scholarly journals Epoxidized methyl ricinoleate bio-plasticizer with a pendant acetate ester for PVC artificial material: circumventing existing limit on achievable migration resistance

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Siyu Pan ◽  
Delong Hou ◽  
Gaofu Yang ◽  
Qiuping Xie ◽  
Sunxian Yan ◽  
...  
Keyword(s):  
Methyl Ricinoleate ◽  
Acetate Ester ◽  
Artificial Material ◽  
Migration Resistance

scholarly journals CircPVT1 attenuates negative regulation of NRAS by let-7 and drives cancer cells towards oncogenicity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joshua Miguel C. Danac ◽  
Reynaldo L. Garcia
Keyword(s):  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Circular Rnas ◽  
Aberrant Expression ◽  
Mesenchymal Transition ◽  
Relative Contribution ◽  
Colorectal Cancer Cells ◽  
Migration Resistance ◽  
Global Action ◽  
A549 Lung

AbstractCircular RNAs have emerged as functional regulatory molecules whose aberrant expression has been linked to diverse pathophysiological processes. Here, we report that circPVT1 interferes with let-7 binding to NRAS, confirming this axis as one route by which circPVT1 can instigate an oncogenic program in A549 lung cancer cells and HCT116 colorectal cancer cells. CircPVT1 knockdown significantly reduced NRAS levels and attenuated cancer hallmark phenotypes such as proliferation, migration, resistance to apoptosis, cytoskeletal disorganization, and epithelial-mesenchymal transition. The effects of circPVT1 knockdown were at least partially rescued by blocking binding of let-7 to NRAS 3′UTR with a target protector, suggesting that a circPVT1/let-7/NRAS axis exists and acts in cells to reverse NRAS downregulation and favor oncogenicity. While the phenotypic effects of circPVT1 knockdown may be attributable to the global action of circPVT1, the target protection assays resolved the relative contribution of the circPVT1/let-7/NRAS axis specifically.

scholarly journals Recent Attempts in the Design of Efficient PVC Plasticizers with Reduced Migration

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 844
Author(s):  
Joanna Czogała ◽  
Ewa Pankalla ◽  
Roman Turczyn
Keyword(s):  
Mechanical Properties ◽  
Partial Replacement ◽  
Total Replacement ◽  
Current Trends ◽  
Poly Vinyl Chloride ◽  
Wide Range ◽  
Migration Resistance ◽  
Secondary Plasticizer ◽  
New Compounds ◽  
Ethylhexyl Phthalate

This paper reviews the current trends in replacing commonly used plasticizers in poly(vinyl chloride), PVC, formulations by new compounds with reduced migration, leading to the enhancement in mechanical properties and better plasticizing efficiency. Novel plasticizers have been divided into three groups depending on the replacement strategy, i.e., total replacement, partial replacement, and internal plasticizers. Chemical and physical properties of PVC formulations containing a wide range of plasticizers have been compared, allowing observance of the improvements in polymer performance in comparison to PVC plasticized with conventionally applied bis(2-ethylhexyl) phthalate, di-n-octyl phthalate, bis(2-ethylhexyl) terephthalate and di-n-octyl terephthalate. Among a variety of newly developed plasticizers, we have indicated those presenting excellent migration resistance and advantageous mechanical properties, as well as those derived from natural sources. A separate chapter has been dedicated to the description of a synergistic effect of a mixture of two plasticizers, primary and secondary, that benefits in migration suppression when secondary plasticizer is added to PVC blend.

scholarly journals Phytochemical Analysis and Potential Biological Activities of Essential Oil from Rice Leaf

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 546 ◽  
Author(s):  
Truong Minh ◽  
Tran Xuan ◽  
Truong Van ◽  
Yusuf Andriana ◽  
Tran Viet ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Essential Oil ◽  
Atmospheric Pressure Chemical Ionization ◽  
Biological Activities ◽  
Methyl Ricinoleate ◽  
Gas Chromatography Mass Spectrometry ◽  
Phytochemical Analysis ◽  
Chemical Compositions ◽  
Rice Leaf ◽  
Rice Leaves

