Late laryngo-tracheal cartilage necrosis with external fistula 44 years after radiotherapy

2003 ◽  
Vol 117 (8) ◽  
pp. 658-659 ◽  
Author(s):  
Yoshitaka Takiguchi ◽  
Hiro-Oki Okamura ◽  
Ken Kitamura ◽  
Seiji Kishimoto
Keyword(s):  
Clinical Course ◽  
Subcutaneous Tissue ◽  
Bacterial Colonization ◽  
Histological Study ◽  
Inflammatory Cells ◽  
Late Complications ◽  
Laryngeal Oedema ◽  
Anterior Neck ◽  
Tracheal Cartilage ◽  
Cutaneous Flap

Major late complications, following radiotherapy of head and neck carcinomas, such as laryngeal oedema, perichondritis and chondronecrosis usually occur between three and 12 months after treatment. However, the present case displayed necrosis of the laryngo-tracheal cartilage and ulceration of anterior neck skin with a tracheal fistula 44 years after irradiation. The reasons for the long interval between irradiation and late complications may be explained by long-standing hypovascularity and/or infection of the irradiated area. Histological study revealed chondronecrosis without inflammatory cells in the laryngo-tracheal cartilage and bacterial colonization of subcutaneous tissue. Necrotic tissue was removed and tracheostomy was performed. The fistula was almost completely closed using a delto-pectoral cutaneous flap and the clinical course of patient has been good. This paper demonstrates the possibility of laryngo-tracheal necrosis in cases that had received radiation as long ago as 44 years.

Diverse disease processes of group A Streptococcus infection including severe invasive infections among members of a family

2021 ◽  
Vol 14 (4) ◽  
pp. e241339
Author(s):  
Kaori Amari ◽  
Masaki Tago ◽  
Naoko E Katsuki ◽  
Shu-ichi Yamashita
Keyword(s):  
Septic Shock ◽  
Distress Syndrome ◽  
Clinical Course ◽  
Group A Streptococcus ◽  
Bloody Stool ◽  
Laryngeal Oedema ◽  
Invasive Infections ◽  
Group A ◽  
The Right ◽  
Close Contacts

We herein report three cases of group A Streptococcus (GAS) infection in a family. Patient 1, a 50-year-old woman, was transferred to our hospital in shock with acute respiratory distress syndrome, swelling in the right neck and erythemata on both lower extremities. She required intubation because of laryngeal oedema. At the same time, patient 2, a 48-year-old man, was admitted because of septic shock, pneumonia and a pulmonary abscess. Five days later, patient 3, a 91-year-old woman, visited our clinic with bloody stool. All three patients were cured by antibiotics, and GAS was detected by specimen cultures. During these patients’ clinical course, an 84-year-old woman was found dead at home after having been diagnosed with type A influenza. All four patients lived in the same apartment. The GAS genotypes detected in the first three patients were identical. When treating patients with GAS, appropriate management of close contacts is mandatory.

scholarly journals the Study of some histopathological changes occurring in white laboratory mice infected with Cutaneous Leishmaniasis in Al – diwaniyah province, Iraq.

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Lubna.A.Al-ibrahimi Edu ◽  
Hind Al-shabani ◽  
Marwa sami alwan
Keyword(s):  
Bile Duct ◽  
Mediterranean Region ◽  
Histological Study ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Intracellular Parasite ◽  
Laboratory Mice ◽  
Histopathological Changes ◽  
Radial Arrangement ◽  
Dermis Layer

