scholarly journals Predictors of renal infarction in patients presenting to the emergency department with flank pain: A retrospective observational study

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261054
Author(s):  
Sangun Nah ◽  
Sangsoo Han ◽  
Han Bit Kim ◽  
Sohyeon Chun ◽  
Sechan Kim ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Emergency Department ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Current Smoker ◽  
Flank Pain ◽  
Renal Infarction ◽  
Clinical Factors ◽  
Male Sex

Objectives Flank pain is a common symptom in the emergency department and can be caused by a variety of diseases. Renal infarction (RI) is a very rare disease, and many RI patients complain of flank pain. However, there is no definitive predictor of RI when patients complain of flank pain. This study aimed to identify the clinical factors for predicting RI in patients with flank pain. Methods This retrospective single-center study was conducted on patients complaining of flank pain from January 2016 to March 2020 at a South Korean tertiary care hospital. Exclusion criteria included patients who did not undergo contrast-enhanced computed tomography, age < 18 years, and trauma. Demographic and laboratory data were obtained from medical records. Logistic regression analysis was conducted to identify predictors of RI occurrence. Results In all, 2,131 patients were enrolled, and 39 (1.8%) had RI. From a multivariable logistic regression analysis, an age ≥ 65 years (odds ratio [OR], 3.249; 95% confidence interval [CI], 1.366–7.725; p = 0.008), male sex (OR, 2.846; 95% CI, 1.190–6.808; p = 0.019), atrial fibrillation (OR, 10.386; 95% CI, 3.724–28.961; p < 0.001), current smoker (OR, 10.022; 95% CI, 4.565–22.001; p < 0.001), and no hematuria (OR, 0.267; 95% CI, 0.114–0.628; p = 0.002) were significantly associated with the occurrence of RI. Conclusions Five clinical factors, i.e., age ≥ 65 years, male sex, atrial fibrillation, current smoker, and no hematuria, were significantly associated with the occurrence of RI in patients with flank pain.

Which Patients Would Be Willing to Change Anticoagulation From Vitamin-K Antagonists to a New Oral Anticoagulant?

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4318-4318
Author(s):  
Job Harenberg ◽  
Svetlana Marx ◽  
Nadja Abou-Ayash ◽  
Christophe Kremer ◽  
Vera Hoeing ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Vitamin K ◽  
Logistic Regression Analysis ◽  
Oral Anticoagulant ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulant ◽  
Willingness To Change

Abstract Abstract 4318 New oral anticoagulants have generated promising data on the prophylaxis of systemic and non-systemic embolism in patients with atrial fibrillation and treatment of acute venous thromboembolism and prolonged prophylaxis of recurrent events. For patients on chronic treatment with vitamin-K antagonists (VKA) we analysed the motivation and willingness to change the anticoagulation from VKA to new oral anticoagulants. Patients (n=110) on stable treatment with VKA for at least 3 months (indication for anticoagulation: atrial fibrillation or VTE) completed a validated personality inventory (Freiburger Persönlichkeitsinventar FPI-R), and a self-developed questionnaire on general attitudes regarding anticoagulant therapy (Q1). Patients were divided in two groups according to the reply to the question weather they were willing to switch to a new oral anticoagulant. Out of these sets of questions 7 questions were identified by means of a logistic regression analysis for the willingness to change anticoagulation with VKA to a new oral anticoagulant. The same patients completed this shortened questionnaire (Q2) (n=85) thereafter. Logistic regression analysis defined the 7 items of the FPI and Q1 questionaires as relevant for willingness of patients to change the medication. The probability to change medication was 98% using the 7 questions (Q2) compared to the 2 comlete questionnaires. The items were: extraversion – introversion scale on the FPI-R consisting of 14 questions, and from Q1: hope for a better quality of life with a new anticoagulant, no scepticism for new drugs, wish of a lack of routine monitoring for dose adjustment, relevance of the practitioners opinion, thoughts in the past of alternatives for anticoagulation, and difficulty to adjust the prothrombin time. Using Q2 85% of patients confirmed to be willing to change the anticoagulant drug compared to Q1 (chi square test p<0.0001). Seven questions were identified and confirmed to identify patients for their willingness to change anticoagulation from VKA to a new oral anticoagulant. Disclosures: No relevant conflicts of interest to declare.

