scholarly journals Prevalence and seroprevalence of Plasmodium infection in Myanmar reveals highly heterogeneous transmission and a large hidden reservoir of infection

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252957
Author(s):  
Hannah M. Edwards ◽  
Ruth Dixon ◽  
Celine Zegers de Beyl ◽  
Olivier Celhay ◽  
Mousumi Rahman ◽  
...  

Malaria incidence in Myanmar has significantly reduced over recent years, however, completeness and timeliness of incidence data remain a challenge. The first ever nationwide malaria infection and seroprevalence survey was conducted in Myanmar in 2015 to better understand malaria epidemiology and highlight gaps in Annual Parasite Index (API) data. The survey was a cross-sectional two-stage stratified cluster-randomised household survey conducted from July-October 2015. Blood samples were collected from household members for ultra-sensitive PCR and serology testing for P. falciparum and P. vivax. Data was gathered on demography and a priori risk factors of participants. Data was analysed nationally and within each of four domains defined by API data. Prevalence and seroprevalence of malaria were 0.74% and 16.01% nationwide, respectively. Prevalent infection was primarily asymptomatic P. vivax, while P. falciparum was predominant in serology. There was large heterogeneity between villages and by domain. At the township level, API showed moderate correlation with P. falciparum seroprevalence. Risk factors for infection included socioeconomic status, domain, and household ownership of nets. Three K13 P. falciparum mutants were found in highly prevalent villages. There results highlight high heterogeneity of both P. falciparum and P. vivax transmission between villages, accentuated by a large hidden reservoir of asymptomatic P. vivax infection not captured by incidence data, and representing challenges for malaria elimination. Village-level surveillance and stratification to guide interventions to suit local context and targeting of transmission foci with evidence of drug resistance would aid elimination efforts.

2021 ◽  
Vol 9 (E) ◽  
pp. 1147-1154
Author(s):  
Istiana Istiana ◽  
Usman Hadi ◽  
Yoes Prijatna Dachlan ◽  
Heny Arwati

BACKGROUND: South Kalimantan is one of province in Indonesia which has endemic area, mainly in the villages at forest area. Understanding the risk factors which can increase the risk of malaria in individuals at forest area will enable more effective use for controlling the disease. The identification of risk factors will provide information about local malaria epidemiology and usefull for making appropriate and effective malaria eradication program policies in this area. AIM: To know the risk factors of malaria prevalence in endemic forest areas in South Kalimantan, Indonesia. METHODS: This cross-sectional study was conducted on 107 adult people who lived in Batu Bulan Village and Batu Paha Village, South Kalimantan. Blood samples for malaria microscopy and rapid diagnostic test is taken from cubital vein. Household factors and demographic data were obtained. Chi-square and logistic regression were performed to analyze the factors associated with malaria prevalence in South Kalimantan. This research didn’t do vector survey, only on the prevalence of malaria and risk factor in human and environment. RESULTS: The prevalence of malaria based RDT examination was 35.5% with 23.68% Plasmodium falciparum, 21.05% Plasmodium vivax, and 55.27% mixed infection. The prevalence malaria based on microscopic examination was 17.75% with 47.36% P. falciparum, 26.32% P. vivax, and 26.32% mix infection. Demographic factors influencing the prevalence of malaria were aged below 25-years-old (p = 0.01, 95% CI, OR = 2.289), villages in Batu Paha (p = 0.048, 95% CI, OR = 3.55), and occupation as a forest worker (p = 0.022, 95% CI, OR = 6.38). House factors that influence the prevalence of malaria were the condition of the walls that are open or not tight (p = 0.048 95% CI, OR = 5.205), the roof is made of plastic (p = 0.015 95% CI, OR = 2.831), and the presence of animal cage around the house (p = 0.015 95% CI, OR = 6.292). CONCLUSIONS: Malaria incidence remains occurs with high prevalence in the pupolation in remote forest areas.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Rila Ratovoson ◽  
Amber Kunkel ◽  
Jean Pierre Rakotovao ◽  
Dolores Pourette ◽  
Chiarella Mattern ◽  
...  

2017 ◽  
Vol 63 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Camila Iasmim de Andrade Souza ◽  
◽  
Daniela Souza Araújo ◽  
Daniele Aparecida de Freitas Teles ◽  
Stéphanie Gomes Lins de Carvalho ◽  
...  

Summary Objective: To assess the prevalence of mammography use and factors related to non-adherence in Boa Vista, capital of Roraima, Brazil. Method: A cross sectional study, quantitative analysis, based on household survey was performed between June and August 2013, using a face-to-face interview with a pre-tested form. Target population was women between 40 and 69 years. The sample size target was 240 participants, and the sampling method was random cluster sampling. The study was approved by the Institutional Review Board of Federal University of Roraima. Results: 241 women were included without refusals. The prevalence of non-use of mammography in the past two years was 55.6% (95CI 49.1-61.9). In univariate analysis, the risk factors for non-adherence to mammography were having low educational level, family income below three minimum wages, receiving government assistance, not having consulted with a doctor and no health insurance. In multivariate analysis, only low educational level and receiving government assistance remained as risk factors. Medical consultation or health worker visiting were protective factors. Conclusion: Adherence to mammography is unsatisfactory in Boa Vista, Roraima, and has a predominantly opportunistic character. Low educational level is confirmed as an independent risk factor, but belonging to a family that receives government assistance can be interpreted as a social marker of families and/or areas lacking of government intervention to increase access to breast cancer control programs.


