scholarly journals Study of Fenugreek Seed Extract Effect (Trigonella foenum-graecum L) on Histomorphic Structure of Cervical Enlargement of the Spinal Cord Development During Gestational Age of 20 day Offspring of Diabetic Rats

2015 ◽  
Vol 8 (2) ◽  
pp. 1333-1340
Author(s):  
EBRAHIM KOUKHDAN ◽  
ZABIHOLLAH KHAKSAR
2012 ◽  
Vol 6 (38) ◽  
pp. 5119-5127 ◽  
Author(s):  
Dinakaran Vasudevan ◽  
Sridharan Subhashree ◽  
Periyasamy Latha ◽  
Sudha Rani Sankaramoorthy

2019 ◽  
Vol 29 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Lucie Widowati ◽  
Ani Isnawati ◽  
Sukmayati Alegantina ◽  
Fifi Retiaty

Abstract The proportion of stunting in children under 5 years old in Indonesia was approximately 30,8% in 2018. One of the things that is presumably related to the occurrence of stunting is lack of nutrition that can be attributed to exclusive breastfeeding. Fenugreek seeds have properties as laktogoga and moringa leaves in addition to having efficacy as lactagoga, also have advantage in nutritional content, particularly high protein content, groups of minerals and vitamins. The aim of the study was to assess the potential of the formula fenugreek seed extract (Trigonella foenum-graecum L) and moringa leaves (Moringa oleifera Lamk.) as a supplement to release milk while at the same having nutrient content. Methods using the test weighting method in pregnant female rats by measuring the volume of milk taken by baby rats. Test were carried out on five groups of mother rats namely groups than were given : fenugreek and moringa extract (1: 1) with different doses I, II and III; comparison group (moloco) and control group (distilled water). Each mother fed five rats, provision of extract was carried out starting the first day after the mother gave birth, and measurement were take on 6th, 11th, 16th to 21st day The volume of milk consumed by five rats was counted as difference of body weight after and before breastfeeding. Moringa nutritional assessment is carried out using standard methods on, iron, calcium and potassium content; vitamin A and vitamin C content and protein level. Fenugreek-moringa extract (1: 1) dose of 30 mg/200g bb, can increase the volume of breast milk of female rat larger than the untreated group (p≤0.05). The cumulative weight gain of rat infants was greater than the control group (p≤0.05), according to the nutrients obtained from the fenugreek-moringa extract. Moringa leaves as a component of extract, have high nutritional value of minerals, vitamins and proteins and have advantages as lactogogum. Conclusion: The administration of moringa leaf and fenugreek seed extract (1: 1) dose of 30 mg / 200 g bb in breastfeeding female rats has a 2.4 times greater potential in increasing milk expenditure compared to breastfeeding female rats who did not get the same extract. Fenugreek-moringa extract has superior potential as laktagogum and at the same time a high nutritional supplement. Abstrak Proporsi kejadian stunting pada anak usia di bawah 5 tahun (balita) di Indonesia tercatat sekitar 30,8% pada tahun 2018. Salah satu hal yang diduga berkaitan dengan terjadinya stunting adalah gizi kurang yang dapat dikaitkan dengan pemberian air susu ibu (ASI) eksklusif. Biji klabet memiliki khasiat sebagai laktagoga dan daun kelor selain mempunyai khasiat sebagai laktagoga, juga mempunyai keunggulan pada kandungan gizinya, terutama kandungan protein yang tinggi, golongan mineral dan vitamin. Penelitian bertujuan untuk menilai potensi formula ekstrak biji klabet (Trigonella foenum-graecum L.) dan daun kelor (Moringa oleifera Lamk.) sebagai suplemen pelancar pengeluaran air susu sekaligus memiliki kandungan nutrisi yang tinggi. Metode menggunakan test weighting method pada tikus betina hamil, dengan cara mengukur volume air susu yang diminum oleh bayi tikus. Dilakukan uji pada lima kelompok induk tikus yaitu: kelompok yang diberi ekstrak klabet dan kelor (1:1) dengan dosis I, II dan III yang berbeda; kelompok pembanding (moloco) dan kelompok kontrol (akuades). Tiap induk tikus menyusui lima ekor anak tikus. Pemberian bahan uji dilakukan mulai hari pertama setelah induk tikus melahirkan, dan pengukuran dilakukan pada hari ke-6, 11, 16 sampai 21. Volume air susu yang diminum lima ekor anak tikus dihitung sebagai selisih berat badan sesudah dan sebelum disusui induknya. Penilaian gizi kelor dilakukan menggunakan metoda standar, terhadap kandungan mineral besi, kalsium dan kalium; kandungan vitamin A dan vitamin C, serta kadar protein. Hasil penelitian menunjukkan ekstrak klabet-kelor (1:1) dosis 30 mg/200g bb, dapat memperbanyak pengeluaran volume air susu induk tikus lebih besar dari kelompok yang tidak diberi perlakuan (p≤0,05). Pertambahan berat kumulatif bayi tikus, lebih besar dibandingkan kelompok kontrol (p≤0,05), sesuai dengan gizi yang didapat dari ekstrak klabet-kelor. Daun kelor sebagai komponen ekstrak, mempunyai nilai gizi mineral, vitamin, dan protein yang tinggi serta memiliki keunggulan sebagai laktogogum. Kesimpulan penelitian adalah pemberian ekstrak biji klabet-daun kelor (1:1) dosis 30 mg/200g bb pada tikus betina menyusui mempunyai potensi 2,4 kali lebih besar dalam meningkatkan pengeluaran air susu dibandingkan kelompok tikus betina menyusui yang tidak mendapatkan ekstrak yang sama. Ekstrak biji klabet-kelor mempunyai potensi unggul sebagai laktagogum dan sekaligus suplemen dengan gizi tinggi.


