Comparison of procalcitonin and high-sensitivity C-reactive protein for the diagnosis of sepsis and septic shock in the oldest old patients

ObjectivesOur aim was to assess the release level of heparin-binding protein (HBP) in sepsis and septic shock under theThird International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3).DesignProspective cohort study.SettingA general teaching hospital in China.ParticipantsAdult infected patients with suspected sepsis and people who underwent physical examination were included. According to the health status and severity of illness, the research subjects were divided into healthy, local infection, sepsis non-shock and septic shock under Sepsis-3 definitions.Main outcome measuresPlasma levels of HBP, procalcitonin (PCT), C reactive protein (CRP) and complete blood count were detected in all subjects. Single-factor analysis of variance was used to compare the biomarker levels of multiple groups. A receiver operating characteristic (ROC) curve was used to assess the diagnostic capacity of each marker.ResultsHBP levels were significantly higher in patients with sepsis non-shock than in those with local infections (median 49.7ng/mL vs 11.8 ng/mL, p<0.01) at enrolment. Moreover, HBP levels in patients with septic shock were significantly higher than in patients with sepsis without shock (median 153.8ng/mL vs 49.7 ng/mL, p<0.01). The area under the ROC curve (AUC) of HBP (cut-off ≥28.1 ng/mL) was 0.893 for sepsis which was higher than those of PCT (0.856) for a cut-off ≥2.05 ng/mL and of CRP (0.699) for a cut-off ≥151.9 mg/L. Moreover, AUC of HBP (cut-off ≥103.5 ng/mL) was 0.760 for septic shock which was higher than the ROC curve of sequential [sepsis-related] organ failure assessment (SOFA) Score (0.656) for a cut-off ≥5.5. However, there was no significant difference between 28-d survivors (n=56) and 28-d non-survivors (n=37) with sepsis in terms of HBP value (p=0.182).ConclusionsA high level of HBP in plasma is associated with sepsis, which might be a useful diagnostic marker in patients with suspected sepsis.

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Clinical Usefulness of Procalcitonin and C-Reactive Protein as Outcome Predictors in Critically Ill Patients with Severe Sepsis and Septic Shock

PLoS ONE ◽

10.1371/journal.pone.0138150 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0138150 ◽

Cited By ~ 38

Author(s):

Jeong-Am Ryu ◽

Jeong Hoon Yang ◽

Daesang Lee ◽

Chi-Min Park ◽

Gee Young Suh ◽

...

Keyword(s):

Septic Shock ◽

Severe Sepsis ◽

Critically Ill ◽

Critically Ill Patients ◽

Clinical Usefulness ◽

Outcome Predictors ◽

C Reactive Protein ◽

Reactive Protein ◽

Sepsis And Septic Shock

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The C-reactive protein to albumin ratio predicts postoperative complications in oldest-old patients with colorectal cancer

International Journal of Colorectal Disease ◽

10.1007/s00384-019-03491-z ◽

2020 ◽

Vol 35 (3) ◽

pp. 423-431 ◽

Cited By ~ 4

Author(s):

Shintaro Hashimoto ◽

Tetsuro Tominaga ◽

Takashi Nonaka ◽

Kiyoaki Hamada ◽

Masato Araki ◽

...

Keyword(s):

Colorectal Cancer ◽

Postoperative Complications ◽

Oldest Old ◽

C Reactive Protein ◽

Old Patients ◽

Albumin Ratio ◽

Reactive Protein

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Relation of heart rate variability to serum levels of C-reactive protein, interleukin 6, and 10 in patients with sepsis and septic shock

Journal of Critical Care ◽

10.1016/j.jcrc.2008.11.010 ◽

2009 ◽

Vol 24 (4) ◽

pp. 625.e1-625.e7 ◽

Cited By ~ 34

Author(s):

Vasilios E. Papaioannou ◽

Christos Dragoumanis ◽

Vasiliki Theodorou ◽

Christos Gargaretas ◽

Ioannis Pneumatikos

Keyword(s):

Heart Rate ◽

Septic Shock ◽

Heart Rate Variability ◽

Interleukin 6 ◽

Serum Levels ◽

C Reactive Protein ◽

Reactive Protein ◽

Sepsis And Septic Shock

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Relation of heart rate variability to serum levels of C-reactive protein in patients with severe sepsis and septic shock

