scholarly journals Economic and disease burden of RSV-associated hospitalizations in young children in France, from 2010 through 2018

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
C. Demont ◽  
N. Petrica ◽  
I. Bardoulat ◽  
S. Duret ◽  
L. Watier ◽  
...  
Keyword(s):  
Young Children ◽  
Economic Burden ◽  
Age Groups ◽  
Preventive Strategies ◽  
Older Children ◽  
Study Objective ◽  
Icd 10 ◽  
Syncytial Virus ◽  
French Hospital ◽  
French Hospital Database

Abstract Background Respiratory syncytial virus (RSV) is the main cause of infant and child hospitalizations. The study objective is to estimate the RSV-associated hospitalizations and economic burden in young children in France to inform future preventive strategies. Methods We conducted a retrospective analysis of RSV-associated hospitalizations data from the French Hospital database (PMSI-MCO) which covers the entire French population. All children aged < 5 years hospitalized with RSV ICD-10 codes (J210, J219, J45, J121, J205, R062) from 2010 to 2018, were included. Descriptive analyses were conducted by RSV seasons (Oct to March), by respiratory years (July to June) and per age groups. Results On average 45,225 RSV-associated hospitalizations (range: 43,715 – 54,616) per season was reported in France, 69% among children < 1 year old. This represents 28% of all-cause hospitalizations that occurred among children < 1 year old, and less than 10% of all-cause hospitalizations in older children. Number of RSV-associated hospitalizations were similar for infants born during (Oct-March) or outside (April–September) their first RSV season. The highest risk being reported for infants born from September through November. The associated hospitalization cost increased between 2010 - 11 and 2017–18, from €93.2 million to €124.1 million, respectively, and infants < 1 year old represented 80% of the economic burden. Conclusion RSV is an important cause of child hospitalization in France. The burden on healthcare system is mainly driven by < 1 year olds, and preventive strategies should be implemented before the first RSV season.

scholarly journals 1105. Vibriocidal Titer Variation and Likelihood of Protection in Children Compared With Adults in a Cholera Endemic Area

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S331-S331
Author(s):  
Alaina Ritter ◽  
Fahima Chowdhury ◽  
Rachel Becker ◽  
Taufiq Bhuiyan ◽  
Ashraful Khan ◽  
...  
Keyword(s):  
Young Children ◽  
Vaccine Development ◽  
Massachusetts General Hospital ◽  
Age Groups ◽  
Older Children ◽  
Baseline Serum ◽  
Household Contacts ◽  
Antibody Titers ◽  
Training Grant

Abstract Background Vibrio cholerae, the causative agent of cholera, is responsible for significant morbidity and mortality worldwide. Children less than 5 years old have the highest disease burden of cholera in endemic areas. While children develop serum vibriocidal antibody responses to cholera vaccines, they derive less protection from vaccination compared with adults. The aim of our study was to determine whether the vibriocidal immune responses to V. cholerae infection are equally accurate as markers of protection in all age groups. Methods Cholera patients and their household contacts, who are known to be at high risk of V. cholerae infection, were enrolled between 2001 and 2017 in Dhaka, Bangladesh. Baseline vibriocidal titers were measured at the time of enrollment of household contacts, and participants were followed prospectively for development of V. cholerae infection. Results We studied 50 contacts &lt; 5 years old (“young children”), 228 contacts 5–16 years old (“older children”), and 548 contacts &gt; 16 years old (“adults”). The baseline serum vibriocidal titer was higher in contacts who remained uninfected from all age groups than in contacts who developed cholera during the follow-up period (young children: P = 0.0092; older children: P = 0.0003, adults: P = 0.0012). Conclusion We found that higher vibriocidal antibody titers were associated with protection against V. cholerae infection across all three age categories. These findings may help increase our understanding of the protective immune response against V. cholerae infection and have importance for future vaccine development strategies. Acknowledgments: This research was supported by Massachusetts General Hospital training grant T32AI007061. Disclosures All authors: No reported disclosures.

scholarly journals Human Metapneumovirus: Etiological Agent of Severe Acute Respiratory Infections in Hospitalized and Deceased Patients with a Negative Diagnosis of Influenza

