scholarly journals Coagulopathy and its associated factors among patients with a bleeding diathesis at the University of Gondar Specialized Referral Hospital, Northwest Ethiopia

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Melak Aynalem ◽  
Elias Shiferaw ◽  
Yemataw Gelaw ◽  
Bamlaku Enawgaw
Keyword(s):  
Chronic Diseases ◽  
Associated Factors ◽  
Test Tube ◽  
Referral Hospital ◽  
Bleeding Diathesis ◽  
Coagulation Test ◽  
Factor Deficiency ◽  
Coagulation Tests ◽  
The University ◽  
Study Participants

Abstract Background Coagulopathy is the major cause of mortality and morbidity throughout the world. Globally, about 26–45% of healthy people have a history of bleeding symptoms, which may be a result of thrombocytopenia, factor deficiency, or pathological inhibitory. Objective To assess coagulopathy and its associated factors among patients with bleeding diathesis at the University of Gondar Specialized Referral Hospital from January to May 2020. Method A cross-sectional study was conducted on 384 study participants with bleeding diathesis recruited by using a convenient sampling technique. Socio-demographic and clinical characteristics were collected by using questioners. Then 6 ml venous blood was collected with a needle and syringe method. About 3 ml blood was transferred to EDTA test tube for platelet count and 2.7 ml blood was transferred to a test tube containing 0.3 ml of 3.2% sodium citrated anticoagulant for coagulation test. For those study participants with prolonged coagulation tests, a mixing test was done. Blood film and stool examination were also done for malaria and intestinal parasite identification, respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS version-20 for analysis. Descriptive statistics were summarized as percentages, means, and standard deviations. Bivariate and multivariate logistic regression was used to identify the associated factors, and a P-value less than 0.05 was considered statistically significant. Results In this study, the prevalence of coagulopathy was 253/384 (65.9%; 95% CI: 61.16, 70.64). From them, 21.3% (54/253), 51.4% (130/253), and 27.3% (69/253) had only thrombocytopenia, only prolonged coagulation test, and mixed abnormality, respectively. Among participants with prolonged coagulation time, the prevalence of factor deficiency was 21.1% (42/199). Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy. Conclusion In this study, coagulopathy due to inhibitory was a public health problem. The participants with cardiac and other chronic diseases were at high risk for coagulopathy. Therefore, mixing tests could be done for all prolonged coagulation tests and it could be considered as a routine laboratory test.

Coagulopathy and Its Associated Factors Among Bleeding Diathesis Patients Attending at University of Gondar Specialized Referral Hospital, Northwest Ethiopia.

2020 ◽  
Author(s):  
Melak Aynalem ◽  
Elias Shiferaw ◽  
Yemataw Gelaw ◽  
Bamlaku Enawgaw
Keyword(s):  
Associated Factors ◽  
Public Health Problem ◽  
Test Tube ◽  
Referral Hospital ◽  
Stool Examination ◽  
P Value ◽  
Bleeding Diathesis ◽  
Coagulation Test ◽  
Factor Deficiency ◽  
Study Participants

Abstract Background: Coagulopathy is the major cause of mortality and morbidity throughout the world. Globally, about 26 - 45% of healthy people have a history of bleeding symptoms, which may be a result of thrombocytopenia, factor deficiency, or pathological inhibitory.Objective: To assess coagulopathy and its associated factors among bleeding diathesis patients attending at University of Gondar Specialized Referral Hospital from January to May 2020.Method: A cross-sectional study was conducted on 384 study participants with bleeding diathesis recruited by using a convenient sampling technique. Socio-demographic and clinical characteristics were collected by using questioners. Then 6ml venous blood was collected with a needle and syringe method. About 3ml blood was transferred to EDTA test tube for platelet count and 2.7ml blood was transferred to a test tube containing 0.3ml of 3.2% sodium citrated anticoagulant for coagulation test. For those study participants with prolonged coagulation tests, a mixing test was done to differentiate the causes of coagulopathy whether factor deficiency or inhibitors. Blood film and stool examination were also done for malaria and intestinal parasite identification, respectively. The data were entered into EPI-Info version 3.5.3 and then transferred to SPSS version-20 for analysis. Descriptive statistics were summarized as percentages, means, and standard deviations. Bivariate and multivariate logistic regression was used to identify the associated factors, and a P-value less than 0.05 was considered as statistically significant.Results: In this study, the prevalence of coagulopathy was 253/384 (65.9%; 95% CI: 61.16, 70.64). From them, 21.3% (54/253), 51.4% (130/253), and 27.3% (69/253) had only thrombocytopenia, only prolonged coagulation test, and mixed abnormality, respectively. Among participants with prolonged coagulation time, the prevalence of factor deficiency was 21.1% (42/199). Cardiac disease (AOR = 4.80; 95% CI: 2.65, 23.1), and other chronic diseases (AOR = 8.1; 95% CI: 1.84, 35.58) were significantly associated with coagulopathy.Conclusion: Coagulopathy due to inhibitory was a public health problem. The participant with cardiac and other chronic disease was associated with coagulopathy. Therefore, mixing tests could done for all prolonged coagulation test and it could be considered as a routine laboratory test.

