scholarly journals Active TB infection and its associated factors among HIV-1 infected patients at Jimma medical center, Southwest Ethiopia

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Temesgen Mulugeta ◽  
Alazar Takale ◽  
Belachew Umeta ◽  
Behailu Terefe
Keyword(s):  
Medical Center ◽  
Clinical Stage ◽  
Cross Sectional Study ◽  
Preventive Therapy ◽  
Human Immune Deficiency Virus ◽  
Good Adherence ◽  
Cross Sectional ◽  
Factors Associated ◽  
Latent Tb ◽  
Hiv 1

Abstract Background Human immune deficiency virus (HIV) increases the susceptibility to primary infection or reinfection and the risk of tuberculosis (TB) reactivation for patients with latent TB. There was no current report on the rate of active TB infection among HIV-1 infected patients in our teaching and referral hospital. Therefore, this study was aimed to determine the prevalence and factors associated with active TB infection among HIV-1 infected patients. Methods Hospital-based retrospective cross-sectional study was conducted at the Anti-Retroviral Therapy (ART) chronic follow-up clinic. Systematic random sampling was used to include the patients. A structured questionnaire was used to collect data. Data were analyzed using SPSS version 25. Descriptive statistics were used to describe the findings and multivariate logistic regression was performed to identify factors associated with active TB infection. Result 150 HIV-1 infected patients (female 54.7%) were included. The median (interquartile range, IQR) age of the patients was 33.5 (25.7, 40.0) years. Twenty-six (17.3%) of the patients had developed active TB infection, which was independently associated with the WHO clinical stage III and IV (AOR: 9.67, 95% confidence interval (CI); 2.21–42.37), p = 0.003). The use of isoniazid preventive therapy (IPT) (AOR: 0.123, 95CI; 0.034–0.44, p = 0.001) and having good adherence to ART medications (AOR: 0.076, 95CI; 0.007–0.80, p = 0.032) was associated with the reduced risk of active TB infection among HIV-1 infected patients. Conclusions Advanced WHO clinical stages increased the risk of active TB infection, while the use of IPT and good adherence to ART medications reduced the risk of active TB infection. Therefore, patients with advanced WHO clinical stage should be screened for TB infection, and starting IPT for the candidate patients should be strengthened to reduce the burden of active TB incidence. ART medication adherence should also be supported.

Characteristics and risk factors associated with stroke subtypes among adult patients admitted to stroke unit of JUMC

2019 ◽  
Vol 15 ◽  
Author(s):  
Bekalu Getachew Gebreegziabher ◽  
Tesema Etefa Birhanu ◽  
Diriba Dereje Olana ◽  
Behailu Terefe Tesfaye
Keyword(s):  
Risk Factors ◽  
Stroke Unit ◽  
Medical Center ◽  
Data Entry ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Associated ◽  
Stroke Subtypes

Background: Stroke is a great public health problem in Ethiopia. According to reports, in-hospital stroke mortality was estimated to be 14.7% in Ethiopia. Despite this, in this country researches done on factors associated with stroke sub-types were inadequate. Objective: To assess the Characteristics and risk factors associated with stroke sub-types among patients admitted to JUMC. Methods and materials: A retrospective cross sectional study was conducted from May 2017 to May 2018 in stroke unit of Jimma University Medical Center. A total of 106 medical charts of patients diagnosed with stroke were reviewed. Checklist comprising of relevant variables was used to collect data. SPSS version 21 was employed for data entry and analysis. Chi-square test was used to point-out association and difference among stroke sub-types. The data was presented using text, tables and figures. Result: From a total of 106 patients, 67(63.2%) were men. The mean ± SD of age was 52.67±12.46 years, and no significant association was found. Of all the patients, 59(55.6%) had ischemic strokes and 47(44.4%) had hemorrhagic strokes. The most common risk factor in the patients was alcohol use with a prevalence of 69.9%. Of all the risk factors, only sex, cigarettes smoking and dyslipidemia were significantly associated to sub-types of stroke. Conclusion: Ischemic stroke was the most common subtype of stroke. Sex of patient, cigarette smoking and dyslipidemia are significantly associated with the two stroke subtypes.

