Influence of organ location and sex of patient on pancreatic neuroendocrine tumor 5-year survival.

e15713 Background: Pancreatic neuroendocrine tumors (PNET) represent a rare tumor histology among patients diagnosed with pancreatic cancer (less than 2% incidence). These tumors arise from the endocrine tissues of the pancreas and can present with a variable clinical course. We sought to examine the overall survival (OS) of patients based upon sex and anatomic location via the SEER database. Methods: Accessing the SEER-Medicare database, we identified 3,242 patients with both Pancreatic Cancer and Neuroendocrine Tumor (NET) histologic validation using ICD-O-3 Codes while excluding Large Cell, Small Cell, and Mixed Endocrine-Exocrine tumors. We then sub-stratified the data to male (N = 1816) and female (N = 1426) sex as well as pancreatic location: Head (Male = 831; Female = 657), Body (Male = 283; Female = 258), or Tail (Male = 701; Female = 510). We excluded PNETs of the pancreatic duct as there were only 2 cases (Male = 1; Female = 1). All comparison tests were run with SEER*STAT 8.3.2 via a Two-Sample t-Test Assuming Equal Variances. OS was analyzed using the Kaplan–Meier method. Results: Overall, both Male and Female patients with PNET have significantly improved 5-Year survival compared with those patients with Pancreatic Adenocarcinoma ((47.47% (n = 3242) vs 6.6% (n = 117,204), p < 0.05). There is no difference in 5-Year OS between Male (44.9%) and Female (50.5%) patients with PNET accounting for all locations. There is a trend towards significance in improved 5-Year OS in Female patients with Tail PNET versus Male patients with Tail PNET (55.8% (n = 510) vs 48.6% (n = 701), p < 0.06). Significantly, Female patients with Tail PNET have a significantly higher 5-Year OS compared to Female patients with Head PNET (55.8% (n = 510) vs 46.9% (n = 657), p < 0.05). There was a trend towards improved 5-Year OS in Female patients with Tail PNET versus those within the Body (55.8% (n = 510) vs 48.6% (n = 258), p < 0.01). Conclusions: Based upon this population study, Female patients with PNET localized to the Tail have a significantly higher 5-Year OS than Female patients with PNET localized to the Head of the Pancreas. These same patients trend towards improved survival when compared with Female patients with Body PNET as well as Male patients with Tail PNET.

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TECHNICAL DETAILS AND RESULTS OF CRYOABLATION IN PANCREATIC CANCER

Clinical Practice ◽

10.17816/clinpract7324-35 ◽

2016 ◽

Vol 7 (3) ◽

pp. 24-35

Author(s):

D A Ionkin ◽

Yu A Stepanova ◽

A B Shurakova ◽

A V Chzhao

Keyword(s):

Quality Of Life ◽

Pancreatic Cancer ◽

Survival Rates ◽

Stage Iv ◽

The Body ◽

Results Of Treatment ◽

Kaplan Meier ◽

Intraperitoneal Bleeding ◽

Head Of The Pancreas

Aim: To improve the results of treatment of terminal stage pancreatic cancer. Materials and methods. Since 2012 cryosurgery was performed in 45 patients - 20 men (44.4%) and 25 women (55.6%) with pancreatic cancer. With mean age of 59 ± 3 years. The head of the pancreas was struck in 20 (44.4%) cases, a head-body - in 13 (28.9%), the body - in 12 (26.7%). The following distribution of patients depending on pacreatic cancer stages were noted: stage IV- 34 patients, stage III- 11. In 8 patients with pancreatic cancer and liver metastases simultaneous cryodestruction of tumorsof the pancreas and liver malformations were performed. Local cryodestruction has been supplemented by bypass in 29 cases (64.4%). In one case, cryosurgery was performed on segment of the portal vein after the pankreatoduoenal resection. All patients subsequently were underwent adjuvant chemotherapy, supplemented by regional chemoembolization in 10 cases.Results. We proposed indications and contraindications for cryoablation. Intraperitoneal bleeding was diagnosed in 2 (4.4%) cases. Acute pancreatitis - in 5 (11.1%) cases. Suppuration manipulation area was noted in 2 (4.4%) cases. Ascites was detected in 9 (20.0%) patients (docked within 5-8 days therapeutically). Wound supporation was observed in 2 (4.4%) cases. Complete pain relief atchieved after cryoablation was reached in 38% of cases or significant reduction of its intensity in 41%. Kaplan-Meier survival in patients with pancreatic cancer for 6 months was 56%, for 12 months - 28%, for 24 months -15% and for 28 months - 4.3%.Conclusion. Сryodestruction for cancer of the pancreas in patients with unrespectable tumors improves the quality of life of cancer patients, primarily due to decrease pain intensity. Application of chemotherapy improves quality of life and can prolong survival rates.