A randomized study of urgent computed tomography–based hematoma puncture and aspiration in the emergency department and subsequent evacuation using craniectomy versus craniectomy only

2012 ◽  
Vol 117 (3) ◽  
pp. 566-573 ◽  
Author(s):  
Bo Xiao ◽  
Fang-Fang Wu ◽  
Hong Zhang ◽  
Yan-Bin Ma
Keyword(s):  
Emergency Department ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Scale Score ◽  
Logistic Regression Analysis ◽  
Randomized Study ◽  
Surgical Decompression ◽  
Pupil Response ◽  
Group A ◽  
Group B

Object When treating patients with a spontaneous supratentorial massive (≥ 70 ml) intracerebral hemorrhage (ICH), the results of surgery are gloomy. A worsening pupil response has been observed in patients preoperatively, despite blood pressure control and diuretic administration. Because open surgery needs time for decompression to occur, the authors conducted a prospective randomized study to determine whether patients who have suffered a massive ICH can benefit from a more urgently performed decompressive procedure. Methods Overall, 36 eligible patients admitted 6 or fewer hours post-ictus were enrolled in the study. In Group A, 12 patients underwent CT-based hematoma puncture and partial aspiration in the emergency department (ED) and subsequent evacuation via a craniectomy; in Group B, 24 patients underwent hematoma evacuation via a craniectomy only. Pupil responses were categorized into 5 grades (Grade 0, bilaterally fixed; Grade 1, unilaterally fixed with the fixed pupil > 7 mm; Grade 2, unilaterally fixed with the fixed pupil ≤ 7 mm; Grade 3, a unilaterally sluggish response; and Grade 4, a bilaterally brisk response). Grades were obtained on admission, at surgical decompression (defined as the point at which liquid hematoma began to flow out in Group A and at dural opening in Group B), and at completion of craniectomy. The Barthel Scale was used to assess survivors' functional outcome at 12 months. Comparisons were made between Groups A and B. Logistic regression analysis was used to evaluate the positive likelihood ratio of all variables for survival and function (Barthel Scale score of ≥ 35 at 12 months). Results Decompressive surgery was undertaken approximately 60 minutes earlier in Group A than B. A worsening pupil reflex before decompression was observed in no Group A patient and in 9 Group B patients. At the time of decompression pupil response was better in Group A than B (p < 0.05). Although only approximately one-third of the hematoma volume documented on initial CT scanning had been drained before the craniectomy in Group A, when partial aspiration was followed by craniectomy, better pupil-response results were obtained in Group A at the completion of craniectomy, and survival rate and 12-month Barthel Scale score were better as well (p < 0.05). Logistic regression analysis revealed that one variable, a minimum pupil grade of 3 at the time of decompression, had the highest predictive value for survival at 12 months (8.0, 95% CI 2.0–32.0), and a pupil grade of 4 at the same time was the most valuable predictor of a Barthel Scale score of 35 or greater at 12 months (15.0, 95% CI 1.9–120.9). Conclusions Patients with massive spontaneous supratentorial ICHs may benefit from more urgent surgical decompression. The results of logistic regression analysis implied that, to improve long-term functional outcome, decompression should be performed in patients before herniation occurs. Due to the fact that most of these patients have signs of herniation when presenting to the ED and because conventional surgical decompression requires time to take effect, this combination of surgical treatment provides a feasible and effective surgical option.

scholarly journals P827 Left atrial contractile function is the main correlate of atrial fibrillation in patients with hypertrophic cardiomyopathy

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Rosca ◽  
L Mandes ◽  
D Ciuperca ◽  
A Calin ◽  
C C Beladan ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Hypertrophic Cardiomyopathy ◽  
Logistic Regression Analysis ◽  
Left Atrial ◽  
Contractile Function ◽  
Multivariable Logistic Regression Analysis ◽  
Multivariable Logistic Regression ◽  
And Function