scholarly journals Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sivaporn Gatechompol ◽  
Weerakit Harnpariphan ◽  
Ruamthip Supanan ◽  
Gompol Suwanpimolkul ◽  
Jiratchaya Sophonphan ◽  
...  
Keyword(s):  
Latent Tuberculosis ◽  
Cross Sectional Study ◽  
Preventive Therapy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ltbi Prevalence ◽  
History Of ◽  
Chest X Ray ◽  
Latent Tb ◽  
Latent Tb Infection

Abstract Background Prisons are considered as major reservoirs for tuberculosis. Preventive therapy for latent TB infection (LTBI) is an adjunctive strategy to control TB. However, LTBI data in Thai prisoners is limited. This study assessed the prevalence of LTBI and feasibility of isoniazid preventive therapy (IPT). Methods A cross-sectional study was conducted among prisoners in Klong Prem Central Prison, Bangkok. Participants were screened for active TB by questionnaire and chest X-ray. LTBI was evaluated by Tuberculin skin test (TST) and QuantiFERON-TB Gold Plus (QFTP) among subgroup. Participants with positive TST or QFTP were considered to have LTBI. Participants with LTBI were offered IPT. Results From August 2018–November 2019, 1002 participants were analyzed. All participants were male with a median age of 38 (IQR 32–50) years. LTBI identified by either TST/QFTP was present in 466 (46.5%) participants. TST was positive in 359 (36%) participants. In the subgroup of 294 participants who had both TST and QFTP results, 181/294 (61.6%) tested positive by QFTP. Agreement between TST and QFTP was 55.1% (Kappa = 0.17). The risk factors associated with LTBI were previous incarceration (aOR 1.53, 95%CI, 1.16–2.01, p = 0.002), history of prior active TB (aOR 3.02, 95%CI, 1.74–5.24, p < 0.001) and duration of incarceration ≥10 years (aOR 1.86, 95%CI, 1.24–2.79, p = 0.003). Majority of LTBI participants (82%) agreed to take IPT. Three hundred and 56 (93%) participants completed treatment whereas 27 (7%) participants discontinued IPT due to the side effects of INH. Conclusion This is the first study to evaluate the prevalence of LTBI and feasibility of IPT among Thai prisoners. LTBI prevalence in male prisoners in Thailand is high. LTBI screening and treatment should be implemented together with other preventive components.

scholarly journals Prevalence of Cognitive Impairment and Its Predictors among HIV/AIDS Patients on Antiretroviral Therapy in Jimma University Medical Center, Southwest Ethiopia

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Getachew Yideg Yitbarek ◽  
Andualem Mossie Ayana ◽  
Moyeta Bariso Gare ◽  
Gashaw Garedew Woldeamanuel
Keyword(s):  
Cognitive Impairment ◽  
Antiretroviral Therapy ◽  
Medical Center ◽  
Clinical Stage ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Face To Face ◽  
Khat Chewing ◽  
Jimma University

Background. Cognitive impairment among human immunodeficiency virus (HIV) infected patients can lead to treatment nonadherence, faster progression of the illness, disability, and bed ridden state if we fail to detect it early. However, there is scarcity of previous published studies in Ethiopia on the assessment of cognitive impairment among HIV-positive patients. Hence, this study aimed to determine the prevalence and associated factors of cognitive impairment among HIV-positive patients receiving antiretroviral therapy (ART) at Jimma University Medical Center, Ethiopia. Methods. Hospital-based cross-sectional study was conducted among 328 HIV-positive patients attending Jimma University Medical Center, Ethiopia. Data were collected from a face-to-face interview and review of medical records using semistructured questionnaire. Validated International HIV Dementia Scale (IHDS) was used to screen for cognitive impairment. Data was analyzed using SPSS version 20. Results. A total of 328 (191 females and 137 males) HIV-positive patients were included in the study with a response rate of 97.04%. The prevalence of cognitive impairment among HIV-positive patients was 35.7%. Factors significantly associated with cognitive impairment were age group of 41−64 years (adjusted odds ratio [AOR] = 3.1, 95% confidence interval [CI] (1.3, 7.4)], plasma HIV-1 RNA load between 1.7log10 and 3log10 copies/ml [AOR = 2.2, 95% CI (1.1,4.3)] and ≥ 3log10 copies/ml [AOR = 7.5, 95% CI (2.6, 21.5)], khat chewing [AOR = 4.4, 95% CI (2.3, 8.3)], and clinical stage III of the disease [AOR = 5.6, 95% CI (1.7, 19.2)]. Conclusion. Despite the use of ART, the burden of cognitive impairment among HIV patients was high. Older age, khat chewing, advanced stage of the disease, and higher viral load were the independent factors associated with cognitive impairment. Thus, continuous screening of cognitive impairment, identification of the possible risk factors, and proper management strategy should be designed.

