scholarly journals Difference between the biologic and chronologic age as an individualized indicator for the skincare intensity selection: skin cell profile and age difference studies

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Yurij Sukhovei ◽  
Elena Kostolomova ◽  
Irina Unger ◽  
Andrey Koptyug ◽  
Denis Kaigorodov
Keyword(s):  
Research Question ◽  
Treatment Strategies ◽  
Skin Aging ◽  
Blood Cholesterol ◽  
Patient Specific ◽  
Age Difference ◽  
Skin Cell ◽  
The Difference ◽  
Study Participants ◽  
Cell Profile

Abstract Background The present research addresses the issue of skin aging and corresponding skin treatment individualization. Particular research question was on the development of a simplified criterion supporting patient-specific decisions about the necessity and intensity of skin treatment. Basing on published results and a wide pool of our own experimental data, a hypothesis is formulated that a difference between biologic and chronologic age can be used as a powerful indicator of skin aging. Methods In the present paper, we report the results of studies with 80 volunteers between 15 and 65 years of age linking skin cell profile parameters to biologic and chronologic age. Biologic age was calculated using the empirical expressions based on the forced vital lung capacity, systolic blood pressure, urea concentration, and blood cholesterol level. Epidermis and derma cellular structures were studied using skin biopsy samples taken from the gluteal region. Results The present study supports the conclusion that biologic and chronologic age difference is changing in the progress of life. Our studies are showing that time point when calculated biologic age becomes equal to the chronologic one reflecting the onset of specific changes in the age dependencies of experimentally measured skin cell profile parameters. Thus, it is feasible that a difference between chronologic and individually assessed biologic age indeed reflects the process of skin aging. Conclusions With all reservations to the relatively small number of study participants, it seems feasible that a difference between biologic and chronologic age can be used as an indicator of skin aging. Additional research linking blood immune profile and skin topography to the difference of biologic and chronologic age (reported in the following paper) provides further support for the formulated hypotheses. So, a difference between calculated biologic age and chronologic age can be used as an individualized criterion supporting decisions on skin treatment strategies. Further research involving larger numbers of participants aimed at optimizing the expressions for calculating biologic age could lead to reliable and easily available express criterion supporting the decision for the individualized skin treatment.

scholarly journals Combined deep CNN–LSTM network-based multitasking learning architecture for noninvasive continuous blood pressure estimation using difference in ECG-PPG features

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Da Un Jeong ◽  
Ki Moo Lim
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Measurement ◽  
Patient Specific ◽  
Peak Time ◽  
Simultaneous Prediction ◽  
Deep Cnn ◽  
Pressure Estimation ◽  
The Difference ◽  
Blood Pressure Estimation ◽  
Continuous Blood Pressure

AbstractThe pulse arrival time (PAT), the difference between the R-peak time of electrocardiogram (ECG) signal and the systolic peak of photoplethysmography (PPG) signal, is an indicator that enables noninvasive and continuous blood pressure estimation. However, it is difficult to accurately measure PAT from ECG and PPG signals because they have inconsistent shapes owing to patient-specific physical characteristics, pathological conditions, and movements. Accordingly, complex preprocessing is required to estimate blood pressure based on PAT. In this paper, as an alternative solution, we propose a noninvasive continuous algorithm using the difference between ECG and PPG as a new feature that can include PAT information. The proposed algorithm is a deep CNN–LSTM-based multitasking machine learning model that outputs simultaneous prediction results of systolic (SBP) and diastolic blood pressures (DBP). We used a total of 48 patients on the PhysioNet website by splitting them into 38 patients for training and 10 patients for testing. The prediction accuracies of SBP and DBP were 0.0 ± 1.6 mmHg and 0.2 ± 1.3 mmHg, respectively. Even though the proposed model was assessed with only 10 patients, this result was satisfied with three guidelines, which are the BHS, AAMI, and IEEE standards for blood pressure measurement devices.

scholarly journals A Computational Analysis of the Influence of a Pressure Wire in Evaluating Coronary Stenosis

Fluids ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. 165
Author(s):  
Jie Yi ◽  
Fang-Bao Tian ◽  
Anne Simmons ◽  
Tracie Barber
Keyword(s):  
Coronary Stenosis ◽  
Severe Case ◽  
Patient Specific ◽  
Fractional Flow ◽  
Ideal Model ◽  
Coronary Pressure ◽  
Flow Reserve ◽  
Pressure Wire ◽  
Physical Presence ◽  
The Difference

