Adherence (adh) to and beliefs about oral anticancer medications (OAMs) in patients (pts) with metastatic renal cell carcinoma (mRCC).

2013 ◽  
Vol 31 (31_suppl) ◽  
pp. 25-25
Author(s):  
Daniel M. Geynisman ◽  
Fay J. Hlubocky ◽  
Masha Kocherginsky ◽  
Walter Michael Stadler ◽  
Christopher Daugherty
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
College Graduates ◽  
Financial Burden ◽  
Illness Perception ◽  
Cross Sectional Study ◽  
Assessment Instruments ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Significant Difference

25 Background: Suboptimal adh to drugs is a problem in chronic diseases. In mRCC, OAMs are the mainstay of treatment (tx). Adh and its determinants in exclusively mRCC pts has not been studied in the US. This study aimed to evaluate adh to OAMs in mRCC pts, and describe pts understanding and beliefs about OAMs and their disease. Methods: Cross-sectional study of pts on OAMs for at least 60 days. Standardized assessment instruments used: Adh—MMAS-8 questionnaire (Q); beliefs and expectations regarding OAMs—Beliefs about Medicines Q (BMQ) and Brief-Illness Perception Q (IPQ); Quality of Life (QOL)—BSI-18, FKSI. Semi-structured interviews assessed financial burden, barriers to adh, understanding of prognosis and goals of therapy. Results: 52 pts interviewed with median age 65 (range 36-90), 73% male, 71% Caucasian, 40% college graduates. OAMs used: 38% sunitinib, 31% pazopanib, 21% everolimus, 8% axitinib. 1st line OAM tx: 46%; 2nd line tx: 33%; 3rd or beyond: 21%. MMAS-8: 10% low adheres, 25% intermediate, 65% high. Income: 35%<40K, 24%=40-60K, 41%>60K. Adh decreased as income increased across the 3 income levels from 82% to 67% to 45% (P=0.02). 13% reported financial difficulty paying for OAMs; 19% had ≥ $100/mo (0-500) out-of-pocket (OOP) cost. BMQ-N: 20 ± 4 (8-25); BMQ-C: 12 ± 4 (5-24). IPQ: 40 ± 12 (6-71). QOL: BSI 9 ± 8 (0-38); FKSI 43 ± 8 (21-60). No significant difference between adherers and non-adherers in regard to demographic, QOL, OOP costs or belief variables was noted. 29% reported not receiving counseling on taking OAMs. 59% believed mRCC is a chronic disease, 41% believed that their OAM can cure them and strongly agreed or agreed with “I expect to be free of cancer in the future.” 48% reported discussing prognosis with their MD. Conclusions: Self-reported adh to OAMs in mRCC is much better than in other chronic diseases, but not ideal. Surprisingly, adherence was negatively associated with income. Many pts felt mRCC was a chronic disease and over 40% believed they could be cured. Further research is needed addressing the development of an oncology-specific adh tool and defining an optimal adh benchmark for OAMs via prospective studies of self-reported adh, serum drug levels, and outcomes.

Adherence (adh) to and beliefs about oral anticancer medications (OAMs) in metastatic renal cell carcinoma (mRCC) patients (pts): A single-center pilot study in the United States.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e17511-e17511
Author(s):  
Daniel M. Geynisman ◽  
Fay J. Hlubocky ◽  
Masha Kocherginsky ◽  
Sarah M. Duster ◽  
Joseline X. Gomez ◽  
...  
Keyword(s):  
Chronic Disease ◽  
College Graduates ◽  
Financial Burden ◽  
Illness Perception ◽  
The United States ◽  
Cross Sectional Study ◽  
Single Center ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Significant Difference

