scholarly journals Higher body mass index indicated better overall survival in pancreatic ductal adenocarcinoma patients: a real-world study of 2010 patients

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ningzhen Fu ◽  
Yu Jiang ◽  
Kai Qin ◽  
Hao Chen ◽  
Xiaxing Deng ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Overall Survival ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Body Mass ◽  
Positive Association ◽  
High Volume ◽  
World Health ◽  
Ductal Adenocarcinoma ◽  
High Volume Center ◽  
Health Organization

Abstract Background The association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear, Method A total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses. Result BMI was linearly related to the OS (total P = 0.004, nonlinear P = 0.124). BMI was analyzed as categorical data based on X-tile software-defined cutoffs and World Health Organization (WHO)-recommended cutoffs. Adjusted with confounding covariates, higher BMI manifested as a positive prognostic predictor. Furthermore, BMI was proven to be associated with the OS in the PS analysis. (UnderweightXtile vs. NormalXtileP = 0.003, OverweightXtile vs. NormalXtileP = 0.019; UnderweightWHO vs. NormalWHOP < 0.001, OverweightWHO vs. NormalWHOP = 0.024). It was also revealed that patients with higher BMI benefitted more from chemotherapy. (Adjusted hazard ratio (aHR): UnderweightXtile vs. NormalXtile vs. OverweightXtile: 0.565 vs. 0.474 vs. 0.409; UnderweightWHO vs. NormalWHO vs. OverweightWHO: 0.613 vs. 0.464 vs. 0.425). Conclusion Among PDAC patients, there was a positive association between BMI and the OS, especially in patients treated with chemotherapy.

scholarly journals Higher BMI Indicated Better Overall Survival Prognosis of Pancreatic Ductal Adenocarcinoma: A Real-World Study Based on 2,010 Cases

2021 ◽  
Author(s):  
Ningzhen FU ◽  
Yu JIANG ◽  
Kai QIN ◽  
Xiaxing DENG ◽  
Hao CHEN ◽  
...  
Keyword(s):  
Overall Survival ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Categorical Data ◽  
High Volume ◽  
World Health ◽  
Ductal Adenocarcinoma ◽  
Survival Prognosis ◽  
Chemotherapy Administration ◽  
High Volume Center ◽  
Health Organization

Abstract Background: Whether body mass index (BMI) was associated with the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) remained controversial and uncertain.Method: A total of 2,010 patients from single high-volume center were enrolled in the study. OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses. Result: BMI was discovered linear related with OS (total P=0.004, non-linear P=0.124). BMI was analyzed as categorical data based on X-tile software defined cutoffs and World Health Organization (WHO) recommended cutoffs, respectively. Adjusted with confounding covariates, higher BMI manifested as a positive prognostic predictor. (PXtile=0.003, PWHO=0.002) Furtherly, BMI was proven associated with OS in PS analysis. (UnderweightXtile vs. NormalXtile P=0.003, OverweightXtile vs. NormalXtile P=0.019; UnderweightWHO vs. NormalWHO P<0.001, OverweightWHO vs. NormalWHO P=0.024). It was also revealed that patients with higher BMI benefitted more from chemotherapy.(adjusted hazard ratio (aHR): UnderweightXtile: 0.565 (0.389-0.819), NormalXtile: 0.474 (0.395-0.567), OverweightXtile: 0.409 (0.337-0.496); UnderweightWHO: 0.613 (0.401-0.940), NormalWHO: 0.464 (0.387-0.557), OverweightWHO: 0.425 (0.353-0.512)). Conclusion: Among PDAC patients, higher BMI manifested as a favorable OS indicator, and the protective impact was probably based on chemotherapy administration. Patients with higher BMI were also observed with more chemotherapy administration and more OS benefits from chemotherapy.

scholarly journals Comparative analysis of children’s physical development in different age groups in Voronezh region 15 years apart (1997-1999 and 2011-2014)

2017 ◽  
Vol 98 (3) ◽  
pp. 433-439
Author(s):  
O A Zhdanova
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Body Height ◽  
Age Groups ◽  
Physical Development ◽  
World Health ◽  
Who Standards ◽  
Voronezh Region ◽  
Health Organization

