Intestinal Permeability in Preterm Neonates is not Related to Gestational Age or Birth Weight. 75

Objective: The aim of this study was to investigate the effect of some maternal and neonatal clinical parameters on the neonatal intensive care unit admission rates of neonates born to mothers who had preeclampsia. Study Design: Study included 402 singleton pregnant women with preeclampsia who admitted to Maternal-Fetal Medicine Unit of Zeynep Kamil Children and Women’s Health Training and Research Hospital. Pregnancies with uterine rupture, chorioamnionitis and congenital malformations were excluded. Some maternal and neonatal clinical characteristics were assessed to predict neonatal intensive care unit admission.Results: Among 402 neonates, 140 (35%) of them had an indication for neonatal intensive care unit admission, among 140 neonates, 136 (97%) of them were preterm neonates. Comparison of groups with and without neonatal intensive care unit admission indicated significant differences between groups in terms of gestational age, Apgar scores at 1st and 5th minutes, birth weight, some maternal laboratory parameters (Hemoglobin, hematocrit, alanine aminotransferase, aspartate aminotransferase, albumin). In multivariate analysis, among all study population, gestational age at delivery, birth weight and Apgar scores were found to be significantly associated with neonatal intensive care unit admission. On the other hand, in subgroup of term neonates, none of the variables was shown to be associated with neonatal intensive care unit admission.Conclusion: Gestational age at delivery and the birth weight are the main risk factors for neonatal intensive care unit admission of neonates born to mothers who had preeclampsia.

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Vaginal Delivery and Low Gestational Age are Key Risk Factors for Hypernatremia in Neonates < 32 Weeks

Klinische Pädiatrie ◽

10.1055/a-1443-6208 ◽

2021 ◽

Author(s):

Nadia S. Eugster ◽

Florence Corminboeuf ◽

Gilbert Koch ◽

Julia E. Vogt ◽

Thomas Sutter ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Vaginal Delivery ◽

Gestational Age ◽

Preterm Neonates ◽

Multiple Birth ◽

Plasma Sodium ◽

Delivery Mode ◽

Antenatal Corticosteroids ◽

Clinical Complications

Abstract Background Preterm neonates frequently experience hypernatremia (plasma sodium concentrations >145 mmol/l), which is associated with clinical complications, such as intraventricular hemorrhage. Study design In this single center retrospective observational study, the following 7 risk factors for hypernatremia were analyzed in very low gestational age (VLGA, below 32 weeks) neonates: gestational age (GA), delivery mode (DM; vaginal or caesarian section), sex, birth weight, small for GA, multiple birth, and antenatal corticosteroids. Machine learning (ML) approaches were applied to obtain probabilities for hypernatremia. Results 824 VLGA neonates were included (median GA 29.4 weeks, median birth weight 1170 g, caesarean section 83%). 38% of neonates experienced hypernatremia. Maximal sodium concentration of 144 mmol/l (interquartile range 142–147) was observed 52 hours (41–65) after birth. ML identified vaginal delivery and GA as key risk factors for hypernatremia. The risk of hypernatremia increased with lower GA from 22% for GA ≥ 31–32 weeks to 46% for GA < 31 weeks and 60% for GA < 27 weeks. A linear relationship between maximal sodium concentrations and GA was found, showing decreases of 0.29 mmol/l per increasing week GA in neonates with vaginal delivery and 0.49 mmol/l/week after cesarean section. Sex, multiple birth and antenatal corticosteroids were not associated hypernatremia. Conclusion VLGA neonates with vaginal delivery and low GA have the highest risk for hypernatremia. Early identification of neonates at risk and early intervention may prevent extreme sodium excursions and associated clinical complications.

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Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates

International Journal of Pediatrics ◽

10.1155/2012/416073 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 9

Author(s):

Shantanu Rastogi ◽

Hariprem Rajasekhar ◽

Anju Gupta ◽

Alok Bhutada ◽

Deepa Rastogi ◽

...