          Leishmaniasis is caused by an intracellular parasite . It is endemic in Asia, Africa, the Americas, and the Mediterranean region. Worldwide, 1.5 to 2 million new cases occur each year .The histological study of the liver tissue of white laboratory mice (Mus musculus) infected with L. major a parasite showed The presence of severe steatosis of hepatocytes Hepatocyte degeneration, And loss of the radial arrangement of hepatocytes, With heavy infiltration in inflammatory cells, especially phagocytes( Macrophage) with  Hyperplasia and congestion of the bile duct  .  As for histological sections of skin lesions taken from ear , Foot , tail ، were showed epidermal ulcerative , Accompanied by severe leaching of the dermis layer neutrophil ,polymorph lymphocytes ، with hemorrhage of ​​the dermis, with necrosis of the epidermal cells of all skin lesions in the ear, foot and tail.

scholarly journals Histological analysis of the biocompatibility of three different calcium hydroxide-based root canal sealers

2006 ◽  
Vol 14 (5) ◽  
pp. 376-381 ◽  
Author(s):  
Heloisa Helena Pinho Veloso ◽  
Roberto Alves do Santos ◽  
Túlio Pessoa de Araújo ◽  
Denise Piotto Leonardi ◽  
Flares Baratto Filho
Keyword(s):  
Calcium Hydroxide ◽  
Study Design ◽  
Inflammatory Reaction ◽  
Root Canal ◽  
Histological Analysis ◽  
Subcutaneous Tissue ◽  
Inflammatory Cells ◽  
Control Groups ◽  
Tissue Reactions ◽  
Root Canal Sealers

OBJECTIVE: To histologically evaluate the behavior of the subcutaneous tissue of rats after placement of polyethylene tubes filled with calcium hydroxide-based root canal sealers (SealapexTM, ApexitTM e Sealer 26TM). STUDY DESIGN: The study employed 60 rats, which were divided into eight groups, being four experimental groups with 10 rats each, and four control groups with five rats. Analysis was conducted at 48 hours, 7, 21 and 60 days. RESULTS: Histological analysis revealed that all sealers were irritant; however, the intensity varied between each sealer and as a function of time. At the initial periods (48 hours and seven days), all materials demonstrated similar outcomes, with inflammatory reaction from severe to moderate, respectively. At the final periods (21 and 60 days), the tissue reactions to the implants containing SealapexTM displayed an active status yet with regression, compared to the ApexitTM and Sealer 26TM. The control groups exhibited less inflammatory cells than the experimental groups, keeping a reaction status with regression. CONCLUSIONS: The results achieved in this study revealed that the SealapexTM sealer was the most compatible, followed by ApexitTM and Sealer 26TM.

scholarly journals Complicated hypopharyngeal perforation caused by a foreign body

2007 ◽  
Vol 60 (7-8) ◽  
pp. 391-396 ◽  
Author(s):  
Karol Canji ◽  
Slobodan Mitrovic ◽  
Ljiljana Jovancevic
Keyword(s):  
Computed Tomography ◽  
Foreign Body ◽  
Neck Pain ◽  
Antibacterial Therapy ◽  
Subcutaneous Tissue ◽  
Good Choice ◽  
Anterior Neck ◽  
Hypopharyngeal Perforation ◽  
Tissue Edema ◽  
Good General Condition

The paper describes a patient who ingested a piece of bone during his meal. A foreign body was suspected and admission to the hospital was recommended as well as esophagoscopy, which he refused. Approximately 48 hours after the meal, the patient was admitted to the hospital for increased temperature, neck pain, and swollen right side of neck. Assuming that the condition was a result of hypopharyngeal perforation cased by a foreign body, computed tomography was performed. A collection of pus was found in the lateral and anterior neck compartments with subcutaneous tissue edema, and a foreign body was found in the projection of the hypopharynx. A wide incision was made under general anesthesia and drainage was performed using surgical drains and nasogastric tube. Antibacterial therapy was also applied. The patient was dismissed from the hospital in good general condition. Complications involving a foreign body in the hypopharynx and/or esophagus require urgent attention and adequate diagnosis and therapy. A correct indication, good choice of surgical procedure and intensive antibacterial therapy increase the chance of cure in such patients. .

