Serum C - Reactive Protein Level and Peripheral Blood Picture in Children with Pneumonia

This cross sectional study aimed to determine the relation between serum C-reactive protein (CRP) levels and peripheral blood picture in children with bronchopneumonia, conducted at the Division of Pulmonology, Sanglah Hospital, Denpasar during 3 months (December 1996 to February 1997). Serum CRP levels, hemoglobin, leukocyte count, neutrophil count and ESR values in 30 cases between 1 month and 4.5 years (20 male and 10 female) were measured. Bronchopneumonia was mostly found in < 1 year old (67%) and with male to female ratio of 2:1. High CRP serum level (>12 microgram/ml) was found in 33% of 30 cases. Anemia was found in 37%, leukocytosis in 50%, increase segment neutrophil ratio in 30%, increase of ESR in 40% and increase of body temperature more than 38°C in 4 7% of the cases. Neutrophilia, increase of ESR and increase of body temperature were found statistically significant difference between the positive CRP and negative CRP group. Most bronchopneumonia patients in this study were probably caused by non bacteria. Neutrophilia, higher ESR and higher body temperature could be used as an indicator of bacterial infection besides the increase of serum CRP levels.

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Leukocyte count and C reactive protein as diagnostic factors in febrile convulsion

Asian Journal of Medical Sciences ◽

10.3126/ajms.v8i2.16331 ◽

2017 ◽

Vol 8 (2) ◽

pp. 56-58

Author(s):

Garima Biyani ◽

Swapan Kumar Ray ◽

Kripasindhu Chatterjee ◽

Sukanta Sen ◽

Pradyut Kumar Mandal ◽

...

Keyword(s):

Leukocyte Count ◽

Febrile Convulsion ◽

Cross Sectional Study ◽

Sectional Study ◽

Medical Sciences ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Significant Difference ◽

Time Of Admission

Background: Febrile convulsion (FC) is the most common seizure disorder in childhood. White blood cell (WBC) and C reactive protein (CRP) are commonly measured in FC. Add a paragraph on Aims and Objectives of the study.Aims and Objectives: To compare WBC and CRP in febrile children, aged 6 months to five years, with and without FC, in order to determine whether leukocytosis and elevated CRP can be used as diagnostic tool for febrile seizure.Materials and Methods: In this cross sectional study 214 children (112 with FC), aged 6 months to 5 years, admitted to in the first 48 hours of their febrile disease, either with or without seizure, were evaluated over a 12 months period. Age, sex, temperature; WBC, CRP and hemoglobin were recorded in all children. There was a significant increase of WBC (P<0.001) in children with FC so we can deduct that leukocytosis encountered in children with FC can be due to convulsion in itself.Results: When comparing FC and non-FC children, we encountered a significant increase of WBC (P =0.0005) in children with FC, measured at the time of admission to pediatric medicine ward. There was no significant difference regarding CRP between the two groups. In fact, elevated CRP is a result of underlying pathology.Conclusion: In stable patients, if there’s no reason to suspect a bacterial infection or who don’t have any indication of lumbar puncture, there’s no need to assess WBC as an indicator of underlying infection. Any child with febrile seizure with a high CRP value should be evaluated for infection.Asian Journal of Medical Sciences Vol.8(2) 2017 56-58

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SEVERE CHRONIC PERIODONTITIS AND C-REACTIVE PROTEIN LEVELS

Revista de Saúde Coletiva da UEFS ◽

10.13102/rscdauefs.v6i2.1168 ◽

2017 ◽

Vol 6 (2) ◽

pp. 1

Author(s):

Johelle De Santana Passos Soares ◽

Isaac Suzart Gomes-Filho ◽

Julita Maria Freitas Coelho ◽

Simone Seixas da Cruz ◽

Luís Claúdio Lemos Correia ◽

...

