scholarly journals Procalcitonin and C-Reactive Protein as a Predictor of Organ Dysfunction and Outcome of Sepsis and Septic Shock Patients in Intensive Care Unit

2017 ◽  
Vol 9 (12) ◽  
pp. 169
Author(s):  
Syafri Kamsul Arif ◽  
Maya P. Suyata ◽  
Syafruddin Gaus ◽  
Muhammad Ramli Ahmad
Keyword(s):  
Septic Shock ◽  
Organ Dysfunction ◽  
Pearson Correlation ◽  
C Reactive Protein ◽  
Chi Square ◽  
Correlation Test ◽  
Positive Correlation ◽  
Reactive Protein ◽  
Chi Square Test ◽  
Sepsis And Septic Shock

BACKGROUND & OBJECTIVE: Sepsis is a potentially life-threatening disorder in ICU. The worst complication is organ dysfunction and mortality. Procalcitonin (PCT) and C-Reactive Protein (CRP) had been proposed as biomarker and predictor for diagnosis, prognosis, and patient deterioration in sepsis and septic shock patients. To know whether PCT and CRP can be used as a predictor of organ dysfunction and outcome in sepsis and septic shock patients in ICU.MATERIALS & METHODS: Data were cohort retrospectively analyzed in 35 sepsis (45.5%) and 42 septic shock patients (54.5%) admitted to ICU Dr. Wahidin Sudirohusodo General Hospital (January 2014 – December 2015). Data were analyzed using Chi-Square test, Pearson Correlation, and Spearman-Rho Correlation test.RESULTS: Total of 77 patients met the inclusion criteria. Cut-off point in predicting organ dysfunction in sepsis and septic shock was significantly higher in PCT (45.7ng/mL) with 76.6% sensitivity and 70.0% specificity, while CRP was 145.75 mg/mL with 70.2% sensitivity and 56.7% specificity. There was a positive correlation of PCT (0.492 [p=0.000]) and CRP (0.336 [p=0.003]) to organ dysfunction reflected on SOFA score using the Pearson Correlation test (p<0.01 statistically significant). Based on Spearman-Rho Correlation test, correlation of PCT (0.191 [p=0.097]) and CRP (0.110 [p=0.340]) to outcome in day-7 was positive but not statistically significant (p≥0.01). While in day-28, there was positive correlation 0.553 (p=0.001) for PCT, 0.460 (p=0.006) for CRP, and statistically significant (p<0.01).CONCLUSIONS: Procalcitonin and CRP can be used as a predictor of organ dysfunction and outcome in sepsis and septic shock patients.

scholarly journals Can we find accessible and relevant markers for sepsis outcome?

2017 ◽  
Vol 25 (1) ◽  
pp. 91-100
Author(s):  
Andreea Paula Cioară ◽  
Mirela Flonta ◽  
Astrid Binder ◽  
Andreea Pop ◽  
Violeta Siladi ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Mortality Rate ◽  
Serum Levels ◽  
Serum Glucose ◽  
Serum Lactate ◽  
C Reactive Protein ◽  
Chi Square ◽  
Reactive Protein ◽  
Chi Square Test

Abstract Background and Aim: Sepsis is a life-threatening disease with high mortality, therefore establishing early diagnostic and finding reliable prognostic biomarkers is vital. We aimed to investigate the prognostic role, as a single value, of serum procalcitonin, C-reactive protein, serum lactate, platelets number and serum glucose level in septic patients, all measured in the first 24 hours after hospital admittance. Materials and methods: This retrospective study included 241 adult patients with sepsis, severe sepsis or septic shock. We use data from patients observation sheets. Data that were collected include: demographic parameters, comorbidities, necessity of mechanical ventilation and laboratory variables. We performed the statistical analysis with the chi square test for nonparametric data and to analyse the accuracy of prediction we used the receiver - operator curves with the level of significance set at p < 0.05. Results: From 241 patients with a median age of 68 years, 127 (52.69%) were male.113 patients had severe sepsis. 89 patients (36.9%) died and male had an increase mortality rate. Most cases were respiratory sepsis (45.20%). The highest mortality rate was in septic shock (51.2%). Procalcitonin, C-reactive protein and glucose serum level at admittance were not correlated with mortality. The serum levels of creatinine >1.67 mg/dL and serum lactate >1.9 mmol/L at admittance were correlated with mortality (p < 0.01). The cutoff value of 121×103/uL platelets number was also correlated with mortality (p < 0.01). Conclusions: Our findings suggest that serum creatinine, serum lactate and the platelets number could be used as prognostic markers in septic patients at admittance.

