scholarly journals Temporal Trends of Intracranial Hemorrhage Among Immune Thrombocytopenia Hospitalizations in the United States from 2007-2016

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 55-55
Author(s):  
Mayank Sharma ◽  
Parth Bhatt ◽  
Marian Ayensu ◽  
Kuhoo Bhal ◽  
Fredrick Dapaah-Siakwan ◽  
...  

Background: Intracranial hemorrhage (ICH) is a rare but severe complication in patients with immune thrombocytopenia (ITP). It is unclear whether the incidence of ICH has changed over time. We aimed study the incidence of ICH among ITP hospitalizations and factors associated with its occurrence from 2007-2016. Additionally, we examined the outcomes of ITP hospitalizations with ICH and resource utilization (length of stay, cost of hospitalization) during this time period. Methods: We used data from the National Inpatient Sample (NIS) database from 2007-2016. ITP hospitalizations were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code '287.31' and ICD-10-CM code 'D69.3'. Pertinent ICD-9-CM and ICD-10-CM codes were used to identify ICH. Baseline characteristics of ITP hospitalizations with and without ICH were compared using chi-square test and Wilcoxon rank-sum test for categorical and continuous variables, respectively. For trend analysis, chi-square test of trend for proportions was used with Cochrane Armitage test. Survey logistic regression was used to analyze factors associated with the occurrence of ICH and mortality in ITP hospitalizations with ICH. To account for the complex design of NIS, hierarchical regression was used to analyze the factors associated with of length of stay (LOS) and cost of hospitalization (COH). Beta coefficient and 95% confidence intervals (CI) were reported. P-value <0.05 was considered significant for all analyses. Results: Between 2007 and 2016, 348,906 ITP hospitalizations were identified. The incidence of ICH was 0.98% (n=3,408). Median age of patients with reported ICH was significantly higher than those without ICH [63.4 (range 47.1-76.7) vs. 51.6 (28.6-70.0), P<0.001]. Rates of mortality (26.6% vs. 3.2%, P<0.001), LOS (4.8 days vs. 2.6 days, P<0.001), and COH ($20,081 s. $8,355, P<0.001) were higher in hospitalizations with ICH. While the overall incidence of ICH remained stable during the study period (P=0.3), it varied by age, gender, and hospital region. Incidence significantly decreased in age ≤24 years (0.7% to 0.4%). On the contrary, it significantly increased among those ≥65 years (1.5% to 1.9%), females (0.9% to 1.1%), and hospitalizations in Northeast region (0.9% to 1.1%). Similarly, trend of mortality in hospitalizations with ICH increased from 28.1% in 2007-08 to 34.6% in 2015-16 (P<0.001). On multivariate regression analysis, factors associated with higher likelihood of ICH were (Table 1): age 25-64 years [odds ratio (OR) 2.23; 95% CI 1.51-3.31], ≥65 years (OR 3.69; 95% CI 2.34-5.84), gastrointestinal (GI) bleed (OR 1.60; 95% CI 1.18-2.16), other bleed (OR 1.69; 95% CI 1.19-2.42), hospitalization in the West region (OR 1.62; 95% CI 1.26-2.08), in a medium (OR 1.64; 95% CI 1.08-2.47) or large hospital (OR 2.42; 95% CI 1.65-3.55) and in an urban-teaching hospital (OR 2.73; 95% CI 1.80-4.13). Female gender (OR 0.81; 95% CI 0.68-0.97) was associated with lower likelihood of ICH. Similarly, factors were associated with higher likelihood of mortality in ICH hospitalizations were: age 25-64 years (OR 6.73; 95% CI 4.11-11.03), ≥ 65 years (OR 16.94; 95% CI 10.14-28.30), GI bleed (OR 3.13; 95% CI 2.72-3.60), other bleeds (OR 1.66; 95% CI 1.31-2.10), hospitalizations at a large hospital (OR 1.17; 95% CI 1.00-1.37), and an urban teaching hospital (OR 1.23; 95% CI 1.02-1.48). Increasing age was associated with longer LOS, which also translated into higher COH (Table 2). Comorbidities such as GI bleed (2.5 days, 95% CI 2.1-2.9; $9,391, 95% CI 8,210-10,572), hematuria (1.1 days, 95% CI 0.6-1.6; $3,586, 95% CI 1,941-5,230), and other bleeding (1.1 days, 95% CI 0.7-1.5; $5,931, 95% CI 4,565-7,296) were also associated with longer LOS and higher COH. LOS decreased from 2007 to 2016 [-0.2 days, 95% CI (-0.3)-(-0.1)], however, the COH did not change. Conclusion: The overall incidence of ICH among ITP hospitalizations is low and remained stable from 2007-2016, which is reassuring. Nonetheless, a quarter of these hospitalizations resulted in mortality. ICH also significantly increased healthcare utilization in ITP hospitalizations through high LOS and COH. Older age and male gender were associated with higher ICH incidence and mortality. Future studies should reassess the ICH trends to study the impact of novel therapeutic options such as thrombopoietin receptor agonists. Disclosures No relevant conflicts of interest to declare.