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Case Report: Grade 2 Metastatic Pancreatic Neuroendocrine Tumor With Progression of One Metastasis After Pregnancy to Grade 3 Large-Cell Neuroendocrine Carcinoma: One Case Cured by Resection With Genomic Characterization of the Two Components

Frontiers in Oncology ◽

10.3389/fonc.2021.646992 ◽

2021 ◽

Vol 11 ◽

Author(s):

Jean-Luc Raoul ◽

Marie-Françoise Heymann ◽

Frédéric Dumont ◽

Alain Morel ◽

Hélène Senellart ◽

...

Keyword(s):

Neuroendocrine Tumor ◽

Pancreatic Neuroendocrine Tumor ◽

Large Cell ◽

Genomic Signatures ◽

Pancreatic Net ◽

Genomic Characterization ◽

Poorly Differentiated ◽

Grade 3

Temporal and spatial tumor heterogeneity can be observed in pancreatic neuroendocrine tumor. We report the case of a young woman with long term stabilization of a G2 metastatic pancreatic NET that, after pregnancy, suddenly progressed into one single liver metastasis corresponding to a transformation into G3 large-cell neuroendocrine cancer. The patient underwent liver resection (the progressive and one dormant metastasis). With a 45 months follow-up the patient is without evolutive disease. Exome sequencing of the two metastases revealed completely different genomic signatures and gene alterations: the dormant metastasis was MSS without any gene alteration; the poorly differentiated tumor was MSI, with gain of many mutations including MEN1, BCL2, MLH1 and TP53 corresponding to a mutational signature 11. Could temozolomide play a role in this transformation?

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Covid-19 infection in patients with a history of everolimus use.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e18744 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e18744-e18744

Author(s):

Metin Pehlivan ◽

Adnan Aydiner

Keyword(s):

Breast Cancer ◽

Neuroendocrine Tumor ◽

Mtor Inhibitor ◽

Thymic Carcinoma ◽

Additional Risk ◽

Female Patients ◽

The Past ◽

The World ◽

History Of ◽

Male Patients

e18744 Background: The COVID-19 infection, declared as a pandemic by WHO in March 2020, continues its effects all over the world. Cancer patients also get COVID infection and in some patients this infection is mortal. In our study, we examined the course of COVID-19 infection in patients who actively or in the past used Everolimus. Methods: Patients who used everolimus actively or in the past were examined in our study. Patients who survive after the first cases seen in Turkey March 11, 2020 ; were evaluated in terms of whether they had COVID-19. Demographic characteristics and primary malignancies of the patients were examined. Patients who had COVID-19 infection and died were identified. Results: Our study consists of 50 patients in total. 14 (28%) of the patients were male and 36 (72%) were female. The average age of the patients is 56.72 (28-82), the average age of the male patients is 52.8 (28-80) and the average age of the female patients is 57.58 (36-82). 17 of the patients were treated for breast cancer, 11 for neuroendocrine tumor, 7 for tuberous sclerosis, 5 for renal cell carcinoma, 4 for thymic carcinoma, 2 for thymoma, 2 for ovarian ca, 2 for perivascular ecrine tumor. While it is the most common breast cancer in women (47.2% of female patients), neuroendocrine tumor is the most common in male patients (35.7% of male patients). While 13 patients were actively using everolimus (26%), 37 patients (74%) had discontinued everolimus treatment for 1 year or more.5 of our patients were diagnosed with COVID-19 infection (10% of all patients). 2 of these five patients are actively using everolimus. Of those diagnosed with COVID-19, 3 are women and 2 are men.The average age of the patients is 50.08 (43-66). While 3 patients had mild illness (60%), 2 patients (40%) died. One of the deceased patients is female and one is male. The female patient had a history of using everolimus for breast cancer, while the male patient died at the age of 52 while actively using everolimus for thymoma. Conclusions: Everolimus is a MTOR inhibitor used in many malignancy treatments. In our study, we found that 10% of our patients had COVID infection and 2 of our patients died due to COVID-19. In the group that discontinued everolimus treatment for a year or more, 1 patient died due to COVID-19, and 1 patient in the group still receiving everolimus treatment. Studies with larger patient populations are needed to determine whether everolimus carries an additional risk of COVID-19 infection.

