scholarly journals Comparison of Body Composition Assessment Methods in Patients with Human Immunodeficiency Virus-Associated Wasting Receiving Growth Hormone

2006 ◽  
Vol 91 (8) ◽  
pp. 2952-2959 ◽  
Author(s):  
John G. Esposito ◽  
Scott G. Thomas ◽  
Lori Kingdon ◽  
Shereen Ezzat

Abstract Context: Bioelectrical impedance spectroscopy (BIS) and skinfold anthropometry (SKF) have been used to monitor body composition among patients with HIV wasting; however, validation of these techniques during recombinant human GH (rhGH) treatment has not been performed. Objective: Our objective was to evaluate the degree of agreement between criterion measurements of dual-energy x-ray absorptiometry (DXA) and those of BIS and SKF in patients with HIV wasting treated with rhGH. Design and Setting: We conducted a randomized, double-blinded, placebo-controlled, two-period crossover trial at the University of Toronto and Mount Sinai Hospital (Toronto, Canada). Patients: A referred sample of 27 community-dwelling men with HIV-associated weight loss (≥10% over preceding 12 months) despite optimal antiretroviral therapy participated in the study. Intervention: Intervention was one daily injection of rhGH (6 mg) or placebo self-administered for 3 months in a crossover fashion with a 3-month washout. Main Outcome Measures: Fat-free mass (FFM) and fat mass (FM) were measured by BIS, SKF, and DXA before and after rhGH and placebo treatment. Results: FFMBIS was not significantly different from FFMDXA after rhGH treatment (P = 0.10). Mean differences (bias ± sd) according to Bland-Altman analysis were smaller for SKF than for BIS (P < 0.05) at all time points, yet treatment-induced change in FM was better detected with BIS than with SKF. BIS estimates of FFM and FM showed better agreement with those of DXA after rhGH treatment (1.6 ± 4.6 kg and −2.1 ± 3.9 kg) compared with baseline (3.8 ± 3.5 kg and −4.1 ± 3.6 kg) and placebo (2.7 ± 4.4 kg and −3.1 ± 4.6) (P < 0.05). BIS overestimated and SKF underestimated the treatment-induced changes in FFM and FM. Conclusions: SKF was more accurate than BIS when measuring body composition in patients with HIV wasting before and after rhGH treatment; nonetheless, the accuracy of BIS increased after treatment. Change in FM because of treatment was not accurately assessed with SKF.

2007 ◽  
Vol 156 (3) ◽  
pp. 395-401 ◽  
Author(s):  
B Lapauw ◽  
S Goemaere ◽  
P Crabbe ◽  
J M Kaufman ◽  
J B Ruige

Objective: The androgen receptor (AR) gene contains a CAG repeat polymorphism coding for a polyglutamine chain, the length of which is inversely correlated with AR transcriptional activity. We explored whether this polymorphism modulates the activities of testosterone (T) related to body composition in elderly men. Design: We performed cross-sectional analyses using data from a 4-year follow-up study in community-dwelling men aged 75–89 years (n=159). Methods: Body composition was assessed by dual-energy X-ray absorptiometry and its relation with T and the AR gene CAG repeat length was assessed by multiple linear regression analyses, adjusting for confounding and exploring effect modification. Results: AR gene CAG repeat length was not directly related to body composition, either with or without adjustment for confounding variables like age, weight, total T or sex hormone binding globulin (SHBG) levels. However, exploration of effect modification showed that CAG repeat length modulated the relation between T and body composition (standardized regression coefficients of interaction term: β=0.12, P<0.01 and β=−0.09, P<0.05 for fat-free mass and fat mass respectively). These results were confirmed using similar models and data of mean T, SHBG and weight of the 2 years’ preceding body composition assessment instead of data of the same year (β=0.09, P<0.05 and β=−0.09, P<0.05 respectively). Conclusion: These findings suggest that the AR gene CAG polymorphism contributes, albeit modestly, to the between-subject variation of T action on body composition in community-dwelling elderly men.


2016 ◽  
Vol 102 (2) ◽  
pp. 488-498 ◽  
Author(s):  
Diego Gomez-Arbelaez ◽  
Diego Bellido ◽  
Ana I. Castro ◽  
Lucia Ordoñez-Mayan ◽  
Jose Carreira ◽  
...  