A novel EUS-guided liquid fiducial marker for image-guided radiotherapy in esophageal cancer: The safety and efficacy in vitro and vivo evaluations.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15573-e15573
Author(s):  
Liangchao Sun ◽  
Xue Meng
Keyword(s):  
Esophageal Cancer ◽  
Subcutaneous Tissue ◽  
Inflammatory Cells ◽  
Fiducial Marker ◽  
Serious Adverse Events ◽  
Image Guided Radiotherapy ◽  
Injection Volume ◽  
Nodule Size ◽  
Tumor Extent

e15573 Background: The true tumor extent of esophageal cancer is hard to visualize on current modalities during radiotherapy. In this study, we evaluated the safety and feasibility of the mixture of N-Butyl Cyanoacrylate and lipiodol to find the most optimal application as the fiducial marker to marking the true tumor extent in esophageal radiotherapy. Methods: Four types of injection matches (1:1-0.1ml, 1:1-0.15ml, 1:3-0.1ml, 1:30.15ml) were injected via syringes in subcutaneous tissue in rats model. Gross histopathological changes, weight, skin score, nodule volume, neutrophil counts and macrophage counts were observed to analyses the effect of different mixing ratios and injection volumes to find the best match. Evaluations following ISO standard criteria are further delivered to test the biocompatibility of the best applicable setting of this fiducial maker. Results: At 7th week, 42 markers (42/48, 87.5%) were still visualized on CT images. No serious adverse events or obvious artifacts were noted through the study. The overall review about the histopathological reaction of the NBCA/Lipiodol was considered to be a combination of acute inflammation, chronic inflammation, granulation tissue, foreign-body reaction and fibrous capsule formation in development. The quantitative analysis showed that when the density of NBCA was low (1:3), lower injection volume (0.1ml) brought the lower weights (p < 0.001). When the injection volume is high (0.15ml), the high NBCA (1:1) caused the lower weight (p < 0.001). At the most time points, the lower injection volume had the lower weights. High injection volume created a 0.079 cm3 increase in nodule size than low volume and high NBCA density also increased the nodule size. As for the inflammatory cells counts, the 3rd week was a key time point, before which the neutrophils decreased sharply and the macrophages keep almost steady, but after that the neutrophils stayed a low level and the macrophages started a rapid growth. On the comparisons of different index (Table), it is showed that the 1:3-0.15ml had an excellent performance as the fiducial marker and final biocompatibility test proved its safety. Conclusions: Overall, our results show that the mixture of NBCA/Lip as the fiducial marker is safe and feasible and the setting of 1:3-0.15ml was most optimal.[Table: see text]

Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy

2011 ◽  
Vol 125 (4) ◽  
pp. 370-375 ◽  
Author(s):  
V Kahya ◽  
A Meric ◽  
M Yazici ◽  
M Yuksel ◽  
A Midi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Acute Inflammation ◽  
Histological Study ◽  
Reactive Oxygen ◽  
Inflammatory Cells ◽  
Oxygen Species ◽  
Sprague Dawley ◽  
Randomised Study ◽  
Sprague Dawley Rats ◽  
Reactive Oxygen Species Concentration

AbstractObjective:To assess the effect of pomegranate extract on acute inflammation due to myringotomy.Design:Prospective, randomised study.Subjects:Thirty Sprague–Dawley rats were divided into three groups. Group one constituted controls. Group two underwent myringotomy. Group three underwent myringotomy and also received 100 µl/day pomegranate extract, via gavage, one day before and two days after surgery. Following sacrifice 48 hours after myringotomy, the animals' right ears were used to determine the concentration of reactive oxygen species, using the chemiluminescence method; left ears were used for histological study.Results:Reactive oxygen species levels were significantly decreased in group three compared with group two (p < 0.01). The density of inflammatory cells in group three was significantly less than that in group two (p < 0.01). Lamina propria thickness and vessel density were also significantly decreased in group three compared with group two (p < 0.01).Conclusion:Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy.