Aim. To investigate physical development of children in Voronezh region in different age groups in 2011-2014 in comparison with the regional studies data in 1997-1999. Methods. The study was performed on 5644 children aged 1-18 years of health groups I and II in comparison with the data of 10 247 children aged 1-14 years examined in 1997-1999. Body height, weight and body mass index Z-scores, calculated using WHO AnthroPlus software, were evaluated. Results. Children’s Z-score values for body height in 2011-2014 were higher than in 1997-1999 in all age groups and at the age of 1-9 years these values exceeded World Health Organization (WHO) standards. Girls’ height approached the standards in 10-14 and 15-18 years, and boys’ height - in 15-18 years. Body weight of children aged 2-8 years was higher than the regional data in 1997-1999 and WHO standards approaching them at the age of 9. Body mass index increase compared to WHO standards was revealed in children aged 1-4 years (p=0.000), and in 2011-2014 the reported differences were less prominent than in 1997-1999. In 2011-2014 among 15-18-years-old girls the shift of body mass index values to the lack of body weight was noted, in 1997-1999 the same changes were found out for 10-14-years-old girls. Conclusion. In 2011-2014 specific attention was required to be paid to physical development of children at the age from 1 to 4 years due to overweight risk of and girls aged 15-18 years due to probable underweight risk.

scholarly journals Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Chunyuan Jiang ◽  
Ruijuan Yang ◽  
Maobin Kuang ◽  
Meng Yu ◽  
Mingchun Zhong ◽  
...  
Keyword(s):  
Body Mass Index ◽  
High Risk ◽  
Diagnostic Criteria ◽  
Body Mass ◽  
Cox Regression ◽  
Risk Groups ◽  
World Health ◽  
Obese People ◽  
Cox Regression Analysis ◽  
Health Organization

Abstract Background Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated. Methods More than 100,000 subjects with normal glucose at baseline received follow-up. The main outcome event of concern was pre-diabetes defined according to the diagnostic criteria recommended by the American Diabetes Association (ADA) in 2018 and the World Health Organization (WHO) in 1999. A Cox proportional hazard regression model was used to evaluate the role of TyG-BMI in identifying people at high risk of pre-diabetes. Results At a mean observation period of 3.1 years, the incidence of pre-diabetes in the cohort was 3.70 and 12.31% according to the WHO and ADA diagnostic criteria for pre-diabetes, respectively. The multivariate Cox regression analysis demonstrated that TyG-BMI was independently positively correlated with pre-diabetes, and there was a special population dependence phenomenon. Among them, non-obese people, women and people under 50 years old had a significantly higher risk of TyG-BMI-related pre-diabetes (P-interaction< 0.05). Conclusions These findings suggest that a higher TyG-BMI significantly increases an individual’s risk of pre-diabetes, and this risk is significantly higher in women, non-obese individuals, and individuals younger than 50 years of age.

scholarly journals Obesity in children and adolescents: diagnosis criteria

2019 ◽  
Vol 16 (1) ◽  
pp. 70-73
Author(s):  
Olga V. Vasyukova
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Physical Development ◽  
World Health ◽  
Diagnostic Parameter ◽  
International Group ◽  
The World ◽  
Health Organization ◽  
Diagnosis Criteria ◽  
Obesity In Children

Currently in the world the main diagnostic parameter for assessing obesity is the magnitude of body mass index. In children, taking into account the growth and body weight indicators that dynamically change as the child grows up, it is common to use not absolute, but relative values of body mass index percentiles or standard deviations. The lecture examined various systems and methods for assessing the physical development of children in the world and in Russia domestic ones, R.N. Dorokhova and I.I. Bakhraha, World Health Organization (WHO), International Group for the Study of Obesity. A comparative analysis of the existing systems and the validity of the currently adopted Federal recommendations on the diagnosis of obesity in children based on the recommendations of WHO has been carried out.

