scholarly journals Elevated serum expression of p53 and association of TP53 codon 72 polymorphisms with risk of cervical cancer in Bangladeshi women

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261984
Author(s):  
Md Shaki Mostaid ◽  
Sadia Biswas Mumu ◽  
Md Aminul Haque ◽  
Shahana Sharmin ◽  
Mohd Raeed Jamiruddin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
P53 Protein ◽  
Elevated Serum ◽  
Healthy Controls ◽  
Codon 72 ◽  
Protein Levels ◽  
Quantitative Trait Analysis ◽  
First Time ◽  
Serum P53

Differential expression of p53 has been reported in cervical cancer, primarily in tumor tissue biopsies. In this study, we examined the association of TP53 codon 47 and codon 72 polymorphisms and serum level expression of p53 in cervical cancer patients (n = 129) and healthy controls (n = 122). We found elevated levels of serum p53 protein levels in cervical cancer patients (p = 0.0442) compared to healthy controls. Moreover, we found higher levels of serum p53 in patients with grade-III tumor (p = 0.001) compared to healthy controls. Examination of SNPs showed TP53 Arg/Pro heterozygosity (adjusted OR = 2.126, 95% CI = 1.181–3.827, p = 0.012), Pro/Pro mutant homozygosity (adjusted OR = 3.564, 95% CI = 1.647–7.713, p = 0.001), along with the combined genotype (Arg/Pro+Pro/Pro) (adjusted OR 2.542, 95% CI = 1.517–4.260, p<0.001) significantly increases the risk of cervical cancer. Expression quantitative trait analysis revealed no significant association with protein expression. Our results represent for the first time the upregulation of serum p53 in cervical cancer in Bangladeshi women and supports the association of TP53 codon 72 polymorphisms with cervical cancer.

scholarly journals Gut microbial diversity and genus-level differences identified in cervical cancer patients versus healthy controls

2019 ◽  
Vol 155 (2) ◽  
pp. 237-244 ◽  
Author(s):  
Travis T. Sims ◽  
Lauren E. Colbert ◽  
Jiali Zheng ◽  
Andrea Y. Delgado Medrano ◽  
Kristi L. Hoffman ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Microbial Diversity ◽  
Cancer Patients ◽  
Healthy Controls ◽  
Genus Level

scholarly journals Effect of p53 codon 72 polymorphism on the survival outcome in advanced stage cervical cancer patients in India

2016 ◽  
Vol 144 (3) ◽  
pp. 359 ◽  
Author(s):  
Rita Mulherkar ◽  
Akanksha Bansal ◽  
Poulami Das ◽  
Sadhana Kannan ◽  
Umesh Mahantshetty
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Survival Outcome ◽  
Advanced Stage ◽  
P53 Codon 72 ◽  
Codon 72 ◽  
Codon 72 Polymorphism ◽  
P53 Codon 72 Polymorphism

scholarly journals Circulating inflammatory markers in cervical cancer patients and healthy controls

2020 ◽  
Vol 17 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Agne Vitkauskaite ◽  
Daiva Urboniene ◽  
Joana Celiesiute ◽  
Kristina Jariene ◽  
Erika Skrodeniene ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Inflammatory Markers ◽  
Healthy Controls ◽  
Circulating Inflammatory Markers

Codon 72 polymorphism of p53 in Israeli Jewish cervical cancer patients and healthy women

2002 ◽  
Vol 12 (6) ◽  
pp. 741-744 ◽  
Author(s):  
S. Arbel-Alon ◽  
J. Menczer ◽  
N. Feldman ◽  
M. Glezerman ◽  
L. Yeremin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Codon 72 ◽  
Healthy Women ◽  
Codon 72 Polymorphism

scholarly journals MiR-221 represents an innovative bio-marker in cervical carcinoma detection

2020 ◽  
Author(s):  
Shuangqing Cao ◽  
Lei Zheng
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Expression Pattern ◽  
Cervical Carcinoma ◽  
Roc Curve ◽  
Figo Stage ◽  
Diagnostic Value ◽  
Expression Level ◽  
Healthy Controls ◽  
Tumorigenesis And Progression