e17511 Background: Suboptimal adh to drugs is a problem in chronic diseases. In mRCC, OAMs are the mainstay of treatment (tx). Adh and its determinants in exclusively mRCC pts has not been studied in the US. This study aimed to evaluate adh to OAMs in mRCC pts, and describe pts understanding and beliefs about OAMs and their disease. Methods: Single center, cross-sectional study of pts on OAMs for at least 60 days. Planned study size is 50 pts. Standardized assessment instruments used: Adh—MMAS-8 questionnaire (Q); beliefs and expectations regarding OAMs—Beliefs about Medicines Q (BMQ) and Brief-Illness Perception Q (IPQ); Quality of Life (QOL)—BSI-18, FKSI. Semi-structured interviews assessed financial burden, barriers to adh, understanding of prognosis and goals of therapy. Results: To date, 40 pts have been studied. Median age 66 (range 36-85), 75% male, 78% Caucasian, 43% college graduates, 58% with income ≤ 60K. OAMs used: 43% sunitinib, 25% pazopanib, 23% everolimus, 8% axitinib. 1st line tx: 45%; 2nd line tx: 30%; 3rd or beyond: 25%. MMAS-8: 7.4 ± 1.1 (range 3-8); 10% low adheres, 30% intermediate, 60% high. 36% reported not receiving counseling on taking OAMs. BMQ-Necessity: 20 ± 4 (range 8-25); BMQ-Concern: 12 ± 4 (range 5-24). IPQ: 40 ± 13 (range 6-71). QOL: BSI 10 ± 9 (range 0-38); FKSI 44 ± 8 (range 26-60). 18% reported financial difficulty paying for OAMs; 25% paid ≥ $100/mo. No significant difference between adherers and non-adherers in regard to demographic, QOL or belief variables was detected. 23% did not believe OAMs are chemotherapy. 67% believed mRCC is a chronic disease, 46% believed that their OAM may be able to cure them and 44% strongly agreed or agreed with “I expect to be free of cancer in the future.” 52% reported not discussing prognosis with their MD. Conclusions: Our data suggest that self-reported adh in mRCC is much better than in other diseases. Most pts felt mRCC was a chronic disease and almost 50% believed they could be cured. Further research is needed addressing the development of an oncology-specific adh tool and defining an optimal adh benchmark for OAMs via prospective studies of self-reported adh, serum drug levels and outcomes.

scholarly journals A cross-sectional study on effect of non-communicable diseases on prevalent oral health conditions

2016 ◽  
Vol 4 (1) ◽  
pp. 246 ◽  
Author(s):  
Aasim Farooq Shah ◽  
Irfan Ashraf Baba ◽  
Subha Soumya Dany ◽  
Manu Batra
Keyword(s):  
Chronic Disease ◽  
Oral Health ◽  
Chronic Diseases ◽  
General Health ◽  
Dental Health ◽  
Cross Sectional Study ◽  
Communicable Diseases ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Communicable Diseases

Background: Non communicable diseases (NCDs) are defined as diseases of long duration, generally progress slowly and are the major cause of adult mortality and morbidity worldwide. NCDs mainly lead by four diseases which include: cardiovascular diseases, diabetes mellitus (DM), cancers and chronic respiratory diseases. Poor oral health reflects the general health, and several oral diseases are related to chronic diseases. The aim and objectives was to find casual association between NCDs with oral disease and further aims to provide evidence to health care providers regarding the significance of oral health while treating the patients for NCDs.Methods: The present cross sectional study was conducted to examine the oral health status of patients with NCD reporting to Dental OPD of Government Dental College and Hospital, Srinagar.  This hospital based study done through a convenience sampling technique, using a questionnaire and oral examination. A self-administered questionnaire was written in English language and was also translated in local language, first part of questionnaire was used to collect the demographic details, second part was designed regarding the medication history, oral habits such as smoking and consumption of betel nuts, medical history and earlier visit to dentist, cleaning of teeth, significance of dental health and its effect on general health and the third part of questionnaire was completely based on dental examination. The data was entered manually on Microsoft excel and then analyzed on statistical package SPSS version 20. Associations between different variables were assessed through application of χ2. The Data was analyzed using SPSS Statistics 20.0.Results: The present study was established with a sample of 300 participants. Male to female ratio was 2:3. Mean age of the participants was 46.6 years. It was observed that out of the total patients who visited the dentist, 42% (n=126) suffered from some chronic disease. 61% (n=183) were oblivious of the importance of dental health. When inquired if oral health affects general health 58.6% (n= 176) acknowledged its importance. 59 participants who lost more than three teeth who had chronic disease, 58.6% (n=176) respondents presented with bleeding gums, 66.3% (n=199) with food deposition, 52% (n=158) had halitosis, 26% (n= 78) had oral ulceration, 22.3% (n=67).Conclusions: It was concluded from this study that majority of participants with chronic diseases had poor oral health which requires immediate attention from the medical practitioners as well as dentists should counsel patients for maintenance and promotion of oral health.

scholarly journals Evaluation of “being healthy, being away from chronic diseases” public service advertisement in Chongqing, China: A cross-sectional study