Abstract Context: Common concerns when using low-calorie diets as a treatment for obesity are the reduction in fat-free mass, mostly muscular mass, that occurs together with the fat mass (FM) loss, and determining the best methodologies to evaluate body composition changes. Objective: This study aimed to evaluate the very-low-calorie ketogenic (VLCK) diet-induced changes in body composition of obese patients and to compare 3 different methodologies used to evaluate those changes. Design: Twenty obese patients followed a VLCK diet for 4 months. Body composition assessment was performed by dual-energy X-ray absorptiometry (DXA), multifrequency bioelectrical impedance (MF-BIA), and air displacement plethysmography (ADP) techniques. Muscular strength was also assessed. Measurements were performed at 4 points matched with the ketotic phases (basal, maximum ketosis, ketosis declining, and out of ketosis). Results: After 4 months the VLCK diet induced a −20.2 ± 4.5 kg weight loss, at expenses of reductions in fat mass (FM) of −16.5 ± 5.1 kg (DXA), −18.2 ± 5.8 kg (MF-BIA), and −17.7 ± 9.9 kg (ADP). A substantial decrease was also observed in the visceral FM. The mild but marked reduction in fat-free mass occurred at maximum ketosis, primarily as a result of changes in total body water, and was recovered thereafter. No changes in muscle strength were observed. A strong correlation was evidenced between the 3 methods of assessing body composition. Conclusion: The VLCK diet-induced weight loss was mainly at the expense of FM and visceral mass; muscle mass and strength were preserved. Of the 3 body composition techniques used, the MF-BIA method seems more convenient in the clinical setting.


Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3626
Author(s):  
Alexandra Jungert ◽  
Gerrit Eichner ◽  
Monika Neuhäuser-Berthold

This prospective study investigates age-dependent changes in anthropometric data and body composition over a period of two decades in consideration of physical activity and diet in community-dwelling subjects ≥60 years. Overall, 401 subjects with median follow-up time of 12 years were examined. Fat-free mass (FFM) and fat mass (FM) were analyzed using bioelectrical impedance analysis. Physical activity was assessed via a self-administered questionnaire. Dietary intake was examined by 3-day dietary records. Linear mixed-effects models were used to analyze the influence of age, sex, physical activity and energy/protein intake on anthropometric data and body composition by considering year of entry, use of diuretics and diagnosis of selected diseases. At baseline, median values for daily energy and protein intakes were 8.5 megajoule and 81 g and physical activity index was 1.7. After adjusting for covariates, advancing age was associated with parabolic changes indicating overall changes from age 60 to 90 years in women and men in body mass: −4.7 kg, −5.0 kg; body mass index: +0.04 kg/m2, −0.33 kg/m2; absolute FFM: −2.8 kg, −3.5 kg; absolute FM: −1.8 kg, −1.2 kg and waist circumference: +16 cm, +12 cm, respectively. No age-dependent changes were found for upper arm circumference and relative (%) FFM. Dietary and lifestyle factors were not associated with changes in anthropometric or body composition parameters. In summary, the results indicate non-linear age-dependent changes in anthropometric data and body composition, which are largely unaffected by the degree of habitual physical activity and dietary protein intake in well-nourished community-dwelling subjects.


2021 ◽  
Author(s):  
Erik Tan ◽  
Matthew P. Gonzalez ◽  
Martin Dietze-Hermosa ◽  
SEE Min ◽  
Sandor Dorgo ◽  
...  

The COVID-19 pandemic has caused mandatory lockdowns leading to disruptions in sports training programs. This study aimed to determine the effects of a 16-week COVID-19 lockdown on body composition as well as kinetic and kinematic parameters of the countermovement jump (CMJ) for professional martial artists. Thirteen (n=13) professional martial artists participated in this retrospective cohort study. Subjects were tested on the CMJ at four timepoints: 1) pre-lockdown (pre), 2) immediately post-lockdown (post), 3) two weeks post-lockdown (post+2), and 4) four weeks post-lockdown (post+4). Body composition was measured via bioelectrical impedance and jump data were collected using a force platform sampling at 1,000 Hz. Individual repeated-measures ANOVAs were conducted with pairwise post-hoc analyzes. Differences were observed in vertical jump height (VJH) of 10.33%, peak velocity (PV) of 3.10%, reactive strength index modified (RSImod) of 13.8%, and peak propulsive power (PPP) of 6.00% (p&lt;0.05). There as an increase from post to post+2 of 13.06% in VJ, 4.12% for PV, 14.0% for RSImod, and PPP of 4.66%. There was an increase from post to post+2 of 10.8% in VJH, 3.1% for PV, 14.0% for RSImod, and PPP of 3.0%. Fat mass (FM) and BF% increased from pre to post by 13% and 11%, respectively, and decreased 8% and 11% from post to post+4 respectively (p&lt;0.05). In contrast, there was an decrease in fat-free mass (FFM) from pre to post of 11% and a decrease of 8% from post to post+4. There were moderate associations between FFM and VJH (rmc=0.47), FMM and PPP (rmc=0.47), FFM and PV (rmc=0.47), BF% and PV (rmc=-0.42), and FM and PV (rmc=0.42). While the lockdown resulted in a significant decrease in CMJ performance and increases in BF and FM, subjects’ performance returned to pre-lockdown levels after only 2-4 weeks of post-lockdown training by decreasing BF, FM, and increasing FFM.


