scholarly journals Effect of intentional restriction of venous return on tissue oxygenation in a porcine model of acute limb ischemia

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243033
Author(s):  
Wonho Kim ◽  
Donghoon Choi ◽  
Yangsoo Jang ◽  
Chung Mo Nam ◽  
Seung-Ho Hur ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Porcine Model ◽  
Arterial Embolization ◽  
Venous Occlusion ◽  
P Value ◽  
Hindlimb Ischemia ◽  
Venous Oxygen Saturation ◽  
Control Limb ◽  
The Common ◽  
The Right

Introduction A sufficient oxygen supply to ischemic limb tissue is the most important requirement for wound healing and limb salvage. We investigated whether partial venous occlusion in the common iliac vein (CIV) causes a further increase of venous oxygenation in a porcine model of acute hindlimb ischemia. Materials and methods In 7 pigs, the model of acute hindlimb ischemia was created with intra-vascular embolization of the common iliac artery (CIA). The arterial and venous oxygen saturation was evaluated at different moments. Oxygen saturation was evaluated at baseline (T0), just after the arterial embolization (T1), at 10 minutes (T2), at 20 minutes (T3), and at 40 minutes (T4). Next, an intentional partial venous occlusion was achieved by inflating the vascular balloon at the level of the right CIV. Then, blood sampling was repeated at 5 minutes (T5), at 15 minutes (T6), and at 25 minutes (T7). Results The arterial oxygen saturation in the right SFA was similar during all phases. In contrast, after arterial embolization, an immediate reduction of venous oxygen saturation was observed (from 85.57 ± 1.72 at T0 to 71.86 ± 7.58 at T4). After the partial venous occlusion, interestingly, the venous oxygen saturations (T5-T7) were significantly increased, again. The venous oxygen saturations evaluated in the hindlimb ischemia with partial venous occlusion and in the control limb (without partial venous occlusion) were significantly over time. Venous oxygen saturations in the experimental limbs were higher than those in the control limbs (79.28 ± 4.82 vs 59.00 ± 2.82, p-value <0.001, 79.71 ± 4.78 vs 60.00 ± 4.24 at T7, p-value <0.001). Conclusions Partial venous occlusion results in an increase of venous oxygen saturation in the ischemic limb, while significant changes in venous oxygen saturation are not observed in the control limb. An explanation for this may be that the oxygen consumption in the limb tissue is increased because it gets congested with the partial venous occlusion in the right CIV.

scholarly journals COMPARISON OF THE EFFECTIVENESS OF TWO LEVELS OF SUCTION PRESSURE ON OXYGEN SATURATION IN PATIENTS WITH ENDOTRACHEAL TUBE

2017 ◽  
Vol 3 (6) ◽  
pp. 693-696
Author(s):  
Muhaji Muhaji ◽  
Bedjo Santoso ◽  
Putrono Putrono
Keyword(s):  
Oxygen Saturation ◽  
T Test ◽  
Mean Difference ◽  
P Value ◽  
Pressure Group ◽  
Endotracheal Suctioning ◽  
Consecutive Sampling ◽  
The Common ◽  
The Mean ◽  
Paired T Test

Background: Endotracheal suctioning is one of the common supportive measures in intensive care units (ICU), which may be related to complications such as hypoxia. However, a questionable efficacy is still identified to choose suctioning pressure between 130 mmHg and 140 mmHg that is effective for patients with endotracheal tube.Objective: To compare the effectiveness of 130 mmHg and 140 mmHg suctioning pressure on oxygen saturation in patients with endotracheal tube.Methods: This research used a quasy experimental design with pretest and posttest group. The study was conducted from 31 January to 1 March 2017 in the Hospital of Panti Wilasa Citarum and Hospital of Roemani Muhammadiyah Semarang. There were 30 samples recruited using consecutive sampling, with 15 assigned in the 130 mmHg and 140 mmHg suctioning pressure group. Pulse oximetry was used to measure oxygen saturation. Paired t-test and Independent t-test were used for data analysis.Results: Findings showed that there was a statistically significant effect of 130 and 140 mmHg suctioning pressure on oxygen saturation in patients with ETT with p-value <0.05. There was a significant mean difference of oxygen saturation between 130 mmHg and 140 mmHg suctioning pressure group with p-value 0.004 (<0.05). The mean difference of oxygen saturation between both groups was 13.157.Conclusion: The 140 mmHg suctioning pressure is more effective compared with 130 mmHg suctioning pressure in increasing oxygen saturation in patients with ETT.

