scholarly journals Age-related slowing down in the motor initiation in elderly adults

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0233942 ◽  
Author(s):  
Nikita S. Frolov ◽  
Elena N. Pitsik ◽  
Vladimir A. Maksimenko ◽  
Vadim V. Grubov ◽  
Anton R. Kiselev ◽  
...  
Author(s):  
Nikita S. Frolov ◽  
Elena N. Pitsik ◽  
Vladimir A. Maksimenko ◽  
Vadim V. Grubov ◽  
Anton R. Kiselev ◽  
...  

AbstractAge-related changes in the human brain functioning crucially affect the motor system, causing increased reaction time, low ability to control and execute movements, difficulties in learning new motor skills. The lifestyle and lowered daily activity of elderly adults, along with the deficit of motor and cognitive brain functions, might lead to the developed ambidexterity, i.e. the loss of dominant limb advances. Despite the broad knowledge about the changes in cortical activity directly related to the motor execution, less is known about age-related differences in the motor initiation phase. We hypothesize that the latter strongly influences the behavioral characteristics, such as reaction time, the accuracy of motor performance, etc. Here, we compare the neuronal processes underlying the motor planning of fine motor tasks between elderly and young subjects. We demonstrate that aging significantly reduces the speed of motor initiation in the dominant hand task due to the different motor planning strategies employed by elderly and young adults. Based on the results of the whole-scalp electroencephalography (EEG) analysis, we suggest that young adults tend to use the efficient and fast mechanism of motor working memory. In contrast, elderly adults involve a more demanding sensorimotor integration process similar to the non-dominant hand task.


Author(s):  
Е.А. Лялюкова ◽  
Е.Н. Логинова

Пациенты пожилого и старческого возраста в силу физиологических причин и коморбидной патологии имеют высокий риск развития запора. Причиной запора чаще всего являются алиментарные факторы и возраст-ассоциированные заболевания и повреждения толстой кишки (дивертикулярная болезнь, ишемия толстой кишки, ректоцеле, геморрой и другие); метаболические, эндокринные расстройства и неврологические заболевания. Возрастные анатомические, структурные и функциональные изменения пищеварительной системы вносят свой вклад в развитие запоров у пожилых. У пациентов «серебряного возраста» отмечено увеличение длины желудочно-кишечного тракта, прогрессирование атрофических, склеротических изменений слизистой и подслизистой оболочки, снижение количества секреторных клеток, замещение мышечных волокон соединительной тканью и др. Все это способствует замедлению транзита по желудочно-кишечному тракту и нарушению акта дефекации. Образ жизни пожилых людей также может способствовать развитию запора. Низкое содержание в рационе клетчатки, употребление преимущественно термически обработанной пищи, нарушение ритма питания (прием пищи 1-2 раза в день) являются одной из причин возникновения запоров у пожилых, чему способствуют трудности при жевании вследствие стоматологических проблем. Колоноскопия показана всем пациентам пожилого и старческого возраста с запором, а выявление «симптомов тревоги» необходимо проводить при каждом визите пациента. Вне зависимости от причины вторичного запора, все пациенты должны осуществлять ряд мер немедикаментозного характера, включающих изменение образа жизни, диету с включением достаточного количества клетчатки и потребление жидкости. Физические методы лечения могут включать лечебную гимнастику, массаж толстой кишки для стимуляции моторной активности кишечника в определенное время. При неэффективности немедикаментозных мероприятий рекомендуется использование осмотических слабительных, а также средств, увеличивающих объем каловых масс. Высокая эффективность и безопасность псиллиума позволяет рекомендовать его в лечении хронического запора у пожилых пациентов. Elderly and senile patients, due to physiological reasons and comorbid pathology, have a high risk of constipation. The causes of constipation are more often nutritional factors and age-associated diseases and damage to the colon (diverticular disease, colon ischemia, rectocele, hemorrhoids, and others); metabolic, endocrine disorders and neurological diseases. Age-related anatomical, structural and functional changes in the digestive system contribute to the development of constipation in the elderly. In patients of «silver age», there was an increase in the length of the gastrointestinal tract, the progression of atrophic, sclerotic changes in the mucous and submucosa, a decrease in the number of secretory cells, replacement of muscle fibers with connective tissue, etc. All this contributes to the slowing down of transit through the gastrointestinal tract and the violation of the act of defecation. Elderly lifestyles can also contribute to constipation. The low fiber content in the diet, the use of mainly thermally processed food, the violation of the rhythm of the diet (eating 1-2 times a day) are one of the causes of constipation in the elderly, which is facilitated by difficulty in chewing due to dental problems. Colonoscopy is ordered for all elderly and senile patients with constipation, and the identification of «anxiety symptoms» should be carried out at each patient visit. Regardless of the cause of secondary constipation, all patients should take a number of non-pharmacological measures, including lifestyle changes, a diet with adequate fiber, and fluid intake. Physical therapies may include medical gymnastics, colon massage to stimulate bowel movement at specific times. If non-drug measures are ineffective, it is recommended to use osmotic laxatives, as well as agents that increase the volume of feces. Psyllium supplementation is recommended for treatment of chronic constipation in elderly patients due to its high efficacy and safety.