Keyword(s):

Chronic Periodontitis ◽

Descriptive Analysis ◽

Cross Sectional Study ◽

Blood Collection ◽

C Reactive Protein ◽

Clinical Attachment Loss ◽

Cross Sectional ◽

Protein Levels ◽

Reactive Protein ◽

Significant Difference

This study aims to analyze the relationship between chronic periodontitis and C-reactive protein (CRP), taking certain associated factors into consideration. A cross-sectional study was conducted on a sample of 75 adults of both sexes. After the participants had been interviewed, they underwent physical and dental examinations and blood collection. CRP levels were evaluated by means of nephelometry. A periodontal clinical examination was conducted by trained examiners and the diagnosis of chronic periodontitis was established when at least 30% of the individual’s teeth presented clinical attachment loss ≥ 5 mm. The analysis procedures consisted of descriptive analysis and linear regression. The results showed that there was no statistically significant difference in CRP levels between the groups with and without periodontitis. The median CRP level in the group with periodontitis was 2.3 mg/l (25-75% interquartile range, IQR = 0.74-5.4) and in the group without periodontitis, 1.8 mg/l (25-75% IQR = 0.79-4.54) (p = 0.417). Log CRP was significantly correlated only with the individual’s body mass index (BMI). The main findings from this study indicate that there is no association between severe chronic periodontitis and CRP, and factors like BMI need to be analyzed carefully in studies on this topic.

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Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

Public Health Nutrition ◽

10.1017/s1368980011000395 ◽

2011 ◽

Vol 14 (11) ◽

pp. 2055-2064 ◽

Cited By ~ 19

Author(s):

Anna Floegel ◽

Sang-Jin Chung ◽

Anne von Ruesten ◽

Meng Yang ◽

Chin E Chung ◽

...

Keyword(s):

Elevated Serum ◽

Cross Sectional Study ◽

Elevated Blood ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Antioxidant Intake ◽

The Mean ◽

Serum Crp

AbstractObjectiveTo investigate the association of antioxidant intakes from diet and supplements with elevated blood C-reactive protein (CRP) and homocysteine (Hcy) concentrations.DesignA cross-sectional study. The main exposures were vitamins C and E, carotene, flavonoid and Se intakes from diet and supplements. Elevated blood CRP and Hcy concentrations were the outcome measures.SettingThe US population and its subgroups.SubjectsWe included 8335 US adults aged ≥19 years from the National Health and Nutrition Examination Survey 1999–2002.ResultsIn this US population, the mean serum CRP concentration was 4·14 (95 % CI 3·91, 4·37) mg/l. Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations >3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8·61 (95 % CI 8·48, 8·74) μmol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma Hcy concentrations >13 μmol/l after adjusting for covariates. Flavonoid intake was not associated with the chance of elevated plasma Hcy concentrations.ConclusionsThese results suggest that high antioxidant intake is associated with lower blood concentrations of CRP and Hcy. These inverse associations may be among the potential mechanisms for the beneficial effect of antioxidant intake on CVD risk mediators in observational studies.

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Role of biomarkers in predicting prognosis of Coronavirus disease 2019 (COVID-19): A retrospective cross-sectional study: Perspective of a tertiary care hospital in India

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2021.11.1.0300 ◽

2021 ◽

Vol 11 (1) ◽

pp. 081-090

Author(s):

Arushi Mohan ◽

Padmini SN ◽

Brunda MS ◽

Abhinaya Shekhar ◽

Paul Matthew ◽

...

Keyword(s):

