Moderate activity, not light or vigorous activity, is associated with a higher percent of circulating classical monocytes positive for CX3CR1 and CCR2

La práctica regular de actividad física sugiere un aumento de la condición física y una mejora de la composición corporal; sin embargo, a pesar de que las personas cumplen con las directrices propuestas no logran obtener buenos indicadores de condición física los cuales brindan más información acerca de la salud. Objetivo: Analizar la relación entre las capacidades físicas de fuerza prensil, potencia en piernas, consumo máximo de oxígeno, actividad física con la composición corporal en adultos. Metodología: Estudio descriptivo correlacional de corte transversal, se evaluaron 100 adultos, se valoró fuerza prensil con dinamometría, potencia en piernas con tres tipos de saltos, VO2máx, la actividad física por cuestionario IPAQ y la composición corporal con bioimpedancia eléctrica. Resultados: Los varones poseen valores mayores de capacidades físicas, masa magra y actividad física realizada con mayor intensidad en comparación con las mujeres; los resultados muestran una estrecha relación entre la práctica de actividad física realizada con intensidades moderadas y altas en relación a las capacidades físicas de fuerza prensil y potencia en piernas en aquellas personas sin peso bajo u obesidad; Además, en todas éstas, mediante el análisis Post Hoc, se encontró que las diferencias se presentan entre la actividad baja en comparación con la vigorosa y en la moderada con respecto a la vigorosa. Conclusiones: Personas con normo y sobrepeso muestran mejores capacidades físicas, así como valores elevados de actividad física, mientras que altos índices de grasa corporal total y un IMC elevado son un factor determinante para el desarrollo de las mismas. Abstract: The regular practice of physical activity suggests an increase in physical condition and an improvement in body composition, despite the fact that people comply with the proposed guidelines, they are unable to obtain good indicators of physical fitness, which provide more information about the Health. Objective: To analyze the relationship between physical capacities of grip strength, leg power, maximum oxygen consumption, physical activity and body composition in adults. Methodology: Cross-sectional correlational descriptive study, 100 adults were evaluated, grip strength was assessed with dynamometry, leg power with three types of jumps, VO2max, physical activity by IPAQ questionnaire and body composition with electrical bioimpedance. Results: Men have higher values of physical capacities, lean mass and physical activity carried out with greater intensity compared to women; The results show a close relationship between the practice of physical activity carried out with moderate and high intensities in relation to the physical capacities of grip strength and power in the legs in those without underweight or obesity; In addition, in all of these, by means of Post Hoc analysis, it was found that the differences are presented between low activity compared to vigorous activity and moderate activity compared to vigorous activity. Conclusions: Normal and overweight people show better physical capacities as well as high levels of physical activity, while high levels of total body fat and a high BMI are a determining factor for their development.

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Modeling and synthesis of antiplasmodial chromones, chromanones and chalcones based on natural products of Kenya

Biofarmasi Journal of Natural Product Biochemistry ◽

10.13057/biofar/f160102 ◽

2018 ◽

Vol 16 (1) ◽

pp. 8-21

Author(s):

MANYIM SCOLASTICA ◽

ALBERT J. NDAKALA ◽

SOLOMON DERESE

Keyword(s):