2017 ◽  
Vol 117 (4) ◽  
pp. 591-601 ◽  
Author(s):  
Ava Kerr ◽  
Gary J. Slater ◽  
Nuala Byrne

AbstractTwo, three and four compartment (2C, 3C and 4C) models of body composition are popular methods to measure fat mass (FM) and fat-free mass (FFM) in athletes. However, the impact of food and fluid intake on measurement error has not been established. The purpose of this study was to evaluate standardised (overnight fasted, rested and hydrated) v. non-standardised (afternoon and non-fasted) presentation on technical and biological error on surface anthropometry (SA), 2C, 3C and 4C models. In thirty-two athletic males, measures of SA, dual-energy X-ray absorptiometry (DXA), bioelectrical impedance spectroscopy (BIS) and air displacement plethysmography (BOD POD) were taken to establish 2C, 3C and 4C models. Tests were conducted after an overnight fast (duplicate), about 7 h later after ad libitum food and fluid intake, and repeated 24 h later before and after ingestion of a specified meal. Magnitudes of changes in the mean and typical errors of measurement were determined. Mean change scores for non-standardised presentation and post meal tests for FM were substantially large in BIS, SA, 3C and 4C models. For FFM, mean change scores for non-standardised conditions produced large changes for BIS, 3C and 4C models, small for DXA, trivial for BOD POD and SA. Models that included a total body water (TBW) value from BIS (3C and 4C) were more sensitive to TBW changes in non-standardised conditions than 2C models. Biological error is minimised in all models with standardised presentation but DXA and BOD POD are acceptable if acute food and fluid intake remains below 500 g.


1996 ◽  
Vol 6 (2) ◽  
pp. 146-164 ◽  
Author(s):  
Linda B. Houtkooper

Body composition assessment techniques provide estimates of percent body fat (%BF), fat mass (FM), and fat-free mass (FFM) based on indirect assessment models and methods. Prediction equations for %BF developed using a two-component model based on adult body composition constants will overestimate %BF in youths, especially prepubescent youths. Body composition prediction equations that have been validated and cross-validated using multiple-component criterion models which include measurements of body density and the water and mineral components of FFM provide the most accurate means for assessment of body composition in youths. Use of appropriate prediction equations and proper measurement techniques, for either bioelectrical impedance or skinfolds, results in body composition estimates with standard errors of estimate (prediction errors) of 3 to 4% BF and 2.0 to 2.5 kg of FFM. Poor measurement technique and inappropriate prediction equations will result in much larger prediction errors.


2019 ◽  
Vol 65 (10) ◽  
pp. 1283-1289
Author(s):  
Christophe Domingos ◽  
Catarina Nunes Matias ◽  
Edilson Serpeloni Cyrino ◽  
Luís Bettencourt Sardinha ◽  
Analiza Mónica Silva

SUMMARY Body composition assessment at the molecular level is relevant for the athletic population and its association with high performance is well recognized. The four-compartment molecular model (4C) is the reference method for fat mass (FM) and fat-free mass (FFM) estimation. However, its implementation in a real context is not feasible. Coaches and athletes need practical body composition methods for body composition assessment, and the bioelectrical impedance analysis method (BIA) is usually seen as a useful alternative. The aim of this study was to test the validity of BIA (Tanita, TBF-310) to determine the FM and FFM of elite judo athletes. A total of 29 males were evaluated in a period of weight stability using the reference method (4C) and the alternative method (Tanita, TBF-310). Regarding the 4C method, total-body water was assessed by deuterium dilution, bone mineral by DXA, and body volume by air displacement plethysmography. The slops and intercepts differed from 1 (0.39 and 1.11) and 0 (4.24 and -6.41) for FM and FFM, respectively. FM from Tanita TBF-310 overestimated the 4C method by 0.2 kg although no differences were found for FFM. Tanita TBF-310 explained 21% and 72% respectively in the estimation of absolute values of FM and FFM from the 4C method. Limits of agreement were significant, varying from -6.7 kg to 7.0 kg for FM and from -8.9 kg to 7.5 kg for FFM. In conclusion, TBF-310 Tanita is not a valid alternative method for estimating body composition in highly trained judo athletes.


