scholarly journals Preschool Mathematics Intervention Can Significantly Improve Student Learning Trajectories Through Elementary School

AERA Open ◽  
2019 ◽  
Vol 5 (4) ◽  
pp. 233285841987944 ◽  
Author(s):  
Denis Dumas ◽  
Daniel McNeish ◽  
Julie Sarama ◽  
Douglas Clements
Keyword(s):  
Elementary School ◽  
Growth Curves ◽  
Developed Countries ◽  
The United States ◽  
Control Group ◽  
Mathematics Intervention ◽  
Mathematics Outcomes ◽  
Mathematical Skill ◽  
Business As Usual

Perhaps more than at any other time in history, the development of mathematical skill is critical for the long-term success of students. Unfortunately, on average, U.S. students lag behind their peers in other developed countries on mathematics outcomes, and within the United States, an entrenched mathematics achievement gap exists between students from more highly resourced and socially dominant groups, and minority students. To begin to remedy this situation, educational researchers have created instructional interventions designed to support the mathematical learning of young students, some of which have demonstrated efficacy at improving student mathematical skills in preschool, as compared with a business-as-usual control group. However, the degree to which these effects last or fade out in elementary school has been the subject of substantial research and debate, and differences in scholarly viewpoints have prevented researchers from making clear and consistent policy recommendations to educational decision makers and stakeholders. In this article, we use a relatively novel statistical framework, Dynamic Measurement Modeling, that takes both intra- and interindividual student differences across time into account, to demonstrate that while students who receive a short-term intervention in preschool may not differ from a control group in terms of their long-term mathematics outcomes at the end of elementary school, they do exhibit significantly steeper growth curves as they approach their eventual skill level. In addition, this significant improvement of learning rate in elementary school benefited minority (i.e., Black or Latinx) students most, highlighting the critical societal need for research-based mathematics curricula in preschool.

Health Care-Related Economic Burden of Polycystic Ovary Syndrome in the United States: Pregnancy-Related and Long-Term Health Consequences

2021 ◽  
Author(s):  
Carrie Riestenberg ◽  
Anika Jagasia ◽  
Daniela Markovic ◽  
Richard P Buyalos ◽  
Ricardo Azziz
Keyword(s):  
United States ◽  
Polycystic Ovary Syndrome ◽  
Economic Burden ◽  
Polycystic Ovary ◽  
The United States ◽  
Reproductive Age ◽  
Cochrane Library ◽  
Control Group ◽  
Ovary Syndrome

Abstract Context Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive-aged women, affecting approximately 5-20% of women of reproductive age. A previous estimate noted that the economic burden of PCOS approximates $3.7 billion annually in 2020 USD when considering only the costs of the initial diagnosis and of reproductive endocrine morbidities, not considering the costs of pregnancy-related and long-term morbidities. Objective To estimate the excess prevalence and economic burden of pregnancy-related and long-term health morbidities attributable to PCOS. Data Sources PubMed, EmBase and Cochrane Library. Study Selection Studies in which the diagnosis of PCOS was consistent with the Rotterdam, National Institutes of Health (NIH), or Androgen Excess & PCOS (AE-PCOS) Society criteria, or that used electronic medical record diagnosis codes, or diagnosis based on histopathologic sampling were eligible for inclusion. Studies that included an outcome of interest and a control group of non-PCOS patients who were matched or controlled for body mass index (BMI) were included. Data Extraction Two investigators working independently extracted data on study characteristics and outcomes. Data Synthesis Data was pooled using random-effects meta-analysis. The I 2statistic was used to assess inter-study heterogeneity. The quality of selected studies was assessed using the Newcastle-Ottawa Scale. Results The additional total healthcare-related economic burden due to pregnancy-related and long-term morbidities associated with PCOS in the United States is estimated to be $4.3 billion annually in 2020 USD. Conclusions Together with our prior analysis, the economic burden of PCOS is estimated at $8 billion annually in 2020 USD.

scholarly journals Changes in historical typhoid transmission across 16 U.S. cities, 1889-1931: Quantifying the impact of investments in water and sewer infrastructures

2019 ◽  
Author(s):  
Maile T. Phillips ◽  
Katharine A. Owers ◽  
Bryan T. Grenfell ◽  
Virginia E. Pitzer
Keyword(s):  
Late Summer ◽  
Water Source ◽  
Developed Countries ◽  
The United States ◽  
Water And Sanitation ◽  
Sewer Systems ◽  
Early Fall ◽  
Sanitation Systems ◽  
The Impact