scholarly journals FAKTOR YANG BERHUBUNGAN DENGAN STRES KERJA PADA PENYELAM DI PT. X

2015 ◽  
Vol 4 (1) ◽  
pp. 54
Author(s):  
Faris Lazwar Irkhami
Keyword(s):  
Correlation Coefficient ◽  
Job Stress ◽  
Pearson Correlation ◽  
Marine Animal ◽  
Chi Square ◽  
Cross Sectional ◽  
Correlation Test ◽  
Pearson Correlation Test ◽  
Chi Square Test ◽  
Cross Sectional Design

ABSTRACTStress can be perceived as a response to threats situations (either physical or psychological) caused by individual inability  to overcome existing threats within his/her environment. Job stress is the result of interaction between an individual (i.e. a worker) and his/her occupation. The objective of this study to identify the factor affecting tojob stress by the divers at PT. X. This study applied cross-sectional design conducted by observing the divers at PT. X. The population of this study was all divers working at PT. X. Data was analyzed by Spearman Correlation Test, Pearson Correlation Test, and Chi-square Test. The results of this study is strong correlation between personality type and job stress (as indicated by correlation coefficient 0.645). The divers’ age (correlation coefficient -0.283), educational level (correlation coefficient -0.220), years of service/experience (correlation coefficient -0.158), length of diving session (correlation coefficient 0.083), and threats of marine animal attack (correlation coefficient 0.156) had lower correlation with job stress. While the divers residence might also affect their job stress (as indicated by correlation coefficient 0.539).Keywords: job stress, diver

scholarly journals Usefulness of the heparin-binding protein level to diagnose sepsis and septic shock according to Sepsis-3 compared with procalcitonin and C reactive protein: a prospective cohort study in China

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e026527 ◽  
Author(s):  
Yixuan Zhou ◽  
Zhen Liu ◽  
Jun Huang ◽  
Guiling Li ◽  
Fengying Li ◽  
...  
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Roc Curve ◽  
Prospective Cohort ◽  
Heparin Binding ◽  
C Reactive Protein ◽  
Suspected Sepsis ◽  
Reactive Protein ◽  
Heparin Binding Protein ◽  
Sepsis And Septic Shock

ObjectivesOur aim was to assess the release level of heparin-binding protein (HBP) in sepsis and septic shock under theThird International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3).DesignProspective cohort study.SettingA general teaching hospital in China.ParticipantsAdult infected patients with suspected sepsis and people who underwent physical examination were included. According to the health status and severity of illness, the research subjects were divided into healthy, local infection, sepsis non-shock and septic shock under Sepsis-3 definitions.Main outcome measuresPlasma levels of HBP, procalcitonin (PCT), C reactive protein (CRP) and complete blood count were detected in all subjects. Single-factor analysis of variance was used to compare the biomarker levels of multiple groups. A receiver operating characteristic (ROC) curve was used to assess the diagnostic capacity of each marker.ResultsHBP levels were significantly higher in patients with sepsis non-shock than in those with local infections (median 49.7ng/mL vs 11.8 ng/mL, p<0.01) at enrolment. Moreover, HBP levels in patients with septic shock were significantly higher than in patients with sepsis without shock (median 153.8ng/mL vs 49.7 ng/mL, p<0.01). The area under the ROC curve (AUC) of HBP (cut-off ≥28.1 ng/mL) was 0.893 for sepsis which was higher than those of PCT (0.856) for a cut-off ≥2.05 ng/mL and of CRP (0.699) for a cut-off ≥151.9 mg/L. Moreover, AUC of HBP (cut-off ≥103.5 ng/mL) was 0.760 for septic shock which was higher than the ROC curve of sequential [sepsis-related] organ failure assessment (SOFA) Score (0.656) for a cut-off ≥5.5. However, there was no significant difference between 28-d survivors (n=56) and 28-d non-survivors (n=37) with sepsis in terms of HBP value (p=0.182).ConclusionsA high level of HBP in plasma is associated with sepsis, which might be a useful diagnostic marker in patients with suspected sepsis.