scholarly journals Burden and Factors Associated with Refractive Errors Post Cataract Surgery at Kilimanjaro Christian Medical Center: A Hospital Based Retrospective Cross-sectional Study

2020 ◽  
pp. 6-16
Author(s):  
Livin Uwemeye ◽  
William U. Makupa
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
Medical Center ◽  
Cross Sectional Study ◽  
Refractive Errors ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Corrected Visual Acuity ◽  
Best Corrected Visual Acuity

Aims: To determine the burden and factors associated with refractive errors after cataract surgery in a training institution. Study Design: A retrospective cross-sectional study. Place and Duration of the Study: Kilimanjaro Christian Medical Center Eye department. Northern Tanzania, from January 2016 to December 2017. Methods: A review of files of all adult patients who have had cataract surgery in 2016 and 2017 was conducted. A total of 626 eyes of 554 patients who had post-operative refraction by experienced optometrists were included. Information were extracted from patients’ files then entered into SPSS version 20 for analysis. The main outcomes were post-operative refraction and best corrected visual acuity.  Results: Mean age was 69.3 years (SD=10.7) and ECCE accounted for 76% of surgeries. At least 84.6% had post-operative refractive error and astigmatism was the most common refractive error (56.8%). Spherical error accounted for 27.8%. Spherical error ranged from -12 to 4DS, mean = -0.42 (SD=1.3) DS and median = 0.00DS. The maximum cylindrical error was -7.5 DC, mean = -1.15 (SD=1.36) DC and median = -1.0DC. At least 56% had spherical equivalent within 1D of emmetropia. A BCVA of 6/18 or better was achieved in 92.8%. Age, poor pre-operative VA, poor presenting VA, astigmatism on keratometry, difference between recommended and inserted IOL, ECCE, grade of surgeon and suturing were associated with refractive errors. Conclusion: Refractive errors following cataract surgery are common. Best corrected visual acuity outcome was in normal recommended range; however, the magnitude of refractive errors was high and the proportion of patients who achieved a final refraction within 1D of emmetropia was below the recommended range. An effort should be made to lower the prevalence and magnitude of refractive errors associated with cataract surgery in training institutions.

scholarly journals Assessment of the Isoniazid Preventive Therapy Uptake and Associated Characteristics: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Francine Mwayuma Birungi ◽  
Stephen Graham ◽  
Jeannine Uwimana ◽  
Brian van Wyk
Keyword(s):  
Healthcare Providers ◽  
Cross Sectional Study ◽  
Preventive Therapy ◽  
Isoniazid Preventive Therapy ◽  
Sputum Smear ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Health Centres ◽  
Index Cases

Objective. To assess the uptake of isoniazid preventive therapy (IPT) by eligible children in Kigali, Rwanda, and associated individual, households, and healthcare systems characteristics. Methods. A cross-sectional study was conducted among child contacts of index cases having sputum smear-positive pulmonary tuberculosis. Data were collected from 13 selected primary health centres. Descriptive statistics were used to generate frequency tables and figures. Logistic regression models were performed to determine characteristics associated with IPT uptake. Results. Of 270 children (under 15 years), who were household contacts of 136 index cases, 94 (35%) children were less than 5 years old and eligible for IPT; and 84 (89%, 95% CI 81–94) were initiated on IPT. The reasons for not initiating IPT in the remaining 10 children were parents/caregivers’ lack of information on the need for IPT, refusal to give IPT to their children, and poor quality services offered at health centres. Factors associated with no uptake of IPT included children older than 3 years, unfriendly healthcare providers, HIV infected index cases, and the index case not being the child’s parent. Conclusion. The National Tuberculosis Program’s policy on IPT delivery was effectively implemented. Future interventions should find strategies to manage factors associated with IPT uptake.