ABSTRACTBackgroundInvestments in water and sanitation systems are believed to have led to the decline in typhoid fever in developed countries, such that most cases now occur in regions lacking adequate clean water and sanitation. Exploring seasonal and long-term patterns in historical typhoid mortality in the United States can offer deeper understanding of disease drivers.MethodsWe fit modified Time-series Susceptible-Infectious-Recovered models to city-level weekly mortality counts to estimate seasonal and long-term typhoid transmission. We examined seasonal transmission separately by city and aggregated by water source. We fit regression models to measure associations between long-term transmission and financial investments in water and sewer systems.ResultsTyphoid transmission peaked in late summer/early fall. Seasonality varied by water source, with the greatest variation occurring in cities with reservoirs. Historical $1 per capita ($25.80 in 2017) investments in construction and operation of water and sewer systems were associated with 8-53% decreases in typhoid transmission, while $1 increases in total value or debt accrued to maintain them were associated with 4-7% decreases.ConclusionOur findings aid in the understanding of typhoid transmission dynamics and potential impacts of water and sanitation improvements, and can inform cost-effectiveness analyses of interventions to reduce the typhoid burden.

Business-Inspired School Reform in the Era of Financialization: Not Business as Usual

2020 ◽  
pp. 089590482090473
Author(s):  
Michael Ian Cohen
Keyword(s):  
Public Schools ◽  
School Reform ◽  
Social Institution ◽  
The United States ◽  
Multiple Stakeholders ◽  
Business World ◽  
Long Term Stability ◽  
Recent Trends ◽  
Business As Usual

Business-inspired school reform policies in the United States date back to the late 19th century. In the last four decades, however, while school reformers have continued to borrow policies and practices from the business world, the dominant business model itself has changed dramatically as part of the financialization of the economy. Once a bureaucratically governed social institution, focused on long-term stability and committed to multiple stakeholders, the corporation has become a destabilized network of temporary contracting relationships, singularly focused on maximizing shareholder value. This conceptual article explores what it means for schools, as public and democratic institutions, to emulate business in the era of financialization. Through analysis of several recent trends in business-inspired school reform policy, I demonstrate the diffusion of financialization logic and practices into public schools. I argue that while business may have historically been a problematic model for educational policy, business is now a uniquely unqualified model.

The impact of food aid on world malnutrition

1981 ◽  
Vol 35 (2) ◽  
pp. 329-354 ◽  
Author(s):  
James N. Schubert
Keyword(s):  
Nutritional Status ◽  
Food Production ◽  
Developed Countries ◽  
Food Aid ◽  
Control Group ◽  
Negative Effects ◽  
Alternative Hypotheses ◽  
Long Term Impact ◽  
The Impact

Does food aid enhance or diminish the nutritional status of recipient populations in less developed countries? In proposing that the long-term impact is negative, critics have argued that aid depresses local food production, is maldistributed and mismanaged such that it does not reach the needy in sufficient quantities, or, where effective, that aid merely reduces the death rate relative to the birth rate, permitting more people to survive at the margin of existence. This study explores the long-term impact of U.S. Public Law 480 food aid through a crossnational analysis of aggregate data on aid receipts and change in nutritional status over the period from 1962 through 1974. Alternative hypotheses are tested through least squares methods and.mean difference tests in the framework of a nonequivalent control group, quasi-experimental design. This study supports the following generalizations: food aid is significantly related with improved nutritional status; the greater the aid, the greater the improvement in nutrition; higher aid recipients do not have significantly lower rates of growth in domestic food production; higher aid recipients do not have higher rates of population growth; and food aid may lead to greater meat consumption among higher aid recipients. Negative effects, experienced in some countries at some times, are not systematically incurred by all food aid recipients over time. In general, food aid does improve nutrition.

scholarly journals FEMALE URINARY INCONTINENCE IN CANADA

2010 ◽  
Vol 16 (3) ◽  
pp. 111
Author(s):  
Harold P. Drutz
Keyword(s):  
Urinary Incontinence ◽  
Well Being ◽  
Developed Countries ◽  
The United States ◽  
Mount Sinai Hospital ◽  
Medical Attention ◽  
Age Group ◽  
Social And Emotional ◽  
Geriatric Center