scholarly journals Triiodothyronine levels and mortality in children with sepsis and septic shock

2018 ◽  
Vol 1 (1) ◽  
pp. 20
Author(s):  
Cynthea Prima Destariani ◽  
Munar Lubis ◽  
Melda Deliana ◽  
Gema Nazri Yanni
Keyword(s):  
Septic Shock ◽  
General Hospital ◽  
Chi Square ◽  
Euthyroid Sick Syndrome ◽  
Risk Of Mortality ◽  
Low T3 ◽  
Chi Square Test ◽  
Observational Cohort ◽  
Sepsis And Septic Shock ◽  
Pelod Score

Background Sepsis is the most common cause of death in infants and children. It can cause hormonal imbalances, such as euthyroid sick syndrome (ESS), which may increase the risk of death.Objective To evaluate a possible correlation between the level of triiodothyronine (T3) and mortality in children with sepsis and septic shock.Methods An observational cohort study was conducted on 80 children with sepsis and septic shock from October 2015 until January 2016 in Haji Adam Malik General Hospital, Medan. Subjects underwent PELOD score and T3 examination on the first day admitted in Haji Adam Malik General Hospital. Chi-square test was used to analyze for a correlation between the T3 values and mortality. Results Of the 80 consecutive subjects, 39 (48.75%) had low T3 level on the first day. Of these 39 children, 36 (92.3%) died. Subjects with low T3 level had a 6.31 times higher risk of mortality(PR 6.31;  95%CI 2.99 to 13.28; P<0.001). Of the 31 subjects with high PELOD score, 23 (74.2%) had decreased T3 (PR=2.27; 95%CI 1.45 to 3.57; P<0.001).Conclusion Low T3 level has significant relationship with mortality in children with sepsis and septic shock.

Relation of heart rate variability to serum levels of C-reactive protein, interleukin 6, and 10 in patients with sepsis and septic shock

2009 ◽  
Vol 24 (4) ◽  
pp. 625.e1-625.e7 ◽  
Author(s):  
Vasilios E. Papaioannou ◽  
Christos Dragoumanis ◽  
Vasiliki Theodorou ◽  
Christos Gargaretas ◽  
Ioannis Pneumatikos
Keyword(s):  
Heart Rate ◽  
Septic Shock ◽  
Heart Rate Variability ◽  
Interleukin 6 ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Sepsis And Septic Shock

scholarly journals Qualitative C-reactive protein as a marker of neonatal sepsis in a tertiary neonatal unit in Sudan

2013 ◽  
Vol 1 (2) ◽  
pp. 21
Author(s):  
Abdelmoneim E. Kheir ◽  
Ghada A. Jobara ◽  
Kamal M. Elhag ◽  
Mohamed Z. Karar
Keyword(s):  
Risk Factors ◽  
Blood Culture ◽  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
University Hospital ◽  
C Reactive Protein ◽  
Chi Square ◽  
Reactive Protein ◽  
Chi Square Test ◽  
A Prospective Study

Sepsis is one of the most common causes of morbidity and mortality in newborns. Diagnosis of neonatal sepsis may be difficult because clinical presentations are often non-specific. The aim of this study was to evaluate the role of qualitative C-reactive protein in the diagnosis of neonatal sepsis, and examine the correlation between C-reactive protein, blood culture and risk factors for sepsis. This was a prospective study, conducted in the Neonatal Intensive Care Unit at Soba University Hospital, Sudan. A total of seventy babies with a clinical diagnosis of sepsis were included. Chi square test was used to determine the association between C-reactive protein and risk factors for sepsis and also the association between C-reactive protein and blood culture. Blood culture was positive in 41.4% of babies, and C-reactive protein was positive in 58% of babies with positive blood culture. There was significant association between C-reactive protein results and blood culture (P=0.00). In conclusion, we can assume that Creactive protein is a reliable diagnostic marker of neonatal sepsis, especially in developing communities with poor resources.

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