1970 ◽  
Vol 4 ◽  
pp. 129-142 ◽  
Author(s):  
Raj Kumar Subedi

Insomnia is one of the major and unsolved problems in older people. Most of the sleep studies report that the different forms of insomnia like Difficulty Initiating Sleep (DIS), Difficulty Maintaining Sleep (DMS) and Non-Restorative Sleep (NRS) are common among the elderly that are associated to many factors. The objective of the study was to measure the prevalence of insomnia and the factors associated to it among the elderly people. A cross-sectional study was conducted among 142 elderly people of and above 60 years of age in Sarangdanda VDC of Panchthar District of Eastern Nepal. The presence or absence of insomnia and the associated factors were assessed on them by the help of interview schedule. The results were analyzed using chi-square test in SPSS (version 11.5). DMS was the most common reported form of insomnia among the elderly followed by DIS and NRS. Association between insomnia and each of factors like use of tobacco before sleeping hours, eating too close to bedtime, use of tea/coffee before sleeping hours and use of alcohol before sleeping hours were statistically significant at 95% level of confidence. Insomnia affects a large proportion of elderly and is triggered by many factors like use of tobacco before sleeping hours, use of tea/coffee before sleeping hours, eating too close to bedtime and use of alcohol before sleeping hours. Keywords: Alcohol; tea/coffee; difficulty initiating sleep (DIS); difficulty maintaining sleep (DMS); non-restorative sleep (NRS); tobacco DOI: 10.3126/dsaj.v4i0.4517 Dhaulagiri Journal of Sociology and Anthropology Vol.4 2010 pp.129-142


2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S244-S244
Author(s):  
Bharath Pendyala ◽  
Prasanth Lingamaneni ◽  
Patricia DeMarais ◽  
Lakshmi Warrior ◽  
Gregory Huhn

