scholarly journals Clinicoradiological Evaluation and Correlation of High-Resolution Computed Tomography Findings with Type 2 Diabetes Mellitus in Coronavirus Disease-19 Patients

2021 ◽  
Vol 10 (37) ◽  
pp. 3242-3246
Author(s):  
Sanjay Tukaram Thorat ◽  
Niyti Vinod Kaila ◽  
Parikshit Gajanan Mankar ◽  
Radhika Ratanlal Bajaj ◽  
Avanti Jayant Damle ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Computed Tomography ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
High Resolution ◽  
Severity Score ◽  
Density Lipoprotein ◽  
Glycated Haemoglobin ◽  
High Resolution Computed Tomography

BACKGROUND Type 2 diabetes mellitus (T2DM) has emerged as the leading comorbidity in patients with coronavirus disease 2019 (COVID-19). However, data obtained on the correlation between the incidences of T2DM with COVID-19 are limited. We wanted to assess the severity of patients with T2DM and COVID-19, and study the correlation between the high-resolution computed tomography (HRCT) findings and hyperglycaemia with disease severity. METHODS This cross-sectional study included 100 patients with a history of diabetes and diagnosed COVID-19 positive. Data were collected using a semi-structured questionnaire. P < 0.05 was considered statistically significant. RESULTS The mean age was 58.81 ± 11.43 years with male preponderance (71 %). The difference was statistically significant in mean glycated haemoglobin (HbA1c) (7.32 ± 1.39 %, P < 0.001), mean high - density lipoprotein (HDL ; 39.78 ± 6.76 mmol / L), low - density lipoprotein (LDL; 63.23 ± 13.36 mmol / L), and triglyceride (TG; 140.70 ± 43.57 mg / dL) levels (P < 0.05) in different CT severity score. Mean HbA1c (P < 0.001), LDL, and CT severity scores (P = 0.034 and P < 0.001) were highly significant in patients who died than the discharged patients. A significant positive correlation was seen between CT severity score with HbA1c, LDL, and TG levels and chances of death (P < 0.001) rates, and also between the patients who died and HbA1c (P < 0.001) and LDL (P = 0.034) levels and CT severity score (P < 0.001). CONCLUSIONS Ideal management of the metabolic equilibrium of glucose was crucial in assuring an improved clinical outcome. Increased surveillance was warranted for diabetic COVID-19 patients. KEY WORDS COVID-19, Glycated Haemoglobin A, Hyperglycaemia, Severe Acute Respiratory Syndrome Coronavirus 2

scholarly journals New clusters of type 2 diabetes mellitus and their outcomes: relation between pharmacological treatment and previous cardiovascular events

2021 ◽  
Vol 31 (Supplement_2) ◽  
Author(s):  
Claudio Santos ◽  
Sonia Brito-Costa ◽  
Luis Margalho ◽  
Pedro Monteiro
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pharmacological Treatment ◽  
Cardiovascular Events ◽  
Glycated Haemoglobin ◽  
Research Unit ◽  
Clinical Research Unit ◽  
History Of

Abstract Background Type 2 Diabetes Mellitus (T2DM) is the most common form of diabetes in adults, with 90% to 95% of cases. This study aims to establish clusters and have knowledge about the relationship between previous cardiovascular events and pharmacological treatment for T2DM. Methods 191 participants (EG) with T2DM with the average of 70.3 years (SD = 8.3) and 36 with pre-diabetes (CG) with an average of 62 years (SD = 10.3) who participated in clinical trials at Clinical Research Unit in Cardiology of Coimbra Hospital and Universitary Centre without cognitive difficulties, were divided in 5 different clusters. These were established based on six different variables: body mass index (BMI), age of each individual, age at diagnosis of DMT2, glycated haemoglobin value (HbA1c), homeostatic model that estimates the function of β cells (HOMA2-B) and insulin resistance (HOMA2-IR). Results Cluster 1 presented pre-diabetic individuals (15.9%), while diabetic individuals were divided into clusters 2 (1.8%), 3 (17.6%), 4 (21.1%) and 5 (43.6%). Regarding the study of the prevalence of previous cardiovascular events, the majority of individuals present in the different clusters had history of acute myocardial infarction (AMI). As for the prevalence of pharmacological treatment for DMT2, it was found that metformin was the most used drug. It was observed a relationship between previous AMI and metformin administration in clusters 3 (P = 0.0027; P &lt; 0.05) and 5 (P = 0.0059; P &lt; 0.05). Conclusions It was possible to create different clusters in a sample of the Portuguese population and to observe the existence of dependency relationships between different previous cardiovascular events and pharmacological treatment.

scholarly journals Effects of Probiotic Supplementation on Dyslipidemia in Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials

Foods ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1540
Author(s):  
Chen Wang ◽  
Chengcheng Zhang ◽  
Sijia Li ◽  
Leilei Yu ◽  
Fengwei Tian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Controlled Trials ◽  
Probiotic Supplementation ◽  
Randomized Controlled

The effectiveness of probiotic consumption in controlling dyslipidemia in type 2 diabetes mellitus (T2DM) has been unclear. We reviewed relevant randomized controlled trials (RCTs) to clarify the effect of probiotic intake on dyslipidemia in T2DM patients. The Web of Science, Scopus, PubMed and Cochrane Library databases were used for searching relevant RCTs published up to October 2020. The total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were selected as the primary indicators for dyslipidemia. The results of 13 eligible RCTs showed that probiotic intake could significantly reduce TC (SMD: −0.23, 95% CI: (−0.37, −0.10)) and TG (SMD: −0.27, 95% CI: (−0.44, −0.11)) levels, but did not regulate LDL-C or HDL-C concentrations. Subgroup analysis showed that multispecies probiotics (≥two species), but not single-species probiotics, significantly decreased TC and TG concentrations. Furthermore, powder, but not liquid, probiotics could reduce TC and TG concentrations. This meta-analysis demonstrated that probiotic supplementation is helpful in reducing TC and TG concentrations in T2DM patients. However, more well-controlled trials are needed to clarify the benefits of probiotics on dyslipidemia in T2DM patients.

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