scholarly journals Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Fatemeh Rahimi-Sakak ◽  
Mahsa Maroofi ◽  
Jamal Rahmani ◽  
Nick Bellissimo ◽  
Azita Hekmatdoost
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Dose Response ◽  
Cardiovascular Mortality ◽  
Meta Analysis ◽  
Group Analysis ◽  
Positive Association ◽  
Response Analysis ◽  
Significant Positive Association ◽  
Cvd Mortality

Abstract Background Cardiovascular disease (CVD) is the leading cause of death worldwide. Some studies have suggested anassociation between serum uric acid levels and cardiovascular mortality; however, the results have not been summarized in a meta-analysis. Methods A comprehensive search of all related studies until April 2018was performed in MEDLINE/PubMed and Scopus databases DerSimonianand Laird random-effects models were used to combine hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out. Results Thirty-two studies containing forty-four arms with 1,134,073 participants reported association between uric acid and risk of CVD mortality were included in our analysis. Pooled results showed a significant positive association between uric acid levels and risk of CVD mortality (HR 1.45, 95% CI 1.33–1.58, I2 = 79%). Sub-group analysis showed this relationshipwasstronger in women compared to men. Moreover, there was a significant non-linear association between uric acid levels and the risk of CVD mortality (r = 0.0709, p = 0.001). Conclusion Our analysis indicates a positive dose-response association between SUA and CVD mortality risk.

scholarly journals Age at Menopause and Risk of Developing Endometrial Cancer: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Yanjun Wu ◽  
Wenjun Sun ◽  
Hui Liu ◽  
Dongfeng Zhang
Keyword(s):  
Endometrial Cancer ◽  
Dose Response ◽  
Meta Analysis ◽  
Positive Association ◽  
Response Analysis ◽  
Age At Menopause ◽  
Relative Risks ◽  
Knowledge Infrastructure ◽  
Study Heterogeneity ◽  
Chinese National Knowledge Infrastructure

Object. The association of age at menopause with endometrial cancer remains controversial. Therefore, we quantitatively summarized the evidence from observational studies with a meta-analysis. Methods. We searched PubMed, Web of Science, Embase, Medline, Chinese National Knowledge Infrastructure (CNKI), and Wan Fang Med online up to March 2019, and all eligible case-control and cohort studies were included in the study. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model. The dose-response relationship was assessed by restricted cubic spline model. The heterogeneity among studies was evaluated by I2. Metaregression was used to explore the potential sources of between-study heterogeneity. Egger’s test was used to estimate publication bias. Results. Eighteen articles including 957242 subjects with 4781 cases were included in the meta-analysis. The pooled RR (95%CI) of endometrial cancer for the highest versus the lowest age at menopause was 1.89 (95%CI: 1.58-2.26). For dose-response analysis, a nonlinear relationship was found between age at menopause and endometrial cancer, and the positive association became statistically significant when age at menopause was greater than 46.5 years old. Conclusions. This meta-analysis suggested that age at menopause was positively associated with endometrial cancer. For women whose menopausal age over 46.5 years old, the risk of endometrial cancer increased with the age at menopause.

scholarly journals Serum uric acid and cardiovascular mortality in chronic kidney disease: a meta-analysis

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Qimei Luo ◽  
Xi Xia ◽  
Bin Li ◽  
Zhenchuan Lin ◽  
Xueqing Yu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Cardiovascular Mortality ◽  
Meta Analysis

scholarly journals Serum Uric Acid Revealed a U-Shaped Relationship With All-Cause Mortality and Cardiovascular Mortality in High Atherosclerosis Risk Patients: The ASSURE Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Yan Cang ◽  
Shaojie Xu ◽  
Jingyin Zhang ◽  
Jingyi Ju ◽  
Zijun Chen ◽  
...  
Keyword(s):  
Uric Acid ◽  
Regression Model ◽  
Serum Uric Acid ◽  
Cardiovascular Mortality ◽  
Cox Regression ◽  
Multicenter Cohort Study ◽  
Male And Female ◽  
Cox Regression Analysis ◽  
All Cause Mortality ◽  
Cvd Mortality