Pathogens ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 85
Author(s):  
Gisela Barrera-Badillo ◽  
Beatriz Olivares-Flores ◽  
Adriana Ruiz-López ◽  
Miguel Ángel Fierro-Valdez ◽  
Rosaura Idania Gutiérrez-Vargas ◽  
...  
Keyword(s):  
Young Children ◽  
Age Groups ◽  
Simultaneous Detection ◽  
Respiratory Viruses ◽  
Human Metapneumovirus ◽  
Late Winter ◽  
Older Individuals ◽  
Severe Acute Respiratory Infection ◽  
Syncytial Virus ◽  
Tract Infections

Human metapneumovirus (HMPV) is one of the four major viral pathogens associated with acute respiratory tract infections (ARI) and creates a substantial burden of disease, particularly in young children (<5 years) and older individuals (≥65 years). The objective of this study was to determine the epidemiological behavior of HMPV in Mexico. This retrospective study was conducted over a nine-year period and used 7283 influenza-negative respiratory samples from hospitalized and deceased patients who presented Severe Acute Respiratory Infection (SARI). The samples were processed with the help of qualitative multiplex RT-PCR for simultaneous detection of 14 respiratory viruses (xTAG® RVP FAST v2). 40.8% of the samples were positive for respiratory viruses, mainly rhinovirus/enterovirus (47.6%), respiratory syncytial virus (15.9%), HMPV (11.1%) and parainfluenza virus (8.9%). Other respiratory viruses and co-infections accounted for 16.5%. HMPV infects all age groups, but the most affected group was infants between 29 days and 9 years of age (65.6%) and adults who are 40 years and older (25.7%). HMPV circulates every year from November to April, and the highest circulation was observed in late winter. The results of this study aim to raise awareness among clinicians about the high epidemiological impact of HMPV in young children and older individuals in order to reduce the economic burden in terms of health care costs.

Why does relational binding improve across early childhood? Testing the effects of interference and sleep-filled delays

2020 ◽  
Author(s):  
Susan L. Benear ◽  
Chi Ngo ◽  
Ingrid R. Olson ◽  
Nora Newcombe
Keyword(s):  
Early Childhood ◽  
Young Children ◽  
Episodic Memory ◽  
Memory Performance ◽  
Age Groups ◽  
Developmental Period ◽  
Older Children ◽  
Spatiotemporal Information ◽  
Episodic Memories ◽  
Over Time

Episodic memory consists of distinctive experiences, with specific spatiotemporal information about what happened maintained over time. These memories typically share overlapping elements in distinctive combinations. In this study, we evaluated: (1) whether overlapping elements pose a differential challenge for younger children; and (2) whether a sleep-filled delay stabilizes or even improves children’s episodic memories, and if so, whether effects vary by age. We compared memory for unique and overlapping pairs of visual stimuli, presented once to 4- and 6-year-old children, tested immediately and after a 24-hour delay. As expected, older children outperformed younger children, and both age groups performed worse on overlapping pairs. However, overlapping elements were not differentially problematic for young children, and a sleep-filled delay in testing resulted in decrements in memory performance, for both age groups on both pair types. Despite overall differences in accuracy, important aspects of episodic memory are similar across this key developmental period.

Differences in Cyto- and Molecular Genetic Abnormalities between Children <2 Years and Older Children with Acute Myeloid Leukemia.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 1830-1830
Author(s):  
Brian V. Balgobind ◽  
Iris H. Hollink ◽  
Dirk Reinhardt ◽  
Jutta Bradtke ◽  
Andrea Teigler-Schlegel ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Young Children ◽  
Myeloid Leukemia ◽  
Molecular Genetic ◽  
Age Groups ◽  
Normal Karyotype ◽  
Older Children ◽  
Ras Mutations ◽  
Genetic Abnormalities ◽  
Acute Myeloid