Abstract Background Given the negative impact of atrial fibrillation (AF) in patients (pts) with hypertrophic cardiomyopathy (HCM), finding new and better predictors of AF is clinically important, especially for patients considered at low or intermediate risk based on current recommendations (i.e. left atrial diameter, LAD &lt;45 mm). Purpose To assess the relationship between left atrial (LA) remodelling (size and function) and the presence of paroxysmal AF in HCM patients with and without increased LAD. Methods A comprehensive echocardiogram was performed in 110 consecutive pts (52 ± 17 years, 50 men) with HCM, in sinus rhythm. Indexed LA volume (LAVi), maximum left ventricular wall thickness (LVWT), LV ejection fraction, E/e’ ratio were determined. Global longitudinal LV strain (GLS) and LA strain parameters (LAɛ, SSr, ASr) were assessed by speckle tracking echocardiography. Patients were divided into two groups according to the presence (30 pts) or absence (80 pts) of documented paroxysmal AF (24/48 h ambulatory ECG recordings) Results Patients with AF were older than pts without AF (p &lt; 0.001). LAD, LAVi, E/e’ were significantly higher, while LAɛ, ESr, ASr were significantly lower in pts with AF compared to pts without AF (p &lt; 0.05 for all). There were no significant differences between pts with and without AF regarding: gender, LVWT, GLS, the presence and severity of LV outflow tract obstruction (p &gt; 0.05 for all). The correlates of AF in the whole HCM study population were: age (OR = 1.05, p = 0.001), ASr (OR = 10.1, p &lt; 0.001), LAVi (OR = 1.03, p = 0.004), LAD (OR = 1.2, p = 0.001), E/e’(OR = 1.05, p = 0.02) and mitral regurgitation degree (OR = 1.6, p = 0.04). ASr had the best area under the curve (AUC: 0.74) with a cutoff of -0.88 s-1 for identifying HCM patients with AF (sensitivity: 80%, specificity: 65%). At multivariable logistic regression analysis, age, LAVi and ASr emerged as the only independent correlates of AF. 14 of the 71 patients with a LAD &lt; 45 mm had paroxysmal AF. In this selected population, pts with AF were older (p = 0.001), had higher values for E/e’ (p = 0.04) and lower values for ASr (p = 0.02) than pts without AF. Moreover, in this subgroup of pts, at multivariable logistic regression analysis, ASr correlated with AF independently of age, LA dimensions, LV hypertrophy or E/e’ (OR = 10.008, 95% CI 1.297-77.219, p = 0.02). Conclusions In pts with HCM, age, LAVi and ASr, were independently related to the presence of AF, while LAD was not. Moreover, in the subgroup of HCM pts with LAD &lt; 45 mm, ASr (reflecting LA contractile function) was the only LA remodelling parameter correlated with the presence of AF. The assessment of LA volume and function can provide further insights into the risk stratification of pts with HCM, especially in pts considered at lower risk for AF based on the assessment of classical risk parameters, such as LAD.

scholarly journals The Association between ADHD and the Severity of COVID-19 Infection

2021 ◽  
pp. 108705472110036
Author(s):  
Eugene Merzon ◽  
Margaret D. Weiss ◽  
Samuele Cortese ◽  
Ann Rotem ◽  
Tzipporah Schneider ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Health Services ◽  
Logistic Regression Analysis ◽  
Significant Risk ◽  
Increased Risk ◽  
Dependent Variables ◽  
Male Sex ◽  
Analysis Models

Objective: Patients with ADHD are at increased risk of acquiring COVID-19. The present study assessed the possibility that ADHD also increases the risk of severe COVID-19 infection. Method: We assessed 1,870 COVID-19 positive patients, aged 5 to 60 years, registered in the database of Leumit Health Services (LHS, Israel), February to -June 2020, of whom 231 with ADHD. Logistic regression analysis models evaluated the association between ADHD and the dependent variables of being symptomatic/referral to hospitalization, controlling for demographic and medical variables. Results: Age, male sex, and BMI were confirmed to be significant risk factors for increased COVID-19 severity. ADHD was found to be associated with increased severity of COVID-19 symptoms ( OR = 1.81, 95% CI [1.29, 2.52], p < .05) and referral to hospitalization ( OR =1.93, 95% CI [1.06, 3.51], p = .03). Conclusion: ADHD is associated with poorer outcomes in COVID-19 infection.

scholarly journals Relationship between CHA2DS2-VASC score on admission to emergency department and in-hospital major adverse cardiovascular events in patients diagnosed with ST-elevation myocardial infarction

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
DUYGU Inan ◽  
DUYGU Genc ◽  
BARIS Simsek ◽  
OZAN Tanik ◽  
EVLIYA Akdeniz ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
P Value ◽  
Killip Class ◽  
No Reflow ◽  
St Elevation ◽  
The Relationship