scholarly journals Collateral development and arteriogenesis in hindlimbs of domestic swine after ligation of arterial inflow

2018 ◽  
Author(s):  
NS Patel ◽  
Y Gao ◽  
S Aravind ◽  
M Fuglestad ◽  
GP Casale ◽  
...  
Keyword(s):  
Iliac Artery ◽  
Internal Iliac Artery ◽  
Hindlimb Ischemia ◽  
Artery Ligation ◽  
Luminal Diameter ◽  
Internal Iliac ◽  
Collateral Pathways ◽  
The Common ◽  
The Right ◽  
Domestic Swine

ABSTRACTIntroductionThe development of collateral vasculature is a key mechanism compensating for arterial occlusions in patients with peripheral artery disease (PAD). We aimed to examine the development of collateral pathways after ligation of native vessels in a porcine model of PAD.MethodsRight hindlimb Ischemia was induced in domestic swine (N=11, male, kg) using two different versions of arterial ligation. Version 1 (N=6) consisted of ligation/division of the right external iliac, profunda femoral (RPFA) and superficial femoral arteries (RSFA). Version 2 (N=5) consisted of the ligation of Version 1 with additional ligation/division of the right internal iliac artery (RIIA). Development of collateral pathways was evaluated with standard angiography at baseline (prior to arterial ligation) and at termination (4-8 weeks later). Relative luminal diameter of the arteries supplying the ischemic right hindlimb were determined by 2D angiography, as percent of the size of the distal aortic diameter.ResultsThe dominant collateral pathway that developed after version 1 ligation connected the RIIA to the RPFA and RSFA/popliteal artery. Mean luminal diameter (± standard error) of the RIIA at termination increased by 38% (P<0.05) compared to baseline. Two co-dominant collateral pathways developed in version: (i) from the common internal iliac trunk and left internal iliac artery to the reconstituted RIIA, which then supplied the RPFA and RSFA/popliteal arteries; and (ii) from left profunda artery to the reconstituted RPFA. Mean diameter of the common internal iliac trunk and left profunda artery both increased at termination in the range of 20% (p < 0.05).ConclusionTwo versions of hindlimb ischemia induction (right ilio-femoral artery ligation with and without right internal iliac artery ligation in swine produced differing collateral pathways, along with changes to the diameter of the inflow vessels (i.e., arteriogenesis). Radiographic and anatomical data of the collateral formation in this porcine model should have value in investigation of the pathophysiology of hindlimb ischemia, and assessment of angiogenic therapies as potential treatments for PAD.

scholarly journals Intrabiliary Migrated Clips and Coils as a Nidus for Biliary Stone Formation: A Rare Complication following Laparoscopic Cholecystectomy

2018 ◽  
Vol 12 (3) ◽  
pp. 686-691 ◽  
Author(s):  
Anne M. Schreuder ◽  
Thomas M. van Gulik ◽  
Erik A.J. Rauws
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Bile Duct ◽  
Stone Formation ◽  
Rare Complication ◽  
Arterial Embolization ◽  
Stone Extraction ◽  
Pseudo Aneurysm ◽  
The Common ◽  
The Right ◽  
And Function

Clips inserted during laparoscopic cholecystectomy (LC) may migrate into the biliary system and function as a nidus for the formation of gallstones. Here, we present a series of 4 patients who presented with this rare complication 5–17 years after LC. All 4 patients presented with symptomatic choledocholithiasis with biochemical and radiological signs of biliary obstruction. Three patients also had fever and infectious parameters, compatible with concurrent cholangitis. All patients successfully underwent endoscopic retrograde cholangiopancreatography (ERCP) with papillotomy and stone extraction. Patients with cholangitis also had antibiotic treatment. In 3 patients, obstruction of the common bile duct was caused by a single, relatively large stone that had formed around a clip (supposedly the cystic duct clip). In 1 patient, multiple stones had formed around an intrabiliary migrated cluster of coils that had been used for arterial embolization of a pseudo-aneurysm of the right hepatic artery. In conclusion, surgical clips and coils can migrate into the biliary tract and serve as a nidus for the formation of bile duct stones. Although rare, this complication should caution surgeons not to place clips “at random” during cholecystectomy. Patients with this rare complication are best managed by ERCP in combination with sphincterotomy and stone extraction.