Keyword(s):

Multivariate Analysis ◽

Birth Weight ◽

Gestational Age ◽

Retrospective Review ◽

Univariate Analysis ◽

Preterm Neonates ◽

Factors Affecting ◽

Factors Influencing ◽

Successful Weaning ◽

Postmenstrual Age

Objective. Identification of the weight and postmenstrual age (PMA) at successful weaning of NCPAP in preterm neonates and the factors influencing the successful wean.Study Design. Retrospective review of 454 neonates ≤32 weeks of gestational age (GA) who were placed on NCPAP and successfully weaned to room air was performed.Results. Neonates had a mean birth weight (BW) of grams with a mean GA of weeks. Neonates were weaned off NCPAP at mean weight of grams and mean PMA of weeks. Univariate analysis showed that chorioamnionitis, intubation, surfactant use, PDA, sepsis/NEC, anemia, apnea, GER and IVH were significantly associated with the time to NCPAP wean. On multivariate analysis, among neonates that were intubated, BW was the only significant factor () that was inversely related to time to successful NCPAP wean. Amongst non-intubated neonates, along with BW (), chorioamnionitis (), anemia (), and GER () played a significant role in weaning from NCPAP.Conclusion. Neonates were weaned off NCPAP at mean weight of grams and mean PMA of weeks. BW significantly affects weaning among intubated and non-intubated neonates, though in neonates who were never intubated chorioamnionitis, anemia and GER also significantly affected the duration on NCPAP.

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OUTCOME OF PRETERM BABIES WITH RESPIRATORY DISTRESS SYNDROME

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i8.2118 ◽

2021 ◽

Vol 5 (8) ◽

Author(s):

Shaitan Singh Balai ◽

Vivek Arora

Keyword(s):

Birth Weight ◽

Mortality Rate ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Prospective Study ◽

Gestational Age ◽

Distress Syndrome ◽

Preterm Neonates ◽

Medical College ◽

Preterm Babies

Background: To study outcome of preterm babies with RDS in babies admitted in NICU. Methods: This study was hospital based prospective study of preterm neonates with respiratory distress syndrome admitted in NICU of MBGH RNT medical college Udaipur, from February 2017 to January 2018. Results: Among 200 preterm neonates included in the study 31 neonates expired. Mortality was 15.5%. The mortality was 10.17% among the preterm neonates with RDS and hospitalized within 6 hrs. It was 31.81% among neonates hospitalized between 6-12 hrs and 62.5% and 66.66% among neonates hospitalized between 12-24 hrs and after 24 hrs of birth respectively. Conclusion: Mortality rate is inversely related to birth weight and gestational age and directly related to age at admission and severity of respiratory distress (Silverman-Anderson score). Keywords: Preterm, Neonates, Birth weight.

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Is Maternal Hypertension a Reducing Factor for Intraventricular Hemorrhage in Iranian Preterm Newborns?

10.21203/rs.3.rs-105166/v1 ◽

2020 ◽

Author(s):

Mandana Kashaki ◽

Maryam Saboute ◽

Maryam Esmaeili Allafi ◽

Elahe Norouzi

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Intraventricular Hemorrhage ◽

Preterm Neonates ◽

Hypertensive Disorders Of Pregnancy ◽

Apgar Scores ◽

Mortality And Morbidity ◽

Predicting Factors ◽

Hypertensive Disorders ◽

Maternal Hypertension

Abstract Background & objective: Hypertensive disorders of pregnancy including preeclampsia can be associated with preterm birth and infant mortality and morbidity. It seems that intraventricular hemorrhage (IVH) in preterm neonates born to hypertensive mothers is less common compared to the other ones. In this study, we assessed the relationship between hypertensive disorders of pregnant mothers and the incidence of intraventricular hemorrhage in preterm neonates weighing less than 1500 grams. Methods: In this case-control study, 305 singleton preterm neonates with a birth weight less than 1500 g were entered. The presence of IVH in all preterm neonates was assessed using brain ultrasonography and its correlation to hypertensive disorders of their mothers were evaluated.Results: The prevalence of preeclampsia in mothers with and without prepregnancy hypertension was 40%, and 15.09% respectively. The prevalence of IVH in preterm neonates was 26.9% (n=82). The incidence of IVH in preterm neonates of mothers with and without preeclampsia was 16.07%, and 29.31% in (p=0.028), respectively. The prevalence of IVH in preterm neonates of mothers with hypertension and without hypertension was 12.5% and 29.05%, respectively (p=0.018). Preterm neonates with IVH had a lower mean birth weight, smaller gestational age and lower Apgar scores compared to preterm neonates without IVH with p values of <0.001, <0.001 and <0.01, respectively.Conclusion: Hypertensive disorders of pregnancy increases the risk of preterm delivery, but incidence of IVH in preterm neonates weighing less than 1500 gr is lower in infants born to mothers with hypertension including preeclampsia compared to non hypertensive mothers. And also lower gestational age, birth weight, and Apgar scores were important predicting factors for IVH in preterm neonates.