Natural Products ◽

Drug Design ◽

Active Site ◽

Docking Studies ◽

Moderate Activity ◽

Vigorous Activity ◽

Structure Based Drug Design ◽

Web Based ◽

Ic50 Values ◽

Accessible Form

Scolastica M, Ndakala AJ, Derese S. 2018. Modeling and synthesis of antiplasmodial chromones, chromanones and chalcones based on natural products of Kenya. Biofarmasi J Nat Prod Biochem 16: 8-21. Despite numerous research that has been done on plants of Kenya resulting in the isolation of thousands of natural products, data on these natural products are not systematically organized in a readily accessible form. This has urged the construction of a web-based database of natural products of Kenya. The database is named Mitishamba and is hosted at http://mitishamba.uonbi.ac.ke. The Mitishamba database was queried for chromones, chromanones, and chalcones that were subjected to structure-based drug design using Fred (OpenEye) docking utility program with 1TV5 PDB structure of the PfDHODH receptor to identify complex of ligands that bind with the active site. Ligand-based drug design (Shape and electrostatics comparison) was also done on the ligands against query A77 1726 (38) (the ligand that co-crystallized with PfDHODH receptor) using ROCS and EON programs, respectively, of OpenEye suite. There was a substantial similarity among the top performing ligands in the docking studies with shape and electrostatic comparison that led to the identification of compounds of interest which were targeted for synthesis and antiplasmodial assay. In this study, a chromanone (7-hydroxy-2-(4-methoxyphenyl) chroman-4-one (48)) and two intermediate chalcones (2',4'-dihydroxy-4-methoxychalcone (45) and 2’,4’-dihydroxy-4-chlorochalcone (47)), were synthesized and subjected to antiplasmodial assay. Among these substances, 45 showed vigorous activity, whereas 47 and 48 had moderate activity against the chloroquine resistant K1 strain of P. falciparum with IC50 values of 4.56±1.66, 17.62 ± 5.94 and 18.01 ±1.66 µg/ml, respectively. Since the synthesized compounds showed antiplasmodial potential, there is a need for further computational refinement of these compounds to optimize their antiplasmodial activity.

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Comparison of Patterns of Physical Activity and Sedentary Behavior Between Children With Cerebral Palsy and Children With Typical Development

Physical Therapy ◽

10.2522/ptj.20140337 ◽

2015 ◽

Vol 95 (12) ◽

pp. 1609-1616 ◽

Cited By ~ 31

Author(s):

Jennifer M. Ryan ◽

Cuisle Forde ◽

Juliette M. Hussey ◽

John Gormley

Keyword(s):

Physical Activity ◽

Cerebral Palsy ◽

Sedentary Behavior ◽

Vigorous Physical Activity ◽

Similar Amount ◽

Moderate Activity ◽

Vigorous Activity ◽

Typical Development ◽

Preadolescent Children ◽

Children With Cerebral Palsy

Background Reduced participation in physical activity and increased time spent in sedentary behavior are associated with overweight, chronic disease, and disability. In order to optimize recommendations and interventions to increase physical activity and reduce sedentary behavior in children with cerebral palsy (CP), knowledge of their physical activity and sedentary behavior is needed. Objectives The aim of this study was to describe light, moderate, and vigorous physical activity and sedentary behavior in preadolescent children with and without CP and compare physical activity and sedentary behavior between the 2 groups. Design This was a cross-sectional study of 33 children, aged 6 to 10 years, with CP (Gross Motor Function Classification System [GMFCS] levels I–III) and 33 age- and sex-matched children with typical development. Methods Physical activity was measured using the RT3 accelerometer over 7 days. Results Children with CP spent more time in sedentary behavior and accumulated less total activity, moderate activity, vigorous activity, and sustained bouts of moderate-to-vigorous activity (MVPA). They also accumulated a fewer number of bouts of MVPA and vigorous activity, despite spending a similar amount of time in each bout. Limitations The small number of children in GMFCS levels II and III did not allow for adjustment for GMFCS level when comparing physical activity between children with and without CP. Conclusions Preadolescent children with CP spent less time in moderate and vigorous activity and more time in sedentary behavior than children with typical development. Children with CP also accumulated less continuous MVPA and vigorous activity as a result of achieving fewer sustained bouts of MVPA and vigorous activity throughout the day.

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Comparison of the Physical Activity Measured by a Consumer Wearable Activity Tracker and That Measured by Self-Report: Cross-Sectional Analysis of the Health eHeart Study (Preprint)

10.2196/preprints.22090 ◽

2020 ◽

Author(s):

Alexander J Beagle ◽

Geoffrey H Tison ◽

Kirstin Aschbacher ◽

Jeffrey E Olgin ◽

Gregory M Marcus ◽

...

