Progesterone receptor gene polymorphism (PROGINS) in 701 women from a mammographic breast cancer screening program (NMPOA) in Southern Brazil

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21048-21048
Author(s):  
J. Giacomazzi ◽  
E. Aguiar ◽  
E. I. Palmero ◽  
L. Kalakun ◽  
L. Schuler-Faccini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Family History ◽  
Progesterone Receptor ◽  
Body Mass ◽  
Screening Program ◽  
Gail Model ◽  
Porto Alegre ◽  
Incidence And Mortality ◽  
History Of

21048 Background: Several genetic polymorphisms in hormone receptor genes have been associated with breast cancer (BC) risk. Among these, a 306 base-pair insertion of the Alu subfamily in intron 7 of the progesterone receptor (PR) gene, (PROGINS), has been associated with decreased BC risk in several populations. In Brazil, BC is a significant public health problem, due to its high incidence and mortality rates. In Porto Alegre, Brazil`s southernmost capital, a multidisciplinary Breast Cancer Prevention Project - the Nucleo Mama Porto Alegre Cohort (NMPOA) was started in 2004 and includes a mammographic screening program for women ages 40–69 years. Goal: Determine the allelic and genotypic frequencies of PROGINS in women undergoing annual BC screening and correlate its presence with mammography results and presence of additional BC risk factors (family history of BC, body mass index, estimated BC risk by the Gail model and age) at baseline and after 10 years. Methods: A sample of 701 women from the NMPOA BC screening program was consecutively enrolled in the study from November/2005 until March/2006. Clinical data, mammography results (as BIRADS categories) and BC risk information was obtained by chart review. PROGINS genotyping was performed by polymerase chain reaction (PCR). Results: Of the 701 patients studied, 504 (71,0%) were wild-type homozygous, 184 (26,2%) heterozygous and 13 (1,8%) homozygous for the PROGINS polymorphism. These genotypic frequencies are similar to those of other reports in different populations. Genotype was correlated with 5-year and vital BC risk estimates (Gail model), body mass index, family history of BC and mammography findings. A statistically significant association was found between the presence of PROGINS and a positive family history of BC (p< 0,05). Conclusions: The genotypic and allelic frequencies of the PROGINS polymorphism were not significantly different from those reported previously for other populations. Prospective clinical evaluation of the women followed in this program and correlation of genotype with clinical findings may be important to elucidate additional risks associated with the PROGINS polymorphism. No significant financial relationships to disclose.

Breast cancer risk estimates using the Gail Model in women from an annual screening program in Southern Brazil

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 20045-20045
Author(s):  
V. Belo Reyes ◽  
G. Skonieski ◽  
J. Zignani ◽  
A. Bedin ◽  
R. Giugliani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Family History ◽  
Screening Program ◽  
Southern Brazil ◽  
Gail Model ◽  
Degree Relative ◽  
Risk Estimates ◽  
History Of ◽  
The Mean

20045 Background: The Gail model is widely used to estimate breast cancer (BC) risk. It has been validated as a reliable risk predictor in North America, but very few studies have been done in other countries. This study intends to examine the estimated BC risk using the Gail Model in a sample of women from Southern Brazil a region with the highest BC incidence and mortality rates of the country. Methods: Lifetime and 5-year BC risk estimates were obtained for the first 1002 asymptomatic women (ages 40–69 years) enrolled in an annual BC screening program. The frequency of each of the model’s variables was recorded and compared to other studies. Information about family history (FH) included: presence of bilateral BC, male BC, first degree relative with BC and/or ovarian cancer (OC), relative with BC under age 50 and ≥ 2 relatives with either BC, OC or colorectal cancer (CRC). Other potential risk factors for BC such as body mass index and smoking were recorded. Results: Mean (± SD) values for age, age at menarche and age at birth of the first live child were 50.4 (± 7.75), 13.0 (± 1.80), and 21.6 (± 5.00) years, respectively. Only 50 (5.0%) women were nulliparous and 62 (6.2%) reported their first live birth after age 30. History of at least one first-degree relative (FDR) affected with BC was reported by 52 (5.2%), and 31 (3.1%) had a previous breast biopsy. The mean estimated BC risk in 5 years was 0.92% (± 0.49); for those under age 60, 24 (2.8%) had an estimated 5-yr risk over 1.66%. The mean estimated lifetime BC risk was 7.80 (± 3.2). Interestingly, a history of cancer in a FDR was reported by 32.6% of the women, and evidence of familial BC was observed in 20.4%. The estimated BC risk using the Gail model was significantly higher in women with a family history of BC < 50ys and with ≥ 2 relatives with either BC, OC or CRC. Smoking and overweight were reported by 28% and 65% of the women, respectively. Conclusions: BC risk estimates obtained with the Gail Model did not differ significantly from those described in other populations. However, specific findings in cancer FH were associated with higher risk estimates. The importance of FH and overweight will be further explored in a larger sample. Population-specific risk factors for BC should be sought in different communities to ensure proper risk estimates. No significant financial relationships to disclose.