2021 ◽  
pp. 351-364
Author(s):  
Nicolae MURGOCI

Introduction. This personal study provides several aspects of the importance of body composition assessment in rehabilitation process in order to manage fat mass (FM), fat-free mas imbalances (FFM), pre-sarcopenia status, sarcopenia and risks association and to improve global functionality. Health outcomes and risk estimations regarding fat mass and skeletal muscle mass (SMM) plays a major role and should be integrated into the rehabilitation process routine in order to avoid functional impairment and physical disability by applying specific kinetic programs. Material and method. A number of 14 subjects classified as outpatients who have received physical therapy at home- kinesiotherapy for post-fracture / dislocation status of the lower limbs in accordance with the medical recommendations and legislation in force. At the end of the rehabilitation phase, the body composition was measured using bio impedance in order to adjust the next step of the active rehabilitation. The measurements were obtained with a completely bioelectrical impedance analyzer (BIA). Single frequency BIA (SF-BIA) was used. For each subject major body compartments determined as FFM (including bone mineral tissue, total body water-TBW and visceral protein), SMM and FM were measured as a tissue-system by means of linear empirical equations stored in the system memory together with personal physical data. IBM SPSS software version 25 was used for statistical analysis. Results and discussions. Four age groups determined as follows: 21.43% for 18-39 years, 50-69 years, >70 years each and 35.71% for 40-49 years, based on the rate of muscle loss, because its integrity is essential for rehabilitation program. From the 14 subjects there are 57.14 % men and 42.86% women, from urban environment 78.57% and rural 21.43%. Mean Age is 48.79 years ± 18.792 Std. Deviation. Fat mass from BIA recorded 21.43% cases low and normal each, and high/very high 57.14% of total cases. Consequently, of BMI (body mass index) association, 57.14% are at normal weight, 35.71% overweight and with obesity and 7.14% underweight. One Sample Chi-Square test applied to BMI Type Associate with FM reveals the statistical significance, < .05(.014). Fat-free mass index (FFMI), fat mass index (FMI), skeletal mass index (SMI) were computed by adjusted with height square. FMI somatotype components results are 64.3% adipose cases, 21.4% intermediate and 14.3% lean. One Sample Chi-Square test applied to FMI Types reveals the statistical significance < .05(.046). Regression equation of standard BMI and FMI with scatter plots for 77.8% of cases was computed in the present study. FFMI somatotype components recorded 57.1% intermediate cases, 21.4% slender and solid each. Regression equation of standard BMI and FFMI with scatter plots for 57.4% of cases was computed. Three patients exceeded 15 seconds at the chair stand test so probable sarcopenia was identified. From BIA were extracted the value for the skeletal mass and SMI was calculated by height adjusted: 13 (92.86%) cases have normal values and one (7.14%) case have optimal value. Regression equation of standard BMI and SMI with scatter plots for 66.4% of cases was computed. Pearson correlation (CI =99%) denotes strong statistical relationship between BMI and FMI (r=0.882), FFMI (r=0.815), Age (r=0.659), Water (r=-0.693). FMI also correlates strongly with Age (r= 0.707), Water (r=-0.925) and Proteins values (r=-0.819). FFMI also correlates strongly with SMI (r=0.984). Water correlates with Protein (r=0.848, CI = 99%). Beta regression analysis strongly correlates SMI prediction with FFMI (ß=0.731), Water (ß=0.138) and Protein (ß=-0.370) for p<0.05. Anova significance of .000 (CI=99%) with applicability of 99.8% of the cases (R2 =0.998) proved that constant predictors: Water (%), FFMI, Proteins (%), FMI, BMI interact to influence SMM variability. 64.25% of subjects recorded an insufficient water level and 71.43% of subjects recorded an insufficient proteins level. Body composition evaluation should be integrated into routine clinical practice for the initial assessment and sequential follow-up and the strongest point of BIA is the possibility to replace invasive laboratory analysis with a quick, noninvasive test that can be carried out in a medical office. Body composition evaluation should be performed at the different stages of the disease, during the course of treatments and the rehabilitation phase. Conclusions. For each patient specific kinetic program will be developed. FMI increase (64.3% adipose cases) denotes the risk of metabolic syndrome and insulin resistance. Consequently, resistive and concentric exercises will be applied. For FFMI loss (57.1% intermediate cases, 21.4% slender) and SMI increasing (92.86% cases have normal values but not optimal ones, 21.43% pre-sarcopenia detected by positive chair test) resistance, eccentric/concentric exercises should be applied. All kinetic programs will be preceded by warm-up and followed by stretching taking into account cardiac reserve for each patient. Maximal/sub-maximal force exercises will be used age-related. Additional water (64.25% of subjects recorded an insufficient water level) and proteins levels (71.43% of subjects recorded an insufficient proteins level) must be balanced by nutritional support in accordance with rehabilitation consult and current physician approval in the interdisciplinary team. BIA may be an important supporting tool for health professionals in order to customize the rehabilitation programs for each patient. Keywords: body composition, rehabilitation, bioelectrical impedance, fat-free mass index, fat mass index, skeletal muscle index,