Keyword(s):

Physical Activity ◽

Self Report ◽

Moderate Activity ◽

Vigorous Activity ◽

Cross Sectional ◽

Active Time ◽

Step Counts ◽

Steps Per Day ◽

Wearable Activity Trackers ◽

Sectional Analysis

BACKGROUND Commercially acquired wearable activity trackers such as the Fitbit provide objective, accurate measurements of physically active time and step counts, but it is unclear whether these measurements are more clinically meaningful than self-reported physical activity. OBJECTIVE The aim of this study was to compare self-reported physical activity to Fitbit-measured step counts and then determine which is a stronger predictor of BMI by using data collected over the same period reflecting comparable physical activities. METHODS We performed a cross-sectional analysis of data collected by the Health eHeart Study, a large mobile health study of cardiovascular health and disease. Adults who linked commercially acquired Fitbits used in free-living conditions with the Health eHeart Study and completed an International Physical Activity Questionnaire (IPAQ) between 2013 and 2019 were enrolled (N=1498). Fitbit step counts were used to quantify time by activity intensity in a manner comparable to the IPAQ classifications of total active time and time spent being sedentary, walking, or doing moderate activities or vigorous activities. Fitbit steps per day were computed as a measure of the overall activity for exploratory comparisons with IPAQ-measured overall activity (metabolic equivalent of task [MET]-h/wk). Measurements of physical activity were directly compared by Spearman rank correlation. Strengths of associations with BMI for Fitbit versus IPAQ measurements were compared using multivariable robust regression in the subset of participants with BMI and covariates measured. RESULTS Correlations between synchronous paired measurements from Fitbits and the IPAQ ranged in strength from weak to moderate (0.09-0.48). In the subset with BMI and covariates measured (n=586), Fitbit-derived predictors were generally stronger predictors of BMI than self-reported predictors. For example, an additional hour of Fitbit-measured vigorous activity per week was associated with nearly a full point reduction in BMI (–0.84 kg/m2, 95% CI –1.35 to –0.32) in adjusted analyses, whereas the association between self-reported vigorous activity measured by IPAQ and BMI was substantially smaller in magnitude (–0.17 kg/m2, 95% CI –0.34 to –0.00; P<.001 versus Fitbit) and was dominated by the Fitbit-derived predictor when compared head-to-head in a single adjusted multivariable model. Similar patterns of associations with BMI, with Fitbit dominating self-report, were seen for moderate activity and total active time and in comparisons between overall Fitbit steps per day and IPAQ MET-h/wk on standardized scales. CONCLUSIONS Fitbit-measured physical activity was more strongly associated with BMI than self-reported physical activity, particularly for moderate activity, vigorous activity, and summary measures of total activity. Consumer-marketed wearable activity trackers such as the Fitbit may be useful for measuring health-relevant physical activity in clinical practice and research.

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Abstract P158: Work-related Exertion And Standing/walking Are Associated With Leisure-time Physical Activity In Latinos

Circulation ◽

10.1161/circ.143.suppl_1.p158 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Rosenda Murillo ◽

Shreya Desai ◽

Tailisha Gonzalez ◽

Sandra Echeverria ◽

Elizabeth Vasquez

Keyword(s):

Physical Activity ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Multinomial Logistic Regression ◽