Cardiovascular disease is one of the world’s leading causes of morbidity and mortality. Fractional flow reserve (FFR) was proposed in the 1990s to more accurately evaluate the functional severity of intermediate coronary stenosis, and it is currently the gold standard in cardiac catheterization laboratories where coronary pressure and flow are routinely obtained. The clinical measurement of FFR relies on a pressure wire for the recording of pressures; however, in computational fluid dynamics studies, an FFR is frequently predicted using a wire-absent model. We aim to investigate the influence of the physical presence of a 0.014-inch (≈0.36 mm) pressure wire in the calculation of virtual FFR. Ideal and patient-specific models were simulated with the absence and presence of a pressure wire. The computed FFR reduced from 0.96 to 0.93 after inserting a wire in a 3-mm non-stenosed (pipe) ideal model. In mild stenotic cases, the difference in FFR between the wire-absent and wire-included models was slight. The overestimation in severe case was large but is of less clinical significance because, in practice, this tight lesion does not require sophisticated measurement to be considered critical. However, an absence of the pressure wire in simulations could contribute to an over-evaluation for an intermediate coronary stenosis.

EXPRESS: Serum Carbohydrate Antigen72-4 levels decrease with age in females but not males in Beijing, China

2021 ◽  
pp. 000456322110269
Author(s):  
Tongmei Duan ◽  
Xun Chen ◽  
Jing Wu ◽  
Ronghai Li ◽  
Huijuan Guo ◽  
...  
Keyword(s):  
Age Groups ◽  
Reference Interval ◽  
Carbohydrate Antigen ◽  
Female Group ◽  
Healthy Population ◽  
Age Difference ◽  
Significant Difference ◽  
The Difference ◽  
And Gender ◽  
Beijing China

Objective: Carbohydrate antigen 72-4 (CA72-4) is widely used in the diagnosis and monitoring of many cancers. However, there are few studies on the differences of CA72-4 levels in terms of age and gender. Methods: 10957 healthy subjects were divided into two groups according to gender and three age groups. The serum CA72-4 were detected. Statistical analysis was performed by SPSS. Results: The CA72-4 level in female group was significantly higher than that in male group. The level of CA72-4 gradually decreased with age. Compared with the age >60 group, the CA72-4 levels were increased in the age 46-60 group and 16-45 group (P >0.05, respectively). To better observe the age difference, the age 16-45 and 46–60 group were combined into the age 16-60 group. In comparison to the age >60 group, the CA72-4 level of age 16-60 group was significantly increased (P =0.000). In the age >60 group, there was no difference between genders. Nevertheless, the difference between the sexes in the age 16-60 group was significant (P =0.023). Conclusions: The reference interval of CA72-4 for local healthy population was established. CA72-4 levels gradually decreased with the increase of age, and CA72-4 level in females aged 16-60 years (0-18.0 U/mL) was higher than in males (0-14.5 U/mL), however there was no gender difference in the age group above 60 years old (0-14.5 U/mL). Moreover, male CA72-4 was no significant difference among all age groups, while the potential mechanism of female changes with age needed further study.

scholarly journals Visualizing molecular structures and shapes: a comparison of virtual reality, computer simulation, and traditional modeling

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Corina E. Brown ◽  
Ben Whaley ◽  
Richard M. Hyslop
Keyword(s):  
Virtual Reality ◽  
Chemistry Education ◽  
Research Question ◽  
Molecular Geometry ◽  
Molecular Structures ◽  
Future Research ◽  
Chemistry Students ◽  
Positive Attitudes ◽  
The Difference ◽  
Students Attitudes

AbstractThe purpose of this study was to compare the effectiveness of three methods used to assist in teaching molecular geometry to college chemistry students. A pre- and post-test quasi-experiment was used to collect data about students’ performance in a given chemistry exercise. One research question was intended to evaluate and compare the effectiveness of the three methods in assisting students to understand the topic and carry out the exercise correctly, and a second research question addressed students’ attitudes towards the use of Virtual Reality (VR) in chemistry education. Results show a positive attitude towards the use of VR as an assisting tool to aid in understanding chemistry concepts. While the difference among the three methods was not significant, the results show that the VR brought more enthusiasm and positive attitudes toward the topic of molecular geometry among the students. Educational implications and recommendations for future research are presented as well.

scholarly journals Determinants of Behavioral Intention of the Use of Self-Order Kiosks in Fast-Food Restaurants: Focus on the Moderating Effect of Difference Age

SAGE Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 215824402110319
Author(s):  
Tae Kyun Na ◽  
Jae Yeon Yang ◽  
Sun Ho Lee
Keyword(s):  
Behavioral Intention ◽  
Fast Food ◽  
Moderating Effect ◽  
Age Difference ◽  
Fast Food Restaurant ◽  
Use Of Technology ◽  
Cognitive Age ◽  
Fast Food Restaurants ◽  
The Difference ◽  
Minimal Effort