Abstract Young children (defined as &lt;2 years old) with acute myeloid leukemia (AML) do not differ in outcome when compared with older children with AML. Previously, distinct cytogenetic aberrations specific for AML in young children have been reported, such as t(7;12), and t(1;22), which is found exclusively in FAB M7. Moreover, young children with AML are characterized by a high frequency of 11q23-rearrangements. However, so far, no information is available on differences in the molecular genetic background of these two age groups. We therefore retrospectively investigated the distribution of different cytogenetic and molecular aberrations in a large cohort (n=435) of pediatric AML cases, of which 75 (17%) were young children. The predominant cytogenetic aberration in infant AML consisted of 11q23-rearrangements, which occurred in 44% of young children versus 17% in older children (p=&lt;0.005), without differences in the distribution of 11q23-translocation partners. We also found significant differences in other cytogenetic subgroups of AML between young and older children, i.e. normal karyotype, 5% vs. 18%, respectively (p=0.008) and complex karyotype, 12% vs. 5% (p=0.03). t(7;12) (n=3) and t(8;16) (n=3) were only detected in young children, in contrast to t(15;17) (n=16) and t(8;21) (n=44), which were only seen in older children. Patients were also screened for molecular abnormalities, including the mutational hotspots of c-KIT (n=229), FLT3 (n=230), N-RAS (n=187), K-RAS (n=187), PTPN11 (n=216), MLL-partial tandem duplications (MLL-PTD) (n=240) and NPM1 (n=291). In the overall cohort, a significantly different age distribution was found for NPM1 mutations (0% young vs. 9% in older children; p=0.05) and FLT3-ITD (0% vs. 21%, respectively; p=0.005). Mutations in the other genes showed no clear correlation with age. Several non-random associations between molecular and cytogenetic abnormalities were detected. 89% of c-KIT mutations were associated with core-binding factor AML in children ≥2 years old. In young children, 2/4 c-KIT-mutated cases were associated with an MLL-rearrangement. NPM1 and FLT3-ITD mutations in older children were significantly correlated with normal karyotype AML (57% of NPM1 mutations, and 75% of FLT3/ITD; p=&lt;0.005). In young children, 71% of RAS mutations were associated with an 11q23-rearrangement vs. 28% in older children (p=0.08). In older children however, 41% of the RAS mutations were associated with a normal karyotype. These data suggest that young children with AML are characterized by differences in the type and frequency of cytogenetic and molecular genetic abnormalities when compared with older children with AML, possibly reflecting differences in underlying biology between these age-groups. These differences may become clinically relevant in the era of molecularly targeted therapy.

scholarly journals Comparison of Memory B Cell, Antibody-Secreting Cell, and Plasma Antibody Responses in Young Children, Older Children, and Adults with Infection Caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh

2011 ◽  
Vol 18 (8) ◽  
pp. 1317-1325 ◽  
Author(s):  
Daniel T. Leung ◽  
Mohammad Arif Rahman ◽  
M. Mohasin ◽  
M. Asrafuzzaman Riyadh ◽  
Sweta M. Patel ◽  
...  
Keyword(s):  
Young Children ◽  
Immune Responses ◽  
B Cell ◽  
Protective Efficacy ◽  
Age Groups ◽  
Older Children ◽  
Secreting Cell ◽  
Content Type ◽  
Antibody Secreting Cell ◽  
Plasma Antibody

ABSTRACTChildren bear a large component of the global burden of cholera. Despite this, little is known about immune responses to cholera in children, especially those under 5 years of age. Cholera vaccine studies have demonstrated lower long-term protective efficacy in young children than in older children and adults. Memory B cell (MBC) responses may correlate with duration of protection following infection and vaccination. Here we report a comparison of immune responses in young children (3 to 5 years of age;n= 17), older children (6 to 17 years of age;n= 17), and adults (18 to 60 years of age;n= 68) hospitalized with cholera in Dhaka, Bangladesh. We found that young children had lower baseline vibriocidal antibody titers and higher fold increases in titer between day 2 and day 7 than adults. Young children had higher baseline IgG plasma antibody levels toVibrio choleraeantigens, although the magnitudes of responses at days 7 and 30 were similar across age groups. As a surrogate marker for mucosal immune responses, we assessed day 7 antibody-secreting cell (ASC) responses. These were comparable across age groups, although there was a trend for older age groups to have higher levels of lipopolysaccharide-specific IgA ASC responses. All age groups developed comparable MBC responses toV. choleraelipopolysaccharide and cholera toxin B subunit at day 30. These findings suggest that young children are able to mount robust vibriocidal, plasma antibody, ASC, and MBC responses againstV. choleraeO1, suggesting that under an optimal vaccination strategy, young children could achieve protective efficacy comparable to that induced in adults.

