scholarly journals Epidemiology, Diagnostics, and Treatment of Narcolepsy in Germany: The DORMIO Study

2021 ◽  
Vol 18 (2) ◽  
pp. 88-99
Author(s):  
Sabrina Müller ◽  
Alina Brandes ◽  
Julia Knierim ◽  
Milan Novakovic ◽  
Thomas Wilke ◽  
...  
Keyword(s):  
Matched Control ◽  
Healthcare Resource ◽  
Treatment Guidelines ◽  
Diagnostic Procedures ◽  
Healthcare Resource Utilization ◽  
Control Group ◽  
German Population ◽  
High Prevalence ◽  
Direct Healthcare Costs ◽  
The Mean

Objectives: This study aimed to investigate the prevalence, incidence, and real-world diagnostic and treatment patterns, healthcare resource utilization (HCRU), and associated costs of narcolepsy in Germany. Methods: This study was based on German claims data (2013–2018). Any patient with at least two outpatient specialist diagnoses and/or one inpatient diagnosis of narcolepsy was eligible for inclusion. Three cohorts were specified: 1) narcolepsy-prevalent patients alive on July 1, 2017; 2) narcolepsy-incident patients; and 3) newly treated patients. Descriptive analyses of the outcome measures were conducted. Results: We identified 133 prevalent narcolepsy patients (mean age: 46.2 years, 36.3% female), 71 incident patients, and 41 treatment starters. The prevalence of narcolepsy was 3.1–9.1 per 100,000 persons within the German population; the cumulative incidence between July 1, 2017, and June 30, 2018, was 0.83/100,000 persons. Among the incident patients, 62.0% underwent at least one predefined diagnostic procedure. Modafinil was the most prescribed medication for the treatment starters (46.3%) and prevalent patients (24.1%), but 59.4% of the prevalent patients did not receive any narcolepsy-specific pharmacological treatment. Prevalent patients with narcolepsy consulted physicians significantly more often than a healthy matched control group and experienced more all-cause hospitalizations. The mean total direct healthcare costs were higher for narcolepsy patients by €2,429 per patient-year. Conclusions: Not all narcolepsy patients undergo appropriate diagnostic procedures or narcolepsy-specific medications, as indicated by the treatment guidelines. More emphasis on the optimization of the management of this disease is needed, given its high prevalence and associated economic burden.

Enlargement of cerebrospinal fluid spaces in long-term benzodiazepine abusers

1987 ◽  
Vol 17 (4) ◽  
pp. 869-873 ◽  
Author(s):  
C. Schmauss ◽  
J.-C. Krieg
Keyword(s):  
Low Dose ◽  
Matched Control ◽  
Control Group ◽  
High Dose ◽  
Withdrawal Therapy ◽  
The Mean ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Age And Sex

SynopsisIn 17 benzodiazepine (BDZ) dependent in-patients a CT scan was performed before initiation of withdrawal therapy. The evaluation of the ventricular to brain ratio (VBR) by standardized and computerized measurements revealed significantly higher mean VBRs for both high-and low-dose BDZ-dependent patients compared to the mean VBR of an age- and sex-matched control group. In addition, the mean VBR of high-dose BDZ-dependent patients (N = 8) was significantly higher than the mean VBR of low-dose BDZ-dependent patients (N = 9). This difference could not be accounted for by the age of the patients or duration of BDZ-dependency and, therefore, suggests a dose-dependent effect of BDZs on the enlargement of internal CSF-spaces. On the other hand, higher values for the width of external CSF-spaces were found to be related to increasing age of the patients and duration of BDZ-dependency.

scholarly journals Enhanced Visualization of the Cervical Vertebra during Intraoperative Fluoroscopy Using a Shoulder Traction Device

2020 ◽  
Vol 14 (4) ◽  
pp. 502-506
Author(s):  
Van Tri Truong ◽  
Fidaa Al-Shakfa ◽  
Ghassan Boubez ◽  
Daniel Shedid ◽  
Sung-Joo Yuh ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Matched Control ◽  
Skin Irritation ◽  
Cervical Vertebra ◽  
Control Group ◽  
Matched Control Group ◽  
Cervical Spine Surgery ◽  
Intraoperative Fluoroscopy ◽  
Traction Device ◽  
The Mean