2017 ◽  
Vol 42 (8) ◽  
pp. 816-828 ◽  
Author(s):  
Seetur R. Pradeep ◽  
Krishnapura Srinivasan

Oxidative stress has a crucial role in the progression of diabetes and its complications. Soluble fibre-rich fenugreek seeds (Trigonella foenum-graecum L.) are understood to have a beneficial effect in the management of diabetes. Previously, we have shown that the amelioration of diabetic hyperglycemia and related metabolic abnormalities was potentiated by onion (Allium cepa L.) in experimental rats. The present study evaluated the additive beneficial effect of dietary fenugreek seeds (10%) and onion (3%) on oxidative stress in diabetic rats. These dietary interventions lowered oxidative stress, the combination producing a higher beneficial effect (p < 0.05), although not additive. Dietary fenugreek, onion, or fenugreek+onion countered hypercholesterolemia (p < 0.05), especially from low-density lipoprotein−associated fraction by 43%, 35%, and 54%, respectively. Elevated concentrations of cholesterol and triglycerides in the liver and heart under diabetic conditions were significantly counteracted by these dietary interventions, with the additive combination resulting in greater effect. These findings were also corroborated by restoration of histopathological abnormalities of heart and liver tissues along with lowered heart and liver weights. It is inferred that an alleviation of oxidative stress contributes further to the antidiabetic influence and this nutraceutical potential of fenugreek seeds and onion was higher when consumed together.


2007 ◽  
Vol 52 (1) ◽  
pp. 1-8
Author(s):  
Radojka Maletic ◽  
Radosav Jevdjovic

Results of a two-year investigation (2005 and 2006) for the yield and quality of fenugreek seed (Trigonella foenum graecum L) obtained on the location in South Banat (around Pancevo) on marsh dark soil are presented in the paper. Fenugreek seed used in this investigation was produced in the collection of the Institute of Medicinal Plant Research "Dr Josif Pancic" in Pancevo. The effect of sowing date on yield (kg/ha) and quality of fenugreek seed (germination energy and total germination) were investigated. Sowing was carried out on seven dates, 10 days between dates of each sowing. Yield of fenugreek seed sowed on different dates differed in both years. Sowing carried out in the first two weeks in April resulted in considerably higher yield compared to sowing at the end of April and during May. The highest yield was produced in the second sowing date from April 10, then in the first (April 1) and the third sowing period (April 20). The lowest yield of fenugreek seed was recorded in sowing carried out at the end of May. Yield of fenugreek seed wasn't significantly different in study years. Earlier dates of sowing resulted in seed of better quality (better germination energy and total germination). In the second sowing date fenugreek seed obtained was of best germination energy and total germination (approx. 99%). Later sowing dates gave seed of lower quality. So, sowing carried out at the end of May resulted in seed with the lowest value of germination energy and total germination (approx. 91%).


2019 ◽  
Vol 6 (5) ◽  
pp. 3142-3150 ◽  
Author(s):  
Gözde ATİLA USLU ◽  
Hamit USLU ◽  
Yasemen ADALI

Introduction: Feeding habits and environmental factors may rival genetic susceptibility as etiological factors related to various cancers. Humans are continuously exposed to many synthetic food additives, one of which is sodium nitrite (NaNO2). There is a direct correlation between increases in consumption of nitrite-treated products and incidence of tissue damage, hepatotoxicity, nephrotoxicity and some types of cancer. The objective of this study was to investigate the protective effects of Trigonella foenum-graecum (TFG) on NaNO2-induced hepatotoxicity and nephrotoxicity. Methods: Forty rats were randomly assigned (10 per group) to control (physiological saline solution), TFG (150 mg/kg/day), NaNO2 (80 mg/kg/day), and NaNO2+TFG (80 mg/kg/day + 150 mg/kg/day) groups. This group was offered TFG seed extract two hours before NaNO2. At the end of three months, the rats were decapitated, and blood, kidney and liver tissues were removed. Results: Three months of oral administration of NaNO2 increased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and pro-inflammatory cytokine levels in the liver and kidney tissues [except for liver Interleukin 1 alpha (IL-1a)] of rats. Serum AST, ALT, urea, creatinine, liver IL-6, and kidney tumor necrosis factor-a (TNF-a), IL-6, IL-1a levels significantly decreased in the NaNO2+TFG group compared to the NaNO2 group. Pathological examinations, it was determined show that exogenously administered TFG could alleviate the effects of NaNO2 hepatotoxicity and nephrotoxicity. Conclusions: Our results suggest that exogenous TFG mitigates NaNO2-administration induced hepatotoxicity and nephrotoxicity. TFG extract exerted antioxidative and anti-inflammatory effects, and played a significant role in preventing hepatic and renal damage induced by chronic NaNO2 administration.  


Sign in / Sign up

Export Citation Format

Share Document