Physical Activities ◽

Moderate Activity ◽

Specific Work ◽

Vigorous Activity ◽

Work Related ◽

Activity Promotion

Introduction: Latinos engage in higher levels of occupational physical activity, yet lower levels of leisure-time physical activity (LTPA), than other racial/ethnic groups. Limited research has examined specific work-based activities that contribute to lower LTPA among Latinos. The purpose of our study was to examine associations between frequency of work-related exertion and standing/walking with LTPA among Latinos. Hypothesis: We hypothesized that higher frequency of work-related exertion and standing/walking would be associated with lower levels of LTPA among Latinos. Methods: We used cross-sectional 2015 National Health Interview Survey (NHIS) data on employed Latinos ≥18 years of age (n=3,305). We examined two types of work-based activities: frequency of exertion and frequency of standing/walking. Frequency of exertion was assessed based on reported frequency of engaging in repeated lifting, pulling, pushing, or bending at work. Frequency of standing/walking was assessed based on frequency with which their work involved standing or walking around. Responses to work-based activity items were on a Likert scale (0=never, 1=seldom, 2= sometimes, 3=often, 4=always). LTPA was measured based on minutes of moderate-to-vigorous LTPA aerobic physical activity per week, which were categorized into none (0 min/week), some LTPA (>0 min/week of activity but less than recommendation), and meeting the LTPA guideline (≥150 min of moderate-vigorous activity or ≥75 min of vigorous activity or 150 min of moderate activity/week). Multinomial logistic regression models that accounted for the complex survey design of NHIS were used to estimate the associations between frequency of work-related exertion and standing/walking with LTPA. All models were adjusted for age, sex, education, shift work, and acculturation proxies (nativity, years living in the US). Results: In adjusted models, compared with those who reported never engaging in exertion at work, individuals reporting always exerting themselves at work were significantly less likely to meet the LTPA guideline (Odds Ratio [OR]: 0.68, 95% Confidence Interval [CI]: 0.50-0.94). In addition, compared with those that reported never standing/walking at work, only those who reported that their job seldom involved standing/walking at work were significantly less likely to meet the LTPA guideline (OR: 0.52, 95% CI: 0.30-0.92). Conclusions: In conclusion, these findings suggest that work-related physical activities may contribute to LTPA levels among Latinos, and associations vary based on the type of physical activities performed at work. Future physical activity promotion efforts among Latinos should consider the role of worksite policies to promote wellness.

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Level of Physical Activity at Lebanese Universities’ Students of Both Genders: A Comparative Study

International Journal of Kinesiology and Sports Science ◽

10.7575/aiac.ijkss.v.9n.3p8 ◽

2021 ◽

Vol 9 (3) ◽

pp. 8

Author(s):

Fadi Fayyad ◽

Milivoj Dopsaj

Keyword(s):

Physical Activity ◽

Extracurricular Activities ◽

Activity Level ◽

Moderate Activity ◽

Vigorous Activity ◽

Metabolic Equivalent ◽

Activity Intensity ◽

University Curriculum ◽

The University ◽

Physical Activity Classes

Background: Examining students’ levels of physical activity is important because these students will be the future leaders of their communities. Objectives: The aim of this study was to generate primary information and describe the lifestyle behavior patterns considering physical activity prevalence among gender-related Lebanese college students. Methods: The study involved 600 students (346 Men, 254 Women with mean age 23.5 ± 3.96). The participants’ levels of physical activity was examined by utilizing the International Physical Activity Questionnaire (IPAQ). The over-all level of physical activity including the four-lifestyle fields: work, transportation, home and gardening, and leisure-time, was presented as metabolic equivalent-min per week (MET-min/week). Results: Findings indicated 22% of students with high physical activity level, 61% and 17 % with moderate and low levels respectively. Based on activity Intensity, 47% (n= 282) of students were engaged in vigorous activity, while 45.2% (n= 271) were engaged in moderate activity, and 68.3% (n=410) were engaged in walking activities. Average time spent sitting for the whole sample was 6.23 daily hours. The level of weekly total physical activity expressed in metabolic equivalent represented 2970.5 MET/min/week in males and 2719.5 MET/min/week in females. Conclusion: In general, Lebanese universities students were equally active, with trivial supremacy for males. Lebanese university students met the (WHO) recommendations for physical activity (>150 min/week of moderate activity or > 75 min/week of vigorous activity or an equivalent combination of both activities). Physical Activity must be developed by the provision of physical activity classes in the university curriculum and extracurricular activities.