Abstract Funding Acknowledgements Type of funding sources: None. Inotroduction . CHA₂DS₂-VASc scoring system, which includes traditional risk factors of coronary artery disease, is actually created to determine the risk of thromboembolism in patients with atrial fibrillation. In this study; the value of CHA₂DS₂-VASc score, which can be calculated easily on admission, was evaluated for predicting in-hospital adverse outcomes in ST elevation miyocardial infarction (STEMI) patients without atrial fibrillation. Method This was a single center cross-sectional study. 1933 STEMI patients enrolled to the study. Primary end points include in-hospital death, cardiopulmonary arrest and cerebrovascular accident and were identified as MACE Results MACE rate was 10% (193 patients), in-hospital mortality rate was 9% (169 patients).In proportional logistic regression analysis, CHA₂DS₂-VASc score was an independent predictor for MACE (OR and CI 95%, 2.31[1.37-3.90]; p value:0.0016). In the regression analysis, the CHA₂DS₂-VASc score was taken as an uncatagorized continuous variable, and the relationship between the CHA₂DS₂-VASc score and MACE was observed to be linear. Additionally heart rate (OR and 95% CI, 1.56 [0.97- 2.50]; p value: 0.0242), killip class on admission (OR and 95% CI, 24.19[10.74-54.46]; p value &lt;0.0001), creatinine level on admission (OR and 95% CI, 1.54 [1.10-2.16]; p value: 0.0024), peak CK-MB level (OR and 95% GA, 1.63 [0.98-2.70]; p value: 0.0001) and presence of no-reflow (OR and 95% CI, 2.45 [1.25-4.80]; p value: 0.0085) were indendified as other independent predictors of MACE. Conclusion CHA₂DS₂-VASc score was observed as an indepented predictor for MACE in STEMI patients. To evaluate the relationship between CHA₂DS₂-VASc score and outcomes, the linear analysis of the CHA₂DS₂-VASc score without categorization in prediction model is used and this is the main difference of our study from others. Table-1 Variables Odss Ratio (OR) and 95% CI p value CHA₂DS₂-VASc ( 0 to 3) 2.31 (1.37-3.90) p = 0,0016 Heart Rate (Beats per minute) ( 68 to 94) 1.56 (0.97-2.50) p =0.0242 Systolic Blood Pressure (mmHg) ( 115 to 156) 0.83 (0.51-1.34) p = 0.3523 Killip Class ( I to IV) 24.19 (10.74-54.46) p &lt; 0.0001 Hemoglobin (g/dL) ( 12 to 15) 0.96 (0.54-1.70) p = 0.4066 Creatinine ( mg/dL) (0.74 to 1.0) 1.54 (1.10-2.16) p = 0.0024 Peak CK-MB (IU/L) (40.8 to 165.1) 1.63 (0.98-2.70) p = 0.0001 No-reflow (yes) 2.45 (1.25-4.80) p = 0.0085 Independent predictors of MACE in STEMI patients according to penalized proportional odds logistic regression analysis Abstract Figure. Partial impact plots of predictors

Prognostic factors, symptoms, and consequences of electrolyte imbalances in patients who suffered from cancer.

2017 ◽  
Vol 35 (31_suppl) ◽  
pp. 74-74
Author(s):  
Pawel Bryniarski
Keyword(s):  
Emergency Department ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Cancer Patients ◽  
Logistic Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Terminal Cancer ◽  
Multivariate Logistic Regression ◽  
Risk Of Death ◽  
Ps Scale

74 Background: Dyselectrolytemia is a common problem in patients with terminal cancer. It worsens the quality of life and increases the amount of complications. The aim of our study was to determine factors connected with dyselectrolytemia in patients with terminal cancer. Methods: 310 terminal cancer patients admitted to Palliative Care Unit were retrospectively analyzed. Detailed physical examination, medical history and laboratory parameters were taken upon admission. Univariate and multivariate logistic regression analysis were used to determine possible predictors, symptoms and consequences of dyselectrolytemia. Results: On admission 67,74% of patients had dyselectrolytemia. They were more frequently admitted to hospital from Emergency Department (OR=Odds Ratio=2,879, p=probability value=0,00004), had higher PS scale note (OR=1,627, p=0,0001), were more often cachectic (OR=1,915, p=0,0083), had more often constipation (OR=1,728,p=0,0275), were more often dehydrated (OR=2,609 ,p=0,0007), had lower albumin level (OR=0,909, p=0,00001). They had 275% higher risk of death (OR=2,758, p=0,0001). Multivariate logistic regression analysis after adjustment for possible confounders reviled that admission to hospital from Emergency Department (OR=2,652, p=0,01), higher PS scale note (OR=1,445, p=0,001), opioids administration (OR=2,747, p=0,003), dehydration (OR=1,966 , p=0,038) and higher risk of death (OR=2,432, p=0,002) remained independently associated with dyselectrolytemia. Conclusions: Higher PS scale note, occurrence of dehydration, admission to hospital from Emergency Department and opioids administration are factors associated with dyselectrolytemia. Patients with electrolytes imbalances had 275% higher risk of death. Project "Extension of life and improvement of its quality and reduction of cancer patients' mortality due to proper control of water and electrolyte management and elimination of risk factors for dehydration and dyselectrolytemia." Co-financed by the European Social Fund under the project of the Ministry of Science and Higher Education of Poland entitled "Best of the best! 2.0 ".

