Hypoglycaemic and hypolipidaemic activities of water extract of Lagerstroemia speciosa (L.) Pers. leaves in diabetic rat
The aim of this study was to know the hypoglycaemic and hypolipidaemic activities of water extract of bungur (Lagerstroemia speciosa [L.] Pers.) leaves in alloxan-induced diabetic rat. Phytochemical studies was conducted to determinate the tannin-contents of the water extract (WE). Male Wistar rats (150- 180 9 BW) were used in this study. The rats were divided into six groups: nonnal control; diabetic control; glibenclamide; WE 0.1 g/200 9 BW; WE 0.2 g/200 9 BW; and WE 0.5 g/200 9 BW. Dried leaves of bungur extracted with boiling water (50 g/L) for 30 minutes. The extract administered orally. Fasting blood glucose, triglyceride, and total cholesterol were determined at 0, 2, 4, 6 hours after treatment. Total phenol, ellagitannin, gallotannin, and condensed-tannin were determined from the WE. The results showed that WE exhibited hypoglycaemic activity at doses 0.2 g/200 9 BW and 0.5 g/200 9 BW. The last dose showed similar hypoglycaemic activity compared with glibenclamide. All doses showed the hypolipidaemic activity higher than glibenclamide. Phytochemical studies showed that the WE containing total phenol 0.025%; ellagitannin 0.011%; gallotannin 0.0199%; and condensed-tannin 0.0167%.