Children Exposed or Unexposed to Human Immunodeficiency Virus: Weight, Height, and Body Mass Index During the First 5 Years of Life—A Danish Nationwide Cohort

2019 ◽  
Vol 70 (10) ◽  
pp. 2168-2177
Author(s):  
Ellen Moseholm ◽  
Marie Helleberg ◽  
Håkon Sandholdt ◽  
Terese L Katzenstein ◽  
Merete Storgaard ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Well Being ◽  
World Health ◽  
Control Group ◽  
Growth Chart ◽  
Significant Difference ◽  
Negative Effect ◽  
Z Scores ◽  
Health Organization

Abstract Background Exposures to human immunodeficiency (HIV) and antiretroviral therapy in utero may have adverse effects on infant growth. Among children born in Denmark and aged 0–5 years, we aimed to compare anthropometric outcomes in HIV-exposed but uninfected (HEU) children with those in children not exposed to HIV. Methods In a nationwide register-based study we included all singleton HEU children born in Denmark in 2000–2016. HEU children were individually matched by child sex, parity, and maternal place of birth to 5 singleton controls born to mothers without HIV. Weight-for-age z (WAZ) scores, length-for-age z (LAZ) scores, and weight-for-length or body mass index–for–age z scores were generated according to the World Health Organization standards and the Fenton growth chart for premature infants. Differences in mean z scores were analyzed using linear mixed models, both univariate and adjusted for social and maternal factors. Results In total, 485 HEU children and 2495 HIV-unexposed controls were included. Compared with controls, HEU children were smaller at birth, with an adjusted difference in mean WAZ and LAZ scores of −0.29 (95% confidence interval [CI], −.46 to −.12) and −0.51 (95% CI, −.71 to −.31), respectively (both P ≤ .001). Over time, there was a trend toward increasing WAZ and LAZ scores in HEU children, and there was no significant difference in adjusted WAZ scores after age 14 days (−0.13 [95% CI, −.27 to .01]; P = .07) and LAZ scores after age 6 months (−0.15 [95% CI, −.32 to .02]; P = .08). Conclusion Compared with a matched control group, HEU children were smaller at birth, but this difference decreased with time and is not considered to have a negative effect on the health and well-being of HEU children during early childhood.

scholarly journals Second-Look Operation for Unresectable Pancreatic Ductal Adenocarcinoma at a High-Volume Center

2007 ◽  
Vol 15 (1) ◽  
pp. 186-192 ◽  
Author(s):  
Christoph W. Michalski ◽  
Jörg Kleeff ◽  
Jeannine Bachmann ◽  
Jaber AlKhatib ◽  
Mert Erkan ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
High Volume ◽  
Ductal Adenocarcinoma ◽  
Second Look ◽  
High Volume Center ◽  
Second Look Operation

scholarly journals Comparison of body mass index values proposed by Cole et al. (2000) and Must et al. (1991) for identifying obese children with weight-for-height index recommended by the World Health Organization

2003 ◽  
Vol 6 (3) ◽  
pp. 307-311 ◽  
Author(s):  
Marcelo Militão Abrantes ◽  
Joel Alves Lamounier ◽  
Enrico Antônio Colosimo
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
World Health ◽  
Overweight Children ◽  
Obese Children ◽  
North East ◽  
Life Pattern ◽  
Definition Of ◽  
Health Organization ◽  
Sensitivity Specificity

AbstractObjectives:To calculate the sensitivity, specificity and agreement of body mass index (BMI) values proposed by Cole et al. (Br. Med. J. 2000; 320: 1) and Must et al. (Am. J. Clin. Nutr. 1991; 53: 839 & 54: 773) with weight-for-height index in the nutritional evaluation of children.Design:Criterion standards for diagnostic tests.Setting:North-east and south-east Brazil.Subjects:Two thousand nine hundred and twenty children studied in Life Pattern Research performed by the Brazilian Institute of Geography and Statistics in 1997. Main outcome measures are the sensitivity, specificity and agreement of BMI values proposed by Must et al. (1991) and Cole et al. (2000).Results:Sensitivity of values proposed by both authors was around 90%. Specificity was almost 100% considering weight-for-height index as the gold standard. The agreement of both values with weight-for-height index, based on kappa results, was good and in pre-school children it was excellent.Conclusions:Values proposed by Cole et al. (2000) and Must et al. (1991) should be used carefully to screen obesity in childhood but can be used to ‘diagnose’ overweight children with a very low chance of having false-positive results. Although the values proposed by both authors performed similarly, use of Cole et al.'s values should be encouraged. The latter cover children from 2 to 6 years old; their values are presented for six-month age intervals; they are based on a larger sample from six different countries; and they are related to the definition of adult obesity.

