Association between fasting plasma glucose and high-sensitivity C-reactive protein: gender differences in a Japanese community-dwelling population

Secretogranin III (SCG3) plays a crucial role in the biogenesis of secretory granules in endocrine cells, and thus affects glucose homeostasis by regulating insulin secretion by pancreatic beta cells. Insulin resistance and compensatory hyperinsulinemia are hallmarks of metabolic syndrome (MetS). However, the role of SCG3 in MetS remains unclear. Therefore, we investigated the relationship between serum SCG3 levels and metabolic parameters in subjects with and without MetS. This was a case control study, and 295 subjects were recruited. Serum SCG3 concentrations were compared between groups. Associations between SCG3 levels and clinico-metabolic parameters were also examined. We found serum SCG3 levels were higher in the MetS group than non-MetS group (122.6 ± 79.2 vs. 90.6 ± 58.5 nmol/L, p = 0.009). Specifically, elevated SCG3 levels were found in subjects with high fasting plasma glucose (FPG) levels, central obesity, or hypertriglyceridemia. Additionally, MetS was an independent factor of serum SCG3 levels in multivariate linear regression analyses. Moreover, FPG, free fatty acids, and waist circumference were positively associated with serum SCG3 concentrations after adjusting for insulin levels, high-sensitivity C-reactive protein, and cardiovascular risk factors. In conclusion, serum SCG3 concentrations were higher in subjects with MetS and were independently associated with FPG levels.

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Reduced High-Molecular-Weight Adiponectin and Elevated High-Sensitivity C-Reactive Protein Are Synergistic Risk Factors for Metabolic Syndrome in a Large-Scale Middle-Aged to Elderly Population: the Shimanami Health Promoting Program Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-0397 ◽

2008 ◽

Vol 93 (3) ◽

pp. 715-722 ◽

Cited By ~ 34

Author(s):

Yasuharu Tabara ◽

Haruhiko Osawa ◽

Ryuichi Kawamoto ◽

Rieko Tachibana-Iimori ◽

Miyuki Yamamoto ◽

...

Keyword(s):

Metabolic Syndrome ◽

Molecular Weight ◽

High Molecular Weight ◽

Metabolic Disorders ◽

High Sensitivity ◽

Community Dwelling ◽

C Reactive Protein ◽

Middle Aged ◽

Reactive Protein ◽

Hmw Adiponectin

Abstract Objective: In Western countries, one of the most important modifiable targets for the prevention of cardiovascular diseases is metabolic syndrome. Adiponectin is an adipose tissue-specific plasma protein that inversely associates with metabolic syndrome. Among several molecular isoforms, high-molecular-weight (HMW) complex is considered the active form. Increased serum high-sensitivity C-reactive protein (hsCRP) concentration also associates with metabolic syndrome, and adiponectin could modulate plasma C-reactive protein levels. Here, through cross-sectional investigation, we investigated whether reduced HMW adiponectin and increased hsCRP levels in plasma are synergistically associated with metabolic syndrome. Measurement of HMW complex of adiponectin is one of the novelties of this study. Design: We analyzed 1845 community-dwelling middle-aged to elderly subjects (62 ± 13 yr). Plasma HMW adiponectin levels were measured by ELISA. Clinical parameters were obtained from the subjects’ personal health records, evaluated at their annual medical check-up. Results: Each component of metabolic syndrome, except for raised blood pressure, showed significantly lower plasma HMW adiponectin concentrations for both men and women (P < 0.001). In contrast, plasma hsCRP levels were significantly higher in subjects with metabolic disorders (P < 0.001). After adjusting for other confounding factors, HMW adiponectin [log normalized, odds ratio 0.084 (95% confidence interval 0.050–0.142), P < 0.001] and hsCRP [3.009 (2.175–4.163), P < 0.001] were identified as independent determinants of metabolic syndrome. In addition to the direct associations, we also observed a synergistic effect between these two molecules (F = 11.8, P < 0.001). Conclusions: Reduced HMW adiponectin and elevated hsCRP are synergistically associated with the accumulation of metabolic disorders. The combination of these markers would be useful for identifying at-risk populations.