Author(s):  
M.Hussein Ahmed ◽  
Dawria Adam ◽  
Abdelbasit. M. Burma Salim ◽  
Belal Abdallah

We  conduct  this  study  to  study risk factors of   protein energy malnutrition  Among Children Under Five years .This  study was conducted in Nyala  Locality in south  Darfur  State in  Sudan. Cross-sectional descriptive study to measure the Prevalence of protein energy malnutrition. This study designed to cover (n=402 child).


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hamid Reza Marateb ◽  
Zahra Tasdighi ◽  
Mohammad Reza Mohebian ◽  
Azam Naghavi ◽  
Moritz Hess ◽  
...  

AbstractIdentifying the possible factors of psychiatric symptoms among children can reduce the risk of adverse psychosocial outcomes in adulthood. We designed a classification tool to examine the association between modifiable risk factors and psychiatric symptoms, defined based on the Persian version of the WHO-GSHS questionnaire in a developing country. Ten thousand three hundred fifty students, aged 6–18 years from all Iran provinces, participated in this study. We used feature discretization and encoding, stability selection, and regularized group method of data handling (GMDH) to classify the a priori specific factors (e.g., demographic, sleeping-time, life satisfaction, and birth-weight) to psychiatric symptoms. Self-rated health was the most critical feature. The selected modifiable factors were eating breakfast, screentime, salty snack for depression symptom, physical activity, salty snack for worriedness symptom, (abdominal) obesity, sweetened beverage, and sleep-hour for mild-to-moderate emotional symptoms. The area under the ROC curve of the GMDH was 0.75 (CI 95% 0.73–0.76) for the analyzed psychiatric symptoms using threefold cross-validation. It significantly outperformed the state-of-the-art (adjusted p < 0.05; McNemar's test). In this study, the association of psychiatric risk factors and the importance of modifiable nutrition and lifestyle factors were emphasized. However, as a cross-sectional study, no causality can be inferred.


2003 ◽  
Vol 131 (3) ◽  
pp. 1091-1096 ◽  
Author(s):  
C. R. MacINTYRE ◽  
P. B. McINTYRE ◽  
M. CAGNEY

The aim was to estimate the community incidence and risk factors for all-cause pneumonia in children in Western Sydney, Australia. A cross-sectional randomized computer-assisted telephone interview was conducted in July 2000, in Western Sydney. Parents of 2020 children aged between 5 and 14 years were interviewed about their child's respiratory health since birth. No verification of reported diagnosis was available. Logistic regression analysis was used to determine risk factors for pneumonia. A lifetime diagnosis of pneumonia was reported in 137/2020 (6·8%) children, giving an estimated incidence in the study sample of 7·6/1000 person-years. Radiological confirmation was reported in 85% (117/137). Hospitalization was reported in 41% (56/137) and antibiotic therapy in 93% (127/137) of cases. Using logistic regression modelling, statistically significant associations with pneumonia were a reported history of either asthma, bronchitis or other lung problems and health problems affecting other systems. In most cases, the diagnosis of asthma preceded the diagnosis of pneumonia. The community incidence of all causes of pneumonia is not well enumerated, either in adults or in children. This study provides community-based incidence data. The incidence of hospitalization for pneumonia in this study is comparable to estimates from studies in comparable populations, suggesting that retrospective parental report for memorable events is likely to be valid. We found a relationship between pneumonia and childhood respiratory diseases such as asthma, which has implications for targeted vaccination strategies.


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Benjamin F. R. Dickson ◽  
Patricia M. Graves ◽  
Ni Ni Aye ◽  
Thet Wai Nwe ◽  
Tint Wai ◽  
...  

