Updated outcomes for patients with completely resected pulmonary recurrent osteosarcoma: A report from the Children’s Oncology Group.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10023-10023
Author(s):  
Alexander J. Chou ◽  
Mark D. Krailo ◽  
Ruxu Han ◽  
Allen Buxton ◽  
Damon R. Reed ◽  
...  
Keyword(s):  
Disease Control ◽  
Oncology Group ◽  
Specific Patient ◽  
Efficacy Analysis ◽  
Investigational Agent ◽  
Phase 2 Trial ◽  
Select Group ◽  
Using Data ◽  
The Stability ◽  
Histological Confirmation

10023 Background: Amongst patients with recurrent osteosarcoma (OS), those with resectable pulmonary-only relapse appear to have the best outcomes. Prior analysis of patients with completely resected recurrent OS enrolled on a Children’s Oncology Group (COG) Phase 2 trial AOST0221, which studied the efficacy of inhaled GMCSF, showed a 12- month disease control rate (DCR12) of only 20% (95% CI, 10 – 34%). DCR12 based on this analysis was used as the historical benchmark for efficacy analysis in two recently completed trials, AOST1321 (completely resected cohort only) and AOST1421. We analyzed the stability of the DCR12 benchmark using data from these contemporary studies. Methods: Patients were eligible for AOST1321 if they had undergone resection of all sites of recurrent or refractory OS within 30 days of enrollment and for AOST1421 if they had lung only recurrent OS completely resected within 4 weeks of enrollment. AOST1321 evaluated denosumab while AOST1421 evaluated dinutuximab. Patients with refractory disease, extrapulmonary recurrence or without histological confirmation of relapse were excluded from this analysis. DCR12 was defined as having at least stable disease 12 months after the start of protocol therapy. We report the DCR12 observed on AOST1321, AOST1421 and AOST0221. Results: One hundred and twenty-eight evaluable patients with completely resected recurrent OS were enrolled on AOST0221 (N=49), AOST1321 (N=38) and AOST1421 (N=41). One hundred and one patients were included in this analysis (AOST0221: 37, AOST 1321: 25, AOST1421:39). DCR12 was 14 % (95% CI, 5% – 26%) for AOST0221, 24% (95%CI 10-42%) for AOST1321, and 31% (95% CI, 17% - 45%) for AOST1421. Risk for disease progression did not differ across the 3 included studies. DCR12 for all three studies combined was 23% (95% CI, 15% – 31%). Conclusions: Prognosis for recurrent OS remains dismal, even for those with resectable pulmonary-only disease. Although not statistically significant, dinutuximab may have activity in a select group of relapsed OS patients; combination studies using dinutuximab are planned. The previously described benchmark of disease control at 12 months remained relatively consistent in recent studies for those patients who have resectable pulmonary-only relapse. Therefore, DCR12 remains a useful outcome measure in fully resected OS with lung only metastases. Analyses are ongoing to better define the appropriate threshold to define investigational agent activity in this specific patient population.

ESTIMATION OF TECHNICAL, SPECIALIZED AND ECONOMIC EFFICIENCY OF CULTIVATED POTATO VARIETIES USING DATA ENVELOPE ANALYSIS METHOD (DEA) IN IRAQ FOR SPRING LUG 2018

2020 ◽  
pp. 119-131
Keyword(s):  
Technical Efficiency ◽  
Economic Efficiency ◽  
Potato Crop ◽  
Economic Status ◽  
Analysis Method ◽  
Envelope Analysis ◽  
Variable Capacity ◽  
Data Envelope Analysis ◽  
Using Data ◽  
The Stability

Research highlights the importance of potato crop, which occupies a prominent food and economic status in food security besides rice, wheat and corn at the local and global level. Despite the expansion of the cultivation of potato crop in Iraq in general and Ameriyah district in particular However, potato productivity remains substandard, this may be due to a lack of knowledge of the most efficient varieties and not to use productive resources at the levels at which technical, specialized and economic efficiency is achieved. Therefore, the aim of the research is to determine the technical, specialized and economic efficiency according to the cultivated seed category. The data envelope analysis (DEA) method was used to estimate technical, specialized and economic efficiency, assuming constant and variable capacity returns. As a result of the study, the Safrana variety achieved the highest average technical efficiency according to the stability of the yield and capacity efficiency in addition to achieving the highest average specialized and economic efficiency, The Lapadia variety achieved the highest average technical efficiency, assuming that capacity returns have changed. Therefore, we recommend the adoption of items that achieve higher efficiency and the need to redistribute the elements of production better and Achieving the optimum levels at which technical, specialized and economic efficiency is achieved and saving what has been wasted.

