Carbon Dots: Scalable Synthesis, Physicochemical Properties, and Biomedical Application

2020 ◽  
pp. 115-124
Author(s):  
Savita Chaudhary ◽  
Pooja Chauhan
Keyword(s):  
Physicochemical Properties ◽  
Carbon Dots ◽  
Biomedical Application ◽  
Scalable Synthesis

scholarly journals CARBON DOTS: A NOVEL PLATFORM FOR BIOMEDICAL APPLICATION

2021 ◽  
Author(s):  
Mohammadreza Behi ◽  
Leila Gholami ◽  
Sina Naficy ◽  
Stefano Palomba ◽  
Fariba Dehghani
Keyword(s):  
Carbon Dots ◽  
Biomedical Application ◽  
Distinctive Features ◽  
Carbon Based

Carbon dots (CDs) are a latterly synthesised class of carbon-based nanostructures known as zero-dimensional (0D) nanomaterials, which have drawn a great deal of researcher’s attention owing to their distinctive features,...

scholarly journals Temperature-controlled spectral tuning of full-color carbon dots and their strongly fluorescent solid-state polymer composites for light-emitting diodes

2019 ◽  
Vol 1 (4) ◽  
pp. 1413-1420 ◽  
Author(s):  
Tantan Hu ◽  
Zhuoqi Wen ◽  
Chan Wang ◽  
Tiju Thomas ◽  
Chuanxi Wang ◽  
...  
Keyword(s):  
Solid State ◽  
Polymer Composites ◽  
Carbon Dots ◽  
Light Emitting Diodes ◽  
Spectral Tuning ◽  
Light Emitting ◽  
White Leds ◽  
Full Color ◽  
Temperature Controlled ◽  
Scalable Synthesis

Temperature-controlled, scalable synthesis of CA-based full-color CDs and subsequent fabrication of white-LEDs with CIE coordinates of (0.32, 0.33) and a CRI of 82.7.

scholarly journals B- and N-doped carbon dots by one-step microwave hydrothermal synthesis: tracking yeast status and imaging mechanism

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Bo Tian ◽  
Tianxin Fu ◽  
Yang Wan ◽  
Yun Ma ◽  
Yanbo Wang ◽  
...  
Keyword(s):  
Yeast Cell ◽  
Carbon Dots ◽  
Biomedical Application ◽  
Basic Research ◽  
Growth Status ◽  
Dose Time ◽  
Microwave Hydrothermal ◽  
One Step ◽  
Doped Carbon Dots ◽  
Energy Dependent

Abstract Background Carbon dots (CDs) are widely used in cell imaging due to their excellent optical properties, biocompatibility and low toxicity. At present, most of the research on CDs focuses on biomedical application, while there are few studies on the application of microbial imaging. Results In this study, B- and N-doped carbon dots (BN-CDs) were prepared from citric acid, ethylenediamine, and boric acid by microwave hydrothermal method. Based on BN-CDs labeling yeast, the dead or living of yeast cell could be quickly identified, and their growth status could also be clearly observed. In order to further observe the morphology of yeast cell under different lethal methods, six methods were used to kill the cells and then used BN-CDs to label the cells for imaging. More remarkably, imaging of yeast cell with ultrasound and antibiotics was significantly different from other imaging due to the overflow of cell contents. In addition, the endocytosis mechanism of BN-CDs was investigated. The cellular uptake of BN-CDs is dose, time and partially energy-dependent along with the involvement of passive diffusion. The main mechanism of endocytosis is caveolae-mediated. Conclusion BN-CDs can be used for long-term stable imaging of yeast, and the study provides basic research for applying CDs to microbiol imaging. Graphical Abstract

Green synthesis of Zingiberis rhizoma-based carbon dots attenuates chemical and thermal stimulus pain in mice

Nanomedicine ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. 851-869
Author(s):  
Meiling Zhang ◽  
Jinjun Cheng ◽  
Yue Zhang ◽  
Hui Kong ◽  
Suna Wang ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Carbon Dots ◽  
Functional Group ◽  
Biomedical Application ◽  
Chemical Stimulus ◽  
Thermal Stimulus ◽  
Hot Plate ◽  
Pyrolysis Method ◽  
Tail Immersion ◽  
Preliminary Study

Aim: To evaluate the analgesic activity of Zingiberis rhizoma-based carbon dots (ZR-CDs). Materials & methods: Novel ZR-CDs were prepared via a facile, green pyrolysis method. Microstructure, optical and functional group properties were characterized. Acetic acid writhing, hot-plate and tail-immersion tests were performed using mice to evaluate the analgesic activity of ZR-CDs, followed by a preliminary study on the analgesic mechanism. Results: ZR-CDs with a quantum yield of 5.2% had a diameter ranging from 2.23 to 3.77 nm. Remarkable analgesic effect of ZR-CDs was observed against both thermal and chemical stimulus tests, possibly mediated by an opioid-like mechanism and the regulation of 5-hydroxytryptamine levels. Conclusion: ZR-CDs have a promising potential for biomedical application in relieving pain-related diseases.

scholarly journals Influence of surface chemistry on optical, chemical and electronic properties of blue luminescent carbon dots