scholarly journals Magnitude of visual impairment and associated factors among patients attending ophthalmic clinics of Debre Markos referral hospital, north West Ethiopia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haimanot Abebe ◽  
Fasil Wagnew ◽  
Haymanot Zeleke ◽  
Bitew Tefera ◽  
Shegaw Tesfa ◽  
...  
Keyword(s):  
Visual Impairment ◽  
Associated Factors ◽  
Care Service ◽  
Referral Hospital ◽  
Multivariable Logistic Regression Analysis ◽  
North West ◽  
Rural Residency ◽  
North West Ethiopia ◽  
Debre Markos ◽  
Study Participants

Abstract Background Globally, visual impairment affects about 285 million (4.25%) people, of those, 266.4 million were adults aged 18 years and above. Ethiopia is one of developing countries estimated to have high prevalence of visual impairment which have an enormous socio-economic impact. Also there is limited available information regarding with the magnitude of visual impairment among adults in our country at large and east Gojjam zone in specific. Therefore the aim of this study was to assess the magnitude of visual impairment and its associated factors among patients attending Debre Markos Referral Hospital ophthalmic clinics in east Gojjam zone, North West Ethiopia. Methods An institutional-based cross-sectional study was conducted at Debre Markos Referral Hospital which is the only hospital in east gojjam zone with ophthalmic care service from March 1 to 30, 2020 by using systematic random sampling technique to select study participants after informed consent was obtained. Data were collected by interview with 5% pretested, structured questionnaire and ocular examinations. Data were cleaned, coded and entered to Epi-data version-3.1, and analyzed using Statistical Package for Social Science software version 26. The descriptive statistics was presented in tables, text and graphs. Bivariable and multivariable logistic regression analysis to identify factors associated with visual impairment was conducted. Covariates with P-value < 0.05 were considered statistically significant. Results A study was conducted among 312 study participants with 96% response rate. The magnitude of visual impairment was 114 (36.5%) [95% CI, (33.8, 39.2%)]. Age > 50 years [AOR = 3.82; 95% CI (1.56, 9.35)], rural residency [AOR = 4.33 95% CI (1.30, 14.44)], inability to read and write [AOR = 3.21; 95% CI (1.18, 8.73)] and Cataract [AOR = 4.48; 95% CI (1.91, 10.52)] were factors significantly associated with visual impairment. Conclusions The overall magnitude of visual impairment was found to be high. Older age, rural residency, inability to read and write and cataract were associated with visual impairment. Increasing literacy, expanded cataract surgery, as well as community based visual acuity screening especially for elders and rural residents is crucial. Zonal police makers should give emphasis on prevention of visual impairment to decrease economic, social and political burden of visual disability.

scholarly journals Stunting at birth and associated factors among newborns delivered at the University of Gondar Comprehensive Specialized Referral Hospital

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245528
Author(s):  
Almaz Tefera Gonete ◽  
Bogale Kassahun ◽  
Eskedar Getie Mekonnen ◽  
Wubet Worku Takele
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Short Stature ◽  
Odds Ratio ◽  
Associated Factors ◽  
Adjusted Odds Ratio ◽  
Referral Hospital ◽  
Factors Associated ◽  
The University

