervention is given to the patient having these risk factors. Methods In our department, the dietician stays in a surgical ward for nutritional management of patients. Ninety-two patients who underwent esophagectomy for esophageal cancer in 2016 were reviewed. Pre-operative and operative factors were correlated with post-operative BWL. The cut-off value of BWL 1 month after esophagectomy was defined with 75 percentile. Results The median body weight change was -4.8% (-18.5% ∼11.7%). The patients were divided into two groups; 24 patients with ≥ 7.3% of BWL (severe BWL group) and 68 with < 7.3% of BWL (mild BWL group). Patients’ characteristics or post-operative morbidities were not statistically different in these 2 groups. The incidence of patients with reconstruction using a colon or jejunum was higher in severe BWL group. Pre-operative body weight, body mass index, and the value of prealbumin was higher in severe BWL group. On postoperative 14 day, the patients in severe BWL group were likely to have lower energy intake per kilogram of pre-operative body weight. On multivariate analysis, high body mass index [odds ratio = 5.90; 95% confidence interval (CI) = 1.03–47.8; P = 0.046], upper location of tumor [odds ratio = 3.38; 95%, CI = 1.04–11.4; P = 0.043] were independently associated with severe BWL at 1 month after surgery. Conclusion High body mass index of ≥ 25, upper location of tumor were unfavorable risk factors for weight loss 1 month after esophagectomy for esophageal cancer. Disclosure All authors have declared no conflicts of interest.

scholarly journals Parental Risk Factors and Child Birth Data in a Matched Year and Sex Group Cleft Population: A Case-Control Study

2021 ◽  
Vol 18 (9) ◽  
pp. 4615
Author(s):  
Inês Francisco ◽  
Francisco Caramelo ◽  
Maria Helena Fernandes ◽  
Francisco Vale
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Odds Ratio ◽  
Maternal Body Mass Index ◽  
Related Factors ◽  
Mass Unit ◽  
Parental Risk Factors ◽  
Increase Odds Ratio ◽  
Birth Data

(1) Background: The etiology of orofacial cleft (OC) is not completely known but several genetic and environmental risk factors have been identified. Moreover, a knowledge gap still persists regarding neonatal characteristics. This study evaluated the effect of parental age and mothers’ body mass index on the risk of having an OC child, in a matched year and sex group (cleft/healthy control). Additionally, birth data were analyzed between groups. (2) Methods: 266 individuals born between 1995 to 2015 were evaluated: 133 OC individuals (85 males/48 females) and 133 control (85 males/48 females). A logistic model was used for the independent variables. ANOVA or Kruskal-Wallis tests were used for comparison between the OC phenotypes. (3) Results: Regarding statistically significant parental related factors, the probability of having a cleft child decreases for each maternal year increase (odds ratio = 0.903) and increases for each body mass index unit (kg/m2) increase (odds ratio = 1.14). On the child data birth, for each mass unit (kg) increase, the probability of having a cleft child decrease (odds ratio = 0.435). (4) Conclusions: In this study, only maternal body mass index and maternal age found statistical differences in the risk of having a cleft child. In the children’s initial data, the cleft group found a higher risk of having a lower birth weight but no relation was found regarding length and head circumference.

Sever’s Disease

2011 ◽  
Vol 101 (2) ◽  
pp. 133-145 ◽  
Author(s):  
Rolf W. Scharfbillig ◽  
Sara Jones ◽  
Sheila Scutter
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Ankle Joint ◽  
Body Mass ◽  
Odds Ratio ◽  
Total Activity ◽  
Activity Levels ◽  
Ankle Joint Dorsiflexion ◽  
Foot Posture ◽  
Calcaneal Apophysitis

Background: Sever’s disease, also known as calcaneal apophysitis, is thought to be an inflammation of the apophysis of the heel, which is open in childhood. This condition has been commented on and looked at in a retrospective manner but has not been examined systematically. We assembled the most commonly cited theoretical causative models identified from the literature and tested them to determine whether any were risk factors. Methods: Children with Sever’s disease were compared with a similarly aged nonsymptomatic population to determine whether identifiable risk factors exist for the onset of Sever’s disease. Areas raised in the literature and, hence, compared were biomechanical foot malalignment, as measured by Root et al–type foot measurements and the Foot Posture Index; ankle joint dorsiflexion, measured with a modified apparatus; body mass index; and total activity and types of sport played. Results: Statistically significant but small odds ratios were found in forefoot to rearfoot determination and left ankle joint dorsiflexion. Conclusions: This study suggests that there is no evidence to support that weight and activity levels are risk factors for Sever’s disease. The statistically significant but clinically negligible odds ratio (0.93) on the left side for decreased ankle joint dorsiflexion and statistically significant and clinically stronger odds ratio bilaterally for forefoot to rearfoot malalignment suggest that biomechanical malalignment is an area for further investigation. (J Am Podiatr Med Assoc 101(2): 133–145, 2011)