2021 ◽  
pp. 1-3
Author(s):  
Ajay Pal Singh ◽  
Kailash Meena ◽  
Surinder Pal Singh ◽  
Avnish Kumar ◽  
Ashish Shukla ◽  
...  

INTRODUCTION: Spirometry is a vital tool for the assessment of pulmonary function status. Spirometry can be used to demonstrate the age-related decline in pulmonary function. The spirometry values can be used as reference values for a particular age group. The aims of our study was to compare spirometry values between the young and elderly groups and evaluate age-related changes in both groups. MATERIAL AND METHODS: A cross-sectional study was conducted on 600 adults, which divided into two healthy groups: one was of young adults (18-35 years), and other was of elderly adults (>60 years) of 300 persons, each taken over a period of one year, in the Department of pulmonary medicine, a tertiary care hospital, Punjab. We conducted spirometry in both age group. Spirometry values were measured FVC, FEV1, FVC/FEV1, PEFR, and FEF25- 75 % of each groups.The subjects were selected based on random sampling RESULT: Spirometry values compared between young and elderly adults. Mean BMI in young and elderly groups was 25.09±2.87 and 25.82±2.45, respectively. Spirometry values in FVC , FEV1, FEV1/FVC , PEFR and FEF25-75% in young was 4.31± 0.18 , 3.84,± 0.88± 0.02, 9.87± 0.38 and 3.75 ±0.26 and elderly age group 3.01±, 2.60 ±0.85± 0.02, 7.70± 0.30 and 2.82 ± 0.26. On statistical analysis, p value <0.001 in all spirometry parameters. CONCLUSION: The study shows that there was a decline in spirometry parameters of healthy adults with the increase in age. This decline was signicant in all spirometric parameters (FVC, FEV1, FEV1/FVC, PEFR, FEF25–75%) measured in the present study


2019 ◽  
Author(s):  
Hwang-Jae Lee ◽  
Su Hyun Lee ◽  
Won Hyuk Chang ◽  
Keehong Seo ◽  
Jusuk Lee ◽  
...  