Study Design: A retrospective, matched cohort study of a prospective database.Purpose: To evaluate the efficacy and safety of the Cervision system (Spinologics, Montreal, Canada), a new shoulder traction device that improves the fluoroscopic visualization of the lower cervical spine using caudal traction of the shoulders out of the radiographic field.Overview of Literature: Operating at a wrong level is a common error that may be committed by nearly 50% of surgeons during their career. Intraoperative fluoroscopy of the cervical vertebrae is an extremely important step in cervical spine surgery. Optimal lateral cervical radiography of the C1–T1 vertebrae is not always possible due to overlap of the shoulders.Methods: In this study, a group of patients (n=33, device group) underwent surgery with the new device used to apply caudal traction to both shoulders, and another group of patients (n=33, matched control group) had surgery with the tape traction. Data about the lowest vertebra visible on lateral fluoroscopic view, installation time, skin irritation under the traction area, and postoperative brachial palsy were recorded, and these parameters were analyzed using the <i>t</i>-test.Results: The mean numbers of visible cervical vertebra were 6.3±0.41 in the device group and 5.6±0.32 in the matched control group (<i>p</i> <0.01, unpaired <i>t</i>-test). The mean installation times were 83.9±5.15 minutes in the device group and 73.7±6.32 minutes in the matched control group (<i>p</i> <0.02). Seven patients from the matched control group presented with skin irritation. However, none of the patients from the device group had the condition (p =0.005, Pearson chi-square test). Postoperative brachial palsy was not observed in both groups.Conclusions: The Cervision system is more effective and superior to tape traction in pulling the shoulders down to improve the visualization of the cervical vertebra on lateral fluoroscopic view during cervical spine surgery.

Psychiatric Morbidity in Sentenced Segregated HIV-Positive Prisoners

1993 ◽  
Vol 163 (6) ◽  
pp. 802-805 ◽  
Author(s):  
Arthur Dorman ◽  
Art O'Connor ◽  
Eamonn Hardiman ◽  
Aideen Freyne ◽  
Helen O'Neill
Keyword(s):  
Drug Abuse ◽  
Matched Control ◽  
Psychiatric Morbidity ◽  
Hiv Positive ◽  
Control Group ◽  
Matched Control Group ◽  
History Of ◽  
The Mean ◽  
Group 2 ◽  
Group 1

In this comparative study with a control group of prisoners, psychiatric morbidity was measured in two groups of sentenced prisoners, each group completing the GHQ-30 and 21-item Beck Depression Inventory (BDI). Group 1 consisted of 40 segregated HIV-positive prisoners and group 2 a matched control group in the main prison who had no history of HIV seropositivity. All members of group 1 had a history of intravenous drug abuse. The mean GHQ-30 and BDI scores were significantly higher in group 1, and 90% of group 1 were psychiatric ‘cases’ compared with just over 42% of group 2. Levels of psychiatric morbidity present in a third group, consisting of HIV-positive prisoners who had not been segregated (prison authorities were unaware of their seropositivity) are an interesting pointer for further research.

Antithyroid Effect of Chlorpropamide?

1983 ◽  
Vol 2 (1) ◽  
pp. 149-153 ◽  
Author(s):  
J. Feely ◽  
S. McLaren ◽  
A.M.M. Shepherd ◽  
D. Maclean ◽  
I.H. Stevenson ◽  
...  
Keyword(s):  
Matched Control ◽  
Control Group ◽  
Diabetic Patients ◽  
Matched Control Group ◽  
Serum Thyroxine ◽  
Chronic Therapy ◽  
The Mean ◽  
Clinically Significant ◽  
The Relationship ◽  
Plasma Chlorpropamide

1 The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy. 2 Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r= 0.33, P< 0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different from that of a matched control group of diabetics treated with diet alone. 3 Serum thyroxine was negatively correlated with the duration of diabetes in both groups. 4 These results suggest that chlorpropamide does not have a clinically significant antithyroid effect.

scholarly journals Association of Hypertension and Smoking with Ischaemic Stroke

2013 ◽  
Vol 3 (1) ◽  
pp. 16-18
Author(s):  
K Kirtania ◽  
N Sultana ◽  
S Ahmed ◽  
A Khatun
Keyword(s):  
Cigarette Smoking ◽  
Ischaemic Stroke ◽  
Matched Control ◽  
Strong Relationship ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
Study Population ◽  
The Mean ◽  
Control Study

