Adherence (adh) to and beliefs about oral anticancer medications (OAMs) in metastatic renal cell carcinoma (mRCC) patients (pts): A single-center pilot study in the United States.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e17511-e17511
Author(s):  
Daniel M. Geynisman ◽  
Fay J. Hlubocky ◽  
Masha Kocherginsky ◽  
Sarah M. Duster ◽  
Joseline X. Gomez ◽  
...  
Keyword(s):  
Chronic Disease ◽  
College Graduates ◽  
Financial Burden ◽  
Illness Perception ◽  
The United States ◽  
Cross Sectional Study ◽  
Single Center ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Significant Difference

e17511 Background: Suboptimal adh to drugs is a problem in chronic diseases. In mRCC, OAMs are the mainstay of treatment (tx). Adh and its determinants in exclusively mRCC pts has not been studied in the US. This study aimed to evaluate adh to OAMs in mRCC pts, and describe pts understanding and beliefs about OAMs and their disease. Methods: Single center, cross-sectional study of pts on OAMs for at least 60 days. Planned study size is 50 pts. Standardized assessment instruments used: Adh—MMAS-8 questionnaire (Q); beliefs and expectations regarding OAMs—Beliefs about Medicines Q (BMQ) and Brief-Illness Perception Q (IPQ); Quality of Life (QOL)—BSI-18, FKSI. Semi-structured interviews assessed financial burden, barriers to adh, understanding of prognosis and goals of therapy. Results: To date, 40 pts have been studied. Median age 66 (range 36-85), 75% male, 78% Caucasian, 43% college graduates, 58% with income ≤ 60K. OAMs used: 43% sunitinib, 25% pazopanib, 23% everolimus, 8% axitinib. 1st line tx: 45%; 2nd line tx: 30%; 3rd or beyond: 25%. MMAS-8: 7.4 ± 1.1 (range 3-8); 10% low adheres, 30% intermediate, 60% high. 36% reported not receiving counseling on taking OAMs. BMQ-Necessity: 20 ± 4 (range 8-25); BMQ-Concern: 12 ± 4 (range 5-24). IPQ: 40 ± 13 (range 6-71). QOL: BSI 10 ± 9 (range 0-38); FKSI 44 ± 8 (range 26-60). 18% reported financial difficulty paying for OAMs; 25% paid ≥ $100/mo. No significant difference between adherers and non-adherers in regard to demographic, QOL or belief variables was detected. 23% did not believe OAMs are chemotherapy. 67% believed mRCC is a chronic disease, 46% believed that their OAM may be able to cure them and 44% strongly agreed or agreed with “I expect to be free of cancer in the future.” 52% reported not discussing prognosis with their MD. Conclusions: Our data suggest that self-reported adh in mRCC is much better than in other diseases. Most pts felt mRCC was a chronic disease and almost 50% believed they could be cured. Further research is needed addressing the development of an oncology-specific adh tool and defining an optimal adh benchmark for OAMs via prospective studies of self-reported adh, serum drug levels and outcomes.

Adherence (adh) to and beliefs about oral anticancer medications (OAMs) in patients (pts) with metastatic renal cell carcinoma (mRCC).

2013 ◽  
Vol 31 (31_suppl) ◽  
pp. 25-25
Author(s):  
Daniel M. Geynisman ◽  
Fay J. Hlubocky ◽  
Masha Kocherginsky ◽  
Walter Michael Stadler ◽  
Christopher Daugherty
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
College Graduates ◽  
Financial Burden ◽  
Illness Perception ◽  
Cross Sectional Study ◽  
Assessment Instruments ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Significant Difference