scholarly journals Association Between Body Mass Index and Blood Pressure Among Medical Students of Tertiary Care Teaching Hospital in Birgunj

2021 ◽  
Vol 6 (2) ◽  
pp. 1535-1539
Author(s):  
Esha Shrestha ◽  
Shreesh Shrestha ◽  
Prashanna Shrestha ◽  
Nirjala Laxmi Madhikarmi
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Medical Students ◽  
Body Mass ◽  
Tertiary Care ◽  
Mean Value ◽  
Overweight And Obesity ◽  
World Health ◽  
The Mean ◽  
Health Organization

Introduction: Body mass index is an important parameter associated with a variety of disease processes. The risk of hypertension and cardiovascular diseases increases with an increase in body mass index. The study was conducted to compare the relationship between body mass index and blood pressure. Objective: To evaluate the prevalence and correlate the Obesity and Hypertension in    medical students  Methodology: The study was conducted in 200 students (113 males and 87 females). Height, weight and blood pressure were recorded from all participants and body mass index was calculated. The recorded body mass index was utilized to divide the student into underweight, normal, over weight and obese category according to the World Health organization body mass index classification. Hypertension was determined from the measure of blood pressure. Then comparison of blood pressure with body mass index was made. Results: Among 200 students 6% were obese, 22% were overweight, 65% were normal and 7% underweight. The mean height was 163cm and mean weight 60.48kg. The mean value of systolic blood pressure (105.85, 115.45, 134.95, 137.16 mmHg) and diastolic blood pressure (70.14, 76.15, 90.72, 93.33 mmHg) increased with increasing body mass index. Conclusion: Overweight and obesity increases the risk of hypertension among students.

scholarly journals Impact of Body Mass Index on Complications and Survival after Surgery for Esophageal and Gastro-Esophageal-Junction Cancer

2017 ◽  
Vol 106 (4) ◽  
pp. 305-310 ◽  
Author(s):  
I. Kruhlikava ◽  
J. Kirkegård ◽  
F. V. Mortensen ◽  
D. W. Kjær
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Survival Rates ◽  
Normal Weight ◽  
World Health ◽  
Danish Population ◽  
Oncological Treatment ◽  
Age At Surgery ◽  
Health Organization ◽  
The Impact

Background and Aims: The impact of body mass index on complications and survival in patients undergoing esophagectomy has been extensively studied with conflicting results. In this study, we assess the impact of body mass index on complications and survival following surgery for esophageal and gastro-esophageal-junction cancer in a Danish population. Material and Methods: We identified 285 consecutive patients, who underwent curative-intended treatment for esophageal and gastro-esophageal-junction cancer in the period 2003–2010. We manually reviewed the electronic medical records of all patients included in the study. Body mass index was calculated as weight in kilograms divided by height in meters squared. We grouped patients according to their body mass index, using the World Health Organization definition, as underweight (body mass index < 18.5 kg/m2), normal weight (body mass index: 18.5–24.9 kg/m2), overweight (body mass index: 25–29.9 kg/m2), and obese (body mass index ⩽ 30 kg/m2). Results: Median age at surgery was 65 years (range: 27–84 years), of which 207 (72.6%) were males. Patients with the lowest body mass index and the obese patients seemed to have a higher frequency of minor complications. Anastomotic leakage occurred in less than 10% of the patients and was equally distributed across the groups as was the other major complications. There were no differences in the 1-, 2-, or 5-year survival rates between the four body mass index groups after adjustment for possible confounders. Five-year survival rates for the four body mass index groups were 31.8%, 28.7%, 27.9%, and 26.1%, respectively. Conclusion: Body mass index over 30 or under 18.5 does not seem to affect survival rates or the presence of serious postoperative complications following esophagectomy in patients with esophageal and gastro-esophageal-junction cancers not receiving neoadjuvant oncological treatment.

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