Abstract Background Neurocysticercosis is a Neglected Tropical Disease and an important public health issue. Our goal was to collect and analyze data regarding clinically significant gender differences among our Neurocysticercosis patients. Methods A retrospective chart search with ICD 9/ ICD 10 diagnostic code for Neurocysticercosis and neuroimaging suggestive of Neurocysticercosis was performed for clinical encounters in the hospital or affiliated clinics between years 2013–2018. After a careful chart review, patients who were clinically diagnosed with Neurocysticercosis were included in the study. T-test was used to compare means of continuous variables and chi-square test to compare proportions of categorical variables. Results Among 90 total patients included, male (49.4%) and female (50.6%) distribution were nearly identical. The mean age in females was found to be higher than males (52.5 vs 42.0, P < 0.0001). Almost an equal number of males and females presented with either seizures (63.6% vs 57.8%, P= 0.85), headaches (25.0% vs 28.9%, p= 0.85), or other symptoms (11.4% vs 13.3%, p= 0.85). Males had more generalized seizures compared to females (60% vs 38%, P= 0.37), although this result was not statistically significant. Females were more likely to present with > 1 lesion (82.2% vs 56.8%, P= 0.01). Males were more likely to have cystic lesions (64.7% vs 27.9%, P < 0.001) compared to females who had more calcified lesions on presentation (65.1% vs 20.6%, P < 0.001). Male patients were more likely to have contrast enhancement or edema surrounding the lesions (61.4% vs 33.3%, P= 0.01) and were more likely to require treatment with Albendazole/Praziquantel (75.8% vs 31.7%, P < 0.001). Conclusion Although previously reported data is limited, there is a suggestion that there are gender differences in host immune response and that inflammation surrounding parenchymal lesions is more intense in females. This study suggests that men either present early in the disease phase or have different immune responses than women and require anti-parasitic therapy more frequently. More research in this aspect is needed. Disclosures All Authors: No reported disclosures


Author(s):  
Kathan Mehta ◽  
Neeraj Shah ◽  
Nileshkumar J Patel ◽  
Ankit Chothani ◽  
Peeyush Grover ◽  
...  

Background: High Risk Percutaneous Coronary Intervention (PCI) is increasingly being performed with the availability of hemodynamic support. The aim of this study was to determine the predictors of length of stay (LOS) for high risk PCI in US. Methods: We explored the Healthcare Cost and Utilization Project’s Nationwide Inpatient Sample (NIS) using the ICD9 procedure code of 36.07 and 36.06 for PCI. NIS is largest all-payer dataset that represents 20% of all US hospitals. We included patients who had PCI from 2005 through 2010 who also underwent Percutaneous Circulatory Assist Device (PCAD) or Intra-aortic Balloon Pump (IABP) placement during the same hospital admission. Severity of comorbidities was defined by Deyo modification of Charlson’s Comorbidity Index (CCI). Hospitals were identified by a unique hospital identification number and hospital volume was determined by calculating the total number of PCI performed by an institution on year to year basis. Complications were based on Patient Safety Indicators (PSI) recognized by Agency for Health Care Research and Quality to monitor in hospital complications. We examined the predictors of LOS by a mixed effects linear regression model including patient demographics, admission characteristics, CCI quartiles with first quartile as a reference, hospital PCI volume quartiles, IABP or PCAD use and periprocedural complications. Hospital ID was incorporated as random effects in the model. Results: A total of 26,300 High Risk PCIs (weighted n = 130,151) were available for analysis. Factors associated with increased LOS were the use of IABP as compared to PCAD (+0.86 days, p=0.03), occurrence of any complication (+4.67 days, P < 0.001), high CCI (+2.5 days for CCI=2 and +4.1 days for CCI≥3, p<0.001 for both), teaching hospital (+0.96 days, p <0.001), presence of myocardial infarction (MI) or shock (+0.55 days, p = 0.002) and highest quartile of hospital PCI volume (+0.86 days, p<0.001). Factors associated with decreased LOS included private insurance (-0.9 days, p < 0.001) and self-pay or no insurance (-0.89 days, p<0.001). Conclusion: In our observational study based on a large database, use of IABP as compared to PCAD, occurrence of complications, CCI, teaching hospital, presence of MI or shock and high PCI volume were associated with increased LOS & having private insurance and self pay or no insurance was associated with decreased LOS.


Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Saqib Chaudhry ◽  
Ibrahim Laleka ◽  
Zelalem Bahiru ◽  
Hassan S Gill ◽  
Mohammad Rauf Chaudhry ◽  
...  