In Canada, Urinary Incontinence (UI) is a significant medical and social problem which can be devastating to a women’s physical, social and emotional well being. As in other developed countries our population is aging. In 1993, 11.8 per cent of all Canadians were over age 65; by the year 2011, the proportion of this age group will be 14.0 per cent; by 2031, it will be 21.7 per cent (1). It is estimated that between 1.5 to 2.0 million Canadians (out of a population of just over 30 million) suffer from UI, yet only 1:12 will seek medical attention for this problem. UI is now the commonest cause of admission to long-term institutionalized centers in the United States and Canada. In Canada, we now spend over 1.5 billion dollars annually on this health care problem. At the Baycrest Geriatric Center (BGC) in Toronto, where we have a urogynecology branch of the unit at Mount Sinai Hospital (MSH), recent budget figures indicate that the hospital spends $320,000 (Cadanian) annually on adult diapers (2).

PD65 The Acquisition Of Eculizumab By Judicial Proceeding In Brazil

2018 ◽  
Vol 34 (S1) ◽  
pp. 153-154
Author(s):  
Flavia Salomon ◽  
Eliete Simabuku ◽  
Jose Beutel ◽  
Eduardo De Oliveira ◽  
Roberta Rabelo ◽  
...  
Keyword(s):  
Atypical Hemolytic Uremic Syndrome ◽  
The United States ◽  
Cochrane Library ◽  
Controlled Study ◽  
European Medicines Agency ◽  
Control Group ◽  
Open Label ◽  
Expensive Drug ◽  
Judicial Proceedings

Introduction:Eculizumab is a monoclonal antibody indicated for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) or with atypical hemolytic uremic syndrome (aHUS). In Brazil in recent years eculizumab was the most expensive drug requested through court orders, obliging public health managers to import it from the USA. From 2012 to 2016, approximately BRL 424 million (USD 112 million) was spent on eculizumab. The purpose of this study was to assess the regulatory situation and the scientific evidence on the safety and efficacy of eculizumab.Methods:A literature search was conducted in PubMed, The Cochrane Library, and the Centre for Reviews and Dissemination databases on September 2017. The websites of regulatory agencies were also searched.Results:In 2007, the use of eculizumab was approved by the United States Food and Drug Administration and the European Medicines Agency. In Brazil, despite the provision of eculizumab through judicial proceedings since 2009, the manufacturer of eculizumab only requested a licence for it in 2017, after several meetings with the government when the company agreed to provide the drug at approximately half the price of the imported product. The efficacy of eculizumab in PNH patients was assessed in one randomized, placebo controlled study, one single arm study, and one long-term extension study. The drug reduced hemolysis and the need for transfusion, although the studies had methodological problems. The efficacy of eculizumab in the treatment of aHUS was assessed in four prospective, controlled open-label studies, two long-term extension studies, and one retrospective study. Eculizumab normalized platelet counts and reduced the need for plasmapheresis, although the studies had no control group. Eculizumab was well tolerated, with no meningococcal infections occurring after patients were immunized.Conclusions:Some companies have no interest in licensing their products in Brazil because their provision by judicial proceedings is more lucrative. This situation promotes litigation and irrational prescription of drugs, and also obligates the Brazilian government to import expensive health products.

Anti-progesterone antibody administration and the impairment of postpartum maternal care in mice

1995 ◽  
Vol 145 (2) ◽  
pp. 363-369 ◽  
Author(s):  
M-W Wang ◽  
D L Crombie ◽  
D E Mais ◽  
J S Hayes ◽  
R B Heap
Keyword(s):  
Maternal Care ◽  
Growth Curves ◽  
Rejection Rate ◽  
Control Group ◽  
Maternal Behaviour ◽  
Maternal Rejection ◽  
High Incidence ◽  
Pup Growth ◽  
And Control