The aim of this study was to derive determinants that affect the behavior associated with using self-order kiosks among fast-food restaurant consumers through the Unified Theory of Acceptance and Use of Technology model, and to analyze the moderating effect of consumers’ difference age (difference between individuals’ cognitive age and chronological age) among the variables. From December 1 to 30, 2019, a survey was conducted on 316 customers using four different fast-food restaurants in the Seoul Station. The results showed that the higher the price value, social influence, performance expectancy, and hedonic motivation, the higher the behavioral intention of ordering through the kiosk; furthermore, the higher the difference age, the higher the behavioral intention of using a kiosk. Therefore, fast-food restaurant operators need to ensure that customers who are unfamiliar with using kiosks can order and make payments through kiosks with minimal effort and reasonable price value.

State of the Art Reviews: Nonpharmacologic Approaches for the Treatment of Insomnia

2007 ◽  
Vol 1 (4) ◽  
pp. 274-282 ◽  
Author(s):  
Ann M. Lynch ◽  
Courtney I. Jarvis ◽  
Ronald J. DeBellis ◽  
Anna K. Morin
Keyword(s):  
Behavioral Therapy ◽  
Treatment Options ◽  
Sleep Onset ◽  
Treatment Strategies ◽  
Economic Consequences ◽  
Patient Specific ◽  
Sleep Onset Latency ◽  
Medline Search ◽  
Wake Time ◽  
Nonpharmacologic Treatment

Insomnia is a common condition resulting in significant clinical and economic consequences. This review discusses the efficacy of nonpharmacologic treatment options commonly recommended for sleep onset and sleep maintenance insomnia. In addition, the efficacy of these approaches as part of a multifaceted intervention and in comparison to that of pharmacologic options is reviewed. The primary literature and review articles on the nonpharmacologic treatment of insomnia were identified through a MEDLINE search between 1966 and August 2006. Articles on the nonpharmacologic treatment of primary insomnia, including clinical trials on the efficacy of individual and combination treatment options, were reviewed. The nonpharmacologic treatment options for insomnia include stimulus control, sleep hygiene educations, sleep restriction, paradoxical intention, relaxation therapy, biofeedback, and cognitive-behavioral therapy. These treatment strategies produce significant changes in several sleep parameters of chronic insomniacs, including sleep-onset latency, wake time after sleep onset, sleep duration, and sleep quality. Many therapeutic options are available to treat insomnia, including nonpharmacologic strategies. Treatment recommendations, both pharmacologic and nonpharmacologic, should be made based on patient-specific insomnia symptoms, treatment history, and medical history.

Avascular Osteonecrosis of the Talus: Current Treatment Strategies

2021 ◽  
pp. 107110072110510
Author(s):  
Hanci Zhang ◽  
Amanda N. Fletcher ◽  
Daniel J. Scott ◽  
James Nunley
Keyword(s):  
Risk Factors ◽  
Clinical Diagnosis ◽  
Treatment Strategies ◽  
Core Decompression ◽  
Bone Grafts ◽  
Current Treatment ◽  
Optimal Treatment ◽  
Patient Specific ◽  
Avascular Osteonecrosis ◽  
Current Trends

Avascular osteonecrosis (AVN) of the talus (AVNT) is a painful and challenging clinical diagnosis. AVNT has multiple known risk factors and etiologies and presents at different stages in severity. Given these unique factors, the optimal treatment solution has yet to be determined. Both joint-preserving and joint-sacrificing procedures are available, including core decompression and arthrodeses. Recently, new salvage and replacement techniques have been described including vascularized pedicle bone grafts and total talus replacement using patient-specific prosthesis; however, evidence remains limited. This review examines the current trends AVNT treatment and the emerging data behind these novel techniques.

AN EPIDEMIOLOGICAL STUDY ON SELECTED RISK FACTORS OF STROKE AMONG ADULTS LIVING IN A SLUM OF KOLKATA.