The Early Findings From A Surveillance Screening Program For Women With A Family History Of Breast Cancer

2008 ◽  
Vol 34 (10) ◽  
pp. 1193
Author(s):  
Jonathan Jones ◽  
E. Vaughan-Williams ◽  
K. Gower-Thomas ◽  
S. Bolt
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Screening Program ◽  
History Of

scholarly journals Blood Pressure and Its Association with Gender, Body Mass Index, Smoking, and Family History among University Students

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hussein H. Alhawari ◽  
Sameeha Al-Shelleh ◽  
Hussam H. Alhawari ◽  
Aseel Al-Saudi ◽  
Dina Aljbour Al-Majali ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Family History ◽  
Cardiovascular Diseases ◽  
University Students ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Mean Difference ◽  
Significant Difference ◽  
History Of

Hypertension is one of the major risk factors associated with cardiovascular diseases. In this study, we will assess the frequency of hypertension among healthy university students and its association with gender, body mass index, smoking, and family history of both hypertension and cardiovascular diseases. We screened healthy university students ranging from 18 to 26 years of age. For each participant, we performed blood pressure measurements using a previously validated device and obtained demographic data, body mass index (BMI), smoking status, and family history of both hypertension and cardiovascular diseases. Out of the total number of 505 participants included in this study, 35.2% have blood pressure between 130/80 and 139/89, and 13.5% have blood pressure of more than 140/90. We found significant gender differences in both systolic pressure (p = 0.003) with mean difference = 18.08 mmHg (CI: 16.13 to 19.9) and diastolic pressure (p = 0.011) with mean difference = 3.6 mmHg (CI: 2.06 to 5.14), higher in males than in females. Upon comparing the mean difference in both systolic and diastolic blood pressure with BMI, we found significant differences in both systolic (p < 0.001) and diastolic (p = 0.002) blood pressure. We also found that smokers have significantly (p = 0.025) higher systolic blood pressure (mean difference = 4.2 mmHg, CI: 3.2 mmHg to 8.8 mmHg), but no significant difference for diastolic blood pressure (p = 0.386), compared to nonsmokers. First-degree family history of both hypertension and cardiovascular diseases affected systolic but not diastolic blood pressure. Taking into account the adverse short- and long-term effect of hypertension, we recommend adopting an awareness program highlighting the importance of screening blood pressure in young adolescent populations, keeping in mind that both high BMI and smoking are important modifiable factors.

scholarly journals Body Mass Index and its Relation with Socio-Demographic Factors among Healthcare Workers

BioMedica ◽  
2021 ◽  
Vol 37 (2) ◽  
pp. 93-99
Author(s):  
Mehnaz Munir ◽  
Hamza Nadeem Malik ◽  
Muhammad Jareer Alam ◽  
Ammara Arif ◽  
Fiza Khalid
Keyword(s):  
Body Mass Index ◽  
Family History ◽  
Marital Status ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
History Of ◽  
Socio Demographic Factors ◽  
History Of Obesity

<p><strong>Background and Objective:</strong> Obesity leads to multiple complications that in turn increase mortality worldwide. There is a rapid rise in obesity in the last decade, especially among physicians. The objective of this study was to find out the frequency and relationship of obesity with socio-economic factors among faculty of a local medical college in Lahore, Pakistan.<br /><strong>Methods: </strong>A descriptive cross-sectional study was conducted on 162 medical and paramedical staff of Fatima Memorial College of Medicine and Dentistry, Lahore for a duration of 7 months from February 2019 to August 2019. Data were collected by filling the questionnaires and standard tools were used for height and weight measurement. Overweight/obesity was defined as a body mass index of &ge;25 kg/m2.<br /><strong>Results:</strong> In this study, out of 86 males and 76 females, the majority of the respondents were between the ages of 21 and 35 years. Seventy three (45.1%) and thirty (18.5%) respondents were overweight and obese, respectively. Out of a total 162 subjects, 38 (24%) were hypertensive and 18 (11%) were suffering from diabetes. There was a statistically significant association of obesity with age (p &lt; 0.05), marital status (p &lt; 0.001), family history of obesity (p &lt; 0.001), and smoking (p &lt; 0.05).<br /><strong>Conclusion: </strong>Risk factors like age, marital status, family history of obesity, and smoking have a strong correlation with obesity in faculty members of a medical school.</p>

scholarly journals Hyperemesis Graviderum: An observational study and outcome at a tertiary teaching hospital in Dhaka city

