Evaluation of pulmonary TB treatment efficiency depending on polymorphism of glutathione-S-transferasexenobiotic biotransformation enzyme and on sensitivity profile

2016 ◽  
Author(s):  
Tetiana Sprynsian ◽  
Lilia Todoriko ◽  
Igor Semianiv
Keyword(s):  
Treatment Efficiency ◽  
Pulmonary Tb ◽  
Biotransformation Enzyme ◽  
Tb Treatment ◽  
Sensitivity Profile

scholarly journals Six-year trend and risk factors of unsuccessful pulmonary tuberculosis treatment outcomes in Thai Community Hospital

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Sakarn Charoensakulchai ◽  
Chaiyapun Lertpheantum ◽  
Chanapon Aksornpusitpong ◽  
Peeranut Trakulsuk ◽  
Boonsub Sakboonyarat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Community Hospital ◽  
Previous History ◽  
Treatment Quality ◽  
Intensive Phase ◽  
Loss To Follow Up ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
Monitoring Tools ◽  
Unsuccessful Treatment

Abstract Objective Tuberculosis (TB) is a major cause of morbidity and mortality globally. Despite efforts to eliminate TB in Thailand, the incidence rate has declined slowly. This study aimed to identify the incidence and risk factors of unsuccessful pulmonary TB treatment (failed, died and loss-to- follow up) in a community hospital in Chachoengsao Province, Thailand from 1st January 2013 to 31st December 2019. Results A total of 487 patients were eligible for the study. The incidence of unsuccessful treatment was 21.67/100 population person year. Risk factors of unsuccessful pulmonary TB treatment were unemployment (adjusted hazard ratio (AHR) 3.12, 95%CI 1.41–6.86), HIV co-infection (AHR 2.85, 95%CI 1.25–6.46), previous history of TB (AHR 2.00, 95%CI 1.04–3.81), positive sputum AFB at the end of the intensive phase (AHR 5.66, 95%CI 2.33–13.74), and sputum AFB was not performed at the end of the intensive phase (AHR 18.40, 95%CI 9.85–34.35). This study can be utilized to improve prevention and intervention of TB treatment by strengthening public health system on treatment quality especially TB patient monitoring tools or methods easy for accessing to patients in communities.

scholarly journals A partially randomised trial of pretomanid, moxifloxacin and pyrazinamide for pulmonary TB

2021 ◽  
Vol 25 (4) ◽  
pp. 305-314
Author(s):  
C. D. Tweed ◽  
G. H. Wills ◽  
A. M. Crook ◽  
E. Amukoye ◽  
V. Balanag ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Randomised Trial ◽  
Group Differences ◽  
Pulmonary Tb ◽  
Intention To Treat ◽  
Tb Treatment ◽  
Grade 3 ◽  
To Receive ◽  
Ongoing Evaluation ◽  
Post Randomisation

BACKGROUND: Treatment for TB is lengthy and toxic, and new regimens are needed.METHODS: Participants with pulmonary drug-susceptible TB (DS-TB) were randomised to receive: 200 mg pretomanid (Pa, PMD) daily, 400 mg moxifloxacin (M) and 1500 mg pyrazinamide (Z) for 6 months (6Pa200MZ) or 4 months (4Pa200MZ); 100 mg pretomanid daily for 4 months in the same combination (4Pa100MZ); or standard DS-TB treatment for 6 months. The primary outcome was treatment failure or relapse at 12 months post-randomisation. The non-inferiority margin for between-group differences was 12.0%. Recruitment was paused following three deaths and not resumed.RESULTS: Respectively 4/47 (8.5%), 11/57 (19.3%), 14/52 (26.9%) and 1/53 (1.9%) DS-TB outcomes were unfavourable in patients on 6Pa200MZ, 4Pa200MZ, 4Pa100MZ and controls. There was a 6.6% (95% CI –2.2% to 15.4%) difference per protocol and 9.9% (95%CI –4.1% to 23.9%) modified intention-to-treat difference in unfavourable responses between the control and 6Pa200MZ arms. Grade 3+ adverse events affected 68/203 (33.5%) receiving experimental regimens, and 19/68 (27.9%) on control. Ten of 203 (4.9%) participants on experimental arms and 2/68 (2.9%) controls died.CONCLUSION: PaMZ regimens did not achieve non-inferiority in this under-powered trial. An ongoing evaluation of PMD remains a priority.