Candy Cigarettes: Do They Encourage Children's Smoking?

PEDIATRICS ◽  
1992 ◽  
Vol 89 (1) ◽  
pp. 27-31
Author(s):  
Jonathan D. Klein ◽  
Billie Forehand ◽  
Janice Oliveri ◽  
Charlotte J. Patterson ◽  
Janis B. Kupersmidt ◽  
...  
Keyword(s):  
Young Children ◽  
Age Groups ◽  
Smoking Behavior ◽  
Older Children ◽  
Snack Foods ◽  
Smoking Behaviors ◽  
Children's Attitudes ◽  
Group Interviews ◽  
Attitudes Toward Smoking

Candy and bubble gum cigarettes are packaged to resemble cigarette brands, and so they may encourage young children to smoke. Two studies of the role of these products in the development of children's attitudes and behaviors toward smoking were conducted. In the first study, six focus group interviews were conducted with 25 children in three age groups (4 through 5, 6 through 8, and 9 through 11 years old). Children in each group were shown five candy and snack foods and asked about their opinions and experiences with each item. In the second study, 195 seventh-grade students in a southeastern city school system were surveyed about their cigarette smoking and candy cigarette use. In the focus groups, candy cigarettes were recognized by most children. Young children played with the candy cigarettes more than with other candy or snack items and made general references to smoking behaviors. Older children made favorable references to smoking behavior; most knew which stores sold candy cigarettes, and many had chosen to buy and use these items, despite parental disapproval. Candy cigarettes may play a role in the development of children's attitudes toward smoking as an acceptable, favorable, or normative behavior. Elimination of these products should be part of efforts to prevent initiation of smoking by children.

scholarly journals Hospitalizations associated with respiratory syncytial virus (RSV) and influenza in children, including children having a diagnosis of asthma

2017 ◽  
Author(s):  
E. Goldstein ◽  
L. Finelli ◽  
A. O’Halloran ◽  
P. Liu ◽  
Z. Karaca ◽  
...  
Keyword(s):  
Young Children ◽  
Additional Data ◽  
Age Groups ◽  
Previous History ◽  
Asthma Diagnosis ◽  
Target Groups ◽  
Relative Risks ◽  
Hospitalization Rates ◽  
Syncytial Virus ◽  
Us Children

AbstractBackgroundThere is uncertainty about the burden of hospitalization associated with RSV and influenza in children, including those with underlying medical conditions.MethodsWe applied previously developed methodology (Goldstein et al., Epidemiology 2012) to HealthCare Cost and Utilization Project (HCUP) hospitalization data and additional data related to asthma diagnosis/previous history in hospitalized children to estimate RSV and influenza-associated hospitalization rates in different subpopulations of US children between 2003-2010.ResultsThe estimated average annual rates (per 100,000 children) of RSV-associated hospitalization with a respiratory cause (ICD-9 codes 460-519) present anywhere in the discharge diagnosis were 2381 (95% CI(2252,2515)) in age <1y; 710.6(609.1,809.2) (age 1y); 395(327.7,462.4) (age 2y); 211.3(154.6,266.8) (age 3y); 111.1(62.4,160.1) (age 4y); 72.3(29.3,116.4) (ages 5-6y); 35.6(9.9,62.2) (ages 7-11y); and 39(17.5,60.6) (ages 12-17y).The corresponding rates of influenza-associated hospitalization were lower, ranging from 181(142.5,220.3) in age <1y to 17.9(11.7,24.2) in ages 12-17y. The relative risks for RSV-related hospitalization associated with a prior diagnosis of asthma in age groups under 5y ranged between 3.1(2.1,4.7) (age <1y) to 6.7(4.2,11.8) (age 2y); the corresponding risks for influenza-related hospitalization ranged from 2.8(2.1,4) (age <1y) to 4.9(3.8,6.4) (age 3y).ConclusionsRSV-associated hospitalization rates in young children are high and decline rapidly with age. Young children with an asthma diagnosis should be target groups for RSV and influenza-related mitigation efforts, possibly including RSV prophylaxis for the youngest children.