Abstract Background MiR-221 has been identified to play an important role in tumorigenesis and progression. In the present study, we aimed at to investigate the expression pattern of serum miR-221 and evaluate its diagnostic value in cervical cancer. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure the expression pattern of miR-221 in cervical cancer patients and healthy controls. The association of miR-221 with clinicopathological data was analyzed with χ2 test. Then receiver operating characteristic (ROC) curve was built to evaluate the diagnostic value of serum miR-221 by calculating the area under the ROC curve (AUC). Results The results indicated that the miR-221 expression level was statistically elevated in cervical cancer patients compared with healthy individuals. The increased miR-221 expression was significantly associated with lymph node metastasis (P = 0.026) and FIGO stage (P = 0.028). ROC curve suggested that serum miR-221 had a high diagnostic value in differentiating cervical cancer patients from healthy controls with AUC of 0.932 (95%CI: 0.903–0.960) corresponding with sensitivity of 77.6% and specificity of 94.8%. Conclusions Taken together, the expression level of miR-221 is increased in cervical carcinoma and it may serve as a promoting bio-marker in the diagnosis of cervical cancer patients.

scholarly journals Serum Tie-1 is a Valuable Marker for Predicting the Progression and Prognosis of Cervical Cancer

2021 ◽  
Vol 27 ◽  
Author(s):  
Rui Bai ◽  
Bowen Diao ◽  
Kaili Li ◽  
Xiaohan Xu ◽  
Ping Yang
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Enzyme Linked Immunosorbent Assay ◽  
Advanced Tumor Stage ◽  
Healthy Controls ◽  
Cervical Lesions ◽  
Advanced Tumor ◽  
Valuable Marker

Objective: To investigate whether serum Tie-1 (sTie-1) is a valuable marker for predicting progression and prognosis of cervical cancer.Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect serum sTie-1 concentrations in 75 cervical cancer patients, 40 cervical intraepithelial neoplasia (CIN) patients, and 55 healthy controls without cervical lesions, and sTie-1 levels were compared between the groups. Receiver operating characteristic curves was used to evaluate the diagnostic value of sTie-1. The relationship between sTie-1 concentrations in patients with cervical cancer and clinicopathological features and prognosis were analyzed, and the risk factors for postoperative recurrence were determined using univariate and multivariable Cox proportional hazards regression.Results: We found that sTie-1 concentrations gradually increased according to lesion severity (i.e., cancer vs. CIN; p &lt; 0.05) and were significantly elevated in adenocarcinoma compared with healthy controls. sTie-1 levels strongly distinguished between cervical cancer patients and the healthy controls (area under the curve = 0.846; cut-off value = 1,882.64 pg/ml; sensitivity = 74.6%; specificity = 96.4%). Moreover, sTie-1 levels in cervical cancer patients were significantly associated with tumor size, advanced tumor stage, lymph node metastasis, and reduced 4-years progression-free survival. Cervical cancer patients with high sTie-1 concentrations had a 3.123-fold [95% confidence interval (CI): 1.087–8.971, p = 0.034] higher risk for tumor recurrence.Conclusions: Elevated sTie-1 levels in patients with cervical carcinoma were associated with tumor progression and poor prognosis, indicating that sTie-1 may be a valuable marker for predicting progression and prognosis of cervical cancer.

scholarly journals p53 codon 72 polymorphism in cervical cancer patients and healthy women from Poland.

2000 ◽  
Vol 47 (4) ◽  
pp. 1179-1182 ◽  
Author(s):  
A Dybikowska ◽  
A Dettlaff ◽  
K Konopa ◽  
A Podhajska
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Squamous Carcinoma ◽  
Control Group ◽  
P53 Codon 72 ◽  
Codon 72 ◽  
Healthy Women ◽  
Codon 72 Polymorphism ◽  
P53 Codon 72 Polymorphism

A polymorphism at codon 72 of gene p53 results in the presence of either arginine or proline at this position. We investigated the distribution of p53 codon 72 polymorphism in cervical cancer patients and a control group of healthy women from Poland. Our results do not confirm the hypothesis that the p53 codon polymorphism could play a role as a factor for squamous carcinoma of the cervix.

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