2019 ◽  
Vol 30 (Number 1) ◽  
pp. 9-13
Author(s):  
R Ferdousey ◽  
R Pervin ◽  
U Naga ◽  
U N S R Chowdhury ◽  
N Khalil
Keyword(s):  
Body Mass Index ◽  
Family History ◽  
Body Mass ◽  
Adverse Outcome ◽  
Positive Family History ◽  
Education Level ◽  
Normal Serum ◽  
Term Pregnancy ◽  
Tertiary Teaching ◽  
History Of

Hyperemesis graviderum is a complication of pregnancy that can lead to severe maternal nutritional deprivation. About 0.14% -1.3% of pregnant women sufferedfrom hyperemesis graviderum. Women with hyperemesis grmidanan causing loss of greater than 5% of their pre-pregnancy weight. And has been linked to fetal growth restriction, wernickes encephalopathy resulting in fetal death in 40% of cases . Ilyperemesis graviderzaninterfire there working life, it is important to know the outcome of hyperemesis graviderum on fetus and mother. A tertiary level hospital based prospective study was conducted on woman suffering from Hyperemesis graviderum and attended in OPD and 1F'D of Holy Family Red Crescent Medical College Hospital, Bangladesh to asses the adverse outcome of Hyperemesis Graviderum on .mother and baby and identifies its determinants. The mean age of the study group was 26.2513.25 years. Regarding parity, 54.0% patients were found primipara and 46.0% patients found multipara. The majority of the subjects (66%) were normal weight, 18% patients had overweight by BM1 (body mass index) 12% patients were underweight and 4% patients were obese. Distribution of the study subjects according to educational status, it was found that 32% were primary, 44% patients were high school, 12% patients were SSC, 8% patients were HSC and 4% patients were graduate and above. Out of 50 cases, 64% were housewife, 18% patients were service, 4% patients were business and 10% patients were student. Majority of patients (70%) had positive family history of hyperemsisgravidenn. Study showed 46% respondent started vomiting within 6-10 gestational weeks, 30% started vomiting more than 10 gestational weeks and 24% started vomiting within 1-5 gestational weeks. Maximum subjects (78%) needed home treatment and 22% patients were hospitalization. Most of the patients (68.0%) hemoglobin level 6- 10mg/d 1 . Maximum were rhesus positive blood group. Most of the patients 98% had normal serum creatinine level, 86% patients had normal serum electrolytes, 94% patients had normal urine R/M/E, 78% patients had normal RS'S level, 100% patients of hyperemesis gravidunn patients ultrasonography reports in pregnancy was normal. Among 50 patients, 4% patients had abortion history, 2% cases had IUD, 44% patients had IUGR and 10% patients had AGA in pre-term pregnancy. Out of 23 term pregnancy, 24% cases had 1UGR and 22% cases had AGA. Two percent neonatal death after delivery. hyperemesis Graviderum is related to maternal age, parity, education level, body mass index, occupation of the patients, education level, family history of hyperemesis graviderum and adverse outcome on mother and baby.

Effect of Obesity and Family History on the Risk of Breast Cancer: Meta Analysis

2020 ◽  
Author(s):  
Enge Surabina Ketaren ◽  
◽  
Bhisma Murti ◽  
Vitri widyaningsih ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Family History ◽  
Body Mass ◽  
English Language ◽  
Meta Analysis ◽  
Random Effect ◽  
Positive Family History ◽  
Random Effect Model ◽  
Central Java

Background: Breast cancer is the most common cancer among women worldwide and currently ranked as the fifth leading cause of death from cancer in general. Studies have indicated that breast cancer was strongly associated with a positive family history of breast cancer.The risk of breast cancer also increased with the increasing levels of body‐mass index. This study aimed to examine the effect of obesity and family history on the risk of breast cancer. Subjects and Method: Meta analysis and systematic review was conducted by collecting published articles from Google Scholar, PubMed, Springer Link, DOAJ, and Science Direct databases.Keywords used “breast cancer” AND “risk factors” AND “BMI” OR “body mass index” AND “obesity”AND “family history” AND “cohort” AND “Asia”. The inclusion criteria were full text, using English language, using cohort study design, and reporting adjusted hazard ratio.The study population was Asian women. Intervention was obesity and family history with comparison non-obesity and no family history. The study outcome was breast cancer. The collected articles were selected by PRISMA flow chart. The quantitative data were analyzed by random effect model using Revman 5.3. Results: 6 studies fromTaiwan, Israel, Japan, Malaysia, Thailand, and Korea were selected for this study. This study showed that obesity (aHR= 1.01; 95% CI= 0.67 to 1.52; p= 0.96), with I²= 90% and family history (aHR= 1.69; 95% CI= 1.09 to 2.62; p= 0.02), with I²= 57%, were associated with breast cancer. Conclusion: Obesity and family history are associated with breast cancer. Keywords: breast cancer, obesity, family history Correspondence: Enge Surabina Ketaren. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 087838583646. DOI: https://doi.org/10.26911/the7thicph.05.56

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