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The relationship between mean platelet volume and fasting plasma glucose differs with glucose tolerance status in a Korean general population: Gender differences

Platelets ◽

10.3109/09537104.2012.715214 ◽

2012 ◽

Vol 24 (6) ◽

pp. 469-473 ◽

Cited By ~ 6

Author(s):

Jin Hwa Kim ◽

Seung Bum Kang ◽

Ji In Kang ◽

Jin Woo Kim ◽

Sang Yong Kim ◽

...

Keyword(s):

Gender Differences ◽

General Population ◽

Glucose Tolerance ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Mean Platelet Volume ◽

Platelet Volume ◽

Fasting Plasma ◽

Glucose Tolerance Status ◽

The Relationship

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A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i5.4918 ◽

2021 ◽

Vol 71 (5) ◽

pp. 1651-55

Author(s):

Shehar Bano Imran ◽

Shabnam Dildar ◽

Sadia Taj ◽

Afshan Khanum ◽

Qasim Ahmed

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

High Sensitivity ◽

P Value ◽

Cross Sectional ◽

Fasting Plasma ◽

Hs Crp ◽

Glycemic Markers

Objective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes. Study Design: Cross sectional study. Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019. Methodology: Consecutive patients aged 18-65 years coming for screening of diabetes mellitus (DM) were included. Blood sample for plasma glucose and glycated hemoglobin (HbA1c), high sensitivity CRP (hs-CRP) were analyzed. Results: Total 93 subjects were included, out of which 42 (45.2%) were males and 51 (54.8%) were females with the mean age of 48.3 ± 12 years and 42.6 ± 14 years respectively. Median concentration of hs-CRP in males and females was 0.7 (IQR1.2) mg/L and 0.6 (IQR1.4) mg/L (p-value=0.844) respectively. A significant positive correlation was observed between hs-CRP levels, HBA1c with r=0.205 (p=0.05) and fasting plasma glucose (FPG) with r=0.225 (p=0.03). However, no significant relationship was found between hs-CRP and age, BMI, waist circumference and systolic blood pressure (SBP) and diastolic blood pressure (DBP), cholesterol, LDL-cholesterol, triglycerides (TG), HDL-cholesterol. Conclusion: HbA1c and fasting plasma glucose is significantly associated with hs-CRP. This implies a significant relation between inflammation and glycemic markers. This leads to the conclusion that patients with diabetes and high hs-CRP need further evaluation, follow-up and therapy for inflammation compared to those with low hs-CRP.

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The ratio of fasting plasma glucose to hemoglobin A1c as a predictor of all-cause mortality in individuals with normal glucose levels: The Jichi Medical School cohort study

SAGE Open Medicine ◽

10.1177/2050312119860398 ◽

2019 ◽

Vol 7 ◽

pp. 205031211986039

Author(s):

Eiichi Kakehi ◽

Kazuhiko Kotani ◽

Tadao Gotoh ◽

Kazunori Kayaba ◽

Shizukiyo Ishikawa

Keyword(s):

Cohort Study ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Hemoglobin A1c ◽

Hazard Ratio ◽

Community Dwelling ◽

Glucose Levels ◽

Fasting Plasma ◽

All Cause Mortality

Objectives: The fasting plasma glucose/hemoglobin A1c ratio is considered a marker associated with glucose metabolism disorders, including fasting hyperglycemia. However, it remains unclear whether this ratio can be used for the prevention of deaths in individuals with normal fasting plasma glucose levels. This study aimed to see the predictive value of the fasting plasma glucose/hemoglobin A1c ratio for all-cause mortality in a general population with normal fasting plasma glucose levels. Methods: The study investigated prospectively a cohort of 1087 multi-regional, community-dwelling Japanese participants (women, 69.2%) for a follow-up period of 11.3 years. We included individuals with fasting plasma glucose levels <6.11 mmol/L and excluded those meeting the diabetes criteria. All-cause mortality was the primary outcome and hazard ratios were calculated using the Cox proportional hazard model after dividing the fasting plasma glucose/hemoglobin A1c ratios into tertiles. Results: There were 54 deaths (25 women) during the follow-up period. The high tertile group had a significantly higher hazard ratio for all-cause mortality than the low tertile group in women (multivariate-adjusted hazard ratio = 4.45; 95% confidence interval = 1.26–15.72), but not clearly in men. Conclusion: The data of the population-based cohort study suggest that a high fasting plasma glucose/hemoglobin A1c ratio can predict all-cause mortality in women with normal fasting plasma glucose levels.

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