scholarly journals Current developments and future directions in COPD

2020 ◽  
Vol 29 (158) ◽  
pp. 200289
Author(s):  
Alexander G. Mathioudakis ◽  
Lowie E.G.W. Vanfleteren ◽  
Lies Lahousse ◽  
Andrew Higham ◽  
James P. Allinson ◽  
...  

The European Respiratory Society journals publish respiratory research and policy documents of the highest quality, offering a platform for the exchange and promotion of scientific knowledge. In this article, focusing on COPD, the third leading cause of death globally, we summarise novel research highlights focusing on the disease's underlying mechanisms, epidemiology and management, with the aim to inform and inspire respiratory clinicians and researchers.

2019 ◽  
Vol 8 (3) ◽  
pp. 77 ◽  
Author(s):  
Ana Rita Cruz ◽  
Rodrigo Nicolau Almeida ◽  
Pedro Costa ◽  
Maria Assunção Gato ◽  
Margarida Perestrelo

The 21st century has witnessed a growth in the importance given to the third mission of Higher Education Institutions (HEI). This third mission refers to the socioeconomic engagement with the surrounding social and business fabric, namely in the form of knowledge transfer (KT) schemes and policies. Despite its widely-recognized importance, the Cultural and Creative Sector (CCS) has remained only marginally engaged with HEI, in part due to the lack of explicit policy by public actors to bring the two types of actors together. This article seeks to explore the institutional frameworks that have been developed for knowledge transfer from HEI to the CCS in selected regions of the Atlantic Area. Towards this goal, it first analyses some of the sectoral specificities of the CCS, identifying three feature which distinguish the sector: the entrepreneurial structure and organization of CCS; the type of knowledge, innovation and motivations of firms; and their absence of connections to HEI. The article seeks then to analyze to what extent existing policy on CCS and KT policies in the regions has tackled these specificities, through a qualitative analysis of reports, policy documents, and academic analysis of the regional economies, before proposing a model for understanding KT policy in the CCS sector, which serves as a preliminary line of inquiry into the knowledge relations in the CCS. Finally, these policy concerns are related to the perceptions of CCS practitioners, attempting to understand the primary concerns of these actors according to their regional context. The article highlights the existing disconnect between public policy, the current state of understanding of the CCS and the industry actors, urging for greater research and policy-development to promote innovation and socioeconomic growth.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yi Xin She ◽  
Qing Yang Yu ◽  
Xiao Xiao Tang

AbstractInterleukins, a group of cytokines participating in inflammation and immune response, are proved to be involved in the formation and development of pulmonary fibrosis. In this article, we reviewed the relationship between interleukins and pulmonary fibrosis from the clinical, animal, as well as cellular levels, and discussed the underlying mechanisms in vivo and in vitro. Despite the effects of interleukin-targeted treatment on experimental pulmonary fibrosis, clinical applications are lacking and unsatisfactory. We conclude that intervening in one type of interleukins with similar functions in IPF may not be enough to stop the development of fibrosis as it involves a complex network of regulation mechanisms. Intervening interleukins combined with other existing therapy or targeting interleukins affecting multiple cells/with different functions at the same time may be one of the future directions. Furthermore, the intervention time is critical as some interleukins play different roles at different stages. Further elucidation on these aspects would provide new perspectives on both the pathogenesis mechanism, as well as the therapeutic strategy and drug development.


2021 ◽  
pp. 026540752110476
Author(s):  
Jennifer A Sharkey ◽  
Jacqueline S Feather ◽  
Sonja Goedeke

This article provides a circumscribed descriptive analysis of the current state of research worldwide related to adult romantic relationship processes and their underlying mechanisms. A scoping review was used to gather data. This yielded 15,418 eligible articles from 1,687 different academic journals. From these, we outline key themes and theories arising in the last seven decades and note the most prolific journals and authors. The study of relational wellbeing has focused on overt behaviors such as communication and commitment, on underlying attitudes and motives such as empathy and contempt, and on substrates and circumstances such as neurobiological functioning and life stressors. The results reveal the strong interdisciplinary research underpinnings of the field of relationship science and show up key influences over its expansion. Results are intended to give an overview of key peer reviewed research that has contributed to the development of current scientific knowledge and theory development in this field.