Although many investigations on phytochemicals in rice plant parts and root exudates have been conducted, information on the chemical profile of essential oil (EO) and potent biological activities has been limited. In this study, chemical compositions of rice leaf EO and in vitro biological activities were investigated. From 1.5 kg of fresh rice leaves, an amount of 20 mg EO was obtained by distillation and analyzed by gas chromatography-mass spectrometry (GC-MS), electrospray ionization (ESI), and atmospheric pressure chemical ionization (APCI) to reveal the presence of twelve volatile constituents, of which methyl ricinoleate (27.86%) was the principal compound, followed by palmitic acid (17.34%), and linolenic acid (11.16%), while 2-pentadecanone was the least (2.13%). Two phytoalexin momilactones A and B were first time identified in EO using ultra-performance liquid chromatography coupled with electrospray mass spectrometry (UPLC/ESI-MS) (9.80 and 4.93 ng/g fresh weight, respectively), which accounted for 7.35% and 3.70% of the EO, respectively. The assays of DPPH (IC50 = 73.1 µg/mL), ABTS (IC50 = 198.3 µg/mL), FRAP (IC50 = 700.8 µg/mL) and β-carotene oxidation (LPI = 79%) revealed that EO possessed an excellent antioxidant activity. The xanthine oxidase assay indicated that the anti-hyperuricemia potential was in a moderate level (IC50 = 526 µg/mL) as compared with the standard allopurinol. The EO exerted potent inhibition on growth of Raphanus sativus, Lactuca sativa, and two noxious weeds Echinochloa crus-galli, and Bidens pilosa, but in contrast, the growth of rice seedlings was promoted. Among the examined plants, the growth of the E. crus-galli root was the most inhibited, proposing that constituents found in EO may have potential for the control of the problematic paddy weed E. crus-galli. It was found that the EO of rice leaves contained rich phytochemicals, which were potent in antioxidants and gout treatment, as well as weed management. Findings of this study highlighted the potential value of rice leaves, which may provide extra benefits for rice farmers.

Study of reaction and kinetics in pyrolysis of methyl ricinoleate

1996 ◽  
Vol 73 (9) ◽  
pp. 1109-1112 ◽  
Author(s):  
Han Guobin ◽  
Liu Zuyu ◽  
Yao Suling ◽  
Yan Rufeng
Keyword(s):  
Methyl Ricinoleate

The influence of different geometries of matrix/scaffold on the remodeling process of a bone and bioresorbable material mixture with voids

2015 ◽  
Vol 22 (5) ◽  
pp. 969-987 ◽  
Author(s):  
Ivan Giorgio ◽  
Ugo Andreaus ◽  
Tomasz Lekszycki ◽  
Alessandro Della Corte
Keyword(s):  
Bone Growth ◽  
Matrix Material ◽  
Porous Solids ◽  
Artificial Material ◽  
Matrix Deposition ◽  
Aspect Ratios ◽  
Adopted Model ◽  
The Matrix ◽  
Bioresorbable Material

Since internal architecture greatly influences crucial factors for tissue regeneration, such as nutrient diffusion, cell adhesion and matrix deposition, scaffolds have to be carefully designed, keeping in mind case-specific mechanical, mass transport and biological requirements. However, customizing scaffold architecture to better suit conflicting requirements, such as biological and mechanical ones, remains a challenging issue. Recent advances in printing technologies, together with the synthesis of novel composite biomaterials, have enabled the fabrication of various scaffolds with defined shape and controlled in vitro behavior. Thus, the influence of different geometries of the assemblage of the matrix and scaffold on the remodeling processes of living bone and artificial material should be investigated. To this end, two implant shapes are considered in this paper, namely a circular inclusion and a rectangular groove of different aspect ratios. A model of a mixture of bone tissue and bioresorbable material with voids was used to numerically analyze the physiological balance between the processes of bone growth and resorption and artificial material resorption in a plate-like sample. The adopted model was derived from a theory for the behavior of porous solids in which the matrix material is elastic and the interstices are void of material.

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