scholarly journals TO STUDY THE IMPACT OF OXYGEN SATURATION OF NEONATES ON THEIR IMMEDIATE OUTCOME BY USING TOPS SCORE

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Priyanka Jain ◽  
Rakesh Jain
Keyword(s):  
Oxygen Saturation ◽  
Pulse Oximeter ◽  
Research Centre ◽  
P Value ◽  
Chi Square ◽  
College Hospital ◽  
Chi Square Test ◽  
Pre Treatment ◽  
The Right ◽  
The Impact

Background & Method: This study was carried out at Index Medical College Hospital & Research Centre, Indore, when baby come to scnu, SPO2 is measured by pulse oximeter (ChoiceMMed MD300C2.). Fit the pulse oximeter on the foot, the light part of the sensor should be placed over soft tissue supported by a bony area. If the foot is cold or blue the pulse oximeter can be attached at the wrist. If the signal is poor re-position the probe. In a resuscitation situation the pulse oximeter should be attached to the right arm to read pre-ductal saturations. Result: In this study, 28.46% newborns oxygen saturation was less than 85% and 71.53% newborns oxygen saturation was more than 85%. In this study, 67.81% newborns having oxygen saturation less than 85% and 1.9% newborns having oxygen saturation more than 85% died during first 48 hrs of admission. Chi square test was applied and p value was <0.05 and was significant. Conclusion: Most of neonatal transports are self transport without any pre-treatment stabilization or care during transport These new born thus transported can become cold, blue and hypoglycaemic. This can have serious clinical implications. As it is seen in this study that all those babies who were given proper care during transportation were less affected & more over survival was also better among these babies. Keywords: Oxygen Saturation, Neonates & TOPS score.

scholarly journals Neovascularization after ischemic injury: evaluation with 99mTc-HYNIC-RGD

2011 ◽  
Vol 26 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Bluma Linkowski Faintuch ◽  
Rodrigo Teodoro ◽  
Erica Aparecida de Oliveira ◽  
Eutimio Gustavo Fernández Nuñez ◽  
Joel Faintuch
Keyword(s):  
Common Femoral Artery ◽  
Hindlimb Ischemia ◽  
Planar Imaging ◽  
Recognition Sequence ◽  
Biodistribution Studies ◽  
Ischemic Tissue ◽  
Control Limb ◽  
Target Amino Acid ◽  
The Common ◽  
And Control

Purpose: Angiogenesis involves many mediators including integrins, and the tripeptide RGD is a target amino acid recognition sequence for many of them. Hindlimb ischemia is a simple and convenient animal model however standardization of the injection procedures in the devascularized and control limb is lacking, thus rendering difficult the interpretation of results. The aim of this investigations was to evaluate neovascularization in a hindlimb murine model by means of 99mTc-HYNIC-ß-Ala-RGD. Methods: 99mTc-HYNIC-RGD analog was prepared using coligands. Ischemia was induced in Wistar rats by double- ligation of the common femoral artery. Radiolabeled RGD was injected after 2h, as well as 1, 3, 5, 7, 10 and 14 days. Uptake was evaluated by planar imaging and biodistribution studies. Results: The highest ratio between ischemia and control was achieved at the 7th day (2.62 ± 0.95), with substantial decrease by the 14th day. For pertechnetate the 7th day ratio was 0.87 ± 0.23. Scintigraphic image confirmed different uptakes. Conclusion: 99mTc-HYNIC-RGD analog concentrated in ischemic tissue by the time of widespread angiogenesis and pertechnetate confirmed reduction in blood flow. In this sense, the protocol can be recommended for ischemic models.

scholarly journals Evaluation of the right atrial venous oxygen saturation as a physiologic monitor in a neonatal model

1993 ◽  
Vol 28 (7) ◽  
pp. 901-905 ◽  
Author(s):  
Ronald B. Hirschl ◽  
Palle Palmer ◽  
Kurt F. Heiss ◽  
Karl Hultquist ◽  
Franco Fazzalari ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Right Atrial ◽  
Venous Oxygen Saturation ◽  
The Right

scholarly journals CARCINOMA OF CAECUM;

2017 ◽  
Vol 24 (01) ◽  
pp. 51-56
Author(s):  
Jabeen Atta ◽  
Abdul Ghafoor Dalwani ◽  
Zubair Ahmed Yousfani ◽  
M. Siddique Khurram ◽  
Roohi Bano ◽  
...  
Keyword(s):  
Iliac Fossa ◽  
Management Strategies ◽  
Female Gender ◽  
Right Hemicolectomy ◽  
University Hospital ◽  
P Value ◽  
The Common ◽  
The Mean ◽  
Level Of Significance ◽  
The Right