Risk Factors for Different Grades of Lower Respiratory Tract Infections in Children Under Five Years Old with Measles: Based on Chest Radiography

2020 ◽  
Vol 16 (2) ◽  
pp. 149-155
Author(s):  
Huanguo Li ◽  
Minming Zhang ◽  
Qun Lao ◽  
Yushuang Ding ◽  
Kaiyu Zhao ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Chest Radiography ◽  
Respiratory Tract Infections ◽  
Clinical Factors ◽  
Lower Respiratory Tract Infections ◽  
Course Of Disease ◽  
Measles Vaccination ◽  
Tract Infections

Background: Although measles epidemic has been controlled effectively after measles vaccination being carried out, China is still the focus of measles epidemic. The lower respiratory tract infections (LRTIs) is the most common complication, and also the most common reason for the death of patients with measles. Purpose: To analyze what clinical factors could affect the grades of LRTIs in children under five years old with measles. Methods: Patients’ 13 clinical factors and chest radiography were analyzed retrospectively. Based on the chest radiography, the LRTIs were divided into 3 grades. The clinical factors and the grades of LRTIs were analyzed by ordered logistic regression analysis. Results: There were 74 cases in grade 0, 77 cases in grade 1, and 36 cases in grade 2. After univariate logistic regression analysis, there were 5 clinical factors whose P value were no more than 0.1, including the children’s course of disease before admission, co-infection other pathogens, vaccination, the first symptoms and gender. After ordinal logistic regression analysis, the difference in the course of disease before admission (OR = 1.134, 95% CI: 1.025 to 1.141), without vaccination (OR = 1.808, 95% CI: 1.065 to 3.065) and co-infected other pathogens other pathogens infections (OR = 1.618, 95% CI: 1.073 to 2.440) during different grades was statistically significant (P < 0.05). Conclusion: In our study, there were three clinical factors, including “with a long course of disease before admission”, “without measles vaccination” and “with other pathogens infections”, as the independent risk factors of the grades of LRTIs in children with measles.

scholarly journals ФЕНОТИПОВІ ОЗНАКИ І ПОЛІМОРФІЗМ RS10465885 ГЕНА КОНЕКСИНУ-40 ЯК ПРЕДИКТОРИ ВИНИКНЕННЯ РЕЦИДИВУ АРИТМІЇ У ПАЦІЄНТІВ З ФІБРИЛЯЦІЄЮ ПЕРЕДСЕРДЬ НЕКЛАПАННОГО ҐЕНЕЗУ ПІСЛЯ ВІДНОВЛЕННЯ СИНУСОВОГО РИТМУ ПРИ 1-РІЧНОМУ СПОСТЕРЕЖЕННІ: РЕЗУЛЬТАТИ НЕЙРОМЕРЕЖЕВОГО АНАЛІЗУ

2018 ◽  
Author(s):  
T. V. Mikhalieva ◽  
O. S. Sychov ◽  
T. V. Getman ◽  
V. G. Gurianov ◽  
K. O. Mikhaliev
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Algorithm ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Heart Rhythm ◽  
Multivariable Logistic Regression Analysis ◽  
Input Selection ◽  
Pharmacological Cardioversion