Journal of Critical Care ◽

10.1016/j.jcrc.2008.03.015 ◽

2008 ◽

Vol 23 (2) ◽

pp. 266-267 ◽

Cited By ~ 1

Author(s):

Vasilios Papaioannou ◽

Christos Dragoumanis ◽

Ioannis Pneumatikos

Keyword(s):

Heart Rate ◽

Septic Shock ◽

Heart Rate Variability ◽

Severe Sepsis ◽

Serum Levels ◽

C Reactive Protein ◽

Reactive Protein ◽

Sepsis And Septic Shock

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Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock

European Journal of Clinical Microbiology & Infectious Diseases ◽

10.1007/s10096-006-0168-1 ◽

2006 ◽

Vol 25 (8) ◽

pp. 481-491 ◽

Cited By ~ 66

Author(s):

Y. Heper ◽

E. H. Akalın ◽

R. Mıstık ◽

S. Akgöz ◽

O. Töre ◽

...

Keyword(s):

Septic Shock ◽

Tumor Necrosis ◽

Interleukin 10 ◽

Prognostic Parameters ◽

C Reactive Protein ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Factor Alpha ◽

Sepsis And Septic Shock ◽

Necrosis Factor

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Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

PLoS ONE ◽

10.1371/journal.pone.0175254 ◽

2017 ◽

Vol 12 (4) ◽

pp. e0175254 ◽

Cited By ~ 33

Author(s):

Juan-Jesús Ríos-Toro ◽

Mercedes Márquez-Coello ◽

José-María García-Álvarez ◽

Andrés Martín-Aspas ◽

Ricardo Rivera-Fernández ◽

...

Keyword(s):

Septic Shock ◽

Severe Sepsis ◽

Interleukin 6 ◽

Prognostic Markers ◽

Membrane Receptors ◽

C Reactive Protein ◽

Reactive Protein ◽

Sepsis And Septic Shock

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Procalcitonin and C-Reactive Protein as a Predictor of Organ Dysfunction and Outcome of Sepsis and Septic Shock Patients in Intensive Care Unit

Global Journal of Health Science ◽

10.5539/gjhs.v9n12p169 ◽

2017 ◽

Vol 9 (12) ◽

pp. 169

Author(s):

Syafri Kamsul Arif ◽

Maya P. Suyata ◽

Syafruddin Gaus ◽

Muhammad Ramli Ahmad

Keyword(s):

Septic Shock ◽

Organ Dysfunction ◽

Pearson Correlation ◽

C Reactive Protein ◽

Chi Square ◽

Correlation Test ◽

Positive Correlation ◽

Reactive Protein ◽

Chi Square Test ◽

Sepsis And Septic Shock

BACKGROUND & OBJECTIVE: Sepsis is a potentially life-threatening disorder in ICU. The worst complication is organ dysfunction and mortality. Procalcitonin (PCT) and C-Reactive Protein (CRP) had been proposed as biomarker and predictor for diagnosis, prognosis, and patient deterioration in sepsis and septic shock patients. To know whether PCT and CRP can be used as a predictor of organ dysfunction and outcome in sepsis and septic shock patients in ICU.MATERIALS & METHODS: Data were cohort retrospectively analyzed in 35 sepsis (45.5%) and 42 septic shock patients (54.5%) admitted to ICU Dr. Wahidin Sudirohusodo General Hospital (January 2014 – December 2015). Data were analyzed using Chi-Square test, Pearson Correlation, and Spearman-Rho Correlation test.RESULTS: Total of 77 patients met the inclusion criteria. Cut-off point in predicting organ dysfunction in sepsis and septic shock was significantly higher in PCT (45.7ng/mL) with 76.6% sensitivity and 70.0% specificity, while CRP was 145.75 mg/mL with 70.2% sensitivity and 56.7% specificity. There was a positive correlation of PCT (0.492 [p=0.000]) and CRP (0.336 [p=0.003]) to organ dysfunction reflected on SOFA score using the Pearson Correlation test (p<0.01 statistically significant). Based on Spearman-Rho Correlation test, correlation of PCT (0.191 [p=0.097]) and CRP (0.110 [p=0.340]) to outcome in day-7 was positive but not statistically significant (p≥0.01). While in day-28, there was positive correlation 0.553 (p=0.001) for PCT, 0.460 (p=0.006) for CRP, and statistically significant (p<0.01).CONCLUSIONS: Procalcitonin and CRP can be used as a predictor of organ dysfunction and outcome in sepsis and septic shock patients.

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