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Laparoscopic enucleation of a neuroendocrine tumor at the back wall of the pancreas - case report and literature review

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh200821115e ◽

2020 ◽

pp. 115-115

Author(s):

Dragan Eric ◽

Vladimir Milosavljevic ◽

Boris Tadic ◽

Dragan Gunjic ◽

Milos Bjelovic

Keyword(s):

Neuroendocrine Tumor ◽

Histopathological Examination ◽

Incidental Finding ◽

Pancreatic Neuroendocrine Tumor ◽

Dorsal Side ◽

The Body ◽

Diagnostic Challenge ◽

Back Wall ◽

Efficient Manner ◽

Laparoscopic Enucleation

Introduction Introduction. Neuroendocrine tumors of the pancreas are rare neoplasms. They are divided into two groups: functional and non-functional. Non-functional tumors represent a diagnostic challenge, given that they often remain asymptomatic and are diagnosed as an incidental finding. Case outline. We present a patient in whom the tumor was discovered at the junction of the body and the tail of the pancreas on the dorsal side. The patient had no specific symptomatology, with no loss in body weight. Considering the conducted diagnostics and the condition of the patient, we decided to perform a laparoscopic enucleation. This procedure has been applied in a safe and efficient manner, so the operative and postoperative course passed without complications. The definitive histopathological examination confirmed the finding that it was a non-functional pancreatic neuroendocrine tumor. Conclusion. Laparoscopic enucleation is an effective and safe treatment modality of these tumors with well-known advantages compared to open surgery, but there is always a tending to improve already existing results and thus to contribute not only to treatment but to greater and better comfort of the patient

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Sex differences in treatment strategy for coronary artery aneurysms: Insights from the international Coronary Artery Aneurysm Registry

Netherlands Heart Journal ◽

10.1007/s12471-021-01649-5 ◽

2021 ◽

Author(s):

F. Arslan ◽

I. J. Núñez-Gil ◽

R. Rodríguez-Olivares ◽

E. Cerrato ◽

M. Bollati ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Aneurysm ◽

Artery Aneurysm ◽

Risk Profile ◽

Female Patients ◽

Coronary Syndrome ◽

Kaplan Meier ◽

Coronary Aneurysms ◽

Male Patients

Abstract Introduction Sex disparities exist in coronary artery disease (CAD) in terms of risk profile, clinical management and outcome. It is unclear if differences are also present in coronary aneurysms, a rare variant of CAD. Methods Patients were selected from the international Coronary Artery Aneurysm Registry (CAAR; ClinicalTrials.gov: NCT02563626), and differences between groups were analysed according to sex. The CAAR database is a prospective multicentre registry of 1565 patients with coronary aneurysms (336 females). Kaplan-Meier method was used for event-free survival analysis for death, major adverse cardiac events (MACE: composite endpoint of death, heart failure and acute coronary syndrome) and bleeding. Results Female patients were older, were more often hypertensive and less frequently smoker. They were treated conservatively more often compared to male patients and received significantly less frequently aspirin (92% vs 88%, p = 0.002) or dual antiplatelet therapy (DAPT) (67% vs 58%, p = 0.001) at discharge. Median DAPT duration was also shorter (3 vs 9 months, p = 0.001). Kaplan-Meier analysis revealed no sex differences in death, MACE or bleeding during a median follow-up duration of 37 months, although male patients did experience acute coronary syndrome (ACS) more often during follow-up (15% vs 10%, p = 0.015). Conclusions These CAAR findings showed a comparable high-risk cardiovascular risk profile for both sexes. Female patients were treated conservatively more often and received DAPT less often at discharge, with a shorter DAPT duration. ACS was more prevalent among male patients; however, overall clinical outcome was not different between male and female patients during follow-up.

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Novel Broccoli Sulforaphane-Based Analogues Inhibit the Progression of Pancreatic Cancer without Side Effects

Biomolecules ◽

10.3390/biom10050769 ◽

2020 ◽

Vol 10 (5) ◽

pp. 769

Author(s):

Christina Georgikou ◽

Laura Buglioni ◽

Maximilian Bremerich ◽

Nico Roubicek ◽

Libo Yin ◽

...