Tuberculosis in native Israeli Arabs and Jews: trends and treatment outcomes, 1999–2011

2015 ◽  
Vol 143 (15) ◽  
pp. 3203-3210 ◽  
Author(s):  
H. BISHARA ◽  
D. GOLDBLATT ◽  
E. RORMAN ◽  
Z. MOR
Keyword(s):  
Treatment Outcomes ◽  
Clinical Laboratory ◽  
Treatment Success ◽  
Developed Countries ◽  
National Average ◽  
Success Rates ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
Lower Treatment ◽  
Israeli Arabs

SUMMARYThe incidence of tuberculosis (TB) in native ethnic minorities remains high in developed countries. Arabs, the major ethnic minority in Israel, comprise 21% of its population. This retrospective study compared TB incidence, demographic, clinical, laboratory, genotyping characteristics and treatment outcomes in all Israeli-born citizens diagnosed with TB between 1999 and 2011 by ethnicity, i.e. Israeli-born Arabs (IA) and Jews (IJ). A total of 831 Israeli-born TB patients were reported. Of those, there were 530 (64%) IJ and 301 (36%) IA, with an average annual TB rate of 1·1 and 1·6 cases/100 000 population, respectively, lower than the national average (7·0 cases/100 000 population). TB rates in IA and IJ declined and converged to 1 case/100 000 residents. IA TB patients were more likely to be older, have more pulmonary TB and have lower treatment success rates than IJ. Older age and HIV co-infection, but not ethnicity, were predictive of non-success in TB treatment. Ten mixed IA–IJ clades were detected by spoligotyping and three mixed IA–IJ clusters were identified by MIRU-VNTR typing. Only one IA–IJ couple recalled mutual contact. In conclusion, TB rate in IA was higher than in IJ, but declined and converged in both to 1 case/100 000. Treatment success was high in both groups, and was unrelated to ethnicity.

Management and Surgical Outcomes of Concurrent Tuberculosis and Lung Cancer

2016 ◽  
Vol 65 (07) ◽  
pp. 542-545 ◽  
Author(s):  
Volkan Baysungur ◽  
Levent Alpay ◽  
Bahadir Uskul ◽  
Aysun Misirlioglu ◽  
Serda Kanbur ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Developing Countries ◽  
Cell Carcinoma ◽  
Lung Resection ◽  
Bronchopleural Fistula ◽  
Postoperative Mortality ◽  
Postoperative Treatment ◽  
Common Disease ◽  
Pulmonary Tb ◽  
Tb Treatment

Background Concurrent pulmonary tuberculosis (TB) and lung cancer are rarely encountered in Western countries; however, it is more common in developing countries. We aim to share the diagnostic and treatment approaches in this study. Materials and Methods Clinical files of all patients undergoing lung resection for non–small cell carcinoma with concurrent pulmonary TB between February 2006 and December 2012 were investigated retrospectively in terms of patient characteristics, operation methods, definite pathology and stage of tumor, postoperative treatment schemes, and associated complications. Results TB was detected in 17 (1.3%) of 1,266 operated carcinoma patients. Eleven had squamous cell carcinoma and six had adenocarcinoma. Mean age was 54.9 years. Two patients received anti-TB treatment preoperatively. Fifteen patients were given anti-TB treatment postoperatively, as soon as definite microbiological confirmation was obtained, and concurrently given adjuvant therapy after 3 weeks of sole four-drug TB treatment. Pneumonectomy was performed in four (23.5%), sleeve lobectomy in three (17.6%), lobectomy in eight (47%), and bilobectomy in two (11.7%) patients. Postoperative complications occurred in four (23.5%) patients, with bronchopleural fistula being seen in only one pneumonectomy patient. No postoperative mortality or reactivation of TB was seen. Mean survival time was 32 ± 2 months. Conclusion Resection following a 3-week anti-TB treatment or concurrent anti-TB and postoperative adjuvant chemotherapy does not constitute an additional postoperative risk for patients with concomitant lung malignancy and pulmonary TB. The determination of optimum treatment for these patients presents a challenge in developing countries, where TB is still a common disease.