Inflammatory Markers ◽

Cross Sectional Study ◽

Sectional Study ◽

C Reactive Protein ◽

Oxygen Requirement ◽

Cross Sectional ◽

Reactive Protein ◽

Significant Difference ◽

D Dimer

Background: COVID-19 is a novel disease triggered by the SARS-CoV-2 virus, a beta coronavirus similar to MERS-CoV and SARS CoV. Inflammatory markers have a vital role in the pathogenesis of nCOVID 19; understanding the importance of these inflammatory markers in determining disease status is essential given the impact of the disease on healthcare. Thus, being able to triage cases with minimal tests is momentous to capture, which we have investigated as per our study guidelines of the role of inflammatory markers such as D-dimer, CRP (C - reactive protein), Ferritin, LDH (Lactate Dehydrogenase) in patients with COVID 19. In addition, limited data is available comparing the utility of these inflammatory markers to predict the following parameters as the need for ICU, oxygen support requirement, and duration of in-hospital stay, which can help guide the management protocol. Aim: This study aims to determine markers associated with poor prognosis in patients with Coronavirus disease 2019 (COVID-19). Objectives: 1) To assess the inflammatory markers that are routinely investigated in COVID- 19 patients. 2) To determine the most probable factor to estimate severity in COVID- 19 and thus predict prognosis. Methods: This is a retrospective cross-sectional observational study of patients who tested SARS COV 2 positive by RT PCR. The laboratory inflammatory markers, namely Lactate Dehydrogenase, C reactive protein, D-dimer, Ferritin, were assessed in the selected patients, and their clinical data and demographic details were taken into account. The parameters considered for contributing to the severity included the number of days of stay in the hospital, oxygen requirement, and ICU needs. Analyses relied upon analysis of variance for cross-sectional study design and a P< 0.05 statistical significance criterion. Results: There was a statistically significant difference found between oxygen requirement and D dimer (p<0.001), LDH (p= 0.002), and CRP (p= 0.024). There was a statistically significant difference found between admission to ICU and D Dimer (p= 0.001). Conclusion: A statistically significant association between the increasing D-dimer levels and all the outcome measures considered was found. The D-dimer, LDH, and CRP help predict oxygen requirement, and all the inflammatory markers can predict the number of days of stay in the hospital.

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Evaluating serum C-reactive protein level in patients with chronic obstructive pulmonary disease – A cross-sectional study

International Journal of Current Research in Physiology and Pharmacology (IJCRPP) ◽

10.31878/ijcrpp.2019.34.1 ◽

2019 ◽

pp. 1-4

Author(s):

Karthika M ◽

Prakash Chandra Bhardwaj ◽

Laimayum Amarnath Sharma ◽

W Kanan ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Cross Sectional Study ◽

Chronic Obstructive ◽

C Reactive Protein ◽

Cross Sectional ◽

Obstructive Pulmonary Disease ◽

Reactive Protein ◽

Copd Patients ◽

Serum Crp

Abstract Patients with the chronic obstructive pulmonary disease have ongoing systemic inflammation, which can be assessed by measuring serum C- reactive protein. Objective: To explore whether CRP could be used as an independent predictor of disease outcome in COPD. Methods: A cross-sectional study was conducted among 50 COPD patients attending Respiratory Medicine outpatient services in the Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSpheraTM CRP Latex Slide test kit was used to estimate serum c-reactive protein. Results and observation: The present study was conducted on fifty COPD patients in which serum CRP level showed positive correlation with COPD (p=0.002) but serum CRP level with spirometric parameters showed significant negative correlation;FEV1 (r=-0.451, p=0.001), FEV1/FVC (r=-0.617, p<0.001) and PEFR (r=-0.398, p=0.004). Conclusion: In our study, we found an association between serum CRP level and severity of COPD and Plasma CRP may be used as a marker of prognosis in COPD as the small increase is associated with poorer prognosis in COPD. Keywords: CRP; Chronic obstructive pulmonary disease (COPD); Imphal.

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Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.37.4.3841 ◽

2021 ◽

Vol 37 (4) ◽

Author(s):

Sikander Munir Memon ◽

Naresh Kumar ◽

Aneela Atta Ur Rahman ◽

Binafsha Manzoor Syed

Keyword(s):

Smokeless Tobacco ◽

Hematological Parameters ◽

White Blood Cells ◽

Cross Sectional Study ◽

Sectional Study ◽

Long Term Effects ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Significant Difference

Objective: To investigate the changes in levels of C-reactive protein (CRP) and hematological parameters among smokeless tobacco (SLT) users. Methods: A comparative cross-sectional study was conducted at the community level in the coastal districts of Sindh province namely Badin, Thatta, and Sujawal from January 2017 to December 2019. The CRP and hematological parameters were evaluated by well-established methods among SLT and non-SLT users. Results: There was a statistically significant difference between SLT users (mean CRP = 0.77) versus non-users (mean CRP = 0.18), p = <0.001. Among hematological parameters, white blood cells (SLT users median = 7.85 versus non-SLT users median = 8.50, p = 0.004), monocytes (SLT users median = 6.00 versus non-SLT users median = 6.00, p = 0.001) and erythrocyte sedimentation rate (SLT users median = 15.00 versus non-SLT users median = 10.00, p = 0.006) showed statistically significant difference. Conclusions: Significantly elevated CRP was observed in SLT users similarly hematological parameters also showed changes. WBCs, monocytes and ESR were significantly deranged among SLT users. Further studies looking into long term effects of these changes would be helpful. doi: https://doi.org/10.12669/pjms.37.4.3841 How to cite this:Memon SM, Kumar N, Atta-Ur-Rahman A, Syed BM. Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3841 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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High sensitivity C-reactive protein level in various manifestations of tuberculosis in children