Background: Recent trials have demonstrated a reduction in death or disability with endovascular treatment in patients with acute ischemic strokes. However, readmission rates and predictors are not known. Objective: To identify rates and factors associated with 30-day readmission after endovascular treatment in ischemic stroke patients. Methods: Nationwide Readmissions Data (NRD) between 2010 and 2017 was utilized to identify endovascular treatment in acute ischemic stroke patients using ICD-9 and ICD-10 codes. We used hierarchical logistic regression model to identify factors associated with 30-day readmissions. Results: Among 17, 562 acute ischemic stroke patients who survived to discharge after endovascular treatment, 2334 (13.29%) were readmitted within 30-days. Age => 65 years (odds ratio [OR]: 1.23, 95% confidence interval [CI]: 1.09 to 1.39, p =0.0005), chronic kidney disease (OR: 1.28, 95%CI: 1.12 to 1.47, p = 0.0004), congestive heart failure (OR: 1.25, 95%CI: 1.13 to 1.39, p <.0001), post procedure intracranial hemorrhage (OR: 1.09, 95%CI: 0.99 to 1.20, p = 0.04) and diabetes mellitus (OR: 1.09, 95%CI: 0.99 to 1.20, p = .09) during the index hospitalization were associated with readmission within 30 days. Conclusion: In this large nationally representative study, nearly one in 10 patients were readmitted within 30 days after discharge in acute ischemic stroke patients undergoing endovascular treatment. Medical comorbidities and post procedure intracranial hemorrhage were associated with 30-day readmission.


2015 ◽  
Vol 28 (3) ◽  
pp. 319-326 ◽  
Author(s):  
Vanessa Ribeiro dos Santos ◽  
Diego Giulliano Destro Christofaro ◽  
Igor Conterato Gomes ◽  
Ricardo Ribeiro Agostinete ◽  
Ismael Forte Freitas Júnior ◽  
...  

OBJECTIVE: To analyze whether sarcopenia is associated with sociodemographic factors and chronic noncommunicable diseases in adults aged 80 years and older. METHODS: The sample consisted of 120 adults aged 80 to 95 years (83.4±2.9 years) from the city of Presidente Prudente (São Paulo, Brazil), of which 76 were females (83.4±3.0 years) and 44 were males (83.4±2.6 years). The study sociodemographic and epidemiological factors were: age stratum, gender, marital status, education level, chronic noncommunicable diseases, ethnicity, and nutritional status. Body composition was determined by Dual-Energy X-Ray Absorptiometry and sarcopenia was identified by the appendicular lean mass ratio (upper limb lean mass + lower limb lean mass [kg]/height [m]2). The Chi-square test analyzed whether sarcopenia was associated with sociodemographic and epidemiological factors and binary logistic regression expressed the magnitude of the associations. The data were treated by the software Statistical Package for the Social Sciences (17.0) at a significance level of 5%. RESULTS: The factors associated with sarcopenia were gender, age, nutritional status, and osteopenia/osteoporosis. CONCLUSION: The factors gender, age, nutritional status, and osteopenia/osteoporosis are independently associated with sarcopenia in adults aged 80 years and older.


2021 ◽  
Vol 4 (1) ◽  
pp. 29-37
Author(s):  
Sitti Marya Ulva ◽  
Sinar Jannah

The percentage of families in Lapulu Village that had healthy latrines was 64,84% who met the health requirements and 35,16% who did not meet the health requirements in 2019. This shows that the ownership of healthy latrines is still lower than the national achievement. This study aims to determine the factors associated with low ownership of healthy latrines in the coastal areas of Lapulu Village, Kendari City. The research design was observational, with a cross-sectional approach. The population in this study was 437 respondents, while the study sample was 209 respondents. The sampling technique used was proportional random sampling technique. The analysis were performed using the Chi-Square test. The results of statistical tests with chi-square obtained the value of land availability (p-value=0,000), knowledge (p-value=0,031), and income (p-value=0,000). It can be concluded that there is a relationship between land availability, knowledge, and income levels associated with low ownership of healthy latrines in the tidal area of ​​Lapulu Village, Kendari City. Therefore, it is hoped that the community and local government will establish this inter sector collaboration with related agencies to increase community ownership of healthy latrines.