RADIOLOGICAL FINDINGS AND CLINICAL COURSE OF CONUS LIPOMA

Neurosurgery ◽  
2008 ◽  
Vol 63 (3) ◽  
pp. 546-552 ◽  
Author(s):  
Izumi Koyanagi ◽  
Kazutoshi Hida ◽  
Yoshinobu Iwasaki ◽  
Toyohiko Isu ◽  
Masami Yoshino ◽  
...  
Keyword(s):  
Clinical Course ◽  
Subcutaneous Tissue ◽  
Clinical History ◽  
Prophylactic Surgery ◽  
Motor Deficits ◽  
Radiological Findings ◽  
Lumbar Level ◽  
Asymptomatic Patients ◽  
Age At Surgery ◽  
Neurological Presentation

ABSTRACT OBJECTIVE A significant variety in morphology of conus lipomas may underlie differences in clinical presentation of the patients and controversy in surgical management. We retrospectively studied 58 patients with conus lipomas at our institutions. The purpose of this study was to infer the clinical course from the radiological findings and to provide information for decision-making in planning for surgical treatment. METHODS The patients underwent untethering surgery between 1984 and 2005. There were 35 transitional and 23 dorsal lipomas. The age at surgery ranged from 1 month to 50 years (median, 4 yr). Preoperative clinical history, radiological findings, and postoperative results were analyzed. RESULTS Fifteen patients were asymptomatic, and 43 patients were symptomatic preoperatively. Twenty-one patients presented with motor deficits of the lower extremities. In seven patients, motor deficits appeared early, before 1 year of age. Massive lipomas compressing the cord or herniation of the spinal cord into the subcutaneous tissue were characteristic findings of such early deterioration. Motor deficits were present in 73% of patients with lipomas extending to the lumbar level, whereas 88% of patients with lipomas confined to the sacral level had only urinary deficits. During a mean postoperative follow-up period of 7.9 years, 4 (27%) of the 15 asymptomatic patients developed urinary and/or motor deficits, and 12 (28%) of the 43 symptomatic patients showed further neurological deterioration. CONCLUSION This study demonstrates that the location and morphology of conus lipomas influence the neurological presentation of the patients. Early prophylactic surgery is a reasonable treatment option if early deterioration is predicted by imaging studies.

Brachytherapy technique for abdominal wall metastases of colorectal cancer: ultrasound-guided insertion of applicator needle and a skin preservation method

2006 ◽  
Vol 47 (2) ◽  
pp. 157-161 ◽  
Author(s):  
K. Kishi ◽  
K. Takifuji ◽  
S. Shirai ◽  
T. Sonomura ◽  
M. Sato ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Subcutaneous Tissue ◽  
Organs At Risk ◽  
Late Complications ◽  
Interstitial Brachytherapy ◽  
Skin Dose ◽  
Tumor Shrinkage ◽  
Saline Injection ◽  
Ultrasound Guided ◽  
Preservation Method

Purpose: To report a technique of interstitial brachytherapy for the treatment of subcutaneous metastatic abdominal wall tumors. Material and Methods: We developed a brachytherapy technique consisting of ultrasound-guided insertion of applicator needles to avoid the organs at risk, such as intestines, and saline injection into the subcutaneous tissue between the tumor and the skin to decrease the skin dose. We encountered three patients with painful metastases from rectal carcinoma in the abdominal wall refractory to external radiotherapy. They were subjected to this brachytherapy with a single dose of 20 Gy. Results: The procedure was safely achieved in all three patients. Long-lasting pain reduction and tumor shrinkage was obtained without early or late complications. Conclusion: This interstitial brachytherapy technique seems to be feasible in the treatment of metastatic abdominal wall tumors.

scholarly journals SUPPORTING THERAPY IN EOSINOPHILIC ESOPHAGITIS: WHY, WHOM, HOW?