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Mobile Elevated Work Platforms versus Ladders in Olive Tree Pruning: Evaluation of Physical Activity and Pruning Performance

Journal of Agricultural Safety and Health ◽

10.13031/jash.12720 ◽

2018 ◽

Vol 24 (3) ◽

pp. 141-153

Author(s):

Roberto Romaniello ◽

Antonia Tamborrino ◽

Alessandro Leone

Keyword(s):

Physical Activity ◽

Energy Expenditure ◽

Olive Tree ◽

Moderate Activity ◽

Vigorous Activity ◽

Metabolic Equivalent ◽

Mean Values ◽

Work Site ◽

The Mean ◽

Tree Pruning

Abstract. The use of mobile elevated work platforms (MEWPs) versus ladders was studied to evaluate the physical activity (PA) of workers and their performance during olive tree pruning. Accelerometers worn by the workers were used to measure triaxial accelerations, which were converted into PA using Freedson’s equation. The mean values of acceleration on the three axes for workers on ladders led to statistically higher results than for workers on MEWPs. The energy expenditure (EE) and metabolic equivalent (MET) values were statistically different (about 1.8 times higher) for the ladder work site than for the MEWP work site. The use of an MEWP leads to more time spent on moderate activity (84.30%) than when using a ladder (71.90%) but no time on vigorous activity compared to a ladder (13.88%). The pruning performance was 3.8 for the MEWP and 1.4 for the ladder, while the labor productivity was 11.4 for the MEWP and 4.2 for the ladder. Thus, it is possible to reduce worker employment and costs by about 2.7 times with MEWPs. Keywords: Accelerometry, Ladders, Mobile elevated work platform (MEWP), Olive tree pruning, Physical activity, Work overhead.

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Physical activity phenotyping with activity bigrams, and their association with BMI

10.1101/121145 ◽

2017 ◽

Author(s):

Louise AC Millard ◽

Kate Tilling ◽

Debbie A Lawlor ◽

Peter A Flach ◽

Tom R Gaunt

Keyword(s):

Physical Activity ◽

Vigorous Physical Activity ◽

Activity Patterns ◽

Moderate Activity ◽

List Type ◽

Activity Levels ◽

Vigorous Activity ◽

Parents And Children ◽

Health Advice ◽

Avon Longitudinal Study

ABSTRACTBackgroundAnalysis of physical activity usually focuses on a small number of summary statistics derived from accelerometer recordings: average counts per minute, and the proportion of time spent in moderate-vigorous physical activity or in sedentary behaviour. We show how bigrams, a concept from the field of text mining, can be used to describe how a person’s activity levels change across (brief) time points. These variables can, for instance, differentiate between two people with the same time in moderate activity, where one person often stays in moderate activity from one moment to the next and the other does not.MethodsWe use data on 4810 participants of the Avon Longitudinal Study of Parents and Children (ALSPAC). We generate a profile of bigram frequencies for each participant and test the association of each frequency with body mass index (BMI), as an exemplar.ResultsWe found several associations between changes in bigram frequencies and BMI. For instance, a 1 standard deviation decrease in the number of adjacent minutes in sedentary then moderate activity (or vice versa), with a corresponding increase in the number of adjacent minutes in moderate then vigorous activity (or vice versa), was associated with a 2.36 kg/m2 lower BMI [95% CI: -3.47, -1.26], after accounting for the time spent at sedentary, low, moderate and vigorous activity.ConclusionsActivity bigrams are novel variables that capture how a person’s activity changes from one moment to the next. These variables can be used to investigate how sequential activity patterns associate with other traits.Key MessagesEpidemiologists typically use only a small number of variables to analyse the association of physical activity with other traits, such as the average counts per minute and the proportion of time spent in moderate-vigorous physical activity or being sedentary.We demonstrate how activity bigrams can be used as a set of interpretable variables describing how a person’s activity levels change from one moment to the next.Testing the association of activity bigrams with exposures or outcomes can help us gain further understanding of how physical activity is associated with other traits; with further research they might provide evidence for more refined public health advice.