scholarly journals The Role of Employment Protection during an Exogenous Shock to an Economy

2011 ◽  
Vol 11 (2) ◽  
pp. 1850225 ◽  
Author(s):  
Miki Malul ◽  
Mosi Rosenboim ◽  
Tal Shavit ◽  
Shlomo Yedidia Tarba
Keyword(s):  
Economic Crisis ◽  
Employment Protection ◽  
Exogenous Shock ◽  
Unemployment Rates ◽  
World Crisis ◽  
Automatic Stabilizer ◽  
Medium Level ◽  
Using Data ◽  
The Stability

This paper explores the role of employment protection when powerful external crises reduce demand for products. We first present a theoretical framework that shows that employment protection has a U-shaped effect on abnormal unemployment during a negative exogenous shock to an economy. Using data from the 33 OECD countries, we analyze how the level of employment protection affected the stability of unemployment rates during the recent global economic crisis. The results suggest that countries with an intermediate level of employment protection will have more stable unemployment rates during a world crisis. The policy implication of our paper is that countries should seek a medium level of employment protection that may act as an automatic stabilizer of the economy on the macro level.

scholarly journals Literacy Culture Development through Class Library at SDIT Salsabila 2 Klaseman Ngaglik Sleman

2019 ◽  
Vol 11 (2) ◽  
pp. 183-203
Author(s):  
Ahmad Safi'i
Keyword(s):  
Life Skills ◽  
Human Life ◽  
School Library ◽  
Field Research ◽  
Class Library ◽  
Reduction Techniques ◽  
The Government ◽  
Using Data ◽  
The Stability ◽  
Culture Development

Life skills are proven to be able to improve human civilization.  Improving literacy culture is one way to develop human life skills.  The National Literacy Movement/ Gerakan Literasi Nasional (GLN) initiated by the government is an effort to realize it.  SDIT Salsabila 2 Klaseman has a Class Literacy Movement/ Gerakan Literasi Kelas (GLK) program.  The limited space available is not a reason to discourage GLK.  This type of research was case study field research.  The institution studied was SDIT Salsabila 2 Klaseman.  The subjects consisted teachers, principals, students and parents.  Data was obtained by observation, interviews and documentation steps.  Analysis was performed by using data reduction techniques, data display, triangulation, and conclusion drawing/verification.  The data showed that the main purpose of GLK was to intensify the culture of school literacy, library revitalization, and maintain the stability of school library functions.  The technical implementation is by creating a class library in each class, fostering a sense of belonging to the class library, supplying books from the school library to the class library, providing educational playgrounds in the area of the class library, giving rewards for students who are diligent in reading, achievements are informed in public, and explore the student guardian support. The problems that arise are the lack of teacher exemplariness, lack of consistency, supply of books from school libraries is still small, and the system of re-education has not been orderly.

scholarly journals NEGOSIASI HETERONORMATIVITAS PADA PERFORMATIVITAS TRANSGENDER DALAM FILM LOVELY MAN

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Nadya Afdholy
Keyword(s):  
Data Collection ◽  
Narrative Analysis ◽  
Qualitative Method ◽  
Narrative Structure ◽  
Judith Butler ◽  
Structure Theory ◽  
Literature Study ◽  
Using Data ◽  
The Stability ◽  
Tzvetan Todorov

This study aims to reveal heteronormativity in the Lovely Man movie by director Teddy Soeriaatmadja by using narrative structure theory from Tzvetan Todorov and the concept initiated by Judith Butler. Heteronormative values that appear in the film directed by Teddy Soeriaatmadja are seen through dialogue between characters in each scene that are divided into three; (1) equilibrium/plenitude, (2) disruption, disequilibrium/disrupting force, and (3) opposing force. This research uses qualitative method by using approach of narrative analysis of model Tzvetan Todorov. The data used for this research is the film of Lovely Man by director Teddy Soeriaatmadja itself. This study uses data collection techniques with observation and literature study, as well as using data collection techniques with data reduction, interpretation, and conclusions. The results of this study indicate that there is a concept of heteronormative values reflected through heterosexuals who are considered to damage the stability of transvestite life, so that heterosexuals are considered as 'the other' heteronormative. Keywords: Film, Lovely Man, Heteronormativity, Other.

