Marine Fungi-Derived Secondary Metabolites: Potential as Future Drugs for Health Care

2020 ◽  
pp. 225-262
Author(s):  
Syed Shams Ul Hassan ◽  
Hui-Zi Jin ◽  
Abdur Rauf ◽  
Saud Bawazeer ◽  
Hafiz Ansar Rasul Suleria
Keyword(s):  
Health Care ◽  
Secondary Metabolites ◽  
Marine Fungi

scholarly journals Species Diversity and Secondary Metabolites of Sarcophyton-Associated Marine Fungi

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3227
Author(s):  
Yuanwei Liu ◽  
Kishneth Palaniveloo ◽  
Siti Aisyah Alias ◽  
Jaya Seelan Sathiya Seelan
Keyword(s):  
Secondary Metabolites ◽  
Soft Coral ◽  
Marine Fungi ◽  
Indole Alkaloids ◽  
Structural Diversity ◽  
Future Research ◽  
Soft Corals ◽  
Diverse Range ◽  
Symbiotic Relationships ◽  
Bioactive Secondary Metabolites

Soft corals are widely distributed across the globe, especially in the Indo-Pacific region, with Sarcophyton being one of the most abundant genera. To date, there have been 50 species of identified Sarcophyton. These soft corals host a diverse range of marine fungi, which produce chemically diverse, bioactive secondary metabolites as part of their symbiotic nature with the soft coral hosts. The most prolific groups of compounds are terpenoids and indole alkaloids. Annually, there are more bio-active compounds being isolated and characterised. Thus, the importance of the metabolite compilation is very much important for future reference. This paper compiles the diversity of Sarcophyton species and metabolites produced by their associated marine fungi, as well as the bioactivity of these identified compounds. A total of 88 metabolites of structural diversity are highlighted, indicating the huge potential these symbiotic relationships hold for future research.

scholarly journals A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000–2018

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 636 ◽  
Author(s):  
Jianzhou Xu ◽  
Mengqi Yi ◽  
Lijian Ding ◽  
Shan He
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Host Response ◽  
Marine Fungi ◽  
Tissue Injury ◽  
Fungal Metabolites ◽  
Bioactive Natural Products ◽  
Anti Inflammatory ◽  
Unique Mechanism ◽  
Inflammatory Action

Inflammation is a generalized, nonspecific, and beneficial host response of foreign challenge or tissue injury. However, prolonged inflammation is undesirable. It will cause loss function of involve organs, such as heat, pain redness, and swelling. Marine natural products have gained more and more attention due to their unique mechanism of anti-inflammatory action, and have considered a hotspot for anti-inflammatory drug development. Marine-derived fungi are promising sources of structurally unprecedented bioactive natural products. So far, a plethora of new secondary metabolites with anti-inflammatory activities from marine-derived fungi had been widely reported. This review covers 133 fungal metabolites described in the period of 2000 to 2018, including the structures and origins of these secondary metabolites.

scholarly journals Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera

Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 608
Author(s):  
Elena V. Girich ◽  
Anton N. Yurchenko ◽  
Olga F. Smetanina ◽  
Phan Thi Hoai Trinh ◽  
Ngo Thi Duy Ngoc ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Secondary Metabolites ◽  
Cell Viability ◽  
Chemical Structure ◽  
Aspergillus Terreus ◽  
Marine Fungi ◽  
2D Nmr ◽  
Natural Source ◽  
Low Molecular Weight ◽  
First Time

Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.

scholarly journals New record of Gymnoascus udagawae associated with Clathria sp. sponge from Indonesia and the potency as anti-Candida

2021 ◽  
Vol 948 (1) ◽  
pp. 012072
Author(s):  
W N Fadillah ◽  
N Sukarno ◽  
D Iswantini ◽  
M Rahminiwati ◽  
S Listiyowati
Keyword(s):  
Secondary Metabolites ◽  
Marine Fungi ◽  
Morphological Characteristics ◽  
First Record ◽  
Positive Control ◽  
Marine Sponges ◽  
Diffusion Method ◽  
Molecular Characteristics ◽  
Fungal Isolation ◽  
Region Detection