Abstract Passive transfer of a monoclonal antibody against progesterone produces a high incidence of maternal rejection in mice after recovery from antibody-induced infertility. To investigate the mechanisms involved in this reduction of maternal care, we have examined whether the effect is due to long-term exposure to antibody. Antibody was administered i.p. either on day 2 or day 17 of pregnancy. When a low dose (1·0 nmol) was given on day 2, pregnancy proceeded normally but 44·8% pups delivered at term were rejected compared with 12·7% in the control group. When a higher dose (4·5 nmol) of antibody was given on day 17, pregnancy continued normally to term and the rejection rate was 48·8% (control: 11·1%). When the same amount of antibody was injected after delivery (day 1 of lactation), no detrimental effect was found on subsequent maternal care to the young, the rejection rate being comparable between antibody-treated and control groups (5·3% vs 4·6%). To determine if the presence of antibody interfered with lactation or suckling, a bolus injection of 10 μCi [3H]H2O was given to mice treated at day 17 with antibody or saline. The levels of radioactivity present in both mothers and pups and the first 5-day pup growth curves showed identical patterns, indicating that milk availability and the suckling process were not affected. Crossfostering studies revealed that antibody-treated mothers rejected 25·5% of fostered pups compared with 8·5% found in the control females when antibody was administered on day 17 of pregnancy and the entire litters were crossfostered between the two groups immediately after delivery. Detailed analyses using a retrieval test further demonstrated that the reduction in maternal care was most pronounced during the first 3 days after delivery. These results demonstrate that antibody-treated mothers show a higher frequency of pup rejection which is (i) not restricted to their own litter; (ii) not due to lack of milk; and (iii) not a result of defects in the pups. They are consistent with the hypothesis that anti-progesterone antibody interferes with the priming mechanism(s) necessary for the onset of maternal behaviour during the 3-day period prior to delivery, leading to impaired maternal care after parturition. Journal of Endocrinology (1995) 145, 363–369

Business as Usual: Heroin Distribution in the United States

1983 ◽  
Vol 13 (1) ◽  
pp. 147-166 ◽  
Author(s):  
Robert B. McBride
Keyword(s):  
United States ◽  
Normal Structure ◽  
The United States ◽  
Heroin Use ◽  
Distinctive Features ◽  
Long Term Stability ◽  
Business As Usual ◽  
Reduced Risk

This article criticizes the predominant analysis of heroin use as a social aberration and argues instead that the normal structure and functioning of U.S. capitalism generate both the market for the drug and the industry which supplies it. The structure of the distribution industry is much like those for comparable legal goods, but with distinctive features which provide reduced risk for dealers and long term stability for the industry as a whole. The expansionary dynamic of the industry and the key role of syndicates in it are analyzed. The heroin industry is deeply integrated into the economy, and far-reaching social and economic change will be necessary if heroin use is to be significantly reduced.

scholarly journals Child-Level Predictors of Responsiveness to Evidence-Based Mathematics Intervention

2017 ◽  
Vol 83 (4) ◽  
pp. 359-377 ◽  
Author(s):  
Sarah R. Powell ◽  
Paul T. Cirino ◽  
Amelia S. Malone
Keyword(s):  
Working Memory ◽  
Word Problem ◽  
Language Comprehension ◽  
Second Grade ◽  
Control Group ◽  
Mathematics Intervention ◽  
Path Analyses ◽  
Control Intervention ◽  
Attentive Behavior ◽  
Business As Usual

We identified child-level predictors of responsiveness to 2 types of mathematics intervention (calculation and word problem) among second-grade children with mathematics difficulty. Participants were 250 children in 107 classrooms in 23 schools pretested on mathematics and general cognitive measures and posttested on mathematics measures. We randomly assigned classrooms to calculation intervention, word-problem intervention, or business-as-usual control. Intervention lasted 17 weeks. Path analyses indicated that scores on working memory and language comprehension assessments moderated responsiveness to calculation intervention. No moderators were identified for responsiveness to word-problem intervention. Across both intervention groups and the control group, attentive behavior predicted both outcomes. Initial calculation skill predicted the calculation outcome, and initial language comprehension predicted word-problem outcomes. These results indicate that screening for calculation intervention should include a focus on working memory, language comprehension, attentive behavior, and calculations. Screening for word-problem intervention should focus on attentive behavior and word problems.

Canadian Involvement in the Brain Drain from Africa: Opportunities for Action

1979 ◽  
Vol 9 (4) ◽  
pp. 19-25
Author(s):  
Michael Sinclair
Keyword(s):  
Brain Drain ◽  
Rural Areas ◽  
Urban Areas ◽  
Third World ◽  
Developed Countries ◽  
Western Country ◽  
The United States ◽  
World Nation ◽  
The Brain

The phenomenon known as the “brain drain” refers to the permanent or long-term migration of educated or skilled individuals from one country to another, usually from a poor Third World nation to an industrialized Western country. However, it also describes the migration of such persons between developed countries, such as from Canada to the United States and within countries, notably from impoverished rural areas to urban areas.

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