Hypertension is one of the most important modifiable risk factors for ischemic stroke. Cigarette smoking is a risk factor for atherosclerotic disease. There is a strong relationship between hypertension and cigarette smoking with ischaemic stroke. A case control study was undertaken to see the association of hypertension and cigarette smoking with ischaemic stroke. The study was done from January to December 2009 in the Department of Biochemistry, Dhaka Medical College, Dhaka. A total of 60 subjects were selected as study population. Among them 30 were diagnosed case of ischaemic stroke and 30 were age-and sex-matched control subjects. It was found that 60% patients of case group and 20% respondents of control group were hypertensive and diffrence was significant. Study showed that 56.66% of cases and 53.33% of controls were smoker and the findings were insignificant. The mean duration of smoking was 27.41 ± 2.98 years in cases and 15.63 ± 2.85 years in controls which was significant. The study suggests that hypertension is significantly associated with ischaemic stroke and longer duration of smoking also associated with ischaemic stroke. DOI: http://dx.doi.org/10.3329/bjmb.v3i1.13802 Bangladesh J Med Biochem 2010; 3(1): 16-18

Increased Mean Platelet Volume in Patients With Aortic Stenosis

2010 ◽  
Vol 17 (6) ◽  
pp. E17-E20 ◽  
Author(s):  
Ercan Varol ◽  
Akif Arslan ◽  
Habil Yucel ◽  
Mehmet Ozaydin ◽  
Dogan Erdogan ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Platelet Activation ◽  
Mean Platelet Volume ◽  
Matched Control ◽  
Control Group ◽  
Study Group ◽  
Platelet Volume ◽  
Echocardiographic Examination ◽  
The Mean ◽  
And Control

Background: Systemic thromboembolism is a serious complication in patients with aortic stenosis (AS). Previous studies have demonstrated that platelet activation occurs in patients with AS. The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with AS. Patients and Methods: The study group consisted of 43 patients with AS. An age-, gender-, and body mass index−matched control group consisted of 35 healthy volunteers. All patients and control participants underwent echocardiographic examination. We measured the serum MPV values in patients and control participants. Results: Mean platelet volume was significantly higher among patients with AS when compared with the control group (8.7 ± 1.0 vs 7.9 ± 0.9 fL, respectively; P = .001). Conclusion: We have shown that MPV was significantly elevated in patients with AS compared to control participant.

Scalp Potentials Evoked by Amplitude-Modulated Tones in Dyslexia

1997 ◽  
Vol 40 (4) ◽  
pp. 939-945 ◽  
Author(s):  
Ken I. McAnally ◽  
John F. Stein
Keyword(s):  
Amplitude Modulation ◽  
Matched Control ◽  
Auditory Brainstem ◽  
Control Group ◽  
Acoustic Stimuli ◽  
Stimulus Energy ◽  
Rapid Changes ◽  
Brainstem Response ◽  
History Of ◽  
The Mean

We recorded the far-field EEG potential evoked by amplitude modulation of acoustic stimuli (the amplitude modulation following response, AMFR) in adults with developmental dyslexia and in a matched control group of adults with no history of reading problems. The mean AMFR recorded from participants with dyslexia was significantly smaller than that recorded from members of the control group. In contrast, the amplitude of the click-evoked auditory brainstem response ABR) was not significantly different between participant groups. Also, there was no difference between participant groups in the latency of the AMFR or ABR. The reduced AMFR in listeners with dyslexia may reflect impaired ability of the auditory system to follow rapid changes in stimulus energy, a cue believed to be important in the perception of speech.

Sex Differences in the Limb Tremor of Morbidly Anxious Patients

1967 ◽  
Vol 113 (504) ◽  
pp. 1265-1266 ◽  
Author(s):  
J. R. G. Carrie
Keyword(s):  
Sex Differences ◽  
Normal Control ◽  
Matched Control ◽  
Control Group ◽  
Normal Male ◽  
Male And Female ◽  
Matched Control Group ◽  
Control Subjects ◽  
The Mean ◽  
Female Subjects

In several previous studies it has been shown that the mean tremor amplitude displayed by morbidly anxious patients is greater than that of normal control subjects. The most detailed experiments were those carried out by Redfearn (1957). He compared the findings obtained in groups of male morbidly anxious patients and controls, and in addition to confirming the existence of a difference in tremor amplitude, he reported that the tremor of male anxious patients showed a greater degree of accentuation of the 8–10 c/sec. components than the tremor of a matched control group. Halliday and Redfearn (1956) compared the tremor spectra obtained from normal male and female subjects, and found that the curve for men was similar to that for women.