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CLINICAL RISK INDEX FOR BABIES (CRIB SCORE) AS A PREDICTOR OF NEONATAL MORTALITY

Journal of University Medical & Dental College ◽

10.37723/jumdc.v10i4.70 ◽

2019 ◽

Vol 10 (4) ◽

pp. 5-10

Author(s):

Zarmast Khan ◽

Nasir Zulﬁqar ◽

Hamid Mahmood et al.

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Neonatal Mortality ◽

Gestational Age ◽

Very Low Birth Weight ◽

Risk Index ◽

Preterm Neonates ◽

Cross Sectional ◽

Study Population ◽

Crib Score

ABSTRACT:OBJECTIVE: It is very important to predict the outcome among preterm and very low birth weight babies as mortality rates are quite high. CRIB score is used to predict the outcomes in preterm neonates. The objective of this study was to determine the strength of CRIB score in detecting neonatal mortality in babies presenting with very low birth weight. STUDY DESIGN: Cross-sectional study. SUBJECTS: A total of 254 newborns with birth weight of between 500 to 1500 grams and gestational age of ≤35 weeks were included. The study was conducted over a period of 6 months in neonatology department of Shifa International Hospital, Islamabad. METHODS: CRIB score was obtained through a prospective way in all neonates and its association was assessed with mortality during neonatal intensive care unit (NICU) stay. RESULTS: The percentage of male and female newborn subjects was 54.3% (n=138) and 45.7% (n=116) respectively. Mean gestational age was 33.3 weeks ± 1.04 and mean birth weight of study population was 1129.9 grams ± 210.6. Mean CRIB score among the study population was 6.3 ± 3.1 and overall mortality was found to be 54.7% (n=139). Mean CRIB score was found to be 8.27 ± 2.1 among mortality group and it was 3.87 ± 3.4 among newborns who were discharged (P<0.05). Mortality was present in 4.3% (n=4) of neonates with CRIB score between 1-5, 87.1% (n=121) who had CRIB score between 6-10 and 100% (n=14) of neonates who had CRIB score between 1115 (P<0.05). CONCLUSION: Signiﬁcantly higher mortality was noted among neonates with higher CRIB scores.

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TO STUDY THE INCIDENCE AND RISK FACTORS OF RETINOPATHY OF PREMATURITY IN A TERTIARY CARE HOSPITAL IN NORTHERN INDIA

10.36106/gjra/4907071 ◽

2021 ◽

pp. 48-50

Author(s):

Kajaldeep Kaur ◽

Gursharn Singh

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Neonatal Intensive Care ◽

Tertiary Care ◽

Preterm Neonates ◽

Care Hospital ◽

Northern India ◽

Retinal Examination

BACKGROUND: Retinopathy of prematurity (ROP) is a multifactorial retinal vaso-proliferative disorder which remains a leading cause of childhood blindness worldwide despite improvements in neonatal care and management guidelines. This study was conducted to determine the incidence of ROP among preterm neonates and to determine the risk factors. METHODS: All preterm infants with birth weight <1750 gm and gestation <34 weeks were screened for ROP at 4 weeks of birth for rst screening. Prenatal and postnatal risk factors, neonatal problems, treatment given, procedures and interventions done during stay in neonatal intensive care unit were recorded as per the proforma. The data from the study was systematically collected, compiled and statistically analyzed with SPSS Statistics-26 version to draw relevant conclusions. RESULTS: The incidence of ROP in 89 infants who were screened was 44%. The mean gestational age of babies with ROP was 32 weeks. In our study, pneumonia, apnea, sepsis, thrombocytopenia, NEC, shock, acidosis, IVH, BPD, the use of Bubble CPAP, Venti-CPAP and mechanical ventilator, the vasopressor use and blood transfusion were signicant risk factors. CONCLUSIONS: The incidence of ROP was signicantly higher in babies <34 weeks. It was observed in our that lower the birth weight and lower the gestational age, higher is the risk for the development of ROP. Careful and timed retinal examination of all at risk infants will minimize the development of ROP and later on blindness.