Abstract Marine sponges are associated with marine fungi. The associated fungi produce secondary metabolites for sponge survival in extreme habitats. Despite the important role of the associated fungi on their host, the research on marine fungi however has not been studied well. This study aimed to isolate sponge-associated marine fungi and analyze the potency of fungal secondary metabolites against Candida albicans. The sponge used was Clathria sp. collected from Pramuka Island, Indonesia. Fungal isolation used the direct inoculation method. Fungal identification was done by morphological and molecular characteristics of ITS rDNA region. Detection of anti-Candida used the well diffusion method. The isolate has typical morphological characteristics of the genus Gymnoascus with noduled chlamydospore and arthroconidia. The isolated fungus was identified as Gymnoascus udagawae based on morphological and molecular analysis. This is the first record of marine fungi G. udagawae from Indonesia. The ethyl acetate extract of fungal filtrate showed 1.4 cm inhibition diameter of 500 mg/μL extract. The inhibition is moderate category compared to that of clotrimazole a drug commonly used for candidiasis as the positive control with showed 2.8 cm inhibition diameter at 100 mg/μL. The fungus is a potential source of the secondary metabolite active against C. albicans.

scholarly journals EFFECT OF CULTURE CONDITIONS FOR ANTIMICROBIAL ACTIVITY OF MARINE - DERIVED FUNGUS ASPERGILLUS FLOCCULOSUS 01NT.1.1.5

2018 ◽  
Vol 15 (4) ◽  
pp. 721-728
Author(s):  
Phan Thi Hoai Trinh ◽  
Ngo Thi Duy Ngoc ◽  
Vo Thi Dieu Trang ◽  
Phi Quyet Tien ◽  
Bui Minh Ly ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Secondary Metabolites ◽  
Incubation Period ◽  
Marine Fungi ◽  
Antibiotic Production ◽  
Morphological Characteristics ◽  
Colony Growth ◽  
Culture Conditions ◽  
Initial Ph

The biosynthesis of compounds with antibiotic activity produced by marine fungi, strongly depends on their growth conditions. A good understanding of the role of culture conditions in the biosynthesis of metabolites may lead to better exploitation of microbial metabolites. In this study, the influence of culture conditions including incubation period, initial pH and salinity on antimicrobial activity and secondary metabolites production of marine fungus 01NT.1.1.5 was investigated. This isolate, obtained from sponge Stylissa sp. in Nha Trang Bay, exhibited a broad spectrum of in vitro antimicrobial activity to Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Listeria monocytogenes ATCC 19111, Streptococcus faecalis ATCC 19433 and Candida albicans ATCC 10231. According to morphological characteristics and sequence analysis of 28S rDNA, the fungus was identified as Aspergillus flocculosus. The results indicated that antimicrobial activity and metabolite amount were highest when the fungus was cultivated in rice medium with incubation period of 20 days. The optimum salinity of 35 g/L and initial pH of 6.0 were found for the maximum antibiotic production. The colony growth, antimicrobial activity and production of secondary metabolites of the strain A. flocculosus 01NT.1.1.5 varied depending on salt concentrations and initial pH of medium. Particularly, extract of this fungus only showed activity against C. albicans when it was cultured in medium with 30-35 g/L salinity and initial pH 4.0-8.0. The results  indicate that salinity and initial pH along with cultivation period are important factors influencing antimicrobial activity and secondary metabolites of A. flocculosus 01NT.1.1.5, and might be for other marine fungi.

An Update Review of Secondary Metabolites from Marine Fungi

2020 ◽  
Vol 20 ◽  
Author(s):  
Syed Shabana ◽  
K. Rajya Lakshmi ◽  
A. Krishna Satya
Keyword(s):  
Secondary Metabolites ◽  
Marine Fungi ◽  
Biological Activities ◽  
Metabolic Stress ◽  
Fungal Growth ◽  
Antibacterial Activities ◽  
Special Focus ◽  
Different Types ◽  
Pharmaceutical Industries ◽  
Novel Drug

: Marine fungi are valuable and richest sources of novel natural products for medicinal and pharmaceutical industries. Nutrient depletion, competition or any other types of metabolic stress which limit marine fungal growth promote the formation and secretion of secondary metabolites. Generally secondary metabolites can be produced by many different metabolic pathways and include antibiotics, cytotoxic and cyto-stimulatory compounds. Marine fungi produce many different types of metabolite that are of commercial importance. This review paper deals about 187 novel compounds and 212 other known compounds with anticancer and antibacterial activities with a special focus on the period from 2011-2019. Furthermore, this review highlights the sources of organisms, chemical classes and biological activities (anticancer and antibacterial) of metabolites, that were isolated and structurally elucidated from marine fungi to throw a helping hand for novel drug development.