2020 ◽  
Vol 11 (2) ◽  
pp. 43-48
Author(s):  
Novitri Sari ◽  
Eko Mirsiyanto

Dehidrasi merupakan kekurangan cairan tubuh karena jumlah cairan yang keluar lebih banyak dari pada jumlah cairan yang masuk. Salah satu pekerjaan yang beresiko mengalami dehidrasi adalah pada perebusan pembuatan tempe dimana menggunakan lingkungan yang cukup panas sehingga banyak mengeluarkan keringat dan mebutuhkan asupan cairan yang lebih. Tujuan penelitian adalah untuk mengetahui faktor-faktor yang berhubungan dengan kejadian dehidrasi pada pekerja pengrajin tempe. Penelitian ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh jumlah pengrajin tempe. Sampel berjumlah 30 responden. Teknik pengambilan sampel dengan cara total sampling. Analisis data dalam penelitian ini secara univariat dan bivariat dengan uji chi square. Hasil penelitian ada hubungan konsumsi cairan (0,004) dan beban kerja (0,007) dengan kejadian dehidrasi pada pekerja pengrajin tempe. Tidak ada hubungan berat badan dengan kejadian dehidrasi pada pekerja pengrajin tempe (p=0,875). Diharapkan pemilik usaha pengrajin tempe untuk dapat selalu menyediakan air minum yang cukup bagi pekerjanya saat pekerja membutuhkan sehingga kejadian dehidrasi dan dampaknya dapat diminimalisir. Dehydration is a lack of body fluids because the amount of fluid that comes out is more than the amount of fluid that is entered. One of the jobs that are at risk of dehydration is in boiling the manufacture of tempeh which uses a hot enough environment so that you sweat a lot and require more fluid intake. The research objective was to determine the factors associated with the incidence of dehydration in tempe craftsmen. This research is a descriptive analytic study with a cross sectional approach. The population in this study were all of the tempe craftsmen. The sample is 30 respondents. The sampling technique was total sampling. Data analysis in this study was univariate and bivariate with the chi square test. The results showed a relationship between fluid consumption (0.004) and workload (0.007) with the incidence of dehydration among workers of tempe craftsmen. There is no correlation between body weight and dehydration in tempe craftsmen workers (p = 0.875). It is expected that the tempe craftsman business owners can always provide sufficient drinking water for their workers when they need them so that the incidence of dehydration and its impact can be minimized.


2006 ◽  
Vol 104 (6) ◽  
pp. 867-875 ◽  
Author(s):  
Michael Söderman ◽  
Göran Edner ◽  
Kaj Ericson ◽  
Bengt Karlsson ◽  
Tiit Rähn ◽  
...  

Object The aim of this study was to assess the clinical efficacy of gamma knife surgery (GKS) in the treatment of dural arteriovenous shunts (DAVSs). Methods From a database of more than 1600 patients with intracranial arteriovenous shunts that had been treated with GKS, the authors retrospectively and prospectively identified 53 patients with 58 DAVSs from the period between 1978 and 2003. Four patients were lost to follow-up evaluation and were excluded from the series. Thus, this study is based on the remaining 49 patients with 52 DAVSs. Thirty-six of the shunts drained into the cortical venous system, either directly or indirectly, and 22 of these were associated with intracranial hemorrhage on patient presentation. The mean prescription radiation dose was 22 Gy (range 10–28 Gy). All patients underwent a clinical follow-up examination. In 41 cases of DAVS a follow-up angiography study was performed. At the 2-year follow-up visit, 28 cases (68%) had angiographically proven obliteration of the shunt and in another 10 cases (24%) there was significant flow regression. Three shunts remained unchanged. There was one immediate minor complication related to the administration of radiation. Furthermore, one patient had a radiation-induced complication 10 years after treatment, although she recovered completely. There was one posterior fossa bleed 2 months after radiosurgery; a hematoma, as well as a lesion, was evacuated, and the patient recovered uneventfully. A second patient had an asymptomatic occipital hemorrhage approximately 6 months postradiosurgery. The clinical outcome after GKS was significantly better than that in patients with naturally progressing shunts (p < 0.01, chi-square test); figures on the latter have been reported previously. Conclusions Gamma knife surgery is an effective treatment for DAVSs, with a low risk of complications. Major disadvantages of this therapy include the time elapsed before obliteration and the possibility that not all shunts will be obliterated. Cortical venous drainage from a DAVS, a risk factor for intracranial hemorrhage, is therefore a relative contraindication. Consequently, GKS can be used in the treatment of both benign DAVSs with subjectively intolerable bruit and aggressive DAVSs not responsive to endovascular treatment or surgery.