Nanoscale ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 2056-2064 ◽  
Author(s):  
Jian Ren ◽  
Fabian Weber ◽  
Florian Weigert ◽  
Yajie Wang ◽  
Sneha Choudhury ◽  
...  
Keyword(s):  
Surface Chemistry ◽  
Physicochemical Properties ◽  
Spectroscopic Study ◽  
Electronic Properties ◽  
Carbon Dots

An in-depth spectroscopic study on blue luminescent carbon dots highlights the role of surface chemistry in their physicochemical properties.

scholarly journals An Overview on Collagen and Gelatin-Based Cryogels: Fabrication, Classification, Properties and Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2299
Author(s):  
Yujing He ◽  
Chunhua Wang ◽  
Chenzhi Wang ◽  
Yuanhang Xiao ◽  
Wei Lin
Keyword(s):  
Cell Culture ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Three Dimensional ◽  
Preparation Process ◽  
Precise Characterization ◽  
Gel Forming Ability ◽  
Insight Into

Decades of research into cryogels have resulted in the development of many types of cryogels for various applications. Collagen and gelatin possess nontoxicity, intrinsic gel-forming ability and physicochemical properties, and excellent biocompatibility and biodegradability, making them very desirable candidates for the fabrication of cryogels. Collagen-based cryogels (CBCs) and gelatin-based cryogels (GBCs) have been successfully applied as three-dimensional substrates for cell culture and have shown promise for biomedical use. A key point in the development of CBCs and GBCs is the quantitative and precise characterization of their properties and their correlation with preparation process and parameters, enabling these cryogels to be tuned to match engineering requirements. Great efforts have been devoted to fabricating these types of cryogels and exploring their potential biomedical application. However, to the best of our knowledge, no comprehensive overviews focused on CBCs and GBCs have been reported currently. In this review, we attempt to provide insight into the recent advances on such kinds of cryogels, including their fabrication methods and structural properties, as well as potential biomedical applications.

Carbon Dots as Nanotherapeutics for Biomedical Application

2020 ◽  
Vol 26 (19) ◽  
pp. 2207-2221 ◽  
Author(s):  
Eemaan N. Cohen ◽  
Pierre P.D. Kondiah ◽  
Yahya E. Choonara ◽  
Lisa C. du Toit ◽  
Viness Pillay
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Carbon Dots ◽  
Water Solubility ◽  
Biomedical Application ◽  
Drug Efficacy ◽  
Cost Effective ◽  
Carbon Nanodots ◽  
Targeted Drug

Carbon nanodots are zero-dimensional spherical allotropes of carbon and are less than 10nm in size (ranging from 2-8nm). Based on their biocompatibility, remarkable water solubility, eco- friendliness, conductivity, desirable optical properties and low toxicity, carbon dots have revolutionized the biomedical field. In addition, they have intrinsic photo-luminesce to facilitate bio-imaging, bio-sensing and theranostics. Carbon dots are also ideal for targeted drug delivery. Through functionalization of their surfaces for attachment of receptor-specific ligands, they ultimately result in improved drug efficacy and a decrease in side-effects. This feature may be ideal for effective chemo-, gene- and antibiotic-therapy. Carbon dots also comply with green chemistry principles with regard to their safe, rapid and eco-friendly synthesis. Carbon dots thus, have significantly enhanced drug delivery and exhibit much promise for future biomedical applications. The purpose of this review is to elucidate the various applications of carbon dots in biomedical fields. In doing so, this review highlights the synthesis, surface functionalization and applicability of biodegradable polymers for the synthesis of carbon dots. It further highlights a myriad of biodegradable, biocompatible and cost-effective polymers that can be utilized for the fabrication of carbon dots. The limitations of these polymers are illustrated as well. Additionally, this review discusses the application of carbon dots in theranostics, chemo-sensing and targeted drug delivery systems. This review also serves to discuss the various properties of carbon dots which allow chemotherapy and gene therapy to be safer and more target-specific, resulting in the reduction of side effects experienced by patients and also the overall increase in patient compliance and quality of life.

How do nitrogen-doped carbon dots generate from molecular precursors? An investigation of the formation mechanism and a solution-based large-scale synthesis

2015 ◽  
Vol 3 (27) ◽  
pp. 5608-5614 ◽  
Author(s):  
Yaoping Hu ◽  
Jing Yang ◽  
Jiangwei Tian ◽  
Jun-Sheng Yu
Keyword(s):  
Formation Mechanism ◽  
Formation Process ◽  
Carbon Dots ◽  
Large Scale ◽  
Molecular Precursors ◽  
Nitrogen Doped ◽  
Scalable Synthesis ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon ◽  
Fluorescent Carbon Dots

A solution-based method is developed for rapid and scalable synthesis of highly fluorescent carbon dots in a monoethanolamine system, and an interesting formation process of carbon dots is directly observed.

scholarly journals Cerium oxide nanoparticles: properties, biosynthesis and biomedical application

RSC Advances ◽  
2020 ◽  
Vol 10 (45) ◽  
pp. 27194-27214 ◽  
Author(s):  
Kshitij RB Singh ◽  
Vanya Nayak ◽  
Tanushri Sarkar ◽  
Ravindra Pratap Singh
Keyword(s):  
Physicochemical Properties ◽  
Cerium Oxide ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Fast Pace ◽  
Biomedical Field

Cerium oxide nanoparticles have revolutionized the biomedical field and is still in very fast pace of development. Hence, this work elaborates the physicochemical properties, biosynthesis, and biomedical applications of cerium oxide nanoparticles.

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