2017 ◽  
Author(s):  
Ping Hu ◽  
Ting ting Wu ◽  
Cheng bin Wu ◽  
Hao Huang ◽  
Zhirong Fu ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
Public Service ◽  
Cross Sectional Study ◽  
Public Health Issue ◽  
Global Public Health ◽  
Unhealthy Lifestyle ◽  
Cross Sectional ◽  
Media Campaigns ◽  
The Public

Background: Chronic diseases have become a global public health issue, and mass media campaigns are often used to encourage and sustain positive behavior change. Our aim was to evaluate the effect of public service advertising on the awareness of Chongqing citizens. Methods: The theme of the public service advertisement launched in Chongqing was “being healthy, being away from chronic diseases.” A self-designed questionnaire was used in an outdoor intercept survey to collect information about the perception of citizens toward the effect of the advertisement on cognitive situations. Results: A total of 985 valid questionnaires were received. Respondents had good understanding of chronic disease (23.6±4.1, total score: 30), but only 58.4% of participants thought cancer is one type of chronic disease. The awareness of cancer as a chronic disease among the group who had seen this advertisement (63.6%) was higher than that of the group who had not seen the advertisement (56.5%) (p=0.046). After watching the advertisement, approximately 77.4% of participants attempted to remind their family and friends to prevent chronic diseases, roughly 78.2% tried to persuade their family and friends to change their unhealthy lifestyle habits, and 73.2% of participants reported that it increased the possibility of their own lifestyle change. Logistic regression analysis indicates that occupation, educational level, watching the advertising through TV, watching the advertising through indoor LED screen, and watching the advertising through mobile TV affected the three post-viewing behavior changes Conclusion : The public service advertisement achieved a certain knowledge propaganda effect. It may help change awareness and improve health behavior of the public. Key words: Public service advertisement , Chronic diseases, Health; Awareness, Behavior

scholarly journals Digital Recruitment and Acceptance of a Stepwise Model to Prevent Chronic Disease in the Danish Primary Care Sector: Cross-Sectional Study (Preprint)

2018 ◽  
Author(s):  
Lars Bruun Larsen ◽  
Jens Sondergaard ◽  
Janus Laust Thomsen ◽  
Anders Halling ◽  
Anders Larrabee Sønderlund ◽  
...  
Keyword(s):  
Primary Care ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Low Cost ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Chi Square ◽  
Cross Sectional ◽  
Interaction Detection ◽  
Health Checks

BACKGROUND During recent years, stepwise approaches to health checks have been advanced as an alternative to general health checks. In 2013, we set up the Early Detection and Prevention project (Tidlig Opsporing og Forebyggelse, TOF) to develop a stepwise approach aimed at patients at high or moderate risk of a chronic disease. A novel feature was the use of a personal digital mailbox for recruiting participants. A personal digital mailbox is a secure digital mailbox provided by the Danish public authorities. Apart from being both safe and secure, it is a low-cost, quick, and easy way to reach Danish residents. OBJECTIVE In this study we analyze the association between the rates of acceptance of 2 digital invitations sent to a personal digital mailbox and the sociodemographic determinants, medical treatment, and health care usage in a stepwise primary care model for the prevention of chronic diseases. METHODS We conducted a cross-sectional analysis of the rates of acceptance of 2 digital invitations sent to randomly selected residents born between 1957 and 1986 and residing in 2 Danish municipalities. The outcome was acceptance of the 2 digital invitations. Statistical associations were determined by Poisson regression. Data-driven chi-square automatic interaction detection method was used to generate a decision tree analysis, predicting acceptance of the digital invitations. RESULTS A total of 8814 patients received an invitation in their digital mailbox from 47 general practitioners. A total of 40.22% (3545/8814) accepted the first digital invitation, and 30.19 % (2661/8814) accepted both digital invitations. The rates of acceptance of both digital invitations were higher among women, older patients, patients of higher socioeconomic status, and patients not diagnosed with or being treated for diabetes mellitus, chronic obstructive pulmonary disease, or cardiovascular disease. CONCLUSIONS To our knowledge, this is the first study to report on the rates of acceptance of digital invitations to participate in a stepwise model for prevention of chronic diseases. More studies of digital invitations are needed to determine if the acceptance rates seen in this study should be expected from future studies as well. Similarly, more research is needed to determine whether a multimodal recruitment approach, including digital invitations to personal digital mailboxes will reach hard-to-reach subpopulations more effectively than digital invitations only.

scholarly journals Evaluation of “being healthy, being away from chronic diseases” public service advertisement in Chongqing, China: A cross-sectional study

