scholarly journals A lymphomagenic role for HIV beyond immune suppression?

Blood ◽  
2016 ◽  
Vol 127 (11) ◽  
pp. 1403-1409 ◽  
Author(s):  
Riccardo Dolcetti ◽  
Annunziata Gloghini ◽  
Arnaldo Caruso ◽  
Antonino Carbone
Keyword(s):  
Immune Suppression ◽  
Current View ◽  
Lymphoid Tissues ◽  
Oncogenic Viruses ◽  
Effective Strategies ◽  
Chronic Antigenic Stimulation ◽  
Biologic Effects ◽  
Current Scenario ◽  
Protein Variants

Abstract Despite the immune reconstitution promoted by combined antiretroviral therapy (cART), lymphomas still represent the most common type of cancer in HIV-infected individuals. Cofactors related to immunodeficiency such as oncogenic viruses, chronic antigenic stimulation, and cytokine overproduction are thought to be the main drivers of HIV lymphomagenesis, although the current scenario does not convincingly explain the still-high incidence of lymphomas and the occurrence of peculiar lymphoma histotypes in HIV-infected patients under cART. Recent findings are challenging the current view of a mainly indirect role of HIV in lymphoma development and support the possibility that HIV may directly contribute to lymphomagenesis. In fact, mechanisms other than immune suppression involve biologic effects mediated by HIV products that are secreted and accumulate in lymphoid tissues, mainly within lymph node germinal centers. Notably, HIV-infected patients with lymphomas, but not those not affected by these tumors, were recently shown to carry HIV p17 protein variants with enhanced B-cell clonogenic activity. HIV p17 protein variants were characterized by the presence of distinct insertions at the C-terminal region of the protein responsible for a structural destabilization and the acquisition of novel biologic properties. These data are changing the current paradigm assuming that HIV is only indirectly related to lymphomagenesis. Furthermore, these recent findings are consistent with a role of HIV as a critical microenvironmental factor promoting lymphoma development and pave the way for further studies that may lead to the design of more effective strategies for an early identification and improved control of lymphomas in the HIV setting.

scholarly journals ROLE OF RASAYANA IN RELATION TO CORONA VIRUS (COVID – 19) DISEASE

2021 ◽  
Vol 9 (2) ◽  
pp. 459-465
Author(s):  
Pooja Pawar ◽  
Sanjay Srivastava ◽  
Rajesh Jain
Keyword(s):  
Management Plan ◽  
Epidemic Disease ◽  
Effective Strategies ◽  
Clinical Observations ◽  
Corona Virus ◽  
The People ◽  
Health Related ◽  
Current Scenario ◽  
Anxiety Depression

The pandemic outbreak of COVID – 19 came with extensive health related hazards which lead to econom-ical and psychological problems like fear, stress, sadness, anxiety, depression among the people and is a challenge for humanity to face and fight this comorbidity. Various clinical Observations indicate the inter-action of SARS CoV– 2 viruses with the immune system which plays a significant role in determining the outcome of infection and it is responsible for controlling the immunopathogenesis of coronavirus infec-tion. Early control of this contagious disease within the host, limits its spread. Yet no system of medicine has any evidence-based treatment for COVID – 19. All the doctrine of medicine in the world has tried to develop effective strategies to overcome this disorder. Panchakarma and Rasayana therapy are indicated as an effective management plan for Janpdhodhwamsa Vyadhi (epidemic disease). Preventive use of Ra-sayana in Corona virus in the current scenario to build strong immunity in the peoples and to explore how it modifies the immunity along with use of certain recipes for its management

Energy Efficiency Analysis in ERA using NFL-BA Algorithm

2020 ◽  
pp. 340-348
Author(s):  
Palky Mehta ◽  
H. L. Sharma
Keyword(s):  
Cluster Head ◽  
Vital Role ◽  
Wireless Sensor ◽  
Energy Usage ◽  
Cluster Heads ◽  
Comparison Results ◽  
Current Scenario ◽  
Energy Efficiency Analysis ◽  
Selection Of

In the current scenario of Wireless Sensor Network (WSN), power consumption is the major issue associated with nodes in WSN. LEACH technique plays a vital role of clustering in WSN and reduces the energy usage effectively. But LEACH has its own limitation in order to search cluster head nodes which are randomly distributed over the network. In this paper, ERA-NFL- BA algorithm is being proposed for selects the cluster heads in WSN. This algorithm help in selection of cluster heads can freely transform from global search to local search. At the end, a comparison has been done with earlier researcher using protocol ERA-NFL, which clearly shown that proposed Algorithm is best suited and from comparison results that ERA-NFL-BA has given better performance.

