scholarly journals Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260001
Author(s):  
Xiaoyang Li ◽  
Qiushi Yang ◽  
Hang Ye ◽  
Shuo Li ◽  
Yuzhu Wang ◽  
...  
Keyword(s):  
Pancreatic Head ◽  
Fat Content ◽  
Diabetic Patients ◽  
Normal Person ◽  
Fat Percentage ◽  
Average Value ◽  
Pancreatic Fat ◽  
Significant Difference ◽  
Fat Fraction ◽  
Pancreatic Fat Content

Objective To compare the reliability of different methods for measuring fat content of pancreas by MR modified Dixon(mDixon) Sequence and accurately evaluate pancreatic fat in as simple a way as possible. Methods This is a retrospective study, 64 patients were included in this study who underwent abdominal MR scan that contained the mDixon sequence from June 2019 to May 2020(Included 7 patients with type 2 diabetes and 4 patients with impaired glucose tolerance (IGT), they were admitted to hospital through the obesity clinic set up by endocrine department, all of them were initially diagnosed and untreated). All of the 64 patients were scanned in 3.0T MR (Philips Ingenia II) due to their condition, 10–34 slice pancreas images were obtained, which were different from each other. Three different methods of measurement were employed by two observers using Philips Intellispace Portal software: (1) All images (whole-pancreas) measurement, the whole-pancreatic fat fraction (wPFF) was calculated by software. (2) Interval slices measurement, that is half-pancreatic slices fat fraction (hPFF) measured in the same way, fat fraction obtained by the interlayer assay was calculated. (3) As usual, the fat content of pancreatic head, body and tail fat was measured respectively, and in order to improve credibility, we also measured head、 body and tail in every layer, and its average value was taken. The elapsed time of the above different measurement methods was recorded. Intra-group correlation coefficient (ICC) was used to analyze the consistency of the measured data within and between observers. T-tests and Friedman tests were applied to compare the difference of measured values among groups. Results No matter in normal person or diabetic or IGT, hPFF has shown good stability (ICChPFF = 0.988), and there was no significant difference compared with wPFF. But the average fat percentage composition of head, body and tail were significantly different from wPFF and hPFF (P < 0.01). At the same time, compared with normal person, pancreatic fat content in IGT and diabetic patients showed progressive significance(P<0.05). Conclusion The distribution of pancreatic fat is not uniform, the method of measuring half pancreas by interlayer data collection can reflect the fat content of the entire pancreas, this suggests that measuring 50% of the pancreas is sufficient, this method effectively saves time and effort without affecting the results, which may have a better clinical application prospect.

No Correlation of Pancreatic Fat and β-Cell Function in Young Women With and Without a History of Gestational Diabetes

2018 ◽  
Vol 103 (9) ◽  
pp. 3260-3266 ◽  
Author(s):  
Daniel Popp ◽  
Stephanie Aertsen ◽  
Charlotte Luetke-Daldrup ◽  
Eva Coppenrath ◽  
Holger Hetterich ◽  
...  
Keyword(s):  
Young Women ◽  
Glucose Tolerance Test ◽  
Cell Function ◽  
Tolerance Test ◽  
Fat Content ◽  
Β Cell ◽  
Pancreatic Fat ◽  
Β Cell Function ◽  
Pancreatic Fat Content

Abstract Context Pancreatic steatosis may contribute to β-cell dysfunction in type 2 diabetes (T2D), but data are controversial. Women who had gestational diabetes mellitus (GDM) are at high risk for developing T2D. Objective To examine the association of pancreatic fat content with early/first-phase insulin secretion (as markers of β-cell function). Design Cross-sectional analysis of a subcohort of the monocentric, prospective cohort study titled Prediction, Prevention, and Subclassification of Type 2 Diabetes. Setting Ludwig Maximilians University Hospital, Munich, Germany. Participants Ninety-seven women, 3 to 16 months after pregnancy [41 normoglycemic women post-GDM, 19 women post-GDM with pathological glucose metabolism, and 37 normoglycemic women after a normoglycemic pregnancy (controls)]. Main Outcome Measures Correlation of MRI-measured pancreatic fat content with early insulin release in an oral glucose tolerance test (OGGT) [insulin increment within the first 30 minutes of the OGTT (IR30)] and first-phase insulin response (FPIR) in an intravenous glucose tolerance test (n = 65), both adjusted for insulin sensitivity index (ISI). Results Pancreatic fat content did not correlate with IR30 and FPIR adjusted for ISI. It correlated positively with body mass index, waist circumference, liver fat, and intraabdominal fat volume. Conclusion Pancreatic fat content does not correlate with β-cell function in a cohort of young women with different degrees of T2D risk.