2018 ◽  
Vol 25 (3) ◽  
pp. 167-172
Author(s):  
N. V. KOROCHANSKAYA ◽  
S. N. SERIKOVA ◽  
M. A. BASENKO ◽  
S. S. SERIKOV
Keyword(s):  
Corticosteroid Therapy ◽  
Eosinophilic Esophagitis ◽  
Selection Criteria ◽  
Clinical Course ◽  
Morphological Changes ◽  
Histological Study ◽  
Elimination Diet ◽  
Esophageal Wall ◽  
History Of ◽  
The Right

Aim. To demonstrate peculiarities of clinic features, difficulties of diagnostics and treatment of eosinophilic esophagitis using a clinic case.Materials and methods. The investigation of the clinic case in young woman with eosinophilic esophagitis is presented. The diagnosis was established 6 years after the manifestation of the disease on the stage of complications developed (esophageal stricture). A complex examination included endoscopy, morphologic methods and consultations with adjacent specialists (llergologist, ENT). Drug therapy was carried out by system and topical corticosteroids according to recommendations of Russian gastroenterological association from 2013.Results. The right diagnosis was established by the assessment of the clinic feature of dysphagia with revealing of mucosal eosinophilic infiltration during histological study of esophageal mucosal biopsies. The elimination diet and corticosteroid therapy improved the clinic course of the disease considerably. However, there were no signs of morphological changes of esophageal wall recovery. As a result, the patient needed to be treated and managed constantly. Based on the literature data the authors described variations of natural history of the disease, discussed the approaches to supporting therapy, and revealed group selection criteria of the patients most of all needed to anti-relapsing therapy.Conclusion. Eosinophilic esophagitis is a chronic immune-antigendependent inflammatory disease of the esophagus with insufficiently investigated etiopathogenesis. A number of questions concerning this disease need to be studied (clinical course, possibility of long-lasted remission and self-recovery, duration of corticosteroid therapy, etc).

scholarly journals Effect Of Unsaturated Fatty Acid Omega-3 On Some Histological Criteria In White New Zealand Rabbits Administrated With Cyclosporine Drug

2021 ◽  
Vol 2 (3) ◽  
pp. 95-101
Author(s):  
Murtadha M. Jawad ◽  
Wijdan Rajh Hamza Al-Kraity
Keyword(s):  
Fatty Acid ◽  
New Zealand ◽  
Side Effects ◽  
Unsaturated Fatty Acid ◽  
Histological Study ◽  
Inflammatory Cells ◽  
Pathological Changes ◽  
Omega 3 ◽  
White Males ◽  
New Zealand Rabbits

The present study was aimed efficiency to evaluate the unsaturated fatty acid omega-3 in reducing the side effects that resulted from administration of cyclosporine drug in white New Zealand rabbits. (60) from white males' rabbits were used in this study, the animals divided into major four groups (15) rabbits per group and its subdivision into three groups (5) rabbits per group. The first group is orally administered with normal saline, second groups were administered cyclosporine (25mg/kg) only. Third groups were administered cyclosporine (25mg/kg) in the first day and Omega-3 (500mg/kg) in the second day, while Fourth groups were administered cyclosporine (25mg/kg) in the first day and omega-3 (1000mg/kg) in the second day for periods (21,30,60) days respectively. After ending study periods, the animals were sacrificed and the blood was collected and samples from liver were taken and the results were showed the following: the histological study showed pathological changes after administration of cyclosporine (25mg/kg) with blood congestion for period (21day), while severe blood congestion with beginning of fibrosis for period (30day) while in the period (60day) very severe blood congestion with aggregation of inflammatory cells and grow of fibroblast cells were showed. while the interaction between cyclosporine and two concentrations (500&1000mg/kg) of omega-3 were showed non-pathological changes in liver tissues. From this study concluded that omega-3 have an important role in the reducing histopathology side effects that result from administration of cyclosporine drug in white rabbits.

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