Abstract Background: Wearable types of gait-assist robots have been developed to provide additional advantages such as being easily transportable, producing a more natural gait pattern, and being simple to control. The purpose of this study was to investigate the effect of intensive gait training with a newly developed wearable hip-assist robot on gait function and cardiopulmonary metabolic energy efficiency in community-dwelling elderly adults. Methods: Total of 27 community-dwelling elderly adults with age-related problems completed in this intervention study (15 experimental group and 12 control group) . The experimental participants received an intensive gait training program with a total of 10 sessions involving five sessions of treadmill and five sessions of over-ground gait training with the wearable hip-assist robot. The control group received gait training without a wearable-hip assist robot. The primary outcomes were gait functions (spatio-temporal parameters and muscle effort). The secondary outcome was cardiopulmonary metabolic energy consumption. Results: Compared to the control group, the experimental group had significantly greater improvements after intervention in spatio-temporal parameters (gait speed, cadence, and stride length) and reduced muscle efforts (trunk and lower extremity) with gait (p < 0.05). In addition, the reduction in oxygen consumption (ml/min/kg) was about 16.31% in the experimental group after intervention. Furthermore, the reduction in the aerobic energy expenditure measurement (Kcal/min) was about 17.36% in the experimental group after intensive gait training with wearable hip-assist robot. All cardiopulmonary metabolic energy consumption parameters in the experimental group were reduced significantly more than in the control group (p < 0.01). Conclusion: The intensive gait training with a wearable hip-assist robot was effective in improving gait function and cardiopulmonary metabolic energy efficiency in community-dwelling elderly adults with age-related problems. Trial registration: NCT02843828, registration date: 07/14/2016 - retrospectively registered


2019 ◽  
Vol 21 (1) ◽  
pp. 125-130 ◽  
Author(s):  
Piotr Paweł Chmielewski

Abstract Over the decades, biogerontology has matured as a scientific discipline. Currently, a number of theoretical frameworks are available to researchers when interpreting empirical data. Despite the great progress that has been made, a comprehensive understanding of biological processes that shape ageing is lacking. Senescence is a dynamic, plastic and highly complex metaphenomenon whose aetiology remains unclear. The paucity of information notwithstanding, some researchers promote ‘anti-ageing’ drugs and formulae every now and again. The rationale behind this concept is that ageing can be reduced to a mixture of biochemical reactions. Furthermore, the distinction between ageing and disease has been questioned on the grounds that ageing is the root of age-related diseases. It has been claimed that disease-oriented approaches can help delay ageing and prevent age-related diseases. Although these methods seem incongruous from an evolutionary standpoint, they become popular amongst the public. Moreover, if ageing is classified as a disease, this situation is likely to be exacerbated. Therefore, it is important to recognise the limitations of these reductionist and disease-oriented approaches. Only holistic and evidence-based strategies might be useful in slowing down ageing and preventing age-related diseases in the future.


1973 ◽  
Vol 32 (1) ◽  
pp. 215-222 ◽  
Author(s):  
Anthony J. Traxler

The role of interference as an age-related variable in RI and PI as a function of anticipation interval and transfer paradigm was studied by employing different transfer paradigms (A-B, A-C; A-B, C-B; A-B, C-D), and by varying the anticipation interval (2 sec. or 4 sec.). 60 young ( M = 27.42 yr.) and 60 elderly adults ( M = 68.73 yr.) learned 2 lists of paired adjectives to an 8/8 criterion and then recalled the lists by means of a written modified method of free recall. Significant age differences in RI and PI were found, with the old Ss showing disproportionately more RI under the 2-sec. A-B, A-C high interference condition. Neither anticipation interval nor transfer paradigm contributed to age differences in PI. Results indicated that adult age differences in RI and PI as measured by the unpaced modified free-recall procedure essentially agree with those in RI and PI studies using relearning and paced recall tests.


2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Shu-Chun Lee ◽  
Li-Chen Wu ◽  
Shang-Lin Chiang ◽  
Liang-Hsuan Lu ◽  
Chao-Ying Chen ◽  
...  