Metabolomic Characteristics of Fatty Pancreas

2019 ◽  
Vol 128 (12) ◽  
pp. 804-810 ◽  
Author(s):  
Benjamin Assad Jaghutriz ◽  
Róbert Wagner ◽  
Martin Heni ◽  
Rainer Lehmann ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Beta Cell ◽  
Visceral Fat ◽  
Beta Cell Function ◽  
Cell Function ◽  
Fat Content ◽  
Pancreatic Fat ◽  
Total Body ◽  
Pancreatic Steatosis ◽  
Pancreatic Fat Content

Abstract Objective Pancreatic steatosis is associated with impaired beta cell function in patients with prediabetes. The pathomechanisms underlying this association still remain to be elucidated. Recent data show that adipocytes are situated within the pancreatic parenchyma and therefore give raise to hypothesize that pancreatic fat together with known and unknown metabolites such as hepatokines affect insulin secretion. Applying a targeted metabolomic approach we investigated possible circulating markers of pancreatic fat in order to better understand its role in the pathophysiology of impaired beta cell function. Methods We included 361 Caucasians, at increased risk of type 2 diabetes, from the Tübingen Family Study. All participants underwent a frequently sampled oral glucose tolerance test to assess insulin secretion and a magnetic resonance imaging to quantify pancreatic fat content, total body fat and visceral fat. Among the 152 subjects with prediabetes (IFG and/or IGT), two groups each with 20 individuals, having the lowest and highest pancreatic fat content were selected. The groups were matched for sex, age, BMI, total fat content, visceral fat content, liver fat content and insulin sensitivity. Metabolites were analyzed using the AbsoluteIDQ® p400 HR Kit by Biocrates. Results Pancreatic fat content of all 152 subjects with prediabetes was negatively associated with insulin secretion represented by AUCC-peptide 0–120/AUCGlucose 0–120 (p=0.04; β=− 3.24). Furthermore, pancreatic fat content was positively associated with BMI, total body and visceral fat (all p<0.005). Levels of aminoacids, biogenic amines and monosaccharides were similar between the groups with high/low pancreatic fat content (p>0.90). Also, levels of polar lipids such as lysophosphatidylcholines, phosphatidylcholines, sphingomyelins and ceramides did not differ significantly between the groups (p>0.90). Investigating the levels of neutral lipids such as aclycarnitines, diglycerides, triglycerides and cholesteryl esters also revealed no differences between the groups (p>0.90). Conclusion The amount of pancreatic fat is not associated with the metabolomic pattern in individuals with prediabetes. This might be due to the relatively low pancreatic fat content compared to the total amount of fat stored in other depots. The impact of pancreatic steatosis on insulin secretion might be mediated by paracrine effects which cannot be detected in the circulation.

Pancreatic Fat Content Detected by Computed Tomography and Its Significant Relationship With Intraductal Papillary Mucinous Neoplasm

Pancreas ◽  
2018 ◽  
Vol 47 (9) ◽  
pp. 1087-1092 ◽  
Author(s):  
Kazuhiro Kashiwagi ◽  
Takashi Seino ◽  
Seiichirou Fukuhara ◽  
Kazuhiro Minami ◽  
Masayasu Horibe ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Significant Relationship ◽  
Fat Content ◽  
Mucinous Neoplasm ◽  
Pancreatic Fat ◽  
Pancreatic Fat Content

Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity

2011 ◽  
Vol 54 (3) ◽  
pp. 545-552 ◽  
Author(s):  
Jarna C Hannukainen ◽  
Ronald Borra ◽  
Kaisa Linderborg ◽  
Heikki Kallio ◽  
Jan Kiss ◽  
...  
Keyword(s):  
Physical Activity ◽  
Monozygotic Twins ◽  
Fat Content ◽  
Pancreatic Fat ◽  
Pancreatic Fat Content

scholarly journals Computed Tomography-Estimated Pancreatic Steatosis is a Risk Factor for Carotid Plaque in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study

2020 ◽  
Author(s):  
Pengtao Sun ◽  
Chunzhi Fan ◽  
Rengui Wang ◽  
Tongwei Chu ◽  
Xiaoli Sun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carotid Plaque ◽  
Fat Content ◽  
Cross Sectional ◽  
Pancreatic Fat ◽  
Pancreatic Steatosis ◽  
Pancreatic Fat Content