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Epidemiology of Inguinal Hernia in Preterm Neonates

PEDIATRICS ◽

10.1542/peds.77.2.246 ◽

1986 ◽

Vol 77 (2) ◽

pp. 246-247 ◽

Cited By ~ 1

Author(s):

KEITH J. PEEVY ◽

FELICITY A. SPEED ◽

CHARLES J. HOFF

Keyword(s):

Inguinal Hernia ◽

Birth Weight ◽

Preterm Infants ◽

Gestational Age ◽

Growth Retardation ◽

Intrauterine Growth Retardation ◽

Preterm Neonates ◽

Intrauterine Growth ◽

Inguinal Hernias

We have studied the epidemiology of inguinal hernias in preterm infants. Inguinal hernias occur with increased frequency in infants ≤32 weeks' gestational age or ≤1,250 g birth weight. Among infants ≤32 weeks' gestational age, intrauterine growth retardation significantly increases the risk for development of inguinal hernias, especially in male infants. Our data demonstrate a previously unrecognized association between neonatal inguinal hernia and intrauterine growth retardation.

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Association of patent ductus arteriosus (PDA) with prematurity and low birth weight neonates

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20190729 ◽

2019 ◽

Vol 6 (2) ◽

pp. 781

Author(s):

Gh Rasool Wani ◽

Nazir Ahmad Parray ◽

Mohd Rafiq Lone ◽

Nisar Ahmad Ganie ◽

Anwar Hussain ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Patent Ductus Arteriosus ◽

Gestational Age ◽

Ductus Arteriosus ◽

Preterm Neonates ◽

Study Cohort ◽

Care Hospital ◽

Number Of Patients ◽

Patent Ductus

Background: Patent ductus arteriosus (PDA) is a major morbidity encountered in preterm neonates, especially in babies less than 28 weeks gestation or 1000g. It may close spontaneously in preterm neonates; however, failure to close spontaneously in preterm neonates results in significant mortality and morbidity in them.Methods: This prospective study was conducted in a tertiary care hospital in north India over a period of one year. The study cohort consisted of preterm, newborn babies admitted in the hospital with gestational age less than 37weeks and birth weight <2500g.Results: In this study total number of patients admitted during the study were 2930. Out of these preterm low birth weight neonates were 432. Among preterm low birth weight neonates admitted, 132 neonates were excluded as per exclusion criteria. Patent ductus arteriosus was detected in 56 among the 300 neonates giving an overall incidence of patent ductus arteriosus 18.6%, the incidence of patent ductus arteriosus was 56.2% for neonates weighing less than 1000gm, 24.7% for neonates weighing between 1000-1499g, 11.6% for neonates weighing between 1500-1999g and 5.6% for the neonates weighing between 2000-2499g.Conclusions: Thus, incidence of patent ductus arteriosus was inversely proportional to gestational age and birth. Data also suggest that immaturity is the major determinant of the persistent patency of ductus arteriosus.

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Impact of umbilical cord arterial pH, gestational age, and birth weight on neurodevelopmental outcomes for preterm neonates

PeerJ ◽

10.7717/peerj.12043 ◽

2021 ◽

Vol 9 ◽

pp. e12043

Author(s):

Roksana Malak ◽

Dorota Sikorska ◽

Marta Rosołek ◽

Ewa Baum ◽

Ewa Mojs ◽

...

Keyword(s):

Birth Weight ◽

Umbilical Cord ◽

Gestational Age ◽

State Regulation ◽

Preterm Neonates ◽

Neurodevelopmental Outcomes ◽

Sensory Stimuli ◽

Arterial Ph ◽

The Impact ◽

Tonic Neck Reflex

Background The aim of this study was to determine the impact of umbilical cord arterial pH, gestational age, and birth weight on neurodevelopmental outcomes for preterm neonates. Methods We examined 112 neonates. Inclusion criteria were: Saturations greater than 88%, and heart rates between 100–205 beats per minute. Measurements We assessed several neurodevelopmental factors as part of the Brazelton Neonatal Behavioral Assessment Scale (NBAS), 4th edition, such as asymmetric tonic neck reflex (ATNR), motor maturity, response to sensory stimuli, habituation, and state regulation. Initial assessment parameters such as APGAR score and umbilical cord arterial pH were used to assess neonates. Results We found a strong correlation between the presence of the sucking reflex and umbilical cord arterial pH (r = 0.32; p = 0.018981). Umbilical cord arterial pH was also correlated with the presence of asymmetric tonic neck reflex (r = 0.27; p = 0.047124), cost of attention (r = 0.31; p = 0.025381) and general motor maturity (r = 0.34; p = 0.011741). Conclusions We found that the sucking reflex may be affected in infants with low umbilical cord arterial pH values. Practitioners and parents can use the NBAS to help determine neurodevelopmental factors and outcomes in preterm infants, possibly leading to safer and more effective feeding practices and interventions.

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