Paediatrica Indonesiana ◽

10.14238/pi61.5.2021.253-60 ◽

2021 ◽

Vol 61 (5) ◽

pp. 253-60

Author(s):

Radita Kusumaningrum ◽

Moh Syarofil Anam ◽

Dwi Wastoro Dadiyanto ◽

Maria Mexitalia ◽

Magdalena Sidhartani

Keyword(s):

Community Health Center ◽

High Sensitivity ◽

Cross Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Pulmonary Tb ◽

Reactive Protein ◽

Significant Difference ◽

Extra Pulmonary ◽

Hs Crp

Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Of all TB patients, 40-50% are children. C-reactive protein (CRP) is produced during the inflammation process and is an indicator of active TB disease. High sensitivity CRP (hs-CRP) test has higher accuracy and sensitivity to detect CRP at lower levels. Objective To compare hs-CRP in children with TB infection, pulmonary TB, and extra-pulmonary TB. Methods This cross-sectional study of children with tuberculosis was conducted at Dr. Kariadi Hospital and the Semarang Community Health Center, Semarang, Central Java, from January 2020–February 2021. Inclusion criteria were patients aged 1–18 years with suspected TB (contact with adult TB patient or clinically suspected to have TB). Results From 95 study subjects, 19 had TB infection, 51 had pulmonary TB, and 25 had extra-pulmonary TB. There was a significant increase in hs-CRP level based on prolonged fever (P<0.001), enlarged lymph glands (P=0.004), joint swelling (P=0.006), low WHZ or BMI for age (P=0.048), positive bacteriological evidence (P<0.001), and negative/not done tuberculin skin test (P=0.001). There was a significant difference of hs-CRP level based on TB status, with the highest hs-CRP level in extra-pulmonary TB [14.3 mg/l (0.16–321.5)], followed by pulmonary TB [0.8 mg/l (0.3–129.1)], and TB infection [0.7 mg/l (0.3–20.2)]. The highest hs-CRP level for extra-pulmonary TB was found in abdominal TB [84.5 mg/l (0.6–321.5)]. Conclusion Children with extra-pulmonary TB have significantly higher hs-CRP than children with TB infection or pulmonary TB.

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Retinal and Choroidal Thickness in relation to C-Reactive Protein on Swept-Source Optical Coherence Tomography

Journal of Immunology Research ◽

10.1155/2021/6628224 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Dawei Fang ◽

Qingjian Li ◽

Ke Yan ◽

Sennan Xu ◽

Jing Jiang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Choroidal Thickness ◽

Retinal Thickness ◽

Cross Sectional Study ◽

Optical Coherence ◽

C Reactive Protein ◽

Cross Sectional ◽

Swept Source ◽

Reactive Protein ◽

Significant Difference

Purpose. To evaluate the relationships between C-reactive protein (CRP) and retinal and choroidal thickness by swept-source optical coherence tomography (SS-OCT). Methods. The participants included in the prospective cross-sectional study underwent a comprehensive ophthalmic examination. Based on the CRP values, the subjects were divided into the CRP (+) group ( CRP ≥ 8.2 mg/L) and the CRP (−) group ( CRP < 8.2 mg/L). The retinal and choroidal thickness was compared between the two groups. Results. This study enrolled 43 right eyes of 43 subjects from the CRP (+) group and 86 right eyes of 86 gender- and age-match subjects from the CRP (−) group. The choroidal thickness in the CRP (+) group was thinner than that in the CRP (−) group except for the outer nasal sector of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. However, the retinal thickness only in the inner temporal sector showed a significant difference. According to Pearson’s correlation analysis, the CRP was significantly negatively correlated with the choroidal thickness in all sectors and the retinal thickness only in the inner temporal and outer nasal sectors of the ETDRS grid. Conclusion. CRP levels are associated with retinal and choroidal thickness. The data related to the retinal and choroidal thickness changes may help understand the pathogenesis of specific ocular abnormalities in patients with systemic inflammation.