scholarly journals Healthcare Resource Uses and Out-of-Pocket Expenses Associated with Pulmonary TB Treatment in Thailand

2017 ◽  
Vol 2 (3) ◽  
pp. 297-308 ◽  
Author(s):  
Pimwara Tanvejsilp ◽  
Mark Loeb ◽  
Jonathan Dushoff ◽  
Feng Xie
Keyword(s):  
Healthcare Resource ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
Out Of Pocket Expenses

scholarly journals Hypercalcemia in Patients with Newly Diagnosed Tuberculosis in Abuja, Nigeria

2006 ◽  
Vol 13 (2) ◽  
pp. 83-87 ◽  
Author(s):  
EA Dosumu ◽  
JA Momoh
Keyword(s):  
Serum Calcium ◽  
Calcium Concentration ◽  
Lung Involvement ◽  
Newly Diagnosed ◽  
National Hospital ◽  
Radiographic Evidence ◽  
Serum Calcium Concentration ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
The Mean

BACKGROUND: The prevalence of hypercalcemia has not previously been determined in newly diagnosed tuberculosis (TB) patients in Nigeria.OBJECTIVE: To determine the incidence of hypercalcemia in Nigerian patients with newly diagnosed TB before the commencement of anti-TB treatment.METHODS: The present study is a prospective examination of consecutive patients with newly diagnosed TB confirmed by bacteriological and/or histological methods at the National Hospital (Abuja, Nigeria) from January 2004 to December 2004.RESULTS: Of 120 patients (70 males and 50 females), 70 had pulmonary TB, 10 had pulmonary and pleural TB, 20 had pleural TB without radiographic evidence of lung involvement, 18 had various other forms of extrapulmonary TB and two had disseminated TB. The mean age of the patients was 38.3±12.0 years. The mean albumin-adjusted serum calcium concentration was 2.53±0.22 mmol/L. Hypercalcemia was present in 27.5% of the patients, but only 12% of these patients showed symptoms of hypercalcemia. The type of TB and, in the case of pulmonary TB, the extent of lung involvement, had no effect on the serum calcium concentration.CONCLUSION: Hypercalcemia is not uncommon among Nigerian patients with newly diagnosed TB, but it is rarely symptomatic.

scholarly journals A randomised controlled trial to evaluate a medication monitoring system for TB treatment

2022 ◽  
Vol 26 (1) ◽  
pp. 44-49
Author(s):  
J. Acosta ◽  
P. Flores ◽  
M. Alarcón ◽  
M. Grande-Ortiz ◽  
L. Moreno-Exebio ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Treatment Success ◽  
Intervention Group ◽  
Controlled Study ◽  
Control Group ◽  
Second Phase ◽  
Open Label ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
Significant Difference

BACKGROUND: Adherence to TB treatment and therefore treatment success could be improved using digital adherence technology.OBJECTIVE: To evaluate the effectiveness of a medication event reminder monitor system (MERM) on treatment success and treatment adherence in patients with drug-susceptible pulmonary TB in Perú.METHODS: This was an experimental, randomised, open-label, controlled study conducted among patients in the second phase of TB treatment. The intervention group received their medications through MERM with the support of a treatment monitor, whereas the control group used the usual strategy. Participants were followed until they completed the 54 doses of the second phase of treatment.RESULTS: The study included 53 patients in each group; four in the intervention group withdrew from the study. Treatment success was significantly more frequent in the MERM group (RR 1.15, 95% CI 1.02–1.30; P = 0.0322). There was no significant difference in the adherence outcomes; however, the percentage of patients who missed at least one dose and patients with more than 10% of total doses missed were lower in the intervention group.CONCLUSION: The use of MERM in the second phase of treatment showed a significant improvement in the treatment success rate in patients with drug-susceptible pulmonary TB.