The role of corporate investment in social responsible practices in the promotion of employees’ organizational citizenship behaviour

2014 ◽  
Author(s):  
Ana Patrícia Duarte ◽  
José Gonçalves das Neves
Keyword(s):  
Job Satisfaction ◽  
Organizational Citizenship ◽  
Economic Uncertainty ◽  
Socially Responsible ◽  
Organizational Survival ◽  
Current Scenario ◽  
Reducing Costs ◽  
Using Data ◽  
Airline Company

In the current scenario of economic uncertainty, where many organizations struggle harder for reducing costs while improving their competitiveness, employees’ organizational citizenship behaviours might have an enhanced importance for organizational survival and success. A model proposing that corporate engagement in internal socially responsible practices enhances employees’ job satisfaction and consequently increases employees’ extra-role behaviours was tested. Using data obtained from a sample of employees from an airline company (n=133), the model was examined and supported. We have therefore concluded that organizations may foster employees’ extra-role behaviours by investing in corporate socially responsible practices that signal corporate concern with employees and promote job satisfaction.

REINSTILLATION OF MORAL AND ETHICAL VALUES IN CHILDREN AND YOUTH: REFLECTING UPON THE ROLE OF PRECEPTORS AND PARENTS IN REKINDLING THE FLAME OF MORALITY IN MORTALSWITH SPECIAL REFERENCE TO INDIAN EDUCATION SYSTEM

2017 ◽  
Vol 4 (24) ◽  
Author(s):  
Rajeev Kaushal
Keyword(s):  
Educational Institution ◽  
Education Programme ◽  
Educational Process ◽  
Indian Education ◽  
Ethical Values ◽  
Moral Value ◽  
Current Scenario ◽  
Pre Service Teacher ◽  
Day By Day

The precious possession of any educational institution worth its name is the treasure of knowledge and skills which it imparts to the educands in the hope that this very treasure proves to be valuable for them in every walk of life. The treasure of values serves as the springboard for determining the various aims of education. In fact, values act as the cornerstone of entire educational process whatsoever be the field. However, it is a matter of grave concern that the monetary value of education is escalating and its moral value is dwindling day by day. It won’t be an exaggeration to say that the real cause and worth of education are plummeting with each passing day. As per the current scenario, there is dire need of instilling moral and ethical values in all those who are related to the field of education and this necessitates the inclusion of value based education the prime onus of which lies on the shoulders of none other than the teacher who is undoubtedly the maker of a nation's destiny.The present paper reflects upon the significance and need of value education and also throws light on how can moral and ethical values be inculcated in students at various levels of education besides giving valuable suggestions pertaining to the use of same in the field of Teaching and Pre-service Teacher Education programme.

scholarly journals Why knowledge is the best way to reduce the risks associated with raw milk and raw milk products

2021 ◽  
pp. 1-6
Author(s):  
Rafael Fagnani ◽  
Luis Augusto Nero ◽  
Carla Prado Rosolem
Keyword(s):  
Raw Milk ◽  
Food Services ◽  
Milk Products ◽  
Effective Strategies ◽  
Highly Effective ◽  
Current Scenario ◽  
Potential Risks ◽  
Milk Pasteurisation ◽  
Current Potential

Abstract In an age of flexible conditions about mandatory milk pasteurisation, this opinion-based research reflection supports the view that the knowledge and the awareness of milk-borne infections are key requirements to decrease the risks associated with raw milk. Providing an analysis of the current potential risks related to consumption of raw milk and raw milk products, we discuss the main reasons to continue to be vigilant about milk-borne pathogens and the current scenario in relation to the formal and clandestine sale of raw milk. Finally, we select some highly effective strategies to reduce the risks associated with raw milk in food services. Regardless of whether a country regulation allows or prohibits the trade of raw milk and its products, this is not the time to be negligent.

scholarly journals Eye contact effect: The role of vagal regulation and reactivity, and self-regulation of attention

2021 ◽  
Author(s):  
Alicja Niedźwiecka
Keyword(s):  
Executive Functions ◽  
Cognitive Performance ◽  
Self Regulation ◽  
Eye Contact ◽  
Autonomic Regulation ◽  
Face To Face ◽  
Effective Strategies ◽  
Contact Effect ◽  
The Individual

AbstractEye contact is a crucial aspect of social interactions that may enhance an individual’s cognitive performance (i.e. the eye contact effect) or hinder it (i.e. face-to-face interference effect). In this paper, I focus on the influence of eye contact on cognitive performance in tasks engaging executive functions. I present a hypothesis as to why some individuals benefit from eye contact while others do not. I propose that the relations between eye contact and executive functioning are modulated by an individual’s autonomic regulation and reactivity and self-regulation of attention. In particular, I propose that individuals with more optimal autonomic regulation and reactivity, and more effective self-regulation of attention benefit from eye contact. Individuals who are less well regulated and over- or under-reactive and who do not employ effective strategies of self-regulation of attention may not benefit from eye contact and may perform better when eye contact is absent. I present some studies that justify the proposed hypothesis and point to a method that could be employed to test them. This approach could help to better understand the complex mechanisms underlying the individual differences in participant’s cognitive performance during tasks engaging executive functions.

scholarly journals PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 164
Author(s):  
Federica Costa ◽  
Valentina Marchica ◽  
Paola Storti ◽  
Fabio Malavasi ◽  
Nicola Giuliani
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Cell Survival ◽  
Immune Suppression ◽  
Metabolic Pathways ◽  
Therapeutic Strategy ◽  
Myeloma Cell ◽  
Immune Microenvironment ◽  
Potential Use