2017 ◽  
Author(s):  
Ping Hu ◽  
Ting ting Wu ◽  
Cheng bin Wu ◽  
Hao Huang ◽  
Zhirong Fu ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
Public Service ◽  
Cross Sectional Study ◽  
Public Health Issue ◽  
Global Public Health ◽  
Unhealthy Lifestyle ◽  
Cross Sectional ◽  
Media Campaigns ◽  
The Public

Background: Chronic diseases have become a global public health issue, and mass media campaigns are often used to encourage and sustain positive behavior change. Our aim was to evaluate the effect of public service advertising on the awareness of Chongqing citizens. Methods: The theme of the public service advertisement launched in Chongqing was “being healthy, being away from chronic diseases.” A self-designed questionnaire was used in an outdoor intercept survey to collect information about the perception of citizens toward the effect of the advertisement on cognitive situations. Results: A total of 985 valid questionnaires were received. Respondents had good understanding of chronic disease (23.6±4.1, total score: 30), but only 58.4% of participants thought cancer is one type of chronic disease. The awareness of cancer as a chronic disease among the group who had seen this advertisement (63.6%) was higher than that of the group who had not seen the advertisement (56.5%) (p=0.046). After watching the advertisement, approximately 77.4% of participants attempted to remind their family and friends to prevent chronic diseases, roughly 78.2% tried to persuade their family and friends to change their unhealthy lifestyle habits, and 73.2% of participants reported that it increased the possibility of their own lifestyle change. Logistic regression analysis indicates that occupation, educational level, watching the advertising through TV, watching the advertising through indoor LED screen, and watching the advertising through mobile TV affected the three post-viewing behavior changes Conclusion : The public service advertisement achieved a certain knowledge propaganda effect. It may help change awareness and improve health behavior of the public. Key words: Public service advertisement , Chronic diseases, Health; Awareness, Behavior

scholarly journals Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

2016 ◽  
Vol 11 (1) ◽  
pp. 6-10
Author(s):  
Mohammad Mushfiqur Rahman ◽  
Md Mazedur Rahman ◽  
Mamun Ibn Munim ◽  
Md Shariful Haque
Keyword(s):  
Single Dose ◽  
Surgical Site Infection ◽  
Financial Burden ◽  
Cross Sectional Study ◽  
Site Infection ◽  
College Hospital ◽  
Cross Sectional ◽  
Group I ◽  
Significant Difference ◽  
Clean Contaminated

Post-surgical wou  infection is a crucial factor in surgical practice. Prolong use of postoperative antibiotic is common practice in our surgical world. This causes financial burden to our patients a antibiotic resistance. But international journals a  literatures suggest using antibiotics as prophylaxis only at the time of operation a  no further postoperative antibiotic is needed in clean contaminated surgery. This comparative cross-sectional study was done at the department of surgery, Sylhet MAG Osmani Medical College Hospital from 1st July 2007 to 30th June 2008. A total number of 100 patients of clean-contaminated elective laparotomy were selected. Patients were ra omly divided into two groups, in Group-I (got single dose preoperative Inj. Ceftriaxone) a  in group-II (got single dose preoperative Inj. Ceftriaxone followed by Inj. Ceftriaxone for 2 days a  then Cap. Cefxime for next 5 days). There is no statistically significant difference in outcome between two groups. So, single dose preoperative Inj. Ceftriaxone (1gm) is sufficient as a prophylaxis of surgical site infection in clean-contaminated elective surgery.Faridpur Med. Coll. J. Jan 2016;11(1): 6-10

scholarly journals Efek Penyakit Kronis terhadap Gangguan Mental Emosional

2013 ◽  
Vol 7 (7) ◽  
pp. 309
Author(s):  
Giri Widakdo ◽  
Besral Besral
Keyword(s):  
Chronic Disease ◽  
Chronic Illness ◽  
Chronic Diseases ◽  
Emotional Disorders ◽  
Disease Risk ◽  
Standard Of Care ◽  
Cross Sectional Study ◽  
Emotional Disorder ◽  
Cross Sectional ◽  
Chronic Disease Risk