Background Stunting at birth is a chronic form of undernutrition majorly attributable to poor prenatal nutrition, which could persist in children’s later life and impact their physical and cognitive health. Although multiple studies have been conducted in Ethiopia to show the magnitude of stunting and factors, all are concentrated on children aged between 6 to 59 months. Therefore, this study was done to determine the prevalence and associated factors of stunting at birth among newborns delivered at the University of Gondar Comprehensive Specialized Referral Hospital, Northwest, Ethiopia. Methods An institution-based cross-sectional study was conducted from February 26th to April 25th/2020. A systematic random sampling technique was used, to select a total of 422 newborn-mother pairs. The binary logistic regression was employed to identify factors associated with stunting and all independent variables were entered into the multivariable logistic regression model to adjust for confounders. Variables that had significant association were identified based on p-value < 0.05 and the adjusted odds ratio with its respective 95% confidence interval was applied to determine the strength as well as the direction of the association. Results About 30.5% (95% CI: 26.3%, 35.1%) of newborns were stunted at birth. Being male [Adjusted odds ratio (AOR) = 2.9(1.62, 5.21)], newborns conceived in Kiremt(rainy season) [AOR = 2.7(1.49, 4.97)], being low birth weight [AOR = 3.1(1.64, 6.06)] were factors associated with stunting at birth. Likewise, newborns born to short stature mothers [AOR = 2.8(1.21, 6.62)] and chronically malnourished mothers [AOR = 15.3(8.12, 29.1)] were at greater risk of being stunted. Conclusion Just under a third of newborns are stunted at birth, implying a pressing public health problem. Newborns born to chronically malnourished and short stature mothers were more stunted. Besides, stunting was prevalently observed among male neonates, newborns conceived in Kiremet, and being low birth weight. Thus, policymakers and nutrition programmers should work on preventing maternal undernutrition through nutrition education to reduce the burden of low birth weight and stunting. Further, paying due attention to newborns conceived in Kiremet season to improve nutritional status is recommended.

scholarly journals Treatment Outcomes and Associated Factors among Hospitalized Stroke Patients at Shashemene Referral Hospital, Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Tegegne Gobezie Temesgen ◽  
Berhanu Teshome ◽  
Peter Njogu
Keyword(s):  
Ischemic Stroke ◽  
Treatment Outcome ◽  
Treatment Outcomes ◽  
Associated Factors ◽  
Common Type ◽  
Referral Hospital ◽  
P Value ◽  
Stroke Patients ◽  
Good Treatment Outcome ◽  
Study Participants

Background. The 2013 Global Burden of Disease report indicated that 80% of stroke deaths occur in low- and middle-income regions. Although stroke has been consistently reported as one of the three leading causes of morbidity and mortality in the past years in Ethiopia, there is a paucity of data regarding treatment outcomes of stroke if sufficient. Hence, the present study aimed to assess patterns of treatment outcomes and associated factors among hospitalized stroke patients at Shashemene Referral Hospital. Methods. A retrospective cross-sectional study was conducted at the medical ward of Shashemene Referral Hospital. A total of 73 hospitalized stroke patients during the period 2012–2017 were included in the study. Demographic characteristics, risk factors, and stroke types and their hospital outcomes were reviewed from the medical records of the patients. The data were entered and analyzed using SPSS version 16.0. Descriptive statistics such as percent and frequency were used to summarize patients’ characteristics. Binary logistic regression was used to investigate the potential predictors of treatment outcome. A p-value ≤0.05 was considered statistically significant. Result. Ischemic stroke was the most common type of stroke (65.8%) diagnosed in our setting. Hypertension (52.05%) was the common comorbid condition. More than half (54.79%) of the stroke patients improved on treatment. Dyslipidemics were prescribed to 68.49% of patients and the most popular antiplatelet was aspirin, which was prescribed to 61.64% of the study participants. Age, sex, type of stroke, and type of comorbidity were not significant factors of stroke treatment outcome. Conclusion. Ischemic stroke was the most common type of stroke diagnosed among the study participants while aspirin and statins were the most frequently used drugs in the management of stroke. Approximately 50% of hospitalized stroke patients had good treatment outcome and none of the investigated variables were significantly associated with the treatment outcomes.

scholarly journals The Prevalence of Intestinal Parasites and Their Associated Factors among Diabetes Mellitus Patients at the University of Gondar Referral Hospital, Northwest Ethiopia

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Sintayehu Ambachew ◽  
Muluneh Assefa ◽  
Yalewayker Tegegne ◽  
Ayalew Jejaw Zeleke
Keyword(s):  
Diabetes Mellitus ◽  
Developing Countries ◽  
Associated Factors ◽  
Intestinal Parasites ◽  
Parasitic Infection ◽  
Educational Background ◽  
Northwest Ethiopia ◽  
Referral Hospital ◽  
Intestinal Parasitic Infection ◽  
The University