2021 ◽  
pp. 8-11
Author(s):  
Tanushree Mondal ◽  
V. Abhinesh ◽  
Soumitra Mondal ◽  
Shibasish Banerjee ◽  
Debasis Das
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Alcohol Consumption ◽  
Public Health Intervention ◽  
Simple Random Sampling ◽  
Blood Cholesterol ◽  
Moderate Intensity ◽  
Cross Sectional ◽  
Permanent Disability ◽  
Study Participants

Introduction: Stroke is a major cause of permanent disability. Currently, the burden of stroke in terms of mortality, morbidity and disability is increasing across the world including India. The main risk factor of stroke are high blood pressure, tobacco smoking, obesity, high blood cholesterol and diabetes mellitus. Lifestyle factors that increase the risk of stroke include smoking, drinking alcohol, high fat diet. Objective: To identify the socio demographic prole of study population and to nd out the proportion of selected risk factors of stroke among the study subjects and to assess different risk factors among them. Methodology:An observational descriptive cross sectional study was undertaken in urban eld practice area of a teaching institute of Kolkata. By 2 using the formula 4pq/l , total 200 participants were selected by simple random sampling and they were interviewed during house to house visit with WHO STEPS questionnaire for Non Communicable Diseases (NCD). Results: The mean age of the participants was 42.39 years and 33.5% participants were overweight with high BMI. Only 26 % participants were hypertensive and most of them (57.69%) had duration of hypertension more than 1 year. Majority (72.03%) did not have diabetes mellitus. Most (61%) of study participants had done moderate intensity physical activity regularly. Almost 25.5% study participants consume tobacco products and Most of the study 92.8% participants consumed alcohol 1-4 times in past 30 days. Signicant association were seen between gender and smoking (p=0.005), Gender and alcohol consumption (p=0.000), Religion and alcohol consumption (p=0.03), Occupation category and alcohol consumption (p=0.002), Marital status and hypertension (p=0.001). Conclusion: Effective public health intervention required promote regular exercise and healthy eating, avoiding alcohol and tobacco. Periodic screening for hypertension and diabetes and early diagnosis and treatment are key strategy for stroke prevention.

scholarly journals Environmental Influence on Stellar Evolution: The Horizontal Branch of NGC 1851

1996 ◽  
Vol 174 ◽  
pp. 357-358
Author(s):  
I. Saviane ◽  
G. Piotto ◽  
M. Capaccioli ◽  
F. Fagotto
Keyword(s):  
Mass Loss ◽  
Loss Rate ◽  
Environmental Influence ◽  
Mass Loss Rate ◽  
Bimodal Distribution ◽  
Age Difference ◽  
Horizontal Branch ◽  
Cluster Area ◽  
The Difference ◽  
Red Clump

The bimodal nature of the horizontal branch (HB) of NGC 1851 is known since Stetson (1981). In order to better understand the properties of its HB, we collected a set of data at the ESO-NTT telescope, which provides a full coverage of the cluster area. Additional archive images from the HST-WFPC camera have been used in order to study the central region. The resulting c-m diagram (CMD) for 20500 stars is presented in Fig. 1 (left). Despite its metallicity ([Fe/H]=−1.3), NGC 1851 presents a well defined blue HB tail, besides the expected red clump. The observed CMD has been compared with the synthetic ones. The bimodal HB can be reproduced assuming that there are two stellar populations in the cluster, with an age difference of ∼ 4 Gyr, hypothesis not supported by other properties of the CMD. On the other side, if we assume that the stars in NGC 1851 are 15 Gyr old (as suggested by the difference between the HB and the TO luminosities), only a bimodal mass loss can reproduce the HB morphology: only stars with higher than standard mass loss rate are able to populate the blue-HB (BHB) tail (Fig. 1,left). There are no observational evidences for a bimodal distribution of other parameters (He, CNO, etc.).

scholarly journals Is stress an important co morbid factor for hypertension among legal professionals

2018 ◽  
Vol 5 (5) ◽  
pp. 1899
Author(s):  
L. Kannan ◽  
Praveena P.
Keyword(s):  
High Stress ◽  
Simple Random Sampling ◽  
Well Being ◽  
Cross Sectional Study ◽  
District Court ◽  
Cross Sectional ◽  
Legal Professionals ◽  
The Difference ◽  
The Right ◽  
Study Participants

Background: Stress is a mental, physical and emotional response to life demands. Long hours of work, client demands, changing laws- creates stress and eventually hypertension among advocates. Well-being of the advocates are being questioned. Hence the main objective of the study is to evaluate the relationship between stress and hypertension among practising advocates.Methods: A cross-sectional study was conducted in a sample of 300 practising advocates at Madurai district court for a period of 1 year by simple random sampling method.Results: Around 133 (44.33%) and 167 (55.66%) of study participants were in level of high stress and low stress respectively. Among high stressed participants, a majority of 113 (84.96%) were found to be hypertensives and among the low stressed participants only 10 (5.98%) were hypertensives. The difference of observation was found to be statistically significant (p=0.0000).Conclusions: In conclusion the study explains that practising advocates with high perceived stress 113 (84.96%) were found to be hypertensives. Stress has a significant association with hypertension. The right way to manage stress is to implement coping strategies.

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