Abstract Background Pancreatic steatosis correlates with the thickness of arterial intima. However, the correlation between pancreatic steatosis and carotid atherosclerosis plaque, which better predict the prognosis of cardiovascular disease, is unclear. We aimed to explore potential effects of pancreatic fat content measured by computer tomography (CT) on carotid plaque in patients with type 2 diabetes mellitus (T2DM).Methods Patients with T2DM who underwent CT scan of the upper abdomen and ultrasound of the carotid artery were consecutively enrolled. Based on ultrasound results, the patients were divided into non-plaque group and plaque group, and the latter was categorized into hypoechoic plaque subgroup and non-hypoechoic plaque subgroup. The CT attenuation of pancreas and spleen were measured. Pancreas-to-spleen attenuation ratio (P/S) and difference between pancreatic and splenic attenuation (P-S) were calculated. The cut-off values of P/S and P-S were obtained using receiver operating characteristic (ROC) curves. Logistic regression models were used to evaluate association of P/S or P-S with carotid plaque or hypoechoic plaque.Results A total of 337 patients with T2DM were enrolled, including 101 cases (30.0%) in the non-plaque group, 146 cases (43.3%) in the hypoechoic plaque subgroup, and 90 cases (26.7%) in the non-hypoechoic plaque subgroup. P/S and P-S in plaque group were lower than those in non-plaque group, with a cut-off value of P/S and P-S as 0.72 and -13.33, respectively. After adjusting for risk factors, P/S and P-S correlated with carotid plaque [for low P/S: OR (95% CI): 3.15 (1.47-6.73), P=0.0031; for low P-S: OR (95% CI): 2.84 (1.42-5.66), P=0.0031] as well as carotid hypoechoic plaque [for low P/S: OR (95% CI): 1.82 (1.07-3.08), P=0.0259; for low P-S: OR (95% CI): 1.82 (1.09-3.02), P=0.021].Conclusions T2DM patients with carotid plaque have higher pancreatic fat content than those without. Pancreatic steatosis correlates with carotid plaque and hypoechoic plaque in T2DM patients.

scholarly journals HEPATIC STEATOSIS IN LIVER DONORS: A COMPARATIVE STUDY BETWEEN COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING – PROTON DENSITY FAT FRACTION BASED HEPATIC FAT GRADINGS.

2021 ◽  
pp. 1-3
Author(s):  
Anandhu Krishnan G ◽  
Rajsekar C S ◽  
Srikanth Moorthy ◽  
Rubalakshmi S ◽  
Saitheja Paidipelly ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Therapeutic Option ◽  
Proton Density ◽  
Fat Percentage ◽  
Mean Values ◽  
Donor Liver Transplantation ◽  
Significant Difference ◽  
Hepatic Fat ◽  
Fat Fraction ◽  
Liver Donors

Background: Living donor liver transplantation is being used as the main therapeutic option in the management of end-stage liver disease patients especially since there is inadequate availability of deceased donors. Degree of hepatic steatosis in prospective liver donors can affect the tissue regeneration in both donors and recipients and as well as the success of the surgery. MRI-PDFF is the best modality for the non-invasive assessment of hepatic steatosis in the literature, however CT is more commonly employed for the same. The qualitative data of hepatic fat using CT based methods are compared with MRI-PDFF based gradings. Methods: The study included 35 prospective liver donors assessed between August 2018 to August 2020. All patients were evaluated with MRI- PDFF (IDEAL) sequence and fat fraction maps were obtained. The mean fat percentage was calculated and grading of hepatic steatosis was done. In plain MDCT 0.5 mm CT cuts, mean values of hepatic CT attenuation values corresponding MRI fat fraction maps were taken. Grading of the hepatic steatosis based on CT parameters like liver-spleen attenuation ratio (L/S) and liver-spleen attenuation difference(L-S) was done. Both CT and MRI based gradings were assessed for any statistical difference. Results: The categorical data (grading) based on MR derived fat fraction and both CT based parameters mentioned above were evaluated with Chi Square test that showed no significant difference (p = 0.083). Conclusion: Grading of hepatic steatosis using CT based parameters shows no statistically significant difference with MRI-PDFF based grading.

scholarly journals The efficacy of healthy drinks based on kaempferia galanga, ginger and garlic as phytobiotics on fat content of breast, percentage of abdominal fat and broiler carcass

2021 ◽  
Vol 332 ◽  
pp. 01004
Author(s):  
Tati Vidiana Sari ◽  
Raja Indah Hamdy Harahap ◽  
Uswatun Hasanah
Keyword(s):  
Active Ingredient ◽  
Water Solution ◽  
Solution Treatment ◽  
Abdominal Fat ◽  
Fat Content ◽  
The Other ◽  
Fat Percentage ◽  
Broiler Meat ◽  
Kaempferia Galanga ◽  
Significant Difference

This study aimed to examine the effect of giving healthy drinks based on Kaempferia galanga, ginger and garlic on broiler rearing on the level of breast fat, percentage of abdominal fat and carcass. This research used a CRD with 7 treatments and 3 replications. The concentration of active ingredient in water solution treatment is 1.06%/L. The result showed that the giving of healthy drinks giving a very significant difference (P<0.01) on all parameters research. The result of DMRT test showed that the M2 treatment had fat content 58,96% which was significantly higher than M6(47.52%), M0(39.24%) and M1(34.65%) while the fat content in M3(32.21%), M4(33.31%) and M5(27.51%) were significantly lower than other treatments. The value of the percentage of abdominal fat at M0(2,28%) was very significantly the highest compared to other treatments and each treatments also gave very significant difference (P<0.01) results. The percentage of broiler carcasses in the M5(83.42%) gave a very significantly higher, while the M0(73,24%) gave a significantly lower than the other treatments. It can be concluded that the best healthy drink was given in the M5 treatments because it produced the lowest fat content and the highest carcass percentage of broiler meat.

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