Background. Worldwide, more than one-sixth of the population is infected by intestinal parasites, of which the majority live in developing countries. On the other hand, the prevalence of diabetes mellitus has been increasing over recent decades in developing countries. Patients with diabetes mellitus encountered impaired immunity and suffer from the consequences of infection particularly intestinal parasitic infection. Objective. This study is aimed at assessing the prevalence of intestinal parasites and associated factors among diabetes mellitus patients at the University of Gondar Referral Hospital, Northwest Ethiopia. Methods and Materials. An institutional-based cross-sectional study was conducted at the University of Gondar Comprehensive Specialized Referral Hospital from February 15 to March 30, 2018. A total of 234 diabetes mellitus patients were enrolled. A systematic random sampling technique was used to select study participants. Sociodemographic and clinical data were collected using a semistructured questionnaire. A 5-gram stool sample was collected to identify parasitic infection using a direct wet mount and formal-ether concentration technique. Data was entered and analyzed by using SPSS version 20. A p value of ≤0.05 was considered as statistically significant. Result. In the current study, the overall prevalence of intestinal parasite infection among diabetics was 45 (19.2%). The parasites identified in this study were Ascaris lumbricoides 15 (6.41%), Entamoeba histolytica/dispar 9 (3.85%), Hookworm 9 (3.85%), Schistosoma mansoni 7 (3%), Enterobius vermicularis 3 (1.3%), and Giardia lamblia 2 (0.9%). Poor educational background ( AOR = 3.62 ; 95% CI (1.038, 12.65); p = 0.043 ), poor hygiene and sanitation ( AOR = 4.67 ; 95% CI (1.82, 12.07); p = 0.001 ), and inappropriate latrine usage ( AOR = 5.41 ; 95% CI (1.43, 20.56); p = 0.013 ) were significantly associated with the prevalence of intestinal parasitic infection among diabetes mellitus patients. Conclusion. The overall prevalence of intestinal parasitic infection among diabetes mellitus patients was relatively high. There should be continued prevention, control, and management of intestinal parasitic infection in such a study population.

scholarly journals Chronic Kidney Disease and associated factors among HIV/AIDS Patients on HAART at University of Gondar Referral Hospital, Northwest Ethiopia

2020 ◽  
Author(s):  
Gizachew Ayele Manaye ◽  
Dejene Derseh Abateneh ◽  
Wondwossen Niguse Asmare
Keyword(s):  
Logistic Regression ◽  
Viral Load ◽  
Associated Factors ◽  
Northwest Ethiopia ◽  
Referral Hospital ◽  
Sub Saharan Africa ◽  
Urine Specimen ◽  
Multivariate Logistic Regression ◽  
Hiv Patients ◽  
Study Participants

Abstract Background In developing countries, both opportunistic infections and chronic diseases account a high HIV associated mortality and morbidity. Chronic kidney diseases (CKD) associated with HIV infection has got increased attention in sub-Saharan Africa as a result of the high HIV prevalence and due to the late diagnosis and initiation of HAART. Thus, this study was conducted to assess CKD and associated factors among HIV patients on HARRT in Northwest Ethiopia. Methods A hospital-based cross-sectional study with a secondary data review was conducted from February 01 to April 30, 2017, at the University of Gondar Referral Hospital, Northwest Ethiopia. The study participants were selected using a systematic random sampling technique. Socio-demographic and clinical data were collected using a semi-structured questionnaire by trained nurses. Venous blood and urine specimen was collected for serum creatinine and urine protein determination respectively. Glomerular filtration rate was estimated using the CKD–EPI estimator. Data were entered into SPSS version 20 for analysis. Bivariate and multivariate logistic regression was employed and p-value < 0.05 was considered statistically significant. Results A total of 336 HIV patients on HARRT participated in the study. The mean (SD) age of the participants was 39.7 ( + 9.7) years. The study participants were on HAART with an average of 7.5 ( + 3) years. Before ART initiation, the majority of patients had WHO clinical stage II and III, 251 (74.7%), CD4+T cell count < 200 cells/mm 3 , 221 (65.8%).The overall prevalence of CKD was 16.1%. About 27 (8.0%), 16 (4.8%), 11 (3.3%) of the participants had stage 1 and stage 2 CKD and chronic renal failure (stage 3a-5) respectively. With multivariate logistic regression analysis being male (AOR=2.05 (1.03-4.09), p=0.04, occupation merchant (AOR=2.91(1.00-8.48),p=0.049)and viral load > 1000 copies/mm 3 (AOR=3.1 (1.38-7.00), P<0.01) were significantly associated with CKD. Conclusions The prevalence of CKD among HIV patients on HARRT is high. Being male, merchant and viral load > 1000 copies/mm 3 were associated factors of CKD. Patients should be regularly monitored and screened for early diagnosis and management of CKD. Those patients with high viral load and male patients should be closely followed.