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Impact of COVID-19 confinement on the time and intensity of physical activity in the Spanish population

10.21203/rs.3.rs-26074/v1 ◽

2020 ◽

Cited By ~ 3

Author(s):

Arkaitz Castañeda-Babarro ◽

Ane Arbillaga-Etxarri ◽

Borja Gutiérrez-Santamaria ◽

Aitor Coca

Keyword(s):

Physical Activity ◽

Young People ◽

Sedentary Time ◽

Physical Activities ◽

Spanish Population ◽

Sitting Time ◽

P Value ◽

Moderate Physical Activity ◽

Moderate Activity ◽

Vigorous Activity

Abstract Background The lockdown and social distancing caused by COVID-19 may influence common healthy behaviour. Due to the unprecedent worldwide confinement in which Spain has been one of the most affected with severe rules governing confinement, physical activity and sedentarism may change due to prolonged stays at home. The aim of this study is to evaluate how physical activity and sedentary time have changed during confinement in the Spanish population. Methods 3800 healthy adults (age ≥ 18 - ≤64 years) residing in Spain were asked during confinement. Sociodemographic data and self-reported physical activity data were collected twice by an International Physical Activity Questionnaire-Short (IPAQ-S) between 23rd March and 1st April, and the analysis was carried out considering the achievement of general physical activity recommendations, different age ranges and baseline physical activity levels. Results Physical activity decreased significantly during confinement in all population. Vigorous activities and walking time decreased by 16.8% (p-value > 0.001) and 58.2% (p-value > 0.001) respectively, whereas sedentary time increased by 23.8% (p-value > 0.001). The fulfilment of 75 min/week of vigorous activity recommendation decreased by 10.7% (p-value < 0.001) while the amount of people who reached to 150 min/week of moderate activity barely changed (1.4%, (p-value 0.117)). The group that performed more vigorous physical activities before confinement showed the greatest decrease (30.5%, p-value > 0.001). Men reduced more the time in vigorous activity than women (21% vs 9%, respectively) who even increased time in moderate physical activity by 11% (p-value < 0.05) and showed less increase in sitting time than men (35% vs 25.3%, respectively). Young people and students showed the highest decrease in all physical activities. Conclusions The Spanish adult population, especially young people, students and very active men, decreased daily physical activity and increased sedentary time during COVID-19 confinement.

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Does Building a Greenway Promote Physical Activity Among Proximate Residents?

Journal of Physical Activity and Health ◽

10.1123/jpah.2012-0411 ◽

2015 ◽

Vol 12 (1) ◽

pp. 52-57 ◽

Cited By ~ 15

Author(s):

Stephanie T. West ◽

Kindal A. Shores

Keyword(s):

Physical Activity ◽

Repeated Measures ◽

Physical Activity Behavior ◽

Control Group ◽

Moderate Activity ◽

Vigorous Activity ◽

Before And After ◽

Context Specific ◽

Study Participants ◽

And Control

Background:Previous research has observed a positive correlation between having greenways or trails proximate to homes and the physical activity behaviors among residents. Few studies using a pre–post research design have been conducted, and each has pointed to the need for more rigorous studies which incorporate an appropriate control group.Methods:Residents from households living within 1 mile of a proposed greenway and those from a control neighborhood located between 2 and 3 miles of the proposed greenway were randomly selected to participate in the study. Participants were mailed a survey before the onset of construction and again 1 year after the trail was opened. Outcomes were the number of days during the previous week that respondents reported participating in walking, moderate activity, and vigorous activity.Results:Repeated measures analyses of variance indicated no significant differences between the experimental and control groups in days of walking, moderate activity, or vigorous activity before and after the greenway was constructed.Conclusions:Findings suggest that building a greenway did not affect the physical activity behaviors of proximate residents. Other studies should consider different trail types from a variety of settings to determine whether physical activity behavior changes may be context specific.

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