scholarly journals Predisposing and Enabling Factors Relationship with Successful Treatment of Pulmonary Tuberculosis (TB)

2021 ◽  
Vol 15 (1) ◽  
pp. 57
Author(s):  
Rafiah Maharani Pulungan ◽  
Putri Permatasari
Keyword(s):  
Medication Adherence ◽  
Successful Treatment ◽  
Occupational Status ◽  
Sampling Technique ◽  
Health Facilities ◽  
Enabling Factors ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
Access To Health ◽  
Success Of Treatment

The increase in pulmonary TB cases is related to the success of treatment. Rough treatment will lead to multi-drug resistant TB (MDR TB). The purpose of this study was to analyze the relationship of Predisposing, and enabling factors with the successful treatment of pulmonary TB in the Cikulur Community Health Center, Lebak Regency. This study used a Case-control research design. The sampling technique was purposive sampling, and a sample size of 82 people. The independent variables were predisposing factors (age, gender, education level, employment status, motivation, knowledge and attitudes), enabling factors (medication adherence, drug side effects, and access to health facilities). The dependent variable was the success of TB treatment. Data analysis using Chi-Square test and multiple logistic regression. The results showed that a person with pulmonary TB with non-working status, adherence to treatment, and access to health facilities was 5.002 times easy to succeed in TB treatment. The factors most related to the success of treatment were occupational status, medication adherence and access to health facilities. It is suggested that health services need to increase the accessibility of TB patients in the fulfillment of treatment so that patients can improve their success in recovery in therapy. Also, sufferers take medication regularly and according to the recommendations for success of treatment

scholarly journals Gambaran Kepatuhan Minum Obat Pada Pasien TB Paru : Literature Review

2021 ◽  
Vol 1 ◽  
pp. 1863-1874
Author(s):  
Pinaka Swasti Ratu Suryantari ◽  
I Irnawati
Keyword(s):  
Literature Review ◽  
Keyword Search ◽  
Pill Count ◽  
World Health ◽  
Drug Resistant ◽  
Pulmonary Tb ◽  
Tb Treatment ◽  
The World ◽  
Mdr Tb ◽  
Elementary School Education

