Tolerability research of complex antiparasitic preparation «Inspector collar»

2016 ◽  
Vol 3 (4) ◽  
pp. 547-553
Author(s):  
Демин ◽  
A. Demin ◽  
Арисов ◽  
M. Arisov ◽  
Гламаздин ◽  
...  

Objective of research: To evaluate the tolerability of the drug, “Inspector Collar” based on Fipronil, Pyriproxyfen and Ivermectin in dogs and cats applied at a therapeutic dose and double increased therapeutic doses. Materials and methods: Research was conducted at the shelter for dogs and cats «Bano Eco» (Moscow). Effect of drug “Inspector Collar” was studied on 15 clinically healthy outbreed dogs between 2 and 6 years with the body mass of 10–14 kg and 15 clinically healthy outbreed cats between 2 and 4 years with the body mass of 2–3,5 kg, receiving complete and balanced nutrition. Animals were divided into six groups (three groups of dogs and three of cats) five animals in each group. Dogs and cats from the first experimental group had put on one collar (equivalent of single therapeutic dose) for 45 days. The second experimental group had put two collars (double therapeutic dose) for 45 days. Animals from the third (control) group did not carry collars. During the experiment, daily supervision of animals was conducted; their general health status, behavior, appetite were observed, body mass and temperature estimated. Before and 15 and 30 days after the beginning of drug application, blood and urine tests were performed to study morphological and biochemical parameters. Statistical processing of data were carried out using Student’s t-test. Results and discussion: The research results showed that the drug “Inspector Collar” is well tolerated even at double therapeutic dose. All observed indicators remained within the physiological norm.

2013 ◽  
Vol 32 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Emina Čolak ◽  
Dragana Pap ◽  
Nada Majkić-Singh ◽  
Ivana Obradović

Summary Background: It has been reported that obesity is associated with metabolic syndrome, insulin resistance, cardiovascular risk but also with nonalcoholic fatty liver disease (NAFLD). The prevalence of obesity in children and adolescents is increasing rapidly all over the world. The aim of this study was to analyze the value of liver enzymes: AST, ALT and γGT in a group of obese students in order to establish their correlation to anthropometric parameters such as: BMI (body mass index), WC (waist circumference), HC (hip circumference), and WHR (waist-to-hip ratio) compared to non-obese students who comprised the control group (CG). Methods: In this study, 238 students from the University of Novi Sad of both sexes (126 men and 112 women) with a mean age of 22.32 ± 1.85 years were included. According to the body mass index (BMI) lower and higher than 25 kg/m2 and waist circumference (WC) lower and higher than 94 cm (80 cm for females) the whole group of 238 students was divided into 2 subgroups: the obese group at increased risk for CVD (Group 1) and the group at lower risk for CVD (Group 2). AST, ALT and γGT activities were determined in fasting blood samples. Results: Statistical processing data revealed significantly higher values of AST, ALT and γGT in the group of students with BMI>25 kg/m2, WC>94 cm for males and WC>80 cm for females, HC>108 cm for males and HC>111 cm for females, and WHR>0.90 for males and WHR>0.80 for females (P<0.001). Significant association was established between anthropometric parameters and liver enzyme levels (P<0.0001). Conclusions: Obese students with higher BMI, WC, HC and WHR values have higher liver enzyme activites and a higher chance to develop NAFLD in the future.


Author(s):  
D.I. Aksyonov ◽  
Yu.N. Mayboroda ◽  
E.A. Bragin ◽  
I.N. Aksyonov

The aim study was to construct artificial dentitions based on the method of mathematical modeling with the progenic and prognatic ratios of toothless frontal segments and to analyze the functional activity of the masticatory muscles in patients using dentures made in this way, compared with standard prosthetic structures. To compare and interpret the data obtained, electromyographic studies were performed in the control group (16 people), whose teeth were made using the traditional method, and the main group (22 people), whose artificial teeth were formed according to individual mathematical calculations, taking into account the size of the sagittal gap of the frontal segments of the progenic and prognatic ratio of toothless jaws. Statistical processing of the results of the electro-myographic study was carried out using the Statistica application software package. The digital data were processed by the method of variational statistics using the Student's t-test. The analysis of the obtained data showed the advantages of using individual mathematical calculations when solving the issue of tactics for constructing dentitions in the frontal segment of toothless jaws, taking into account the degree of the sagittal gap in the progenic and prognatic correlation of the jaws and their possible combinations.