The emerging role of the PD-1/PD-L1 axis in MM immune-microenvironment has been highlighted by several studies. However, discordant data have been reported on PD-1/PD-L1 distribution within the bone marrow (BM) microenvironment of patients with monoclonal gammopathies. In addition, the efficacy of PD-1/PD-L1 blockade as a therapeutic strategy to reverse myeloma immune suppression and inhibit myeloma cell survival still remains unknown. Recent data suggest that, among the potential mechanisms behind the lack of responsiveness or resistance to anti-PD-L1/PD-1 antibodies, the CD38 metabolic pathways involving the immune-suppressive factor, adenosine, could play an important role. This review summarizes the available data on PD-1/PD-L1 expression in patients with MM, reporting the main mechanisms of regulation of PD-1/PD-L1 axis. The possible link between the CD38 and PD-1/PD-L1 pathways is also reported, highlighting the rationale for the potential use of a combined therapeutic approach with CD38 blocking agents and anti-PD-1/PD-L1 antibodies in order to improve their anti-tumoral effect in MM patients.

scholarly journals The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity

Vaccines ◽  
2015 ◽  
Vol 3 (3) ◽  
pp. 703-729 ◽  
Author(s):  
Jacques Mbongue ◽  
Dequina Nicholas ◽  
Timothy Torrez ◽  
Nan-Sun Kim ◽  
Anthony Firek ◽  
...  
Keyword(s):  
Immune Suppression ◽  
Indoleamine 2

Adopting Technology in Third World Classrooms: Students' Viewpoint about Computers in Science Teaching and Learning

1992 ◽  
Vol 20 (4) ◽  
pp. 327-334 ◽  
Author(s):  
Olugbemiro J. Jegede ◽  
Peter Akinsola Okebukola
Keyword(s):  
Grade Level ◽  
Teaching And Learning ◽  
Third World ◽  
Economic Status ◽  
Effective Strategies ◽  
School Subjects ◽  
Nigerian Students ◽  
Senior Secondary ◽  
Developed World

The use of computers in education, which has emerged as a result of the considerable growth in information technology, has several implications for the global search for effective strategies in teaching school subjects. In contrast to what happens in the developed world, several developing countries like Nigeria are yet to fully appreciate the full benefits of computers and their usage in every day life. In Nigeria the Federal Government has only just taken the bold step to introduce computers into some selected classrooms as a modest beginning to the full scale use of computers in the society. The literature is replete with accounts indicating that the importation of several ideas into environments other than where they have been developed or meant, has often caused pedagogic and cultural problems. The paradigm of constructivism argues for the need to begin any instructional endeavor with pupils constructing their own knowledge using prior knowledge. This proposition motivated this study with the aim of seeking information that could be relevant to the effective introduction and use of computer in Third World classrooms. What for example, do Nigerian pupils perceive as the role of computers in the classroom? What is their concept of a computer and do they nurse any apprehensions? What sociocultural consequences would this have? This study was designed to gather and provide answers to these and other related questions. Using a four-part questionnaire with a total of 29 items, data were collected from a sample of 200 senior secondary one (grade level 10) students from the Lagos metropolitan area. The results of this study strongly suggest that the majority of Nigerian students: welcome and are enthusiastic about the introduction of computers into their classrooms; are concerned about their socio-economic status; demonstrate possession of computers have significant effect on their attitudes; and most of the students nurse some social and cultural apprehensions regarding the presence of computers in their classrooms.

Immunomodulatory role of thyroid hormones: in vivo effect of thyroid hormones on the blastogenic response of lymphoid tissues

1983 ◽  
Vol 103 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Sadhana Chatterjee ◽  
Amar Singh Chandel
Keyword(s):  
Thyroid Hormones ◽  
Pokeweed Mitogen ◽  
Lymphoid Tissues ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Hormone Administration ◽  
Blastogenic Response ◽  
Significant Depression

Abstract. In an attempt to find out the mechanism of immunomodulation by thyroid hormones (T3 and T4), their in vivo effect on the blastogenic response of lymphocytes from various lymphoid tissues of hormonetreated and thyroidectomized rats were studied. The blastogenic response of lymphocytes from thymus, peripheral blood and mesenteric lymph nodes to pokeweed mitogen (PWM) was found to be increased significantly following T3 or T4 administration for 15 days or 30 days. However, the response to phytohaemagglutinin (PHA) increased only after 1 month of T3 or T4 administration. The blastogenic response of spleen cells to both PHA and PWM was, on the other hand, found to be depressed following 15 days of hormone administration. Thyroidectomy invariably induced significant depression in the blastogenic response to both PHA and PWM in lymphocytes of all the lymphoid tissues. Thyroid hormone (T3) administration was found to restore the blastogenic response of the lymphocytes of thyroidectomized animals.

Sign in / Sign up

Export Citation Format

Share Document