scholarly journals Prevalence and factors associated with pelvic organ prolapse among women attending the gynecology outpatient clinic at a tertiary hospital in southwestern Uganda

2021 ◽  
Author(s):  
RODGERS TUGUME ◽  
Henry Mark Lugobe ◽  
Paul Kalyebara Kato ◽  
Rogers Kajabwangu ◽  
Hamson Kanyesigye ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Outpatient Clinic ◽  
Clinical Stage ◽  
Multiple Logistic Regression Analysis ◽  
Stage Iv ◽  
Tertiary Hospital ◽  
Pelvic Organ ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Factors Associated

Abstract Purpose To determine the prevalence, clinical stage at presentation and factors associated with pelvic organ prolapse (POP) among women attending the gynecology outpatient clinic at Mbarara Regional Referral Hospital (MRRH), Uganda. Methods We conducted a cross sectional study at the gynecology outpatient clinic of MRRH from September 2019 to January 2020. Multiple logistic regression analysis was done to determine factors associated with pelvic organ prolapse. Results Of 338 participants enrolled, the prevalence of POP was 27.5% (n = 93). POP stages were: stage I 11.8% (n = 11), stage II 63.4% (n = 59), stage III 16.1% (n = 15) and stage IV 8.9% (n = 8). Grand-multiparity (aOR 17.1, 95% CI: 1.1–66.6), birth weight more than 3.5kg (aOR 3.7, 95% CI: 1.1–12.6), perineal tears (aOR 6.5, 95% CI: 2.1–20.2), peasant farmer (aOR 6.9, 95% CI: 1.6–29.9) and duration of labour in the first delivery > 24 hours (aOR 5.7, 95% CI: 1.2–29) were significantly associated with POP.

scholarly journals Association of delivery procedure with APGAR scores among neonates born to healthy Pakistani mothers: a pilot study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 346
Author(s):  
Muhammad Ali Khalid ◽  
Rida Ghani ◽  
Muhammad Fahad Khalid ◽  
Muhammad Saad Malik ◽  
Ahmed Waqas
Keyword(s):  
Regression Analysis ◽  
Maternal Age ◽  
Medical Center ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Apgar Scores ◽  
Maternal Characteristics ◽  
Factors Associated ◽  
Vaginal Deliveries

Background: The present study explores the factors associated with poor APGAR scores among singletons born to healthy Pakistani mothers. Methods: This cross-sectional study was conducted at a Tara Urea Medical Center, Iskandarabad Colony, district Mianwali, Pakistan from April 1 to August 30, 2017. Data was collected using a preformed proforma by a gynecologist and pediatrician during the birth procedure. The questionnaire comprised of two sections including neonatal and maternal characteristics. All data were analyzed in SPSS v.20. Results: Regression analysis revealed that vaginal deliveries were associated with higher APGAR scores at five minutes than those delivered by cesarean section. However, maternal age and BMI and weight of the baby did not yield significant association with APGAR scores at five minutes. APGAR scores assessed at one minute were significantly associated with weight of the neonate. Conclusion: APGAR scores of the neonates at birth are significantly associated with birth procedures. Therefore, birth procedure should be selected and managed effectively to reduce the risk of low APGAR scores.

scholarly journals Factors associated with latent tuberculosis among international migrants in Brazil: a cross-sectional study (2020)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sonia Vivian de Jezus ◽  
Thiago Nascimento do Prado ◽  
Ricardo Alexandre Arcêncio ◽  
Keila Cristina Mascarello ◽  
Carolina Maia Martins Sales ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Sao Paulo ◽  
Type I ◽  
São Paulo ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Brazilian State ◽  
Latent Tb ◽  
International Migrants