Effect of salinity on the growth, biological activity and secondary metabolites of some marine fungi

2011 ◽  
Vol 30 (3) ◽  
pp. 118-123 ◽  
Author(s):  
Jingjing Huang ◽  
Chunhua Lu ◽  
Xiaoming Qian ◽  
Yaojian Huang ◽  
Zhonghui Zheng ◽  
...  
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Marine Fungi

scholarly journals Biomedical Effects of Popular Phytonutrients and Their Phytochemicals: A Comprehensive Review

2021 ◽  
Author(s):  
Yamixa Delgado ◽  
Céline Cassé ◽  
Yancy Ferrer-Acosta ◽  
Ivette J. Suárez-Arroyo ◽  
José Rodríguez-Zayas ◽  
...  
Keyword(s):  
Health Care ◽  
Immune Response ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Therapeutic Effects ◽  
Primary Metabolites ◽  
Comprehensive Review ◽  
Plant Foods

Phytonutrients are plant foods that contain many natural bioactive compounds, called phytochemicals, which expose specific biological activities. These phytonutrients and their phytochemicals may play an important role in health care maintaining normal organism functions (as preventives) and fighting against diseases (as therapeutics). Phytonutrient’s components are the primary metabolites (i.e., proteins, carbohydrates, and lipids) and phytochemicals or secondary metabolites (i.e., phenolics, alkaloids, organosulfides, and terpenes). For years, several phytonutrients and their phytochemicals have demonstrated specific pharmacological and therapeutic effects in human health such as anticancer, antioxidant, antiviral, anti-inflammatory, antibacterial, antifungal, and immune response. This review summarizes the effects of the most studied or the most popular phytonutrients (i.e., turmeric, garlic, cinnamon, graviola, and oregano), and any contraindication found. This article also calculated the physicochemical properties of the main phytochemicals in the selected phytonutrients using Lipinski’s, Veber’s and Ghose’s rules. Based on our revisions for this article, all these phytonutrients have consistently shown several in vitro, in vivo, and clinical studies with great potential as preventives and therapeutics on many diseases.

scholarly journals INFLUENCE OF PHYSICO-CHEMICAL PARAMETERS ON SECONDARY METABOLITE PRODUCTION BY MARINE FUNGI

2017 ◽  
pp. 112-118
Author(s):  
Anuhya G. ◽  
Jyostna V. ◽  
Aswani Kumar Yvv ◽  
Bodaiah B. ◽  
Sudhakar P.
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Secondary Metabolites ◽  
Secondary Metabolite ◽  
Inhibitory Concentration ◽  
Marine Fungi ◽  
Mineral Salts ◽  
Potato Dextrose Broth ◽  
Physico Chemical ◽  
Bioactive Secondary Metabolites

Objective: Our study aimed to characterize and optimize the physico-chemical properties which render the high yield of bioactive secondary metabolites from marine fungi and its antibacterial activity against clinical pathogens.Methods: Bioactive secondary metabolites extracted from marine fungi of Nijampatnam mangroves, Guntur district Andhra Pradesh, India. By using different solvent systems, secondary metabolite was screened for antimicrobial activity against clinical pathogen, Optimization of cultural conditions for maximizing the yield of biomass and compared the yield in different broth media and minimum inhibitory concentration of the optimised compound done for both compounds.Results: fungal extracts GAPS-1 and GAPS-2 was affectively extracted in ethyl acetate. Isolated compound showed antibacterial activity highest zone of inhibition against E. coli and least to Pseudomonas. Maximum yield of the compound was achieved in modified potato dextrose broth (PDB) medium containing 20% w/v Potato 2% w/v Dextrose broth containing1% w/v glucose and sucrose,1% w/v beef extract and ammonium chloride and 0.01 % mineral salts(MGSO4 and MNSO4) at 25 °C and 30 °C and pH 7.0 and 8.0 with 144 h of incubation period. The yield was observed maximum in potato dextrose broth compared to czapek dox broth, sabaraud’s broth and nutrient broth and minimum inhibitory concentration of the optimized compound ranges from 250 μg for gaps-1 and 300 μg for gaps-2.Conclusion: Secondary metabolite yield maximum in potato dextrose broth and its potential anti-bacterial activity needs further investigation for pharmaceutical applications.

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