AbstractCompliance in treatment and taking Anti Tuberculosis Drugs (OAT) in pulmonary TB Patients is very necessary for consistency in increasing the success rate of treatment. Pulmonary TB Treatment must be done regularly. Otherwise, resistance to Anti Tuberculosis Drugs (OAT) will occur, the duration of taking the drug will be longer, and there will be an increase in the dose consumed. Especially, it is about an adherence to take OAT in patients with Multy-Drug Resistant (MDR) TB and TB with HIV. To find out the description of medication adherence in pulmonary TB patients and and characteristics in pulmonary TB patients. This study used a literature review design. The pill count compliance measurement method was conducted through a keyword search and used 5 articles from Google Scholar, ProQuest, and PubMed published in 2017 – 2021. From the 5 articles reviewed, the results showed that most of the respondents were male (68% or 314 respondents). The education level of most of the respondents was elementary school education (34% or 105 respondents). Most of the respondents were employed (62% or 164 respondents). Compliance with taking medication in pulmonary TB patients was 322 (70%) compliant, given intervention was 159 (92%) compliant, without intervention was 163 (56%) compliant, MDR TB non-adherent was 105 (95%), and TB with HIV 135 was (86%) complied. Compliance with taking Anti Tuberculosis Drugs (OAT) in pulmonary TB patients must be continuously improved and maintained to achieve the World Health Organization's target of increasing the success of pulmonary TB treatment consistently at results of 90%.Keywords: Compliance, Taking Medicines, TB Drugs, Pill Count, and Pulmonary TB AbstrakKepatuhan dalam pengobatan dan minum Obat Anti Tuberkulosis (OAT) pada pasien TB Paru sangat diperlukan konsistensinya dalam meningkatkan angka keberhasilan pengobatan. Pengobatan TB Paru harus dilakukan secara teratur, jika tidak akan terjadi resistensi pada Obat Anti Tuberkulosis (OAT), semakin lama durasi minum obat dan terjadi peningkatan dosis yang dikonsumsi. Terutama kepatuhan minum OAT pada pasien TB Multy Drug Resistant (MDR) dan TB dengan HIV. Mengetahui gambaran kepatuhan minum obat pada pasien TB Paru dan karakteristik pada pasien TB Paru. Desain Literature Review dengan metode pengukuran kepatuhan pill count melakukan pencarian melalui kata kunci dan menggunakan 5 artikel dari database hasil penulusuran elektronik pada Google Cendekia, ProQuest, Pubmed yang dipublish pada tahun 2017 – 2021. Dari 5 artikel yang di review di dapatkan hasil responden pada artikel sebagian besar berjenis kelamin laki – laki yaitu 314 (68%). Tingkat pendidikan responden sebagian besar berpendidikan SD yaitu 105 (34%), dan sebagian besar responden bekerja yaitu 164 (62%). Kepatuhan minum obat pada pasein TB dengan mengabaikan intervensi yang diberikan yaitu 322 (70%) patuh, diberikan intervensi 159 (92%) patuh, tanpa intervensi yang diberikan 163 (56%) patuh, TB MDR tidak patuh 105 (95%), dan TB dengan HIV 135 (86%) patuh. Kepatuhan minum Obat Anti Tuberkulosis (OAT) pada pasien TB Paru harus terus ditingkatkan dan dipertahankan untuk mencapai target World Heatlh Organisation dalam meningkatkan keberhasilan pengobatan TB Paru secara konsisten pada hasil ≥ 90%.Kata kunci: Kepatuhan; Minum Obat; Obat TB; Pill Count; dan TB Paru

scholarly journals HUBUNGAN TINGKAT PENGETAHUAN TENTANG TUBERKULOSIS PARU DENGAN MOTIVASI PASIEN DALAM MENJALANKAN PENGOBATAN DI PUSKESMAS UMBULHARJO 1 YOGYAKARTA

2021 ◽  
Vol 9 (1) ◽  
pp. 64-73
Author(s):  
Alima Frida Merani ◽  
Bambang Iskamto ◽  
Yafi Sabila Rosyad
Keyword(s):  
Health Center ◽  
Sampling Technique ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Patient Motivation ◽  
Tb Treatment ◽  
Psychological Mechanism ◽  
Level Of Knowledge ◽  
Cross Sectional Design ◽  
Internal And External Factors

Background: Motivation is a strength, drive, need, pressure and a psychological mechanism that is forced to be an accumulation of internal and external factors. Knowledge also has an important role in pulmonary TB patients while undergoing pulmonary TB treatment. The Objective: To examine the relationship between the level of knowledge about pulmonary tuberculosis and the motivation of patients to carry out treatment at the Umbulharjo 1 health center in Yogyakarta. The Research Methods: This type of research is quantitative, the method used is correlation with cross sectional design approach. The population in this study were 46 people with up to 30 respondents taken using purposive sampling technique. The Results: Somer’s D correlation test results of .346 are smaller than 0.005, meaning that there is a significant relationship between the level of knowledge and patient motivation in undergoing treatment at the Umbulharjo 1 Health Center in Yogyakarta. The Conclusion:  There is a relationship between the level of knowledge and patient motivation in undergoing treatment at the Umbulharjo 1 Health Center in Yogyakarta.  

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