25 Background: Suboptimal adh to drugs is a problem in chronic diseases. In mRCC, OAMs are the mainstay of treatment (tx). Adh and its determinants in exclusively mRCC pts has not been studied in the US. This study aimed to evaluate adh to OAMs in mRCC pts, and describe pts understanding and beliefs about OAMs and their disease. Methods: Cross-sectional study of pts on OAMs for at least 60 days. Standardized assessment instruments used: Adh—MMAS-8 questionnaire (Q); beliefs and expectations regarding OAMs—Beliefs about Medicines Q (BMQ) and Brief-Illness Perception Q (IPQ); Quality of Life (QOL)—BSI-18, FKSI. Semi-structured interviews assessed financial burden, barriers to adh, understanding of prognosis and goals of therapy. Results: 52 pts interviewed with median age 65 (range 36-90), 73% male, 71% Caucasian, 40% college graduates. OAMs used: 38% sunitinib, 31% pazopanib, 21% everolimus, 8% axitinib. 1st line OAM tx: 46%; 2nd line tx: 33%; 3rd or beyond: 21%. MMAS-8: 10% low adheres, 25% intermediate, 65% high. Income: 35%<40K, 24%=40-60K, 41%>60K. Adh decreased as income increased across the 3 income levels from 82% to 67% to 45% (P=0.02). 13% reported financial difficulty paying for OAMs; 19% had ≥ $100/mo (0-500) out-of-pocket (OOP) cost. BMQ-N: 20 ± 4 (8-25); BMQ-C: 12 ± 4 (5-24). IPQ: 40 ± 12 (6-71). QOL: BSI 9 ± 8 (0-38); FKSI 43 ± 8 (21-60). No significant difference between adherers and non-adherers in regard to demographic, QOL, OOP costs or belief variables was noted. 29% reported not receiving counseling on taking OAMs. 59% believed mRCC is a chronic disease, 41% believed that their OAM can cure them and strongly agreed or agreed with “I expect to be free of cancer in the future.” 48% reported discussing prognosis with their MD. Conclusions: Self-reported adh to OAMs in mRCC is much better than in other chronic diseases, but not ideal. Surprisingly, adherence was negatively associated with income. Many pts felt mRCC was a chronic disease and over 40% believed they could be cured. Further research is needed addressing the development of an oncology-specific adh tool and defining an optimal adh benchmark for OAMs via prospective studies of self-reported adh, serum drug levels, and outcomes.

scholarly journals Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

2016 ◽  
Vol 11 (1) ◽  
pp. 6-10
Author(s):  
Mohammad Mushfiqur Rahman ◽  
Md Mazedur Rahman ◽  
Mamun Ibn Munim ◽  
Md Shariful Haque
Keyword(s):  
Single Dose ◽  
Surgical Site Infection ◽  
Financial Burden ◽  
Cross Sectional Study ◽  
Site Infection ◽  
College Hospital ◽  
Cross Sectional ◽  
Group I ◽  
Significant Difference ◽  
Clean Contaminated

Post-surgical wou  infection is a crucial factor in surgical practice. Prolong use of postoperative antibiotic is common practice in our surgical world. This causes financial burden to our patients a antibiotic resistance. But international journals a  literatures suggest using antibiotics as prophylaxis only at the time of operation a  no further postoperative antibiotic is needed in clean contaminated surgery. This comparative cross-sectional study was done at the department of surgery, Sylhet MAG Osmani Medical College Hospital from 1st July 2007 to 30th June 2008. A total number of 100 patients of clean-contaminated elective laparotomy were selected. Patients were ra omly divided into two groups, in Group-I (got single dose preoperative Inj. Ceftriaxone) a  in group-II (got single dose preoperative Inj. Ceftriaxone followed by Inj. Ceftriaxone for 2 days a  then Cap. Cefxime for next 5 days). There is no statistically significant difference in outcome between two groups. So, single dose preoperative Inj. Ceftriaxone (1gm) is sufficient as a prophylaxis of surgical site infection in clean-contaminated elective surgery.Faridpur Med. Coll. J. Jan 2016;11(1): 6-10

scholarly journals Meta-Analysis the Effect of Chronic Disease on Catastrophic Health Expenditure

2020 ◽  
Author(s):  
Yeny Ristaning Belawati ◽  
◽  
Didik Gunawan Tamtomo ◽  
Bhisma Murti ◽  
◽  
...  
Keyword(s):  
Chronic Disease ◽  
Odds Ratio ◽  
Health Expenditure ◽  
English Language ◽  
Adjusted Odds Ratio ◽  
Financial Burden ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Catastrophic Health Expenditure ◽  
Cross Sectional