Abstract Background Myanmar commenced a lymphatic filariasis (LF) elimination programme in 2000. Whilst the country has made considerable progress since then, a number of districts have demonstrated persistent transmission after many rounds of mass drug administration (MDA). The causes of unsuccessful MDA have been examined elsewhere; however, there remains little information on the factors that contribute in Myanmar. Methods We conducted an analysis of factors associated with persistent infection, LF-related hydrocoele and MDA participation in an area with ongoing transmission in 2015. A cross-sectional household survey was undertaken in 24 villages across four townships of Mandalay Region. Participants were screened for circulating filarial antigen (CFA) using immunochromatographic tests and, if positive, for microfilaria by night-time thick blood slide. Individuals 15 year and older were assessed for filariasis morbidity (lymphoedema and, if male, hydrocoele) by ultrasound-assisted clinical examination. A pre-coded questionnaire was used to assess risk factors for LF and for non-participation (never taking MDA). Significant variables identified in univariate analyses were included in separate step-wise multivariate logistic regressions for each outcome. Results After adjustment for covariates and survey design, being CFA positive was significantly associated with age [odds ratio (OR) 1.03, 95% CI 1.01–1.06), per year], male gender (OR 3.14, 1.27–7.76), elevation (OR 0.96, 0.94–0.99, per metre) and the density of people per household room (OR 1.59, 1.31–1.92). LF-related hydrocoele was associated with age (OR 1.06, 1.03–1.09, per year) and residing in Amarapura Township (OR 8.93, 1.37–58.32). Never taking MDA was associated with male gender [OR 6.89 (2.13–22.28)] and age, particularly in females, with a significant interaction term. Overall, compared to those aged 30–44 years, the proportion never taking MDA was higher in all age groups (OR highest in those < 5 years and > 60 years, ranging from 3.37 to 12.82). Never taking MDA was also associated with residing in Amarapura township (OR 2.48, 1.15–5.31), moving to one’s current village from another (OR 2.62, 1.12–6.11) and ever having declined medication (OR 11.82, 4.25–32.91). Decreased likelihood of never taking MDA was associated with a higher proportion of household members being present during the last MDA round (OR 0.16, 0.03–0.74) and the number visits by the MDA programme (OR 0.69, 0.48–1.00). Conclusions These results contribute to the understanding of LF and MDA participation-related risk factors and will assist Myanmar to improve its elimination and morbidity management programmes.


2021 ◽  
Vol 19 (S1) ◽  
Author(s):  
Sanne M. Thysen ◽  
◽  
Charlotte Tawiah ◽  
Hannah Blencowe ◽  
Grace Manu ◽  
...  

Abstract Background Electronic data collection is increasingly used for household surveys, but factors influencing design and implementation have not been widely studied. The Every Newborn-INDEPTH (EN-INDEPTH) study was a multi-site survey using electronic data collection in five INDEPTH health and demographic surveillance system sites. Methods We described experiences and learning involved in the design and implementation of the EN-INDEPTH survey, and undertook six focus group discussions with field and research team to explore their experiences. Thematic analyses were conducted in NVivo12 using an iterative process guided by a priori themes. Results Five steps of the process of selecting, adapting and implementing electronic data collection in the EN-INDEPTH study are described. Firstly, we reviewed possible electronic data collection platforms, and selected the World Bank’s Survey Solutions® as the most suited for the EN-INDEPTH study. Secondly, the survey questionnaire was coded and translated into local languages, and further context-specific adaptations were made. Thirdly, data collectors were selected and trained using standardised manual. Training varied between 4.5 and 10 days. Fourthly, instruments were piloted in the field and the questionnaires finalised. During data collection, data collectors appreciated the built-in skip patterns and error messages. Internet connection unreliability was a challenge, especially for data synchronisation. For the fifth and final step, data management and analyses, it was considered that data quality was higher and less time was spent on data cleaning. The possibility to use paradata to analyse survey timing and corrections was valued. Synchronisation and data transfer should be given special consideration. Conclusion We synthesised experiences using electronic data collection in a multi-site household survey, including perceived advantages and challenges. Our recommendations for others considering electronic data collection include ensuring adaptations of tools to local context, piloting/refining the questionnaire in one site first, buying power banks to mitigate against power interruption and paying attention to issues such as GPS tracking and synchronisation, particularly in settings with poor internet connectivity.


2021 ◽  
Vol 3 (3) ◽  
pp. 77-81
Author(s):  
Shuaibu A. Hudu ◽  
Nabil S. Hamal

Background: Viral hepatitis is a deadly disease which can manifest as acute, chronic, hepatocellular carcinoma, and liver failure and responsible for 1.34 million deaths globally, a number comparable to deaths caused by tuberculosis and higher than those caused by HIV. Objectives: The goal of this survey was to find the vastness of different risk factors associated with Viral Hepatitis and to describe the connection between these risk and sociodemographic factors among adults in Sokoto-Nigeria. Methods: This cross-sectional survey was carried in nine local government areas in the state. A two-stage cluster sampling was utilized and adults who were living in the selected household were interviewed. A multivariate linear regression model was used to evaluate the relationship between sociodemographic indicators and different viral hepatitis risk factors. Results: Seven hundred and twenty eight respondents were recruited for this survey. Sharing nail cutters, body piercing, and razor blade use were the most pervasive risk factors among respondents. Males, married couples, respondents somewhere in the range of 27 and 40 years of age, and people with low educational achievement were more likely to be exposed to risk factors associated with Viral Hepatitis. Conclusion: The risk of viral hepatitis was moderately high among the survey subject. Consequently, explicit projects like forum, classes and persistent instruction on preventive measures for viral hepatitis ought to be custom fitted to these forums. These projects could be directed by government specialists like the Ministry of Health Sokoto and other support agencies and non-governmental organizations. 


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