Author(s):  
Leônidas de Oliveira Neto ◽  
Larissa Praça de Oliveira ◽  
Pedro Moraes Dutra Agrícola ◽  
Vagner Deuel de Oliveira Tavares ◽  
Igor Conterato Gomes ◽  
...  

ABSTRACT Background The diagnosis of sarcopenia is based on the analysis of strength, functionality and muscle mass. The objective was to verify the factors associated with sarcopenia in institutionalized elderly. Methods In total, 219 elderly individuals (≥60 years old) living in long-term institutions in Natal/RN were included in the study. After defining the elderly as sarcopenic or non-sarcopenic, anthropometric, biochemical, sociodemographic and health-related were analyzed. The Student t-test and Mann–Whitney test were used to analyze the quantitative, while the chi-square test was used for the qualitative variables. Finally, Poisson regression was used to provide prevalence ratios for those variables that presented differences in the bivariate analyses. Results Physical capacity and anthropometry were associated with sarcopenia. For each 1 cm of knee height, the elderly presented 2.71% more chance of not having sarcopenia, and eutrophic or overweight individuals (according to BMI) presented 37.71 and 91.81% chances, respectively, of not presenting sarcopenia. Elderly individuals who ambulate have a 30.08% chance of not being considered sarcopenic. In addition, biochemical and anthropometric indicators demonstrated a relationship of sarcopenia with malnutrition. Conclusion Sarcopenia is associated with a loss of body mass, not only selective muscle mass, and greater physical inability to ambulate.


2017 ◽  
Vol 51 (0) ◽  
Author(s):  
Franco Cazembe Mufinda ◽  
Fernando Boinas ◽  
Carla Nunes

ABSTRACT OBJECTIVE The objective of this study is to estimate the seroprevalence of human brucellosis in livestock professionals and analyze the factors associated with brucellosis focusing on sociodemographic variables and the variables of knowledge and practices related to the characteristics of the activities carried out in livestock. METHODS This is a cross-sectional seroepidemiological study with a population of 131 workers of butchers, slaughter rooms, and slaughterhouse and 192 breeders sampled randomly in Namibe province, Angola. The data were obtained from the collection of blood and use of questionnaires. The laboratory tests used were rose bengal and slow agglutination. The questionnaire allowed us to collect sociodemographic information and, specifically on brucellosis, it incorporated questions about knowledge, attitudes, and behaviors of livestock professionals. In addition to the descriptive statistical approach, we used the Chi-square test of independence, Fisher’s test, and logistic regression models, using a significance level of 10%. RESULTS The general weighted prevalence of brucellosis was 15.6% (95%CI 13.61–17.50), being it 5.3% in workers and 16.7% (95%CI 11.39–21.93) in breeders. The statistical significance was observed between human seroprevalence and category (worker and breeder) (p < 0.001) and education level (p = 0.032), start of activity (p = 0079), and service location (p = 0.055). In a multivariate context, the positive factor associated with brucellosis in professionals was the professional category (OR = 3.54; 95%CI 1.57–8.30, related to breeders in relation to workers). CONCLUSIONS Human brucellosis in livestock professionals is prevalent in Namibe province (15.6%), where the professional category was the most important factor. The seroprevalence levels detected are high when compared with those found in similar studies.


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