2016 ◽  
Vol 5 (4) ◽  
pp. 201 ◽  
Author(s):  
Ewald Kiel ◽  
Thomas Lerche ◽  
Markus Kollmannsberger ◽  
Viktor Oubaid ◽  
Sabine Weiss

<p>Lee S. Shulman deplores that the field of education as a profession does not have a pedagogic signature, which he characterizes as a synthesis of cognitive, practical and moral apprenticeship. In this context, the following study has three goals: 1) In the first theoretical part, the basic problems of constructing a pedagogic signature are depicted. 2) In the empirical part, based on a multi-method approach, teachers’ and teacher educators’ beliefs and attitudes about a pedagogic signature are identified and ranked. It is argued that beliefs are of particular importance because they have a filter effect on how teachers deal with scientific knowledge. 3) The third part, the discussion, explains the findings, particularly the fact that moral aspects and aspects referring to a particular attitude play an overwhelming role. The explanation leads to some basic considerations on how to construct a pedagogic signature and on how such a signature can be turned into a viable concept for teacher education.</p>


2021 ◽  
Vol 15 (8) ◽  
pp. 384-391
Author(s):  
Linda Nazarko

The old adage, ‘sitting will be the death of you’, is proving to be a grim prediction that is borne out by research. Globally, physical inactivity leads to approximately 5 million deaths per year and is the fourth leading cause of death and disability ( Kohl et al, 2012 ; World Health Organization (WHO), 2020 ). Evidence suggests that, in the UK, inactivity leads to around 69 000 preventable deaths annually ( Heron et al, 2019 ). This article, the third in a series, explores inactivity, its consequences and how readers can remain healthy and well by maintaining or increasing activity levels.


2012 ◽  
pp. 600-607
Author(s):  
Y. P. Chang ◽  
D. H. Zhu

The adoption of social networking sites has become an international phenomenon. This encyclopedia entry synthesizes the literature concerning adoption of social networking sites. It offers a definition about adoption of social networking sites. It provides an overview on historical development by specifying the pioneering scholars of danah boyd and Nicole Ellison and current knowledge status of the adoption of social networking sites. It introduces the current scientific knowledge by specifying leading scholars’ researches from five representative areas, namely adopters’ characteristics, adopters’ motivation, antecedents of adoption, adopters’ behavior and consequences of adoption. It also concludes the entry and outlines future directions.


Author(s):  
Isabel Lopes Teixeira ◽  
Inna Sousa Paiva

This chapter examines the problems related to the international taxation of electronic commerce and identifies the alternative solutions that have been adopted in the current fiscal framework. The results obtained demonstrate the proposed models of e-commerce taxation based on existing international legislation, notably origin-based taxation, tax withheld at source and technology based solutions. This study argues that any legislative change should be implemented by a number of countries or through international efforts to harmonize practices, and sets out the future directions in the taxation of e-commerce. This chapter contributes to the scientific knowledge to accounting and tax research on the taxation of e-commerce.


2020 ◽  
pp. 383-388
Author(s):  
Perry Elliott ◽  
Pier D. Lambiase ◽  
Dhavendra Kumar

Stroke is the third most common cause of death, and the most common cause of disability in developed countries. This chapter examines the genetics of stroke, and single gene causes (although stroke is often just one component of the phenotype). It then describes Anderson—Fabry disease, CADASIL, RVCL, autosomal-dominant porencephaly and infantile hemiparesis, hereditary cerebral haemorrhage with amyloidosis, Moya-Moya disease, sickle cell disease, and MELAS.


Author(s):  
Nicolas Toro-Urrego ◽  
Marco Avila-Rodriguez ◽  
María Inés Herrera ◽  
Andrea Aguilar ◽  
Lucas Udovin ◽  
...  

Hypoxic–ischemic brain injury is a number one cause of long-term neurologic disability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inefficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic–ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic–ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.


2016 ◽  
Vol 73 (2) ◽  
Author(s):  
X. Dhalluin ◽  
A. Scherpereel

Previously considered to be rare, malignant pleural mesothelioma (MPM) is a highly aggressive tumour that has become a very important issue over recent years due to its poor prognosis and its increasing incidence mostly linked to previous asbestos exposure. An optimal treatment for MPM is not established yet; new therapies and predictive tools are still needed in the management of this cancer. Thus the aim of this review is to provide clinicians clear and up-to-dated data on the latest therapeutic strategies for MPM patients in 2010. The guidelines recently proposed by the European Respiratory Society (ERS) and the European Society of Thoracic Surgeons (ESTS) taskforce are summarized here. The authors also briefly reviewed the future directions in MPM treatment including targeted therapies, gene or cell therapies.


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