ABSTRACT Background: The growing prevalence of chronic diseases contributed to high financial risks of health care. High total out-of-pocket health expenditure relative to income can result in catastrophic health expenditure. This meta-analysis was performed to assess the effect of chronic disease on catastrophic health expenditure. Subjects and Method: Meta-analysis and systematic review was conducted by collecting articles from Google Scholar, PubMed, Springer Link databases, which published from year 2000 to 2020. Keywords to collect the articles including,” chronic disease” OR “chronic illness” AND “catastrophic health expenditure” OR “financial burden” AND “cross sectional” AND “adjusted odds ratio”. The inclusion criteria were full text, in English language, using cross-sectional study design, and reporting adjusted odds ratio. Catastrophic health expenditure criteria if capacity to pay was ≥40% (excluding primary needs). The study population was households. The intervention was chronic disease with comparison non chronic disease. The study outcome was catastrophic health expenditure. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using Revman 5.3. Results: 9 studies from Tanzania, Korea, China, Ghana, and India were selected for this study. This study showed that chronic disease increased catastrophic health expenditure (aOR= 1.94; 95% CI= 1.45 to 2.54; p<0.001). Conclusion: Chronic disease increases catastrophic health expenditure. Keywords: chronic disease, catastrophic health expenditure Correspondence: Yeny Ristaning Belawati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57216, Central Java. Email: [email protected]. Mobile: 082243302740. DOI: https://doi.org/10.26911/the7thicph.04.49

scholarly journals Trends and Challenges in Rural Homeless Populations

2021 ◽  
Author(s):  
Celena Derderian ◽  
Anthony Easterday ◽  
David Driscoll ◽  
Sriram Ramaswamy
Keyword(s):  
United States ◽  
Health Care ◽  
Social Services ◽  
Health Care Services ◽  
The United States ◽  
Cross Sectional Study ◽  
Public Health Issue ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Homeless Veterans

Background: Homelessness is a significant public health issue in the United States. Living in rural locations has been associated with an increase in poverty. Additionally, it has been found that veterans are at greater risk for homelessness than the general population. The aim of this research was to characterize rural homeless veterans and non-veterans living in Nebraska, United States. Methods: A cross-sectional study was conducted comprising 50 veterans and 64 non-veterans recruited from rural locations in Nebraska. Fully structured interviews were conducted by the research staff that consisted of questions regarding participant sociodemographics, housing, clinical characteristics, psychosocial factors, and utilization of health care and social services. Results: In comparison to non-veterans, rural homeless veterans were found to be older, more qualified, and more likely to have ever been married. Veterans spent fewer nights in a shelter and more nights in a halfway house. Regarding clinical features, veterans were more likely to report posttraumatic stress disorder and alcohol misuse. Veterans also reported shorter travel times to reach health care services and used them more often compared to non-veterans. Conclusion: These findings suggest that homeless veterans and non-veterans within rural settings have unique needs to be addressed when it comes to providing health care and social services, as well as in attempts to eliminating homelessness. Further research will help in the development of improved methods to support rural veterans and non-veterans.

scholarly journals Neospora caninum Infection in Cattle in the Province of Kohgiluyeh and Boyer Ahmad, Southwest of Iran: Seroprevalence and Molecular Assessment

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Atefeh Darijani ◽  
Nasir Arefkhah ◽  
Sepehr Shahriarirad ◽  
Sina Zoghi ◽  
Mehdi Namavari ◽  
...  
Keyword(s):  
Neospora Caninum ◽  
Financial Burden ◽  
Cross Sectional Study ◽  
High Rate ◽  
Seroprevalence Rate ◽  
Caninum Infection ◽  
Cross Sectional ◽  
Significant Difference ◽  
Cattle Herds ◽  
Southwest Of Iran