Keyword(s):

Pancreatic Cancer ◽

Side Effects ◽

Cancer Treatment ◽

Target Genes ◽

The Body ◽

New Drugs ◽

C Elegans ◽

Highly Active ◽

Kaplan Meier ◽

Sulfinyl Group

The naturally occurring isothiocyanate sulforaphane, found in Brassicaceae vegetables, is promising in cancer treatment, e.g., by the normalization of enhanced levels of NF-κB-signaling in tumor stem cells. We chemically synthesized seven sulforaphane analogues by substitution of the sulfinyl group (S(O)) to either sulfimidoyl (S(NR)) or sulfonimidoyl (S (O) (NR)) groups, and characterized them in the cell lines of pancreatic cancer and several other tumor entities, including the NCI-60 cell panel. MTT and colony forming assays, flow cytometry, immunohistochemistry, microRNA arrays, bioinformatics, tumor xenotransplantation, and Kaplan Meier survival curves were performed. Compared to sulforaphane, the analogue SF102 was most efficient in inhibition of viability, colony formation, tumor growth, and the induction of apoptosis, followed by SF134. Side effects were not observed, as concluded from the body weight and liver histology of chick embryos and survival of C. elegans nematodes. Among 6659 differentially regulated microRNAs, miR29b-1-5p, and miR-27b-5p were downregulated by sulforaphane compared to controls, but upregulated by SF102 and SF134 compared to sulforaphane, suggesting differential signaling. Each substance was involved in the regulation of several NF-κB-related target genes. In conclusion, sulforaphane analogues are promising for the development of highly active new drugs in cancer treatment.

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Effects of Iodixanol on Respiratory Functions during Coronary Angiography and the Role of Body Composition

Cardiology Research and Practice ◽

10.1155/2018/2140219 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Derya Guzel ◽

Mustafa Gokhan Vural ◽

Ramazan Akdemir

Keyword(s):

Body Composition ◽

Coronary Angiography ◽

Contrast Media ◽

Pulmonary Function Tests ◽

Forced Expiratory Volume ◽

The Body ◽

Female Patients ◽

Significant Impairment ◽

Male Patients ◽

Body Compositions

Purpose. The purposes of this study are to assess the acute effects of iodixanol, an iso-osmolar contrast media, on pulmonary functions and to evaluate the body composition in order to find out its role in causing this deterioration. Methods. 35 male and 25 female patients undergoing diagnostic coronary angiography (CA) were enrolled in the study. Before CA, all patients’ body compositions were evaluated by measuring their body mass indexes (BMIs) and waist-to-hip ratios (WHRs). Total body waters (TBWs), fat masses (FMs), fat-free masses (FFMs), and basal metabolism rates (BMRs) were measured via bioimpedance analysis. The CA was performed via radial artery route using iodixanol in every patient. The pulmonary function tests of these patients were performed before, during, and 2 hours after the CA. FEV1∆, FEF25–75%∆, and FVC∆ parameters were calculated by subtracting the measured baseline value from the measurement after the CA. Results. Angiography caused significant reduction in forced expiratory volume in 1 sec (FEV1, from 94.17 ± 18.83 to 84.45 ± 18.31, p<0.0001), forced vital capacity (FVC, from 96.57 ± 15.82 to 88.31 ± 17.96, p<0.0001), and forced expiratory flow at 25–75% (FEF25–75% from 82.54 ± 24.26 to 72.11 ± 25.41, p=0.001) and remained lower after 2 h after CA in male patients, respectively. FEV1 values were 103.40 ± 17.79 to 94.96 ± 17.063 (p=0.004); FVC values were 107.20 ± 19.03 to 99.08 ± 20.56 (p=0.009); and FEF25–75% values were 83.92 ± 24.30 to 73.24 ± 20.45 (p=0.005) before and after CA and remained lower after 2 h after CA in female patients, respectively. FEV1/FVC ratio remained unchanged. FEF25–75%∆ was statistically correlated with FFM, TBW, and WHR (p<0.05; r=−0.344, r=−0.347, and r=0.357, resp.), and FVC∆ was correlated with WHR in male patients (p=0.018, r=397). Conclusions. Our data suggested that diagnostic CA using iodixanol, an iso-osmolar contrast media, leads significant impairment in respiratory functions. Due to the persistence of these reductions even 2 hours after CA, ventilatory functions should be considered especially in patients whose body compositions or hydration levels are not within the desired physiological range.