Atrial fibrillation (AF) is a violation of the heart rhythm associated with 1 % (or even more) of the health budget expenditure in Europe. Despite the fact that there is a constant increase in the socio-economic burden of AF, and there has been significant progress in understanding the pathophysiology of this arrhythmia, the effectiveness of its treatment is still far from satisfactory. One of the reasons for the insufficient effectiveness of modern strategies for the prevention and treatment of AF is the existence of limitations in understanding the complex pathophysiology of this disturbance of the heart rhythm.The aim of the study – to leran the phenotypic and genotypic (rs10465885 polymorphism in connexin-40 [Cx40] gene) predictors of arrhythmia recurrence in patients with non-valvular atrial fibrillation (AF) after sinus rhythm restoring (SRR ) at 1-year follow-up (AF360), in particular by the use of artificial neural networks (ANN ) analysis.Materials and Methods. We enrolled 104 patients (pts) with non-sustained non-valvular AF (average age (53±10) years, 80 (76.9 %) men). The distribution of rs10465885 polymorphic variants in Cx40 gene (n=73) was as follows: TT – 17 (23.3 %) pts, CT – 33 (45.2 %), СС – 23 (31.5 %). We analyzed 122 cases of SR restoring: 32 (26.2 %) – pharmacological cardioversion (29 pts); 63 (51.6 %) – electrical cardioversion (53 pts); 27 (22.2 %) – radiofrequency catheter ablation (22 pts). AF360 occurred in 76 (65.5 %) of 116 cases. In order to identify AF360 predictors, we used logistic regression analysis, as well as ANN analysis (building the linear [LIN] and nonlinear [multilayer perceptron (MLP )] ANN`s).Results and Discussion. Genetic algorithm Input Selection revealed 16 parameters, associated with AF360, including SRR type, rs10465885 polymorphism, and certain clinical (in particular, CHA 2DS 2-VAS c score), lab and echo parameters. CHA 2DS 2-VAS c score was the only independent AF360 predictor, according to the results of multivariable logistic regression analysis. The area under curve (AU C) for MLP , included all 16 variables, revealed by the Genetic algorithm, was significantly higher than in linear LIN: 0.874 (95 % confidence interval [CI] 0.798–0.929) vs. 0.678 (CI 0.583–0.763), respectively (p<0.001). In order to obtain the maximal reduction of predictors, we built the MLP , included the set of 5 variables (MLP 5): SRR type; rs10465885 polymorphism; the heart failure presence and its stage; AF type (recurrent or first diagnosed); and antero-posterior left atrial dimension. MLP 5 AU C (0.808 (95 % CI 0.723–0.876)) was significantly higher than those for LIN (р = 0.027).Conclusion. AF360 was non-linearly associated with SRR type, rs10465885 polymorphism in Cx40 gene, as well as certain phenotypic parameters. The further search of the most significant genetic and epigenetic predictors of AF recurrence at different terms after SRR is of crucial importance.

scholarly journals Computed Tomography-Based Radiomics for Preoperative Prediction of Tumor Deposits in Rectal Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Yumei Jin ◽  
Mou Li ◽  
Yali Zhao ◽  
Chencui Huang ◽  
Siyun Liu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Rectal Cancer ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Characteristic Curve ◽  
Clinical Factors ◽  
Combined Model ◽  
Portal Venous Phase ◽  
Preoperative Prediction

ObjectiveTo develop and validate a computed tomography (CT)-based radiomics model for predicting tumor deposits (TDs) preoperatively in patients with rectal cancer (RC).MethodsThis retrospective study enrolled 254 patients with pathologically confirmed RC between December 2017 and December 2019. Patients were divided into a training set (n = 203) and a validation set (n = 51). A large number of radiomics features were extracted from the portal venous phase images of CT. After selecting features with L1-based method, we established Rad-score by using the logistic regression analysis. Furthermore, a combined model incorporating Rad-score and clinical factors was developed and visualized as the nomogram. The models were evaluated by the receiver operating characteristic curve (ROC) analysis and area under the ROC curve (AUC).ResultsOne hundred and seventeen of 254 patients were eventually found to be TDs+. Rad-score and clinical factors including carbohydrate antigen (CA) 19-9, CT-reported T stage (cT), and CT-reported peritumoral nodules (+/-) were significantly different between the TDs+ and TDs- groups (all P &lt; 0.001). These factors were all included in the combined model by the logistic regression analysis (odds ratio = 2.378 for Rad-score, 2.253 for CA19-9, 2.281 for cT, and 4.485 for peritumoral nodules). This model showed good performance to predict TDs in the training and validation cohorts (AUC = 0.830 and 0.832, respectively). Furthermore, the combined model outperformed the clinical model incorporating CA19-9, cT, and peritumoral nodules (+/-) in both training and validation cohorts for predicting TDs preoperatively (AUC = 0.773 and 0.718, P = 0.008 and 0.039).ConclusionsThe combined model incorporating Rad-score and clinical factors could provide a preoperative prediction of TDs and help clinicians guide individualized treatment for RC patients.

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