Hasil Riset Kesehatan Dasar tahun 2007 menunjukkan 11,6% penduduk Indonesia berumur 15 tahun ke atas mengalami gangguan mental emosional. Penelitian ini bertujuan untuk mengetahui efek penyakit kronis terhadap gangguan mental emosional. Desain penelitian ini adalah potong lintang mengggunakan data Riskesdas tahun 2007. Sebanyak 660.452 responden berusia di atas 15 tahun yang tidak mengalami gangguan jiwa dijadikan sampel. Gangguan mental emosional dinyatakan ada jika responden mem-punyai paling tidak enam dari 20 gangguan. Penyakit kronis seperti tuberculosis (TB) paru, hepatitis, jantung, diabetes, kanker, dan stroke diukur melalui wawancara yang didasarkan pada diagnosis petugas kesehatan. Hasil penelitian menunjukkan bahwa dari sepuluh penderita penyakit kronis, dua sampai lima penderita akan mengalami gangguan mental emosional. Analisis regresi logistik multivariat memperlihatkan bahwa risiko gangguan mental emosional semakin tinggi bersamaan dengan semakin banyak jumlah penyakit kronis yang diderita oleh responden. Responden yang menderita satu penyakit kronis berisiko 2,6 kali lebih besar untuk mengalami gangguan mental emosional, yang menderita dua penyakit kronis berisiko 4,6 kali, yang menderita tiga penyakit kronis atau lebih berisiko 11 kali. Kementerian Kesehatan disarankan untuk mengembangkan standar pelayanan penyakit kronis terkait dengan pengurangan dampak pada gangguan mental emosional dan dibentuknya tim bimbingan teknis pelayanan penyakit kronis.Basic Health Research (Riskesdas) year 2007 showed that 11.6 percent of Indonesia’s population aged 15 years and above suffering from mental emotional disorder. This study aimed to examine the effects of chronic illness to the mental emotional disorders. A cross-sectional study was performed that used Riskesdas 2007 data. Atotal of 660,452 respondents aged 15 years and over who are mentally health become sample of this study. Mental emotional disorders exist if they have at least six of the 20 disorder. Chronic diseases such as pulmonary tuberculosis, hepatitis, heart disease, diabetes, cancer, and stroke were measured based on diagnosis by health pro-fesional. The results showed that out of ten respondents with chronic illness, aproximately two to five will suffering from mental emotional disorder. Multivariat logistic regression analysis shows that the risk of developing mental emotional disorders higher as more number of chronic illnesses suffered by the respondent. Respondents suffering from one chronic disease were 2.6 times greater risk for emotional mental disorder, suffering from two chronic dis-ease have risk 4.6 times, which had three or more chronic disease risk have risk 11 times. It is suggested that the Ministry of Health to develop a standard of care of chronic diseases associated with reducing impact on the mental emotional disorders and establishment of teams for technical guidance chronic disease care.

scholarly journals Meta-Analysis the Effect of Chronic Disease on Catastrophic Health Expenditure

2020 ◽  
Author(s):  
Yeny Ristaning Belawati ◽  
◽  
Didik Gunawan Tamtomo ◽  
Bhisma Murti ◽  
◽  
...  
Keyword(s):  
Chronic Disease ◽  
Odds Ratio ◽  
Health Expenditure ◽  
English Language ◽  
Adjusted Odds Ratio ◽  
Financial Burden ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Catastrophic Health Expenditure ◽  
Cross Sectional

ABSTRACT Background: The growing prevalence of chronic diseases contributed to high financial risks of health care. High total out-of-pocket health expenditure relative to income can result in catastrophic health expenditure. This meta-analysis was performed to assess the effect of chronic disease on catastrophic health expenditure. Subjects and Method: Meta-analysis and systematic review was conducted by collecting articles from Google Scholar, PubMed, Springer Link databases, which published from year 2000 to 2020. Keywords to collect the articles including,” chronic disease” OR “chronic illness” AND “catastrophic health expenditure” OR “financial burden” AND “cross sectional” AND “adjusted odds ratio”. The inclusion criteria were full text, in English language, using cross-sectional study design, and reporting adjusted odds ratio. Catastrophic health expenditure criteria if capacity to pay was ≥40% (excluding primary needs). The study population was households. The intervention was chronic disease with comparison non chronic disease. The study outcome was catastrophic health expenditure. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using Revman 5.3. Results: 9 studies from Tanzania, Korea, China, Ghana, and India were selected for this study. This study showed that chronic disease increased catastrophic health expenditure (aOR= 1.94; 95% CI= 1.45 to 2.54; p<0.001). Conclusion: Chronic disease increases catastrophic health expenditure. Keywords: chronic disease, catastrophic health expenditure Correspondence: Yeny Ristaning Belawati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57216, Central Java. Email: [email protected]. Mobile: 082243302740. DOI: https://doi.org/10.26911/the7thicph.04.49

scholarly journals Multimorbidity, polypharmacy and primary prevention in community-dwelling adults in Quebec: a cross-sectional study