scholarly journals Magnitude of Anemia in Geriatric Population Visiting Outpatient Department at the University of Gondar Referral Hospital, Northwest Ethiopia: Implication for Community-Based Screening

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Mulugeta Melku ◽  
Wondimu Asefa ◽  
Ahmed Mohamednur ◽  
Tesfahun Getachew ◽  
Bayechish Bazezew ◽  
...  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Associated Factors ◽  
Geriatric Patients ◽  
Northwest Ethiopia ◽  
Referral Hospital ◽  
Outpatient Department ◽  
Geriatric Population ◽  
Erythrocyte Sedimentation ◽  
The University

Objective. This study is aimed at assessing the magnitude and its associated factors of anemia in geriatric population visiting outpatient department at the University of Gondar referral hospital, northwest Ethiopia.Method. A cross-sectional study was conducted among elder patients in Gondar town, North Gondar District, in May 2013. A total of 200 randomly selected geriatric population participated in the study. Summary statistics were computed and presented in tables and figure. Both bivariate and multivariable binary logistic regression were fitted to identify associated factors. APvalue < 0.05 was considered as statistically significant.Result. The median age of the study participants was 65 years (Interquartile range (IQR): 8 years). The prevalence of anemia in the geriatric patients was 54.5% (n=109), of which 61.5% (n=67) were males. Mild type anemia was predominant, 55.96% (n=61). Geriatric patients with an elevated erythrocyte sedimentation rate (AOR = 9.04, 95% CI: 4.2–19.7) and who are vegetarians (AOR = 2.2, 95% CI: 1.03–4.71) were at high risk of developing anemia.Conclusion. The magnitude of anemia was high in geriatrics. Mild anemia was the predominant type. Vegetarians and geriatrics with elevated erythrocyte sedimentation rate were more likely to develop anemia. Hence, early diagnosis and management of anemia have paramount importance to prevent adverse outcomes in geriatrics.

scholarly journals Anemia among Women Attending Antenatal Care at the University of Gondar Comprehensive Specialized Referral Hospital, Northwest Ethiopia, 2017

Anemia ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Wubet Worku Takele ◽  
Amare Tariku ◽  
Fasil Wagnew Shiferaw ◽  
Amare Demsie ◽  
Wondale Getinet Alemu ◽  
...  
Keyword(s):  
Public Health ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Associated Factors ◽  
Water Source ◽  
Northwest Ethiopia ◽  
Referral Hospital ◽  
Immunodeficiency Virus ◽  
The University ◽  
Prevalence Of Anemia

Background. In Ethiopia, prenatal anemia is a major public health concern affecting both the health of the woman and babies. The World Health Organization recommends to conduct repeated prevalence studies concerning prenatal anemia . However, there is no recent evidence on the magnitude of the prenatal anemia. Therefore, the aim of this study was to determine the prevalence and the associated factors of prenatal anemia among women attending the Antenatal Care Clinic at the University of Gondar Referral Hospital.Methods. A facility-based cross-sectional quantitative study was conducted among 362 participants from June 03-July 08, 2017, at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. The systematic random sampling technique was employed. Structured interviewer administered questionnaire was used. Human Immunodeficiency Virus (HIV) screening was conducted. Nutritional status of the participants was assessed. Blood sample was collected by capillary tube . Intestinal parasite was examined by stool wet mount test. HIV serostatus was detected. Anemia was defined as hemoglobin concentration below 11 g/dl. The multivariable logistic regression model was employed to identify associated factors and to control the possible effects of confounders.Result. The prevalence of anemia was 22.2% (95% CI: 18.11, 27.1%). The highest odds of anemia were observed among pregnant women with family size of >five [AOR = 3 (95% CI: 1.03, 8.65)], unprotected water source users, [AOR = 4.09 (95% CI: 1.75, 9.55)], HIV infected [AOR = 2.94(95% CI: 1.37, 6.35)], and multigravida women [AOR = 3.5 (95% CI: 1.35, 9.17)].Conclusion and Recommendations. The prevalence of anemia among pregnant women attending the University of Gondar Referral Hospital was a moderate public health problem. Unprotected water source, large family size, Human Immunodeficiency Virus infection, and repeated pregnancies were factors that predicted anemia. Thus, prevention of Human Immunodeficiency Virus infection, family planning utilization, and accessing pure water are recommended.

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