Ethanol stability of casein micelles – a hypothesis concerning the role of calcium phosphate

1987 ◽  
Vol 54 (3) ◽  
pp. 389-395 ◽  
Author(s):  
David S. Horne
Keyword(s):  
Ionic Strength ◽  
Skim Milk ◽  
Buffer System ◽  
Casein Micelles ◽  
Buffer Solutions ◽  
Relative Response ◽  
Using Data ◽  
The Stability ◽  
Ethanol Stability

SummaryThe ethanol (EtOH) stability of skim milk and the stability towards aggregation of casein micelles diluted into ethanolic buffer solutions were compared using data obtained from previously published experiments. Differences in absolute stability and in relative response were observed when Ca2+ level and pH were adjusted, the buffer system results lying below those from skim milk in both cases. Increasing the ionic strength of skim milk adjusted to pH 7·0 lowered its EtOH stability whereas increasing the ionic strength of the diluting buffer increased the stability of the casein micelles. The hypothesis is put forward that the differences are due to the simultaneous precipitation of Ca phosphate when EtOH is added to skim milk. This draws calcium from the caseinate sites of the micelle, counteracting the destabilizing effects of the EtOH towards the micelle. Such removal and the consequent restructuring are kinetically controlled and micellar precipitation in skim milk finally occurs when the micellar coagulation time falls within the time scale of the restructuring reactions.

scholarly journals Efficacy and safety of bevacizumab in recurrent sex cord-stromal ovarian tumors: Results of a phase 2 trial of the Gynecologic Oncology Group

Cancer ◽  
2013 ◽  
Vol 120 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Jubilee Brown ◽  
William E. Brady ◽  
Julian Schink ◽  
Linda Van Le ◽  
Mario Leitao ◽  
...  
Keyword(s):  
Gynecologic Oncology ◽  
Ovarian Tumors ◽  
Gynecologic Oncology Group ◽  
Phase 2 ◽  
Efficacy And Safety ◽  
Oncology Group ◽  
Phase 2 Trial

scholarly journals The Future of Hyperspectral Imaging

2019 ◽  
Vol 5 (11) ◽  
pp. 84 ◽  
Author(s):  
Stefano Selci
Keyword(s):  
Hyperspectral Imaging ◽  
Age Determination ◽  
Plant Diseases ◽  
Potato Tubers ◽  
Dynamic Scenes ◽  
New Methods ◽  
The Future ◽  
Using Data ◽  
The Stability

The Special Issue on hyperspectral imaging (HSI), entitled “The Future of Hyperspectral Imaging”, has published 12 papers. Nine papers are related to specific current research and three more are review contributions: In both cases, the request is to propose those methods or instruments so as to show the future trends of HSI. Some contributions also update specific methodological or mathematical tools. In particular, the review papers address deep learning methods for HSI analysis, while HSI data compression is reviewed by using liquid crystals spectral multiplexing as well as DMD-based Raman spectroscopy. Specific topics explored by using data obtained by HSI include alert on the sprouting of potato tubers, the investigation on the stability of painting samples, the prediction of healing diabetic foot ulcers, and age determination of blood-stained fingerprints. Papers showing advances on more general topics include video approach for HSI dynamic scenes, localization of plant diseases, new methods for the lossless compression of HSI data, the fusing of multiple multiband images, and mixed modes of laser HSI imaging for sorting and quality controls.

Investigation of a Joint Venture-Ship between Two Firms in Ghana Using Linear Programming

2013 ◽  
Vol 824 ◽  
pp. 479-489
Author(s):  
Stephen B. Twum
Keyword(s):  
Sensitivity Analysis ◽  
Linear Programming ◽  
Joint Venture ◽  
Joint Problem ◽  
Using Data ◽  
The Stability

Investigation of the prospects of a joint venture-ship between two Firms in Ghana is reported. The novelty of this work is in the fact that it explores the ground of co-operation instead of competition that characterise the operations of these Firms. The goal was to find an optimum investment which was more profitable to both in a joint investment than in separate ones using linear programming (LP). LP models for both Firms were first formulated separately (one of them in an earlier work) using data and information obtained from both, following which a joint problem was posed, formulated, and solved. A sensitivity analysis was performed on the solutions to assess the stability of the models and the results used to determine range of possibilities for the optimum solutions for the Firms separately and jointly. The results showed that a joint investment could prove more rewarding for the two Firms than in separate investments.

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