Japanese children’s awareness of the effects of psychological taste experiences on biological processes

2016 ◽  
Vol 40 (5) ◽  
pp. 408-419
Author(s):  
Noriko Toyama
Keyword(s):  
Young Children ◽  
Psychological Factors ◽  
Age Groups ◽  
Biological Processes ◽  
Older Children ◽  
Bodily States

The present study examined Japanese children’s and adults’ awareness of the effects of psychological taste experiences on biological processes such as growth and illness. Studies 1 and 2 showed the following: (1) preschoolers tended to assume that good-tasting experiences would make one grow taller and gain more weight, while adults seldom accepted such ideas. Concerning illness, participants in all age groups were reluctant to accept the effects of taste experiences. (2) Process-dependent awareness (i.e., effects of psychological factors were assumed to depend on biological processes) was observed not only among young children, but also in older children and adults. Compared with younger children, adults’ responses were more process sensitive. (3) When adults explained why they assumed that different taste experiences would lead to different bodily states, they often relied on vitalistic causality. The use of vitalistic concepts was uncommon among children. Finally, (4) Japanese participants seem to be more likely than Americans to assume that bad-tasting experiences would make them non-resistant to a cold.

scholarly journals Disease Burden Due to Respiratory Syncytial Virus in Indian Pediatric Population: A Literature Review

2021 ◽  
Vol 15 ◽  
pp. 117955652110292
Author(s):  
Canna Ghia ◽  
Gautam Rambhad
Keyword(s):  
Respiratory Syncytial Virus ◽  
Young Children ◽  
Literature Review ◽  
Indian Pediatric ◽  
Disease Burden ◽  
Pediatric Population ◽  
Age Groups ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
Tract Infections

Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infections in young children. Globally, there is huge disease burden, high treatment cost, and health impact beyond acute episodes due to RSV which necessitate development and implementation of preventive strategies for the control of RSV infection. The disease burden due to RSV in pediatric population across India is still not clearly understood so this literature review was therefore conducted to gather data on disease burden due to RSV in Indian pediatric population. Systematic literature search was performed using PubMed and Google search with different medical subject headings from 2007 to 2020. Studies performed in Indian pediatric population were selected for review. Literature review revealed that in India, epidemiology of RSV infection is well documented in young children (0-5 years) as compared to children from other age groups. The rates of RSV detection in various studies conducted in younger children (0-5 years) vary from 2.1% to 62.4% in India which is higher as compared to children from other age groups. In India, RSV mainly peaks around rainy to early winter season, that is, during months of June through October while smaller peak was noted during December, January, and February. In 2020, higher RSV-associated disease burden was reported among children (<5 years) in low-income and lower-middle-income countries. Considering significant disease burden due to RSV in young Indian children, availability of RSV vaccine would be crucial to prevent RSV infections in children and its spread in the community.

Anticipatory Coarticulation in the Speech of Adults and Young Children

1991 ◽  
Vol 34 (6) ◽  
pp. 1222-1232 ◽  
Author(s):  
William F. Katz ◽  
Clarissa Kripke ◽  
Paula Tallal
Keyword(s):  
Young Children ◽  
Age Groups ◽  
Video Data ◽  
The Other ◽  
Older Children ◽  
Adults And Children

Three experiments investigated anticipatory lingual and labial coarticulation in the [sV] productions of children and adults. Acoustic, perceptual, and video data were used to trace the development of intrasyllabic coarticulation in the speech of adults and children (ages 3, 5, and 8 years). Although children show greater variability in their articulatory patterns than adults, the data do not support claims that young children produce a greater degree of intrasyllabic coarticulation than older children or adults. Rather, the acoustic and video data suggest that young children and adults produce similar patterns of anticipatory coarticulation, and the perceptual data indicate that coarticulatory cues in the speech of 3-year-old children are less perceptible than those of the other age groups.

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