Introduction. Among the protozoa of veterinary importance, Neospora caninum is responsible for large economic and productive losses in cattle herds. Dogs are being considered the definitive hosts of the parasite. Neospora caninum has gained considerable attention through its role in the etiology of bovine abortion. The current study aimed at assessing the status of Neospora infection in cattle in Boyer-Ahmad County in Kohgiluyeh and Boyer-Ahmad province, southwest of Iran. Methods. In this cross-sectional study, 150 cattle blood samples were collected and samples were screened for N. caninum antibodies using a modified direct agglutination test (MAT). For the same samples, 130 buffy coats were collected and tested, by PCR, for the presence of N. caninum DNA, targeting the Nc-5 gene. Results. Anti-N. caninum antibodies were detected in the sera of 49 out of 150 cattle which is corresponding to a seroprevalence rate of 32.7%. Neospora DNA was detected in buffy coats of 26 out of 127 (20.47%) cattle. Even though Neospora infection was more common in females and in five-year-old cattle by serology and molecular methods, yet there was no statistically significant difference between age, sex, and Neospora infection in both molecular and serological methods ( p > 0.05 ). Conclusion. Findings of the current study indicate a high rate of N. caninum infection in cattle of Boyer-Ahmad region in the southwest of Iran. This issue should be further investigated and the prevention and control of this parasite in livestock, due to the high financial burden of this parasite in the livestock industry, should be considered.

scholarly journals A survey of violence and vulgarity in children television programs: a content analysis, and assessment of perceptions of parents and children (ViCTiM study)

2021 ◽  
Author(s):  
Ashraf Jahangeer ◽  
Manahil Akmal ◽  
Bushra Perveen ◽  
Maaz Bin Nazir ◽  
Faryal Mustafa ◽  
...  
Keyword(s):  
Content Analysis ◽  
Federal Communication Commission ◽  
World Health Organisation ◽  
The United States ◽  
Cross Sectional Study ◽  
World Health ◽  
Television Programs ◽  
Cross Sectional ◽  
Parents And Children ◽  
Significant Difference

Abstract Objectives: To quantify the depiction of violence and vulgarity in television programmes for children, and to assess the perception and practices of parents and children about television programmes meant for children. Methods:  We conducted this mixed-methods cross-sectional study in Karachi, Pakistan in the months of August-September 2018, after approval from the ethics review board of Dow University of Health Sciences, Karachi. First, a content analysis of over 102 hours of various television programmes meant for children was performed in the light of the guidelines set out by the World Health Organisation, the United States Federal Communication Commission and the Pakistan Electronic Media Regulatory Authority. Seven trained researchers sampled the children prime time throughout a week, including the weekends, using a structured tally sheet. Subsequently, interviews were conducted with dyad of parent-children from the employees’ list of a public-sector university. A questionnaire was also administered to assess the practices and perceptions of the parents-children dyad about the programmes.  Data was analysed using SPSS 24. Results: Of the 173 subjects, 84(48.6%) were parents and 89(51.4%) were children. The mean age of the children was 89 children 9.8±3.7 years. Content analysis comprised 6130 minutes, of which 5442(88.8%) had depictions of violence and vulgarity. Depiction of violence and vulgarity was prevalent on television channels that were watched the most, but there was no significant difference in this regard (p=0.238). Of the parents, 68(81%) expressed concern over the effect of screen time and content on the mental health of their children.

scholarly journals Single-Blind and Double-Blind Peer Review: Effects on National Representation

2021 ◽  
Author(s):  
Meghana Kalavar ◽  
Arjun Watane ◽  
David Wu ◽  
Jayanth Sridhar ◽  
Prithvi Mruthyunjaya ◽  
...  
Keyword(s):  
Peer Review ◽  
Country Of Origin ◽  
The United States ◽  
Cross Sectional Study ◽  
Double Blind ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Us ◽  
Double Blinded ◽  
Single Blind

AbstractBackground/ObjectivesTo assess whether the type of peer-review (single-blinded vs double-blinded) has an impact on nationality representation in journals.MethodsA cross-sectional study analyzing the top ten nationalities contributing to the number of articles across 16 ophthalmology journals.ResultsThere was no significant difference in the percentage of articles published from the journal’s country of origin between the top single-blind journals and top double-blind journals (SB= 42.0%, DB = 26.6%, p=0.49) but there was a significant difference between the percentage of articles from the US (SB=48.0%, DB=22.8%, p=0.02). However, there was no significant difference for both country of origin (SB =38.0%, DB =26.6%, p=0.43) and articles from the US (SB=35.0%, DB=22.8%, p=0.21) when assessing the top 8 double-blind journals matched with single-blind journals of a similar impact factor. The countries that most commonly made the top ten lists for highest number of articles were the US (n=16, 100%) and England (n=16, 100%). This held true even for journals established outside the United States (US=11/12, England=11/12).ConclusionsThere was no statistically significant difference in country-of-origin representation between single-blind journals and double-blind journals. However, higher income countries contributed most often to the journals studied even among journals based outside the US.