Abstract Background Migrants are a high priority group for TB control measures due to their high exposure to risk factors such as poverty and social vulnerability. The study aimed to identify factors associated with latent TB among international migrants living in four Brazilian state capitals. This was a cross-sectional study conducted in September and October 2020 in a sample of 903 international migrants living in four Brazilian state capitals: Boa Vista/RR (458), Manaus/AM (136), São Paulo/SP (257), and Curitiba/PR (52). Data were collected with a questionnaire consisting of open and closed questions on personal characteristics, information on TB, and use of preventive measures. Tuberculin skin test (TST) was performed, with reading after 72 h by trained nurses and using 5 mm induration as the positive cutoff. Chi-square test (X2) and Fisher’s exact test, both two-tailed, were used to compare statistically significant levels of association between the migrants´ sociodemographic characteristics, vulnerability, and latent TB infection (LTBI). Binary logistic regression was applied to calculate odds ratios and respective 95% confidence intervals. For all the tests, type I error of 5% was defined as statistically significant (p < 0.05). Results Prevalence of LTBI among migrants was 46.1% in Manaus/AM, 33.3% in São Paulo/SP, 28.1% in Curitiba/PR, and 23.5% in Boa Vista/RR. Factors associated with latent infection were age, male gender, and brown or indigenous race. Conclusions The study showed high prevalence of latent TB among international migrants.

Thalassemia Phenotypes and Associated Mortality among Yemeni Patients: A Single-Center Retrospective Analysis

2020 ◽  
Vol 14 (1) ◽  
pp. 7-12
Author(s):  
Thaker A.A. Abdulrahman ◽  
Ali Alhaj ◽  
Mokhtar E.M. Saif
Keyword(s):  
Medical Center ◽  
Cross Sectional Study ◽  
Blood Disorders ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Associated ◽  
Gender And Age ◽  
Genetic Abnormalities ◽  
Mortality Incidence ◽  
Related Mortality

Objective: To retrospectively analyze thalassemia phenotypes and associated mortality among Yemeni patients seeking healthcare in Sana’a city, Yemen. Methods: This retrospective, cross-sectional study was conducted in the medical center of Yemen Society for Thalassemia and Genetic Blood Disorders (YSTGBD) in Sana'a city from January 2010 to December 2016. Data about gender, age, governorate of origin, type of thalassemia and thalassemia-related mortality were retrieved from the records of 496 thalassemia patients. Data were then entered into an Excel spreadsheet, cross-checked for accuracy and presented as frequencies and proportions. Factors associated with deaths among thalassemia patients were analyzed using chi-square or Fisher’s exact tests. Results: A total number of 496 patients attended the medical center of YSTGBD in Sana’a city in the period from January 2010 to December 2016. The majority of thalassemia patients were males (57.9%), and approximately half of the patients were aged 10 years or younger with a comparable proportion to those older than 10 years. Most thalassemia patients had β-thalassemia (92.7%), while 7.3% had α-thalassemia. The majority of patients were from Hajjah governorate (16.5%) followed by those from Sana'a (13.1%) and Amran (11.9%), while lower proportions ranging from 0.2% to 8.1% were recorded for patients from other governorates. Thirty out of the total attending thalassemia patients died, and mortality was significantly associated with recurrent transfusions of whole blood but not with the gender and age of the patients or thalassemia phenotype. Conclusions: The majority of thalassemia patients seeking healthcare in Sana’a city suffer from thalassemia, where males represent more than half of them and the patients are almost equally distributed in relation to the cut-off age of 10 years. The mortality incidence among Yemeni thalassemia patients seeking healthcare is lower than that reported elsewhere in the world, and mortality was significantly associated with recurrent blood transfusions. Further studies to identify the genetic abnormalities associated with thalassemia are recommended together with the need for the launch of a national center for counseling, research and supervision of voluntary activities related to thalassemia and genetic blood disorders in Yemen. Keywords: Thalassemia, Phenotype, Mortality, Yemen

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