Improved survival following transarterial radioembolization of infiltrative-appearance hepatocellular carcinoma.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15591-e15591
Author(s):  
Michael J Nisiewicz ◽  
Reema Anil Patel ◽  
Adam J Dugan ◽  
Joseph W Owen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Systemic Therapy ◽  
Treatment Guidelines ◽  
International Normalized Ratio ◽  
Hazard Ratio ◽  
Control Group ◽  
Transarterial Radioembolization ◽  
Pugh Class ◽  
The Mean

e15591 Background: Infiltrative-appearance hepatocellular carcinoma (IHCC), also known as diffuse HCC, presents a distinct challenge to clinicians as evidence-based treatment guidelines have yet to be established. While transarterial radioembolization (TARE) has shown efficacy in HCC, many studies exclude IHCC in their analysis. The purpose of this study was to evaluate whether TARE of IHCC improves survival. Methods: With IRB approval, patients with IHCC were identified. Patient were divided into two groups: TARE versus systemic therapy/palliative care. Demographics, date of diagnosis, date of expiry, albumin, international normalized ratio (INR), sodium, alpha-fetoprotein (AFP), creatinine, Child-Pugh class, model for end-stage liver disease (MELD) score, and bilirubin were collected. Patients with bilirubin >3 were excluded. Mann-Whitney U test and Fisher’s exact test assessed for differences between groups. Kaplan-Meier survival analysis and Cox proportional hazard analysis were performed. Results: Forty-one patients were identified, 10 underwent TARE while the remaining 31 served as a control. Mean age was 62, 30 patients were male. The mean overall survival of the TARE treatment group was 16.6 months (506 days) and the mean overall survival of the control group was 5.6 months (170 days) (Log-rank p < 0.004), with a combined overall survival of 8.5 months (259 days). Cox proportional regression analysis revealed statistically significant associations between survival and albumin (hazard ratio 0.12, 0.032-0.41, p < 0.001), Child-Pugh class B (hazard ratio 0.25, 0.064-0.941, p < 0.041), and sorafenib therapy (hazard ratio 0.246, 0.071 – 0.847, p < 0.026). Conclusions: Transarterial radioembolization for patients with IHCC improves life expectancy compared to treatment with comfort measures or systemic therapy.[Table: see text]

Comparing major joint injuries, interventions and late sequelae in elite male handball players with an age-matched control group

2020 ◽  
Author(s):  
Raphael Vogel ◽  
Vilijam Zdravkovic ◽  
Michael Badulescu ◽  
Gábor J. Puskás ◽  
Bernhard Jost
Keyword(s):  
Matched Control ◽  
Knee Injuries ◽  
Control Group ◽  
Recreational Sports ◽  
Late Sequelae ◽  
Surgical Interventions ◽  
Matched Control Group ◽  
The Mean

Abstract Introduction Handball is a contact sport which involves throwing and jumping, exposing players to serious physical stress. There is a high risk of injuries leading to possible long-term sequelae. The aim of this study was to assess the incidence of musculoskeletal injuries in elite male handball players compared with an age-matched control group. Patients and methods Former elite handball players, who had played on the Swiss national team between 1980 and 1985, answered a questionnaire about injuries, surgical interventions and their current health status. A total of 34 athletes were compared with 58 age-matched volunteers, who only engaged in recreational sports or no sports at all. Results The mean age of the athletes was 58.4 years (range 52–68 years) and did not differ significantly from the mean age of the control group of 58.7 years (range 53–69 years). In the control group, 70 % engaged in recreational sports. There was no statistical difference regarding the life-long incidence of shoulder injuries and surgical interventions, sequelae or persistent shoulder pain. Athletes had more interventions after elbow injuries (0.09 vs. 0, p = 0.047), but the difference with respect to chronic pain or late sequelae was not statistically significant. For knee injuries, there were no significant differences regarding the incidence of injuries or interventions, the prevalence of secondary consequences or persistent pain. Concerning the foot and ankle, there was a significantly higher incidence of injuries (0.5 vs. 0.03, p < 0.001) and interventions (0.5 vs. 0.09, p < 0.001) in athletes, but no statistical difference regarding sequelae or persistent pain. Overall quality of life had identical ratings in both groups (athletes mean 85.9 %, controls mean 85.8 %). Discussion Top handball players did not sustain more shoulder or knee injuries than the age-matched control group. The elbow was more at risk in these top athletes, but long-term consequences appeared to be less severe. The most distinctive difference was seen in foot and ankle injuries. Conclusions A career as an elite handball player had no adverse effect on the overall quality of life of elite handball players 25 to 30 years after retiring from professional sports.

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