2019 ◽  
Vol 36 (6) ◽  
pp. 706-712 ◽  
Author(s):  
Tu N Nguyen ◽  
Patrice Ngangue ◽  
Jeannie Haggerty ◽  
Tarek Bouhali ◽  
Martin Fortin
Keyword(s):  
Chronic Disease ◽  
Primary Prevention ◽  
Chronic Diseases ◽  
Strong Association ◽  
Renin Angiotensin System ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Concurrent Use ◽  
History Of

Abstract Background Polypharmacy carries the risk of adverse events, especially in people with multimorbidity. Objective To investigate the prevalence of polypharmacy in community-dwelling adults, the association of multimorbidity with polypharmacy and the use of medications for primary prevention. Methods Cross-sectional analysis of the follow-up data from the Program of Research on the Evolution of a Cohort Investigating Health System Effects (PRECISE) in Quebec, Canada. Multimorbidity was defined as the presence of three or more chronic diseases and polypharmacy as self-reported concurrent use of five or more medications. Primary prevention was conceptualized as the use of statin or low-dose antiplatelets without a reported diagnostic of cardiovascular disease. Results Mean age 56.7 ± 11.6, 62.5% female, 30.3% had multimorbidity, 31.9% had polypharmacy (n = 971). The most common drugs used were statins, renin–angiotensin system inhibitors and psychotropics. Compared to participants without any chronic disease, the adjusted odds ratios (ORs) for having polypharmacy were 2.78 [95% confidence interval (CI): 1.23–6.28] in those with one chronic disease, 8.88 (95% CI: 4.06–19.20) in those with two chronic diseases and 25.31 (95% CI: 11.77–54.41) in those with three or more chronic diseases, P < 0.001. In participants without history of cardiovascular diseases, 16.2% were using antiplatelets and 28.5% were using statins. Multimorbidity was associated with increased likelihood of using antiplatelets (adjusted OR: 2.98, 95% CI: 1.98–4.48, P < 0.001) and statins (adjusted OR: 3.76, 95% CI: 2.63–5.37, P < 0.001) for primary prevention. Conclusion There was a high prevalence of polypharmacy in community-dwelling adults in Quebec and a strong association with multimorbidity. The use of medications for primary prevention may contribute to polypharmacy and raise questions about safety.

scholarly journals Neospora caninum Infection in Cattle in the Province of Kohgiluyeh and Boyer Ahmad, Southwest of Iran: Seroprevalence and Molecular Assessment

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Atefeh Darijani ◽  
Nasir Arefkhah ◽  
Sepehr Shahriarirad ◽  
Sina Zoghi ◽  
Mehdi Namavari ◽  
...  
Keyword(s):  
Neospora Caninum ◽  
Financial Burden ◽  
Cross Sectional Study ◽  
High Rate ◽  
Seroprevalence Rate ◽  
Caninum Infection ◽  
Cross Sectional ◽  
Significant Difference ◽  
Cattle Herds ◽  
Southwest Of Iran

Introduction. Among the protozoa of veterinary importance, Neospora caninum is responsible for large economic and productive losses in cattle herds. Dogs are being considered the definitive hosts of the parasite. Neospora caninum has gained considerable attention through its role in the etiology of bovine abortion. The current study aimed at assessing the status of Neospora infection in cattle in Boyer-Ahmad County in Kohgiluyeh and Boyer-Ahmad province, southwest of Iran. Methods. In this cross-sectional study, 150 cattle blood samples were collected and samples were screened for N. caninum antibodies using a modified direct agglutination test (MAT). For the same samples, 130 buffy coats were collected and tested, by PCR, for the presence of N. caninum DNA, targeting the Nc-5 gene. Results. Anti-N. caninum antibodies were detected in the sera of 49 out of 150 cattle which is corresponding to a seroprevalence rate of 32.7%. Neospora DNA was detected in buffy coats of 26 out of 127 (20.47%) cattle. Even though Neospora infection was more common in females and in five-year-old cattle by serology and molecular methods, yet there was no statistically significant difference between age, sex, and Neospora infection in both molecular and serological methods ( p > 0.05 ). Conclusion. Findings of the current study indicate a high rate of N. caninum infection in cattle of Boyer-Ahmad region in the southwest of Iran. This issue should be further investigated and the prevention and control of this parasite in livestock, due to the high financial burden of this parasite in the livestock industry, should be considered.

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