2004 ◽  
Vol 5 (3) ◽  
pp. 59-65 ◽  
Author(s):  
Ali Alp Sağlam ◽  
Gülperi Şanli

Abstract Objectives The relationship between condylar asymmetry and handedness of the patients with temporomandibular disorders (TMD) and patients with no signs or symptoms of TMD was investigated. The experimental group consisted of 25 patients aged 15 to 52 years who were referred for treatment of TMD. The mean age of this group was 26.24 years. The control group consisted of 25 patients aged 14 to 52 years (mean age: 26.16 years). Methods The formula by Habets et al.14 was used to express the symmetry between the condyles and the rami on the orthopantomogram (OPG) image. Differences between bothgroups and subgroups (condyle, ramus, condyle plus ramus) regarding symmetry were calculated with the Student's t-test. Results The mean of condylar asymmetry was found to be 11.11 ± 11.03% in the TMD group. However, in the control group, the mean of condylar asymmetry was found to be 8.36 ± 6.27%. No statistically significant differences were found between condylar asymmetry in both groups (p>0.05). Conclusions No statistically significant differences were found between condylar asymmetry index in patients with TMD according to myogenous problems and in patients with no signs or symptoms of TMD. Citation Sağlam AA, Şanli G. Condylar Asymmetry Measurements in Patients with Temporomandibular Disorders. J Contemp Dent Pract 2004 August;(5)3:059-065.


2016 ◽  
Vol 38 (12) ◽  
pp. 1574-1594 ◽  
Author(s):  
Mei-Ying Chang ◽  
Hsiao-Yu Chen

Aging causes various changes in body composition, which are critical implications for health and physical functioning in aging adults. The aim of this study was to explore the body composition outcomes of a qigong intervention among community-dwelling aging adults. This was a quasi-experimental study in which 90 participants were recruited. Forty-eight participants (experimental group) attended a 30-min qigong program 3 times per week for 12 weeks, whereas 42 participants (control group) continued performing their usual daily activities. The experimental group achieved a greater reduction in the fat mass percentage at the posttest, and exhibited increased fat-free mass, lean body mass percentage, and lean body mass to fat mass ratio compared with the controls. No difference between the two groups in body mass index, fat mass, and lean body mass was observed. These results indicated that the qigong intervention showed beneficial outcomes of body composition among community-dwelling aging adults.


2018 ◽  
Vol 8 (8) ◽  
pp. 1
Author(s):  
Dora R.M. Ledo ◽  
Paulo A.C. Ferreira ◽  
Armando M.M. Silva

Objective: Educational nursing intervention is a strategy that can be useful for changing behaviours in a person’s health. Hospitalisation for coronary surgery is a valuable opportunity for the nurse to implement the knowledge which aims to promote healthy behaviours and secondarily, prevent coronary and cardiovascular disease, as these continue to be the main causes of death worldwide. The purpose of this study is to evaluate the influence of educational nursing intervention in the promotion of a healthy diet and in the anthropometric values (body mass index and waist perimeter) of people who have undergone coronary surgery.Methods: A quantitative and quasi-experimental study was conducted on a control group (20 participants in each group). The experimental group was submitted to a personalised structured educational intervention during hospitalisation, in the nursing follow-up visit (two to three weeks after surgery) and over the phone (two months after surgery). Each group went through two evaluations: the first before the surgery, and the second three months after the surgery. The instruments used to collect data included: the sociodemographic and clinical characterisation questionnaire and the Eating Habits Scale. Non-parametric tests were used.Results: The findings showed that 77.5% of the participants were male and 22.5% female. The participants’ average age was 67.35 ± 8.151. Results showed a significant improvement in the eating habits of both groups, with higher relevance in the experimental group and a reduction of the body mass index and waist perimeter exclusively in the experimental group.Conclusions: Regarding people who have undergone coronary surgery, personalised structured educational nursing intervention is a useful tool in obtaining health benefits and in secondary prevention of cardiovascular disease. More extensive and comprehensive studies are recommended to verify the results and enhance their success.


Author(s):  
Nazlı Yanar ◽  
Melek Güler

This study aims to determine whether the number of daily steps is effective in the body composition and mental well-being of university students during the COVID-19 pandemic. The research group of the study consisted of 40 volunteer students studying at the Faculty of Sport Sciences by being randomly assigned to the experimental (n:20) and control (n:20) groups. The research is in the experimental model with a pre-test/post-test control group. As a data collection tool in the study, the 'Warwick-Edinburgh Mental Well-Being Scale' was used to determine the personal information form and mental well-being. The obtained data were analysed in the Jamovi 1.8.2 statistical software program with a 95% reliability interval and 5% margin of error. In the analysis of the data, percentage (%), frequency (f), and mean (x̄) values were used in the descriptive data, Paired Samples t-test was used in the pre-test/post-test comparison, and Multinomial Regression analysis was used in the relational analysis. According to the findings of the study, 75% of the students in the experimental group and 70% of the students in the control group were in the normal weight class according to the body mass index classification. According to waist-hip ratio classification, 85% of the experimental group and 70% of the control group were in the group that did not have cardiovascular disease risk. After two months of application, the daily average number of steps of the experimental group (12.5751898.1) and the daily average number of steps of the control group were determined as (5381.272026.2). While there was a statistically significant difference in the pre-test/post-test body mass index averages of the experimental group who were asked to take at least 10,000 steps per day (p0.05), although there was an increase in the mean waist-hip ratio and mental well-being, there was no statistically significant difference (p0.05). It was determined that the step average had a statistically significant effect on the experimental group according to the body mass index classification (p0.05). As a result, while taking at least 10,000 steps per day was effective in the body mass index of the students, it was not so in the waist-hip ratio and mental well-being. In this context, physical activity, and especially walking, can be recommended at the point of protecting health. <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0881/a.php" alt="Hit counter" /></p>