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BODY CELL MASS DURING LONG-TERM TREATMENT WITH CORTISONE AND ANABOLIC STEROIDS IN ASTHMATIC SUBJECTS

Acta Endocrinologica ◽

10.1530/acta.0.0550222 ◽

1967 ◽

Vol 55 (2) ◽

pp. 222-239 ◽

Cited By ~ 17

Author(s):

Björn Lindholm

Keyword(s):

Anabolic Steroids ◽

Cell Mass ◽

Relative Increase ◽

The Body ◽

Body Cell Mass ◽

Body Cell ◽

Female Patients ◽

Long Term Treatment ◽

Male Patients ◽

Normal Men

ABSTRACT Thirty-six patients (17 males and 19 females) with severe bronchial asthma were treated for more than two years with cortisone and norandrolone. The patients were followed by repeated estimations of the body cell mass (BCM) using total exchangeable potassium (Ke) as a parameter of cell mass. In ten of the female patients, determinations of total body water (TBW) were also performed at the end of anabolic treatment. BCM increased significantly in both male (3.3 kg) and female (4.5 kg) patients. The relative increase in BCM was more pronounced in the female (25%) than in the male patients (13%). After one year of anabolic therapy, no further increase in BCM was demonstrated in either sex. The male patients did not increase more than was seen in male patients on cortisone only and previously reported. The average body weight was unchanged during the study, indicating a decrease in body fat. In the female patients, the final relative body cell mass was higher than in normal women and similar to that of normal men. TBW also increased in proportion to Ke and at the end of treatment the quotient TBW/B.W. was not different from that of normal men. The regression of Ke on TBW was normal. The significance of these findings are discussed. During treatment, one woman developed radiological signs of osteoporosis and two males showed progression of bone atrophy, which was diagnosed before the study.

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Study on Gender Differences in Acne Vulgaris Associated with Insulin Resistance:A Cross-Sectional Study

10.21203/rs.3.rs-519946/v1 ◽

2021 ◽

Author(s):

Wenyao Mi ◽

Xia Feng ◽

Zheng-Qun Wang ◽

Xin Ye ◽

Hui-Ling Shu ◽

...

Keyword(s):

Gender Differences ◽

Sex Hormones ◽

Plasma Glucose ◽

Acne Vulgaris ◽

Sex Hormone ◽

The Body ◽

Insulin Levels ◽

Female Patients ◽

Significant Difference ◽

Male Patients

Abstract Objective The present study investigated the clinical characteristics and gender differences of acne vulgaris associated with insulin resistance (IR).Methods The present study was conducted in 100 patients, comprising 52 males and 48 females, having acne vulgaris. Of the total, 18 male patients and 9 female patients exhibited IR, whereas 34 male patients and 39 female patients exhibited non-IR (NIR). The height, weight, acne grade, sex hormone, lipid metabolism, plasma glucose, and insulin levels of all the patients were measured and statistically analyzed.Results In the male group, the body mass index of the group with IR was significantly higher than that of the group with NIR (P < 0.05). No significant difference was observed in the sex hormones and insulin-like growth factor-1 (IGF-1) between female patients having acne associated with IR and those having acne associated with NIR. Levels of testosterone and sex hormone-binding globulin in male patients having acne associated with IR were lower than those in patients having acne associated with NIR, whereas the estrogen and IGF-1 levels in male patients with acne in the IR group were higher than those in the NIR group. Significant differences were observed in the fasting plasma glucose and fasting and 2-h postprandial plasma insulin levels between male and female groups (P < 0.05).Conclusion Disorders of sex hormone in male patients with acne vulgaris are related to IR; however, this correlation is not significant in women. Levels of sex hormones and metabolism in male patients having acne associated with IR must be actively monitored, and appropriate intervention must be administered.

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Unusual sites of dermoid cysts

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20180424 ◽

2018 ◽

Vol 4 (2) ◽

pp. 459

Author(s):

Sathyaki D. C. ◽

Mereen Susan Roy ◽

Razal Mohammed Sherif ◽

Ashish Rao

Keyword(s):

Differential Diagnosis ◽

Head And Neck ◽

Neck Region ◽

Complete Removal ◽

Descriptive Study ◽

The Body ◽

Head And Neck Region ◽

Epidermoid Cysts ◽

Female Patients ◽

Male Patients

Background: Epidermoids are ectoderm lined inclusion cysts which can be present anywhere in the body, but are rare in head and neck. Although only 7% of the dermoid cysts occur in head and neck region they are a part of differential diagnosis of neck swellings. They are more common in midline. This study presents to you the dermoids which present in unusual sites.Methods: It was a descriptive study. Cases which were proven as dermoid or epidermoid cysts by FNAC or by histopathology were included in this study. Results: Male patients were more affected than female patients.Conclusions: Complete removal should be carried out to prevent recurrence.

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