Background. Grip-force performance can be affected by aging, and hand-grip weakness is associated with functional limitations of dasily living. However, using an appropriate digital hand-held dynamometer with continuous hand-grip force data collection shows age-related changes in the quality of hand-grip force control may provide more valuable information for clinical diagnoses rather than merely recording instantaneous maximal hand-grip force in frail elderly adults or people with a disability. Therefore, the purpose of this study was to indicate the construct validity of the digital MicroFET3 dynamometer with Jamar values for maximal grip-force assessments in elderly and young adults and confirmed age-related changes in the maximal and the quality of grip-force performance using the MicroFET3 dynamometer in elderly people. Methods. Sixty-five healthy young (23.3±4.5 years) and 50 elderly (69.5±5.8 years) adults were recruited and asked to perform a validity test of the grip-force maximum voluntary contraction (MVC) using both the dominant and nondominant hands with a Jamar dynamometer and a MicroFET3 dynamometer. Results. A strong correlation of maximal grip-force measurements was found between the MicroFET3 dynamometer and Jamar standard dynamometer for both hands in all participants (p<0.05). Although, the results showed that a lower grip force was measured in both hands by the MicroFET3 dynamometer than with the Jamar dynamometer by 49.9%~57% (p<0.05), but confidently conversion formulae were also developed to convert MicroFET3 dynamometer values to equivalent Jamar values for both hands. Both dynamometers indicated age-related declines in the maximum grip-force performance by 36.7%~44.3% (p<0.05). We also found that the maximal hand-grip force values generated in both hand by the elderly adults were slower and more inconsistent than those of the young adults when using the MicroFET3 dynamometer. Conclusions. This study demonstrated that the digital MicroFET3 dynamometer has good validity when used to measure the maximal grip force of both hands, and conversion formulae were also developed to convert MicroFET3 dynamometer force values to Jamar values in both hands. Comparing with the Jamar dynamometer for measuring grip force, the MicroFET3 dynamometer not only indicated age-related declines in the maximum grip-force performance but also showed slower and more inconsistent maximal hand-grip strength generation by the elderly.


2013 ◽  
Vol 56 (5) ◽  
pp. 1552-1566 ◽  
Author(s):  
Neeraja Sadagopan ◽  
Anne Smith

PurposeThe study was aimed at characterizing age-related changes in speech motor performance on a nonword repetition task as a function of practice and nonword length and complexity.MethodNonword repetition accuracy, lip aperture coordination, and nonword production durations were assessed on 2 consecutive days for 16 young and 16 elderly participants for the production of 6 novel nonwords increasing in length and complexity.ResultsThe effect of age on the ability to accurately and rapidly repeat long, complex nonwords was significant. However, the authors found no differences between the speech motor coordinative patterns of young and elderly adults. Further, the authors demonstrated age- and nonword-specific within- and between-session gains in speech motor performance.ConclusionsThe authors speculate that cognitive, sensory, and motor factors interact in complex ways in elderly individuals to produce individual differences in nonword repetition ability at the levels of both behavioral and speech motor performance.


1989 ◽  
Vol 10 (1) ◽  
pp. 49-66 ◽  
Author(s):  
Susan Kemper ◽  
Donna Kynette ◽  
Shannon Rash ◽  
Kevin O'Brien ◽  
Richard Sprott

ABSTRACTThree different language samples were collected from a group of young adults, 18 to 28 years of age, and a group of elderly adults, 60 to 92 years of age: an oral questionnaire eliciting information about the adults' background, education, and current health and activities; an oral statement describing the person they most admired; and a written statement recounting the most significant event in their lives. In addition, the WAIS vocabulary and digit-span tests were administered to the adults. Age-related changes in the length, clause structure, and fluency of the adults' oral answers and oral and written statements were investigated. There was an overall decrement in the complexity of adults' oral and written statements attributable to an age-related loss of left-branching clauses which occurred in all three language samples. Correlations between the length, clause, and fluency measures from the language samples and the education, health, and WAIS vocabulary and digit-span tests revealed that better-educated adults scored higher on the WAIS vocabulary test, produced longer utterances, and used more right-branching clauses, and that adults with greater memory capacity, as measured by the WAIS Digits Backward test, produced more complex utterances and used more right- and left-branching clauses. Judges found the statements from the elderly adults to be more interesting and clearer than those from the young adults. This finding suggests that there is a trade-off between producing complex syntactic structures and producing clear and interesting prose.


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