scholarly journals Assessing the adherence to treatment among patients with cardiovascular diseases in Kermanshah, Iran

2021 ◽  
Vol 11 (1) ◽  
pp. 80-86
Author(s):  
Parisa Janjani ◽  
Mohammad Reza Majzoobi ◽  
Amir Sanjabi ◽  
Mojtaba Movahed ◽  
Alireza Rai ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Meaning In Life ◽  
Pearson Correlation ◽  
Illness Perception ◽  
Cross Sectional Study ◽  
Life Questionnaire ◽  
Adherence To Treatment ◽  
Cross Sectional ◽  
Significant Difference ◽  
Physician Empathy

Background: The present study aimed to investigate the psychological determinants of adherence to treatment among patients with cardiovascular diseases (CVDs) referring to Imam Ali Hospital in Kermanshah, Iran. Methods: This cross-sectional study was conducted on 227 patients (mean age=58.10, SD = 13.44) with CVDs, randomly selected amongst those admitted to Imam Ali cardiovascular center of Kermanshah in 2018. Data were collected through Meaning in Life Questionnaire (MLQ), the Jefferson Scale of Patient’s Perceptions of Physician Empathy (JSPPPE), the Illness Perception Questionnaire (IPQ), and Adherence to Treatment Questionnaire. The relationships between the criterion and predictor variables were assessed using Pearson correlation coefficient and linear regression (stepwise method) in IBM SPSS Statistics-23. Results: The adherence to treatment was associated with meaning in life (r=0.367), patients’ perceptions of physician empathy (r=0.218), and illness perception (r=-0.238), at the 0.01 level. Meaning in life, patient’s perceptions of physician empathy, and illness perception explained 18.6% of the variance in adherence to treatment. Meaning in life (beta=0.367 and P≤0.001) was the most influential predictor of adherence to treatment. Additionally, there was a significant difference in the score of adherence to treatment by gender (23.46±4.42 for female vs. 24.77±3.53 for male, P = 0.030). Conclusion: The patients’ perceptions of physician empathy, meaning in life, and illness perception were important factors to predict adherence to treatment in patients with CVDs. Gender was a significant predictor of the adherence to treatment.

scholarly journals Need for Diabetic Screening an a Periodontal Setup

2020 ◽  
Vol 3 (10) ◽  
pp. 335-337
Author(s):  
Sneha Agarwal ◽  
K. Rekha Rani ◽  
D. Satyanarayana Naidu
Keyword(s):  
Chronic Disease ◽  
Early Detection ◽  
Cross Sectional Study ◽  
Research Data ◽  
Diabetes Research ◽  
Sectional Study ◽  
Initial Sample ◽  
Cross Sectional ◽  
Significant Difference ◽  
Diabetic Screening

INTRODUCTION: Periodontitis has been proved to be linked deeply with the chronic ailment diabetes. Research data shows that their relationship is direct and bifacial. The prevalence of both these diseases is on the rise but still there is a scarcity of diabetic screening in periodontal set-ups.AIM: To lay emphasis on the need of diabetic screening in a periodontal set-upMATERIAL AND METHODS: An observational, cross-sectional study with an initial sample size of 200 patients was conducted. Periodontitis was evaluated with the CPI index and RBS was measured using a blood glucometer.RESULTS: Significant difference in the periodontitis patients who were aware and unaware of their diabetic status.CONCLUSION: Screening for diabetes in a periodontal clinic is conducive to the creation of awareness and early detection and treatment of such a chronic disease and can help avoid the setting in of related complications by giving the patient a chance to initiate an early intervention.

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