Objectives: To determine the frequency, clinical presentation and managementstrategies for carcinoma of caecum among pathologies in right iliac fossa excludinggynaecological disorders at Liaquat university hospital Hyderabad / Jamshoro. Study Design:Cross sectional multi-disciplinary study. Period: Thirty months. Setting: Liaquat UniversityHospital Hyderabad / Jamshoro. Patients and Methods: All the patients presented with GIsymptoms, intestinal obstruction, and appendicitis or had mass in the right iliac fossa wereselected and recruited and further evaluated for existence of carcinoma of caecum andpreceded for management strategies. The data was analyzed in SPSS 16 and the frequencyand percentage was calculated and the level of significance was p-value ≤0.05. Results: Total50 patients were diagnosed as caecum cancer during thirty months study period. The cancerof caecum was common in older age group. The mean age ± SD for whole population andmale as well as female gender was 67.53±6.98, 66.32±8.75 and 65.34±5.96 and of fifty cases,thirty two (64%) were males and eighteen (36%) were females respectively. The commonpresentation identified was mass in right iliac fossa in 28 patients (p=0.03) while the commonoperative procedure performed was ileotransverse anastomosis with right hemicolectomy in 34patients which is non-significant in relation to age (p=0.7) whereas it was significant in contextto gender (p=0.04) respectively. Conclusion: The common presentations for carcinoma ofcaecum detected was right iliac fossa mass while the predominant age, gender and operativeprocedure performed were seventy plus years, male gender population and Ileotransverseanastamosis with right hemicolectomy.

scholarly journals Right lateral position can improving oxygen saturation and respiratory rate on under-five children with pneumonia

2021 ◽  
Vol 43 (s1) ◽  
Author(s):  
Novita Agustina ◽  
Nani Nurhaeni ◽  
Happy Hayati
Keyword(s):  
Oxygen Saturation ◽  
Respiratory Rate ◽  
Lateral Position ◽  
Control Group ◽  
P Value ◽  
Under Five ◽  
Under Five Children ◽  
Significant Difference ◽  
Before And After ◽  
The Right

Pediatric patients with pneumonia experience respiratory distress in the form of shortness of breath and rapid breathing, which affects oxygen saturation. Oxygen saturation and respiratory rate can be increased by providing the right lateral position. Fulfillment of oxygen will affect the healing of children and can reduce the length of stay in hospital. The purpose of this study was to identify the effect of right lateral positioning on oxygen saturation and respiratory rate in under-five children with pneumonia. The study design was a quasi-experimental pre-posttest with control group design. Respondents were 32 infants with pneumonia, (right lateral=16 and control group=16), selected by consecutive sampling. Univariate and bivariate analyzes were performed. There was a significant difference in oxygen saturation before and after right lateral position (p-value=0.000) and there was a significant difference in the respiratory rate before and after right lateral position (p-value=0.000). The results can be used to improve health services by promoting the right lateral position as a selftreatment intervention for increasing oxygen saturation and stabilizing respiratory rate in infants with pneumonia.

Our Bodies, Whose Property?

2013 ◽  
Author(s):  
Anne Phillips
Keyword(s):  
Labor Markets ◽  
Personal Autonomy ◽  
The Body ◽  
Body Parts ◽  
Complex Issue ◽  
Human Organs ◽  
Property Owners ◽  
The Common ◽  
The Difference ◽  
The Right

No one wants to be treated like an object, regarded as an item of property, or put up for sale. Yet many people frame personal autonomy in terms of self-ownership, representing themselves as property owners with the right to do as they wish with their bodies. Others do not use the language of property, but are similarly insistent on the rights of free individuals to decide for themselves whether to engage in commercial transactions for sex, reproduction, or organ sales. Drawing on analyses of rape, surrogacy, and markets in human organs, this book challenges notions of freedom based on ownership of our bodies and argues against the normalization of markets in bodily services and parts. The book explores the risks associated with metaphors of property and the reasons why the commodification of the body remains problematic. The book asks what is wrong with thinking of oneself as the owner of one's body? What is wrong with making our bodies available for rent or sale? What, if anything, is the difference between markets in sex, reproduction, or human body parts, and the other markets we commonly applaud? The book contends that body markets occupy the outer edges of a continuum that is, in some way, a feature of all labor markets. But it also emphasizes that we all have bodies, and considers the implications of this otherwise banal fact for equality. Bodies remind us of shared vulnerability, alerting us to the common experience of living as embodied beings in the same world. Examining the complex issue of body exceptionalism, the book demonstrates that treating the body as property makes human equality harder to comprehend.

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