Background: Previous studies have demonstrated an association between hyperuricemia and cardiovascular disease (CVD). The Framingham study confirmed that patients with high atherosclerotic risks (HARs) had worse prognoses. However, after adjusting for confounding factors, the association between serum uric acid (SUA) and all-cause mortality and cardiovascular mortality remains unclear, especially for HAR patients.Objective: The aim of this study was to reveal the relationship of SUA with all-cause and cardiovascular mortality in HAR patients.Methods: This multicenter cohort study enrolled 3,047 participants, and the follow-up was 68.85 ± 11.37 months. Factors related to cardiovascular and all-cause mortality were tested by multivariate Cox regression analysis. Restricted cubic splines (RCSs) with knots were used to explore the shape of the dose–response relationship with SUA and the hazard ratio (HR) of all-cause and CVD mortality. SUA transformed by RCS was added to the Cox regression model as an independent variable, and all-cause and CVD mortality scores were calculated. Survival receiver operating characteristic curves were produced using a regression model predicting the score.Results: SUA demonstrated a “U-shaped” relationship with all-cause and cardiovascular mortality. SUA predicted all-cause and CVD mortality, with cutoff values of values of >370.5 μmol/L for males and >327.65 μmol/L for females and <180.5 μmol/L for males and <165.7 μmol/L for females, respectively. The survival ROC curve indicated that SUA is able to predict all-cause and CVD mortality, with areas under the curve of 0.702 and 0.711, respectively. The HRs of all-cause mortality (male and female) with hyperuricemia and hypouricemia were 2.08 and 2.01 and 2.04 and 1.98, respectively, and the HRs of CVD mortality (male and female) were 2.09 and 1.79, and 2.02 and 1.89, respectively.Conclusion: Abnormal SUA levels were significant and independent risk factors for all-cause and CVD mortality. Hyperuricemia and hypouricemia increased mortality in both males and females. Routine SUA evaluation and intensive management are needed for HAR patients.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03616769.

scholarly journals Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-Analysis of Prospective Studies

2015 ◽  
Vol 100 (11) ◽  
pp. 4198-4207 ◽  
Author(s):  
Huiping Yuan ◽  
Chenglong Yu ◽  
Xinghui Li ◽  
Liang Sun ◽  
Xiaoquan Zhu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Dose Response ◽  
Prospective Studies ◽  
Meta Analysis

scholarly journals Serum uric acid and risk of incident chronic kidney disease: a national cohort study and updated meta-analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Nianwei Wu ◽  
Jing Xia ◽  
Sen Chen ◽  
Chuan Yu ◽  
Ying Xu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Cohort Studies ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Positive Association ◽  
Effect Estimate ◽  
Logistic Regression Models ◽  
Increased Risk

Abstract Background We prospectively examined the association between serum uric acid (SUA) levels and chronic kidney disease (CKD) in China and updated the evidence through a comprehensive meta-analysis of prospective studies worldwide. Methods Our original analyses were based on data from the China Health and Retirement Longitudinal Study. The primary exposure of interest was SUA at baseline, and the main outcome was incident CKD. Logistic regression models were used to examine the association between SUA levels and incident CKD. A meta-analysis was performed to pool our effect estimate and those from other cohort studies. Results During a 4-year follow-up, 180 participants developed incident CKD. Participants in the highest SUA quartile were 2.73 times as likely to develop incident CKD compared to those in the lowest quartile (multivariable-adjusted OR, 2.73; 95% CI, 1.65–4.50). Each 1 mg/dL increment in the SUA levels was associated with a 49% increased risk of incident CKD (multivariable-adjusted OR, 1.49; 95% CI, 1.28–1.74). In the meta-analysis of 30 cohort studies (including the current study), pooled relative risks (95% CIs) of incident CKD were 1.15 (1.10–1.21) for SUA each 1 mg/dL increment, 1.22 (1.14–1.30) for the highest versus lowest SUA group, and 1.17 (1.12–1.23) for hyperuricemia versus no hyperuricemia. Conclusions Baseline SUA levels were associated with higher risk of incident CKD in middle-aged and elderly Chinese adults, and this positive association was confirmed in the meta-analysis of multiple cohort studies. Our findings may imply that SUA levels need to be routinely monitored for future CKD risk.

Alpha lipoic acid supplementation affects serum lipids in a dose and duration-dependent manner in different health status

2021 ◽  
Author(s):  
Mahsa Mahmoudinezhad ◽  
Mahdieh Abbasalizad Farhangi
Keyword(s):  
Lipid Profile ◽  
Dose Response ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Response Analysis ◽  
Dependent Manner ◽  
Beneficial Effects ◽  
Strong Conclusion ◽  
Polynomial Modeling