Author(s):  
Joan Grossman ◽  
Ronald Deitrick

Purpose: The purpose of this study was to examine the effect of resistance exercise (RE) on body composition using air-displacement plethysmography (ADP) within 2 hours of completing RE. Methods: Thirteen university students (9 males and 4 females; 18.8±0.5 yrs; mean ± SD) volunteered for this study. The RE program (55.4±8.7 min) consisted of a combination of upper- and lower-body extremity exercises and abdominal exercises for a total of nine different exercises. Relative body fat (BF) was assessed (1.76+0.4 hr) using ADP before and after the RE along with skinfold (SF) measures, body mass (BM) and respiratory quotient. Results: Statistically significant reductions in pre-post RE relative BF measurements (p=0.036) were observed using ADP along with statistically significant reductions in body volume (BV) (p=0.005), body mass (BM) (p=0.038) and fat mass (FM) (p=0.020). The mean intraclass correlation coefficients (ICC) for these variables was 0.99. No significant pre-post differences in fat-free mass (FFM), body mass index (BMI) or skinfold (SF) values were reported. Conclusions: This study demonstrates the potential adverse effects of assessing relative BF within 2 hours after RE. Significant differences in pre-post relative BF were supported by significant reductions in BV, BM, and FM. The results of this study support the manufacturer guidelines using ADP and RE restriction prior to body composition assessment.


Author(s):  
Francesco Campa ◽  
Catarina N. Matias ◽  
Pantelis T. Nikolaidis ◽  
Henry Lukaski ◽  
Jacopo Talluri ◽  
...  

The accurate body composition assessment comprises several variables, causing it to be a time consuming evaluation as well as requiring different and sometimes costly measurement instruments. The aim of this study was to develop new equations for the somatotype prediction, reducing the number of normal measurements required by the Heath and Carter approach. A group of 173 male soccer players (age, 13.6 ± 2.2 years, mean ± standard deviation; body mass index, BMI, 19.9 ± 2.5 kg/m2), members of the academy of a professional Italian soccer team participating in the first division (Serie A), participated in this study. Bioelectrical impedance analysis (BIA) was performed using the single frequency of 50 kHz and fat-free mass (FFM) was calculated using a BIA specific, impedance based equation. Somatotype components were estimated according to the Heath-Carter method. The participants were randomly split into development (n = 117) and validation groups (n = 56). New anthropometric and BIA based models were developed (endomorphy = −1.953 − 0.011 × stature2/resistance + 0.135 × BMI + 0.232 × triceps skinfold, R2 = 0.86, SEE = 0.28; mesomorphy = 6.848 + 0.138 × phase angle + 0.232 × contracted arm circumference + 0.166 × calf circumference − 0.093 × stature, R2 = 0.87, SEE = 0.40; ectomorphy = −5.592 − 38.237 × FFM/stature + 0.123 × stature, R2 = 0.86, SEE = 0.37). Cross validation revealed R2 of 0.84, 0.80, and 0.87 for endomorphy, mesomorphy, and ectomorphy, respectively. The new proposed equations allow for the integration of the somatotype assessment into BIA, reducing the number of collected measurements, the instruments used, and the time normally required to obtain a complete body composition analysis.


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