Body Mass Index is a Risk Factor of Pancreatic Fistula after Pancreaticoduodenectomy

2012 ◽  
Vol 78 (2) ◽  
pp. 190-194 ◽  
Author(s):  
Mitsugi Shimoda ◽  
Masato Katoh ◽  
Iso Yukihiro ◽  
Junji Kita ◽  
Tokihiko Sawada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Risk Factor ◽  
Pancreatic Fistula ◽  
Body Mass ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Remnant Pancreas ◽  
Soft Pancreas

Pancreatic fistula (PF) after pancreaticoduodenectomy (PD) is still a severe complication and a challenging problem. The common risk factors are the soft pancreas and small pancreatic duct of the remnant pancreas. Those two risk factors were recognized during surgery. On the other hand, a preoperatively determined risk factor of PF is unclarified. We conducted a retrospective analysis of 203 patients consecutively treated by PD from April 2000 to October 2010. PF was defined according to the criteria of the International Study Group of Pancreatic Fistula. Clinical and pre-and intraoperative data were compared between PF and non-PF patients. The recommended cutoff value of body mass index (BMI) as 20 kg/m2 was defined by receiver operating characteristic curve analysis. PF occurred in 53 (26.1%) of 203 patients. In univariate analysis, BMI and soft remnant pancreas were found to be risk factors of PF ( P = 0.027, P = 0.005). In multivariate analysis, BMI and soft pancreas were also risk factors of PF ( P = 0.040, P = 0.005). Patients with PF had a significantly longer hospital stay than non-PF patients ( P = 0.005). High BMI and soft pancreas were significant risk factors for PF.

scholarly journals Prevalence and risk factors of moderate to severe hepatic steatosis in patients with rheumatoid arthritis: an ultrasonography cross-sectional case–control study

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110427
Author(s):  
Gian Luca Erre ◽  
Floriana Castagna ◽  
Assunta Sauchella ◽  
Pierluigi Meloni ◽  
Arduino Aleksander Mangoni ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Body Mass Index ◽  
Confidence Interval ◽  
Hepatic Steatosis ◽  
Body Mass ◽  
Odds Ratio ◽  
Rheumatoid Arthritis Group ◽  
Healthy Controls ◽  
Male Sex

Background: The independent association between hepatic steatosis and rheumatoid arthritis is poorly defined. Methods: The presence of moderate to severe steatosis was assessed, using liver ultrasonography, in 364 consecutive non-diabetic subjects (223 patients with rheumatoid arthritis and 141 age- and sex-matched healthy controls). Adjusted multiple regression analysis was performed to explore the association between rheumatoid arthritis and moderate to severe steatosis in the overall sample and identify independent risk factors in the rheumatoid arthritis subgroup. Results: The prevalence of moderate to severe steatosis in the overall sample was 31.3%, with a significantly higher prevalence in patients with rheumatoid arthritis than healthy controls (38.7% versus 19.7%, p < 0.0001). After adjustment for sex, age, cholesterol, triglycerides, body mass index, waist, hypertension and smoke, rheumatoid arthritis remained significantly associated with moderate to severe steatosis [odds ratio (95% confidence interval) = 2.24 (1.31, 3.84); p = 0.003]. In the rheumatoid arthritis group, male sex, higher body mass index, higher triglycerides concentrations and higher cumulative dosage of methotrexate [odds ratio (95% confidence interval) = 1.11 (1.01, 1.23); p = 0.026] were significantly associated with moderate to severe steatosis, while systemic inflammation, disease activity, use of steroids and biologics were not. Conclusion: Rheumatoid arthritis is independently associated with moderate to severe steatosis, with male sex, higher body mass index and cumulative dose of methotrexate being predisposing factors. Further prospective studies are warranted to confirm our findings and to investigate the effect of steatosis on liver outcomes in the rheumatoid arthritis population.

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