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NEONATAL SEPSIS;

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.04.3362 ◽

2019 ◽

Vol 26 (04) ◽

Author(s):

Mohammad Irshad ◽

Mohsin Hayat ◽

Hina Parvez ◽

Ihsan Ullah ◽

Zia ur Rehman

Keyword(s):

Neonatal Sepsis ◽

Gold Standard ◽

Antibiotic Use ◽

Cross Sectional Study ◽

Blood Cultures ◽

C Reactive Protein ◽

Cross Sectional ◽

Predictive Values ◽

Female Ratio ◽

Reactive Protein

Objectives: To determine the diagnostic accuracy of C-reactive protein in the diagnosis of neonatal sepsis keeping blood cultures as gold standard. Study Design: Descriptive cross-sectional study. Setting: Pediatric Unit of Lady Reading Hospital Peshawar Pakistan. Duration: Six months from 09-06-2012 to 08-12-2012. Methodology: Total of 196 patients meeting the required inclusion criteria with clinical suspicion of sepsis. Those neonates were subjected to investigations. C.R.P. was tested using the Quantitative method according to the instructions provided with the kit. By keeping blood culture as gold standard, patients with both positive and negative cultures were taken and the results compared to the results of C.R.P. in these subjects being positive or negative. Results: Among the 196, majority of the neonates included were less than a week old having a mean age of 4.5 days. There were 57 (29%) females and 139 (71%) males, with male to female ratio of 2.4:1. Blood cultures were positive in 85 (43%) and negative in 111 (57%) cases, while C.R.P. was positive in 95 (48%) and negative in 101 (52%) cases. Sensitivity, specificity, and positive and predictive values of C-reactive protein were calculated using formulas, and they turned out to be 77.6%, 73.8%, 69.4%, and 81.2% respectively with accuracy being 0.41%. Conclusion: An accurate and timely diagnosis of early onset neonatal sepsis remains challenging to the clinician as well as laboratory. Physicians can prevent unnecessary antibiotic use by performing the qualitative estimation CRP as a single, rapid and inexpensive test with a negative predictive value of 81.2%.

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Serum C-reactive protein levels in severe and very severe pneumonia in children

Paediatrica Indonesiana ◽

10.14238/pi52.3.2012.161-4 ◽

2012 ◽

Vol 52 (3) ◽

pp. 161

Author(s):

Ni Putu Sucita Wahyu Dewi ◽

Putu Siadi Purniti ◽

Roni Naning

Keyword(s):

Severe Pneumonia ◽

Cross Sectional Study ◽

Sectional Study ◽

C Reactive Protein ◽

Cross Sectional ◽

Pneumonia Severity ◽

Protein Levels ◽

Reactive Protein ◽

Median Serum ◽

Serum Crp

Background Pneumonia is a major cause of death in children fromdeveloping countries. It is difficult to assess pneumonia severity ifclinical symptoms of pneumonia are unclear, co-morbidities occursimultaneously, or there is an absence of consolidation or infiltrateson chest radiograph. Examination of C-reactive protein (CRP)levels can help to determine the severity of pneumonia.Objective To compare serum CRP levels in severe and very severepneumonia cases.Methods This was a cross-sectional study on pediatric patientsaged> 28 days up to 60 months v.ith a diagnosis of severe or verysevere pneumonia. Subjects were hospitalized at the Departmentof Child Health, Udayana University Medical SchooliSanglahHospital, Denpasar from May 2010 to January 2011. There were30 subjects in each group, severe or very severe pneumonia. Datawere analyzed using Mann-Whitney and ANCOVA tests withstatistical significance set at P < 0.05.Results There were significant differences in median serum CRPlevels in the severe and very severe pneumonia groups. The verysevere pneumonia group had a median CRP level of 54.75 mgiL(lQrange 0.22 to 216.00) and the severe pneumonia group had amedian CRP level ofl6.06 mgiL (IQ range 0.97 to 89.35). SerumCRP levels were influenced by the severity of pneumonia (P =0.002) and the timing of the CRP examination (P = 0.001).Conclusion Subjects with very severe pneumonia hadsignificantly higher median CRP level compared to that of subjectswith severe pneumonia. [Paediatr Indones. 2012;52:161A].

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