Abstract. Background: Many studies have investigated the effect of ALA supplementation on lipid profile, and different results have been obtained from these studies. The current systematic review and dose-response meta-analysis was conducted to achive a strong conclusion about the effect of ALA supplementation on lipid profile including total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL, HDL) and triglyceride (TG). Methods: A systematic search was performed in PubMed, SCOPUS, ProQuest and Embase for randomized placebo-controlled human trials that examined the effect of ALA supplementation on lipid profile up to November 2020. The dose and duration of ALA supplementation for included studies were ranged between 300–1200 mg/d and 2–16 weeks respectively. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were used to evaluate the effect size. Cochran’s Q and I2 tests were also used to assess between-study’s heterogeneity. In addition, subgroup analysis was performed to investigate potential sources of heterogeneity. Dose-response relationship was done using fractional polynomial modeling. Results: Among all eligible studies, 12 studies with a total number of 548 participants were selected. ALA caused a significant reduction on TC (WMD): −10.78 mg/dl, 95% CI: −20.81, −0.74, P=0.002), LDL (WMD: −10.88 mg/dl, 95% CI: −19.52, −2.24, P=0.014) and TG (WMD: −31.02 mg/dl, 95% CI: −49.63, −12.42, P<0.001). There was also a non-significant increaes in HDL concentrations. In addition, dose-response analysis showed a positive association between LDL (Pnon-linearity=0.026), TG (Pnon-linearity<0.001) and duration of intervention in a non-linear model. Conclusion: The present meta-analysis revealed the beneficial effects of ALA supplementation on TC, LDL and TG levels. Moreover, the beneficial effects of ALA supplementation on LDL and TG levels was duration-dependent.

scholarly journals Positive Association of Cardiovascular Disease (CVD) with Chronic Exposure to Drinking Water Arsenic (As) at Concentrations below the WHO Provisional Guideline Value: A Systematic Review and Meta-analysis

2020 ◽  
Vol 17 (7) ◽  
pp. 2536 ◽  
Author(s):  
Lingqian Xu ◽  
Debapriya Mondal ◽  
David A. Polya
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Drinking Water ◽  
Dose Response ◽  
Linear Models ◽  
Meta Analysis ◽  
Positive Association ◽  
P Value ◽  
Significant Positive Association ◽  
Guideline Value

To the best of our knowledge, a dose-response meta-analysis of the relationship between cardiovascular disease (CVD) and arsenic (As) exposure at drinking water As concentrations lower than the WHO provisional guideline value (10 µg/L) has not been published yet. We conducted a systematic review and meta-analyses to estimate the pooled association between the relative risk of each CVD endpoint and low-level As concentration in drinking water both linearly and non-linearly using a random effects dose-response model. In this study, a significant positive association was found between the risks of most CVD outcomes and drinking water As concentration for both linear and non-linear models (p-value for trend < 0.05). Using the preferred linear model, we found significant increased risks of coronary heart disease (CHD) mortality and CVD mortality as well as combined fatal and non-fatal CHD, CVD, carotid atherosclerosis disease and hypertension in those exposed to drinking water with an As concentration of 10 µg/L compared to the referent (drinking water As concentration of 1 µg/L) population. Notwithstanding limitations included, the observed significant increased risks of CVD endpoints arising from As concentrations in drinking water between 1 µg/L and the 10 µg/L suggests further lowering of this guideline value should be considered.

scholarly journals Association Between Serum Uric Acid and Triglycerides in Chinese Children and Adolescents With Short Stature

2020 ◽  
Author(s):  
Yuntian Chu ◽  
Qianqian Zhao ◽  
Mei Zhang ◽  
Bo Ban ◽  
Hongbing Tao
Keyword(s):  
Uric Acid ◽  
Children And Adolescents ◽  
Short Stature ◽  
Serum Uric Acid ◽  
Density Lipoprotein ◽  
Positive Association ◽  
Nonlinear Relationship ◽  
Significant Positive Association ◽  
The Relationship ◽  
Chinese Children And Adolescents

Abstract Background: Elevated triglyceride (TG) levels are a biomarker of CVD risk. The relationship between serum uric acid (SUA) and TG in adults and obese children is well established. However, studies on children with short stature with SUA and TG are limited. Aim: The aim of this study was to examine the relationship between SUA and TG in Chinese children and adolescents with short stature.Methods: This study is a cross-sectional analysis of a cohort study. A total of 1095 children and adolescents with short stature (720 males and 375 females) were included. The related clinical characteristics, including body mass index (BMI), serum uric acid (SUA), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), were determined.Results: The univariate analysis results showed a significant positive association between SUA and TG (P < 0.001). Furthermore, a smooth curve fitting after adjusting for potential confounders was performed, and a nonlinear relationship between SUA and TG was observed. A multivariate piecewise linear regression model revealed a significant positive association between SUA and TG when the SUA level was greater than 7 mg/dL (β 0.13, 95% CI 0.05, 0.22; P = 0.002). However, we did not observe a significant relationship between SUA and TG when the SUA level was lower than 7 mg/dL (β 0.01, 95% CI -0.01, 0.04; P=0.799).Conclusion: This study described a nonlinear relationship between UA and TG in children and adolescents with short stature. When SUA rises to a certain level, there is a strong positive association between UA and TG. This finding suggests that elevated UA levels may be another risk indicator of cardiovascular disease in children and adolescents with short stature.

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