Author(s):  
A. V. Mifatkhudinov ◽  
A. S. Aleshina

The researchers elaborated pharmacological complex of SM at the Chair of Morphology, Physiology and Pharmacology atSouth-UralStateAgrarianUniversity. The complex contains butafosfan, vitamins, vitamin-like substances, selected on the basis of synergistic effect on the body. The parameters of acute toxicity of the SM-complex were explored in the experiment on clinically healthy adult white mice of both genders by a single injection of the solution in the maximum permissible dose according to GOST 31926-2013. Intolerance on the skin of animals was detected in line with GOST R ISO 10993.10-2009. GOST R ISO 10993.10-99 became a guideline for evaluating SM-complex intolerance on the eye conjunctiva. Chronic toxicity was investigated on non-linear rats; the rates were divided into 4 groups of 6. The first group became a control group, the second group received the SM-complex in a therapeutic dose (255mg/kg), the third group - in a 5 -fold therapeutic dose (1275mg/kg), the fourth group - in a 10-fold dose (2550mg/kg). Pharmacological substance was applied through the probe in the form of an aqueous solution for 30 days. The researchers found out that at single oral introduction of SM-complex in the maximum possible doses it does not affect mice organism and it is referred to the 4th class of danger according to GOST 12.1.007-76. Local application in the form of applications on the skin and mucous membranes of rabbits, the complex does not have a local irritant effect. Long-term application of pharmacological composition (30 days) in high doses causes functional and morphological changes of the liver in the form of gray foci and flabbiness, as well as it increases the volume of the organ. Due to the fact that the therapeutic doses are 5 and 10 times lower than the toxic ones and the period of application does not exceed 7-14 days, the authors make a conclusion that SM-complex is safe and secure and can be used in the recommended doses.


2008 ◽  
Vol 21 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Kelly Pereira Coca ◽  
Ana Cristina Freitas de Vilhena Abrão

OBJECTIVE: To evaluate the effect of anhydrous lanolin-based ointment in the process of healing nipple injuries. METHODS: This is a descriptive experimental study was performed in two Maternity Hospitals in Sao Paulo. The random sample consisted of 50 puerperium women with nipple injuries, hospitalized in the period of June 2002 to July 2003. Participants were randomly assigned into control and experimental groups, by the means of a draw. Statistical analysis was performed using Qui-square, Student's t test, and ANOVA (á at 5%). RESULTS: The size of the injury in the control group reduced in 0.41 ± 0.11 cm (right breast) and 0.29 ± 0.06 cm (left breast) compared to the experimental group, from the first to the second evaluation (p < 0.001), showing to be statistically significant. CONCLUSION: The lanolin is effective in treating nipple injuries.


Mathematics ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 247 ◽  
Author(s):  
Lara Orcos ◽  
Cristina Jordán ◽  
Alberto Magreñán

This study aims to implement and evaluate a methodological proposal using the hologram as a teaching medium for the learning of concepts related to areas and volumes of geometrical bodies. The study has been carried out with a sample of 78 students in the third year of secondary education from a privately-owned but state-funded school in Madrid. Thirty-five students who have been taught traditionally formed the control group, and 43 formed the experimental group in which the methodology was implemented. To evaluate its goodness, we have used the Student's t-test to assess the existence of significant differences between both groups. The results reported by the test show that there is a difference of 3.9 points between the scores of both groups which is significant at the level of 0.05. In addition, the user experience in the experimental group has also been evaluated to assess the students’ opinions of the hologram in the learning process. The overall results have assisted us in corroborating the efficacy of the hologram as a teaching medium.


2019 ◽  
Vol 17 (Suppl.1) ◽  
pp. 774-779
Author(s):  
Tsveta Traykova

The aim of our investigation was to establish the dynamics of Body Mass index (BMI) of preschool children as a result of an enriched physical activity program. 208 children were included in the investigation. Methods used: Theoretical analysis of literature, pedagogical experiment, anthropometry, statistical methods Results: Children with BMI in normal levels have the highest percentage, which range from 56.2 to 72.4% for 5-year-old boys, from 70.6 to 81.8% for the girls of the same age, from 65.8 to 84.3% for the boys 6 years old and from 57.2 to 65.4% for the girls of the same age. A high percentage of the overweight and obese children in all groups was also found. The 6-year-old girls from the experimental group have the highest BMI values – 38.5%, followed by the 5-year old boys from the control group. Another negative trend in our study was that there are some underweight children from the three degrees as the values ranged from 10.8% for the 6-year-old girls (control group) up to 27.5% for the 5 year old boys from the experimental group. In conclusion, we would like to underline that overweight and obesity are an important medical and social problem escalating the last years. However, we should have in mind the other extreme trend – the existence of underweight children – II and especially III degree, so our efforts should be to directed towards regulating the body weight in two directions – both reduction or increasing in dependence of any individual case.


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